Journal
JOURNAL OF DERMATOLOGICAL SCIENCE
Volume 93, Issue 1, Pages 2-7Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2018.11.008
Keywords
B cells; Regulatory B cells; Effector B cells; Systemic lupus erythematosus; Systemic sclerosis; Cytokine; IL-6; IL-10; BAFF
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B cells have moved to the center stage in many autoimmune diseases including autoantibody-mediated diseases and T cell-mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. B cells play an important role for immune response beyond antibody production through mechanisms like antigen presentation and cytokine production. However, not all B cells positively regulate immune responses. Regulatory B cells negatively regulate immune responses by production of anti-inflammatory cytokines such as IL-10, IL-35, and TGF-beta. Regulatory B cells have been found to be decreased and/or functionally impaired in various autoimmune diseases. In contrast, B cells also produce pro inflammatory cytokines, such as IL-6, IFN-gamma and GM CSF. These effector B cells contribute to the pathogenesis of autoimmune diseases. Regulatory and effector B cell balance regulates immune response through the release of cytokines. Furthermore, a protocol that selectively depletes effector B cells while sparing regulatory B cells would represent a potent therapy for autoimmune diseases rather than pan-B cell depletion using anti-CD20 mAb. (C) 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
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