Journal
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
Volume 47, Issue 3, Pages 523-529Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jcms.2019.01.015
Keywords
OSCC; HNSCC; miRNA; Biomarker; Recurrence; FFPE
Categories
Funding
- Department of Oral and Maxillofacial Plastic Surgery
- Comprehensive Cancer Center Mainfranken (CCCMF), University Hospital Wurzburg, Germany
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Objectives: Locoregional disease recurrence and metastatic events are the leading causes of death and the most important prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). A major goal of oncology is the identification of clinical and molecular parameters to evaluate the individual risk of recurrence. MicroRNAs (miRNAs) have been shown to correlate well with tumor size and differentiation. Therefore, they are candidate biomarkers for estimating clinical outcomes. Materials and methods: In this study, the expression levels of distinct miRNAs extracted from formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were compared. Results: Statistical analysis revealed significant correlations between distinct miRNAs and disease recurrence (miR-99*, miR-194*; p < 0.05) and overall survival (miR-99*; p < 0.05). The results were then validated via data from The Cancer Genome Atlas (TCGA). Conclusions: Our data show that miR-99* and miR-194* can possibly serve as biomarkers for clinical outcome in HNSCC. These findings may help to identify high-risk patients, who could profit from a more individualized treatment and follow-up. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
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