Review
Public, Environmental & Occupational Health
Wenjia Chen, Nigel Chong Boon Wong, Yi Wang, Yaroslava Zemlyanska, Dimple Butani, Suchin Virabhak, David Bruce Matchar, Thittaya Prapinvanich, Yot Teerawattananon
Summary: This study aimed to determine the heterogeneity in the value for money of precision medicine (PM) across different application types and contexts. The analysis of cost-effectiveness of PM interventions showed that publicly sponsored studies found genetic testing and gene therapy to be not cost-effective, while studies funded by commercial entities and early stage evaluations had contradictory results. Evidence of cost-effectiveness was found in genetic tests for screening, diagnosis, or companion diagnostics, as well as multigene panel testing, but only in specific disease areas and high-income countries. Incremental effectiveness was a key driver for value in genetic tests but not in gene therapy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Oncology
Athaya Febriantyo Purnomo, Besut Daryanto, Kurnia Penta Seputra, Taufiq Nur Budaya, Nurul Cholifah Lutfiana, Fahrul Nurkolis, Sanghyun Chung, Jin Young Suh, Moon Nyeo Park, Byung-Kwan Seo, Bonglee Kim
Summary: This research examines how gene variations, specifically in the MTHFR gene, contribute to the development of bladder cancer. The study conducts a meta-analysis of seven relevant studies and finds a significant association between a specific genetic variant (rs1801133) and bladder cancer risk, particularly in the Asian population. Individuals with the T-allele or TT genotype have a higher likelihood of developing bladder cancer compared to those with the C-allele. This research is important for enhancing our understanding of the genetic factors involved in bladder cancer and can potentially lead to targeted prevention and personalized treatment strategies.
Article
Oncology
Istvan Petak, Maud Kamal, Anna Dirner, Ivan Bieche, Robert Doczi, Odette Mariani, Peter Filotas, Anne Salomon, Barbara Vodicska, Vincent Servois, Edit Varkondi, David Gentien, Dora Tihanyi, Patricia Tresca, Dora Lakatos, Nicolas Servant, Julia Deri, Pauline du Rusquec, Csilla Hegedus, Diana Bello Roufai, Richard Schwab, Celia Dupain, Istvan T. Valyi-Nagy, Christophe Le Tourneau
Summary: The study introduces an artificial intelligence-assisted computational method, the digital drug-assignment (DDA) system, to prioritize potential molecularly targeted agents (MTAs) for each cancer patient based on their individual molecular profile. Results from the clinical trial show that patients with higher DDA scores experienced better disease control and longer progression-free survival compared to those with lower scores, indicating promising potential of AI-based systems like DDA in improving precision oncology outcomes.
NPJ PRECISION ONCOLOGY
(2021)
Review
Chemistry, Physical
Susana Campuzano, Rodrigo Barderas, Paloma Yanez-Sedeno, Jose M. Pingarron
Summary: Precision medicine aims to provide detailed characterization of diseases through the interactive system of multiple layers of molecular markers, while the simultaneous analysis of multiple layers of molecular markers leads to novel strategies for early detection, prevention, and treatment of diseases. Electrochemical biosensing, showing versatility for simultaneous monitoring of different omics layers biomarkers, can contribute to the advent of precision medicine and help face the challenges ahead.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vivek Bhakta Mathema, Partho Sen, Santosh Lamichhane, Matej Oresic, Sakda Khoomrung
Summary: Cancer progression is influenced by gene-environment interactions, and biomarkers can be used to improve diagnosis and treatment. High-throughput profiling technologies have enabled data-driven biomarker discoveries, but traditional statistical techniques have limitations. Machine learning and deep learning approaches have been increasingly used to investigate diseases and optimize prediction models.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Theodoros Karampitsakos, Brenda M. Juan-Guardela, Argyris Tzouvelekis, Jose D. Herazo-Maya
Summary: Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal chronic lung disease. Precision medicine approaches have not been effectively implemented in IPF clinical practice, despite the existence of numerous diagnostic, prognostic, and theragnostic biomarker candidates.
Review
Medicine, General & Internal
Zihan Yin, Tao Xu, Mingsheng Sun, Ling Zhao, Fanrong Liang
Summary: This study aims to systematically review the efficacy and safety of acupuncture treatment for breathlessness in patients with advanced cancer, based on existing randomized controlled trials. Data will be retrieved from multiple databases and clinical registry platforms, with primary outcome being the alleviation of breathlessness. Meta-analysis and trial sequential analysis will be conducted to assess the quality of evidence from randomized controlled trials.
Article
Medicine, General & Internal
Kristine J. Rosenberger, Haitao Chu, Lifeng Lin
Summary: This study compared the performance of bivariate linear mixed model (LMM) and bivariate generalized linear mixed model (GLMM) in meta-analyses of diagnostic studies. The results showed that bivariate GLMM generally produced narrower confidence intervals compared to bivariate LMM, and could produce different results in specific situations.
Review
Gastroenterology & Hepatology
Peter A. Dobranowski, Alain Stintzi
Summary: Resistant starches have the potential to modulate health by affecting the gut microbiome, but there is significant inter-individual variation in their effects, suggesting that the choice of resistant starch and the individual's baseline microbiome are crucial factors.
Review
Health Care Sciences & Services
Vianney Gilard, Stephane Derrey, Stephane Marret, Soumeya Bekri, Abdellah Tebani
Summary: Neurosurgeons have always defined themselves as physicians with a surgical practice, and they are now striving to effectively embrace the era of data-driven medicine in the ongoing precision medicine surge that drives patient-centric healthcare. The convergence between surgery and precision medicine is best illustrated in neuro-oncology, paving the way for new medical perspectives. Prominent advances in healthcare and big data challenge the medical community to deeply rethink current and future medical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Jincheng Lei, Mingjie Shao
Summary: This research plan aims to use meta-analysis to examine the association between marijuana smoking and asthma, in order to enhance the understanding of the potential adverse effects of marijuana smoking on pulmonary health and facilitate the development of asthma prevention strategies. The study will systematically search relevant observational studies, extract effect sizes for pooled analyses, and assess the quality and risk of bias. The findings will be disseminated through publication in a peer-reviewed journal or relevant conferences.
Review
Nutrition & Dietetics
Ji Hee Jun, Tae Young Choi, Hye Won Lee, Lin Ang, Myeong Soo Lee
Summary: RCT studies on herbal medicine decoctions for treating Behcet's disease showed significant effects on the total response rate and erythrocyte sedimentation rate, but not on C-reactive protein level. Herbal medicine also significantly decreased the recurrence rate after three months of follow-up.
Review
Medicine, General & Internal
Darya Smetanina, Shamsa Al Awar, Howaida Khair, Meera Alkaabi, Karuna M. Das, Milos Ljubisavljevic, Yauhen Statsenko, Kornelia Teresa Zareba
Summary: This article aims to systematically review and synthesize existing data to establish the link between breastfeeding and sexual dysfunction. A comprehensive literature search will be conducted, and a random-effects model meta-analysis will be used to calculate pooled frequency measures and effect size. The findings will be published in a peer-reviewed journal and presented at scientific conferences based on previously published original studies.
Review
Biotechnology & Applied Microbiology
Yan Jia, Jigao Sun, Yan Zhao, Kaiqiang Tang, Ruizheng Zhu, Wei Zhao, Rongtian Wang, Yanqiong Zhang, Na Lin, Weiheng Chen
Summary: A meta-analysis of randomized controlled trials showed that Chinese patent medicine (CPM) as a first-line treatment for osteoporosis (OP) in adults can significantly improve bone mineral density (BMD) and relieve pain symptoms, with a higher total effectiveness rate and lower risk of adverse events compared to standard western treatment.
Review
Plant Sciences
Lin Ang, Eunhye Song, Junhua Zhang, Hye Won Lee, Myeong Soo Lee
Summary: This overview of systematic reviews on herbal medicine interventions for COVID-19 shows that although there is some evidence supporting the advantages of herbal therapy, the quality of the evidence is inadequate to make definitive and accurate judgments.
Article
Cardiac & Cardiovascular Systems
Shuang Zhou, Zhe Wang, Zhiyan Liu, Guangyan Mu, Qiufen Xie, Zining Wang, Qian Xiang, Yanjun Gong, Yimin Cui
Summary: This study analyzed genetic polymorphisms and found that certain SNPs may increase the risk of in-stent restenosis and revascularization after the first PCI in Chinese patients.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Nan Zhao, Zhiyan Liu, Qiufen Xie, Zhe Wang, Zhongyi Sun, Qian Xiang, Yimin Cui
Summary: The study investigated the complex rivaroxaban dose regimen for Asian NVAF patients, exploring the relationship between individual factors, biomarkers, and bleeding events. It concluded that fixed doses of rivaroxaban could be prescribed for NVAF patients without adjustment for certain covariates. Randomized studies are needed to assess the efficacy and safety of low-dose rivaroxaban in Chinese NVAF patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Qiufen Xie, Yuan Li, Zhiyan Liu, Guangyan Mu, Hanxu Zhang, Shuang Zhou, Zhe Wang, Zining Wang, Jie Jiang, Xin Li, Qian Xiang, Yimin Cui
Summary: This study identified genetic variations that affect the metabolism of dabigatran in healthy Chinese subjects. These findings provide insights into the individual differences in dabigatran metabolism and the potential for personalized medicine.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Zhuo Zhang, Hanxu Zhang, Jiao Yu, Ling Xu, Xiaocong Pang, Qian Xiang, Qianxin Liu, Yimin Cui
Summary: The study found that many miRNAs may be associated with NAC response and prognosis in BC patients. Further well-designed studies are needed to elucidate the molecular mechanisms underlying these associations.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Zhiyan Liu, Guangyan Mu, Qiufen Xie, Hanxu Zhang, Jie Jiang, Qian Xiang, Yimin Cui
Summary: This study validated the Hemoclot thrombin inhibitor assay as a quantitative detection method for dabigatran and provided expected peak and trough levels. Analysis of healthy subjects and patients showed good agreement between HTI and HPLC-MS/MS measurements.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qian Xiang, Zhe Wang, Guangyan Mu, Qiufen Xie, Zhiyan Liu, Shuang Zhou, Hanxu Zhang, Zining Wang, Kun Hu, Hongtao Song, Dongdong Yuan, Quan Xia, Yan Huang, Yimin Cui
Summary: This study identified 15 potential biomarkers associated with high bleeding propensity in East Asian patients with ACS using ticagrelor.
Article
Pharmacology & Pharmacy
Zhiyan Liu, Yaou Liu, Guangyan Mu, Hanxu Zhang, Shuang Zhou, Zhe Wang, Qiufen Xie, Zining Wang, Ninghong Guo, Jie Huang, Liping Guo, Yan Huang, Jian Li, Guoping Yang, Dongdong Yuan, Hongtao Song, Jie Jiang, Qian Xiang, Yimin Cui
Summary: Based on PK/PD data from healthy subjects and patients, this study aimed to establish an integrated approach towards population PK and the PD model of ticagrelor. The results showed that a fixed dose of ticagrelor could be used in patients with acute coronary syndromes after considering factors such as food status, body weight, and sex.
CLINICAL PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Junyu Xu, Nan Zhao, Jie Huang, Jinlei Li, Xia Zhao, Qian Xiang, Sibo Yang, Yanli Dong, Honghui Wang, Yijing Li, Guoping Yang, Yimin Cui
Summary: This study aimed to evaluate the safety, pharmacokinetics, and pharmacodynamics of SHR2285, a small molecule FXIa inhibitor, in healthy Chinese volunteers. The results showed that SHR2285 was well tolerated and exhibited a predictable pharmacokinetic profile and an exposure-related pharmacodynamic profile across a wide range of doses.
CLINICAL DRUG INVESTIGATION
(2023)
Review
Clinical Neurology
Yongzhao Zhao, Qian Xiang, Shuai Jiang, Longjie Wang, Jialiang Lin, Chuiguo Sun, Weishi Li
Summary: This systematic review aimed to summarize the existing evidence on the prevalence, diagnostic measures, and impact on clinical outcomes of dural ossification (DO) in thoracic ossification of the ligamentum flavum (TOLF). The prevalence of DO in surgically treated TOLF was 27%, and eight diagnostic measures were proposed. DO did not affect neurological recovery but was associated with a high risk of complications.
EUROPEAN SPINE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Juqi Zhang, Wenhui Li, Mingli Gong, Yanlun Gu, Hanxu Zhang, Bingqi Dong, Qi Guo, Xiaocong Pang, Qian Xiang, Xu He, Yimin Cui
Summary: This study found that the use of Janus kinase (JAK) inhibitors in patients with immune-mediated inflammatory diseases may increase the risk of venous thrombosis (VTE), especially with high doses of tofacitinib. Compared to placebo or tumor necrosis factor (TNF) inhibitors, JAK inhibitors did not show a significant difference in VTE incidence. These findings are important for physicians considering the use of JAK inhibitors in patients with immune-mediated inflammatory diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jingyi Hou, Ruiyang Xie, Zhuo Zhang, Qianxin Liu, Qian Xiang, Yimin Cui
Summary: The risk of treatment-related hematologic toxicity in patients with advanced and metastatic gastrointestinal cancers treated with immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy is unclear. This study found that using ICIs alone had a low incidence of causing hematologic mortality and adverse events, while combining ICIs with chemotherapy might magnify the side effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Zhi-Yan Liu, Min-Xue Sun, Man-Qi Hua, Han-Xu Zhang, Guang-Yan Mu, Shuang Zhou, Zhe Wang, Qian Xiang, Yi-Min Cui
Summary: Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a protein synthesized from platelet alpha particles and plays an important role in heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic thrombocytopenia (VITT). The PF4-VWF complex, formed by the interaction of PF4 with negatively charged polyanions, is involved in immune-associated thrombosis and may serve as a potential biomarker for early thrombotic events.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Qian Xiang, Zhe Wang, Guangyan Mu, Qiufen Xie, Zhiyan Liu, Shuang Zhou, Hanxu Zhang, Zining Wang, Jie Jiang, Kun Hu, Yatong Zhang, Zinan Zhao, Dongdong Yuan, Liping Guo, Tingting Wu, Jinhua Zhang, Na Wang, Jing Xiang, Zhichun Gu, Jianjun Sun, Yimin Cui
Summary: This study aimed to identify genetic variants associated with the variability of pharmacodynamics and bleeding risk of rivaroxbaban in patients with nonvalvular atrial fibrillation (NVAF). The peak anti-FXa level was significantly related to bleeding events within 12 months. SUSD3 rs76292544 was associated with 12-month bleeding events and five SNPs (NCMAP rs4553122, PRF1 rs885821, PRKAG2 rs12703159, rs13224758, and POU2F3 rs2298579) were associated with peak anti-FXa level.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Guangyan Mu, Qiufen Xie, Zhiyan Liu, Hanxu Zhang, Xianmin Meng, Jinfang Song, Shuang Zhou, Zhe Wang, Zining Wang, Xia Zhao, Jie Jiang, Maoxing Liao, Jiachun Bao, Fan Zhang, Qian Xiang, Yimin Cui
Summary: This study aimed to identify genetic biomarkers associated with the pharmacokinetics and pharmacodynamics of apixaban in healthy Chinese subjects. The results showed that ABCG2 variants were associated with the concentration and response of apixaban, while ABLIM2, F13A1, and C3 variants were associated with the pharmacokinetic and pharmacodynamic characteristics of apixaban.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaocong Pang, Xu He, Zhiwei Qiu, Hanxu Zhang, Ran Xie, Zhiyan Liu, Yanlun Gu, Nan Zhao, Qian Xiang, Yimin Cui
Summary: Integrins are cell-adhesion receptors that play important roles in cell signaling and communication. Targeting integrins for therapeutic purposes has been challenging due to their complexity and opposing characteristics. Currently, there are only seven approved drugs targeting integrins on the market, but there are ongoing efforts to develop new therapies and diagnostic tools. Understanding the regulatory mechanisms of integrins and addressing unmet clinical needs are crucial for successful development of integrin-targeted therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
