Article
Ecology
Zhuxiang Jiang, Shuangshuang Ping, Cuili Jin, Chuandeng Tu, Xiaojian Zhou
Summary: This study investigates the mechanisms of histamine-induced larval settlement in barnacles. Transcriptomic analyses reveal differentially expressed genes involved in the mitogen-activated protein kinase signaling pathway. Functional genes related to cyprid settlement are identified, including those involved in energy metabolism. AdipoR is identified as an important gene that affects cyprid settlement through regulation of energy metabolism.
MARINE ECOLOGY PROGRESS SERIES
(2022)
Article
Engineering, Biomedical
Mohammad Assadizadeh, Nima Goodarz, Amir Hossein Mahdavi Pak, Seyyed Mohammad Hasan Haghayeghi, Maryam Azimzadeh Irani
Summary: This study used artificial intelligence-based structure prediction and molecular docking to investigate the potential role of two proteins in the formation of amyloid-like nanofibers in barnacles. The results showed that these proteins have specific structural properties that can be used in developing bioadhesives and designing antifouling substances.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Maja Rischer, Huijuan Guo, Christine Beemelmanns
Summary: This article summarizes the biochemical and microbial knowledge about microbial signaling molecules, con-specific signals, and synthetic compounds that induce or prevent recruitment, settlement, and metamorphosis in invertebrate larvae. The research field has recently gained significant momentum and provides insights for future research directions in marine chemical ecology.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Applied
Yongxin Teng, Ting Zhang, Hongmin Dai, Yabin Wang, Jianteng Xu, Xin-An Zeng, Bin Li, Xiangwei Zhu
Summary: Chickpea protein has low solubility, limiting its application in food. To overcome this, pea protein was coassembled with chickpea protein, resulting in increased solubility and improved stability against environmental stresses. This study provides a novel approach for modifying chickpea protein and formulating protein-based products.
Article
Materials Science, Multidisciplinary
Wetra Yandi, Bela Nagy, Andreas Skallberg, Kajsa Uvdal, Ralf Zimmermann, Bo Liedberg, Thomas Ederth
Summary: Polyampholytic poly(2-aminoethyl methacrylate-co-sulfopropyl methacrylate) thin films prepared by self-initiated photopolymerization and photografting showed promising potential as an alternative to zwitterionic poly(sulfobetaine methacrylate) films for antifouling applications. The films exhibited similar fouling behavior to zwitterionic films, suggesting suitability for high-salinity conditions such as marine or physiological environments.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Physical
Anna Luise Grab, Dirk Hose, Patrick Horn, Elisabetta Ada Cavalcanti-Adam, Anja Seckinger, Martin Mueller
Summary: This study introduces an interfacial delivery system for local treatment of MM and induced bone disease using PEC NP loaded with BMP-6. The BMP-6 loaded PEC NP showed sustained release of BMP-6 and induced apoptosis in MMCs, suggesting a potential for local treatment of MM induced bone lesions.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Temponeras, George Stamatakis, Martina Samiotaki, Dimitris Georgiadis, Harris Pratsinis, George Panayotou, Efstratios Stratikos
Summary: Recent studies have found that pharmacological inhibition of ER aminopeptidase 2 (ERAP2) could potentially improve the efficacy of cancer immunotherapy. In this study, MOLT-4 T lymphoblast leukemia cells were treated with a selective ERAP2 inhibitor, resulting in significant shifts in the immunopeptidome. The newly generated peptides induced by the inhibitor could trigger cytotoxic responses against cancer cells and enhance the therapeutic effect of immune-checkpoint inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Vasiliki-Dimitra C. Tsolaki, Sofia K. Georgiou-Siafis, Athina Tsamadou, Stefanos A. Tsiftsoglou, Martina Samiotaki, George Panayotou, Asterios S. Tsiftsoglou
Summary: The study investigated the kinetics of intracellular accumulation of hemin in human transformed proerythroid K562 cells, revealing that the process is time and temperature-dependent and affected by the properties of hemin. Hemin-uptake exhibited saturation kinetics and involved a carrier-cell surface receptor-mediated process, with most hemin accumulating in the cytoplasm and a portion entering the nucleus. Analysis identified a variety of hemin-binding proteins (HeBPs) in different cellular compartments, suggesting their role in the homeostatic regulation of heme.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Vasiliki-Iris Perivolidi, Foteini Violitzi, Elisavet Ioannidou, Vagelis Rinotas, George Stamatakis, Martina Samiotaki, George Panayotou, Eleni Douni
Summary: This study identified the interactome of SLC2SA46, a mitochondrial protein, and found that it interacts with multiple proteins involved in mitochondrial architecture, energy production, and inter-organellar contacts. Tissue-specific enrichment of interactors was observed.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Plant Sciences
Aliki Xanthopoulou, Theodoros Moysiadis, Christos Bazakos, Evangelos Karagiannis, Ioanna Karamichali, George Stamatakis, Martina Samiotaki, Maria Manioudaki, Michail Michailidis, Panagiotis Madesis, Ioannis Ganopoulos, Athanassios Molassiotis, Georgia Tanou
Summary: The study provides new insights into plant biology through the integration of genomics and proteomics, identifying a large number of genes and proteins in sweet cherries. Analysis reveals differences between gene and protein quantities, key regulators of fruit development, and novel cherry proteins. Additionally, a new protein-level annotation and database were developed for further research in Prunus species.
Article
Cell Biology
Konstantina Katsarou, Charith Raj Adkar-Purushothama, Emilios Tassios, Martina Samiotaki, Christos Andronis, Purificacion Lison, Christoforos Nikolaou, Jean-Pierre Perreault, Kriton Kalantidis
Summary: In this study, advanced bioinformatic analysis, in vitro experiments, and LC-MS/MS were used to search for small viroid peptides of the PSTVd. Results suggest that under the experimental conditions, no produced peptides were identified, indicating that the presence of PSTVd in ribosomes is most likely not related to peptide production but rather to another unknown function that requires further study.
Article
Neurosciences
Nasia Antoniou, Kanella Prodromidou, Georgia Kouroupi, Ioanna Boumpoureka, Martina Samiotaki, George Panayotou, Maria Xilouri, Ismini Kloukina, Leonidas Stefanis, Regis Grailhe, Era Taoufik, Rebecca Matsas
Summary: Combining high throughput screening with iPSC-based disease modeling, a small molecule with neuroprotective actions for Parkinson's disease has been identified.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemical Research Methods
Aikaterini G. Karra, Aikaterini Sioutopoulou, Vyron Gorgogietas, Martina Samiotaki, George Panayotou, Anna-Maria G. Psarra
Summary: This study characterized mitochondrial glucocorticoid receptor interacting proteins, revealing potentially new regulatory roles of the receptor in mitochondria. The interactions between mtGR and PDH, as well as mtGR and HSP60, suggest involvement of mtGR in energy production regulation and mitochondrial import processes. These findings uncover potential novel regulatory roles of mtGR in coordinating nuclear and mitochondrial functions.
JOURNAL OF PROTEOMICS
(2022)
Article
Neurosciences
Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M. C. Skoulakis, Katerina Papanikolopoulou
Summary: Tau accumulation is associated with Alzheimer's disease and other Tauopathies. This study identifies Mical as a novel protein that interacts with human Tau and alters its interactions with microtubules and the Actin cytoskeleton. Mical's redox activity, specifically the oxidation of Cys322, is shown to play a crucial role in Tau aggregation propensity and toxicity.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maria Paschou, Panagiota Papazafiri, Chrysanthi Charalampous, Michael Zachariadis, Skarlatos G. Dedos, Epaminondas Doxakis
Summary: This study reveals that miR-124-3p and miR-153-3p regulate the expression of RyRs and IP(3)Rs, and maintain Ca2+ homeostasis by reducing ER Ca2+ release. Furthermore, these miRNAs alleviate cytosolic Ca2+ overload and protect protein-folding capacity by attenuating PERK signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Plant Sciences
Christina Skodra, Michail Michailidis, Theodoros Moysiadis, George Stamatakis, Maria Ganopoulou, Ioannis-Dimosthenis S. Adamakis, Lefteris Angelis, Ioannis Ganopoulos, Georgia Tanou, Martina Samiotaki, Christos Bazakos, Athanassios Molassiotis
Summary: This study reveals the protective role of low-salt pre-exposure in olive trees under high salinity stress, and identifies the sugar regulation mechanisms and hormone signaling pathways involved. Additionally, proteogenomic analysis uncovers the differences between the transcriptome and proteome in response to salinity, as well as key protein post-translational modifications and interaction networks related to salt priming.
Article
Cell Biology
Patricia A. Gomes, Cristian Bodo, Carlos Nogueras-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana M. Silva, Barbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Summary: Background: Extracellular vesicles (EVs) have great potential in the diagnosis and treatment of brain disorders, and are a valuable tool for precision medicine. However, the collection and characterization of physiologically relevant EVs are of utmost importance.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Medicinal
Elli-Anna Stylianaki, Christiana Magkrioti, Eleni M. Ladopoulou, Konstantinos D. Papavasileiou, Panagiotis Lagarias, Georgia Melagraki, Martina Samiotaki, George Panayotou, Skarlatos G. Dedos, Antreas Afantitis, Vassilis Aidinis, Alexios N. Matralis
Summary: Robust experimental evidence has shown the importance of the ATX/LPA axis in chronic inflammatory conditions, fibroproliferative diseases, and cancer. Various ATX inhibitors have been discovered, with the first-in-class inhibitor currently in advanced clinical trials for idiopathic pulmonary fibrosis. The mode of inhibition and binding mechanism of these inhibitors to ATX have been studied.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Nikolaos Bekas, Martina Samiotaki, Maria Papathanasiou, Panagiotis Mokos, Athanasios Pseftogas, Konstantinos Xanthopoulos, Dimitris Thanos, George Mosialos, Dimitra Dafou
Summary: This study reveals the important regulatory role of CYLD in the early stages of somatic cell reprogramming. CYLD DUB deficiency reduces reprogramming efficiency and hinders the mesenchymal-to-epithelial transition (MET) process. These findings expand our understanding of early reprogramming mechanics and highlight the significance of CYLD as an extracellular matrix regulator.
Article
Genetics & Heredity
Paraskevi Karousi, Martina Samiotaki, Manousos Makridakis, Jerome Zoidakis, Diamantis C. Sideris, Andreas Scorilas, Thomas Carell, Christos K. Kontos
Summary: This study investigates the role of 3'-tRF-Cys(GCA) in gene expression regulation in HEK-293 cells and finds that it can regulate gene expression by affecting multiple cellular pathways. Additionally, the study identifies the direct interaction between 3'-tRF-Cys(GCA) and thymopoietin and its modulation of the protein's levels.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Athanasios Armakolas, Vasiliki Dimopoulou, Adrianos Nezos, George Stamatakis, Martina Samiotaki, George Panayotou, Maria Tampaki, Martha Stathaki, Spyridon Dourakis, John Koskinas
Summary: This study investigated diagnostic markers for the early detection of hepatocellular carcinoma (HCC) based on proteome analysis, microRNAs, and circulating tumor cells (CTCs). The results showed that miR-200b, APOA2, and APOC3 proteins are sensitive markers and can potentially be used for the early diagnosis of HCC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)