A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels

A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT SyndromeNovelty and Significance

(2016) Worawan B. Limpitikul et al.   CIRCULATION RESEARCH

Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation

(2016) Ivy E. Dick et al.   Nature Communications

Large Ca2+-dependent facilitation of CaV2.1 channels revealed by Ca2+photo-uncaging

(2015) Shin-Rong Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Apocalmodulin Itself Promotes Ion Channel Opening and Ca2+ Regulation

(2014) Paul J. Adams et al.   CELL

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

(2014) Hyun Seok Hwang et al.   CIRCULATION RESEARCH

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Ca2+ channel nanodomains boost local Ca2+ amplitude

(2013) M. R. Tadross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

(2013) Manu Ben Johny et al.   Nature Communications

Theoretical study of L-type Ca2+current inactivation kinetics during action potential repolarization and early afterdepolarizations

(2012) Stefano Morotti et al.   JOURNAL OF PHYSIOLOGY-LONDON

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels

(2010) Michael R. Tadross et al.   JOURNAL OF GENERAL PHYSIOLOGY

Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium

(2009) Keith F. Decker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes

(2009) S. Ikeda et al.   MOLECULAR AND CELLULAR BIOLOGY

Calmodulin Mediates Differential Sensitivity of CaMKII and Calcineurin to Local Ca2+ in Cardiac Myocytes

(2008) Jeffrey J. Saucerman et al.   BIOPHYSICAL JOURNAL

Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel

(2008) Michael R. Tadross et al.   CELL

Role of Ca V β Subunits, and Lack of Functional Reserve, in Protein Kinase A Modulation of Cardiac Ca V 1.2 Channels

(2008) Jayalakshmi Miriyala et al.   CIRCULATION RESEARCH

A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels

(2008) Ivy E. Dick et al.   NATURE

A Rabbit Ventricular Action Potential Model Replicating Cardiac Dynamics at Rapid Heart Rates

(2007) Aman Mahajan et al.   BIOPHYSICAL JOURNAL

Physiological modulation of voltage-dependent inactivation in the cardiac muscle L-type calcium channel: A modelling study

(2007) Ian Findlay et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY