Review
Cell Biology
Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: The Hippo-YAP signaling pathway plays critical roles in cell functions, interacts with the RUNX transcription factors in proliferation, differentiation, and cell fate determination, and contributes to development and tumorigenesis.
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Review
Oncology
Carmen Salguero-Aranda, Joaquin Olmedo-Pelayo, Enrique de alava, Ana Teresa Amaral, Juan Diaz-Martin
Summary: Cancer is a genetic disease caused by changes in genes controlling cell growth. The Hippo pathway, a developmental signaling system, plays a critical role in tissue and organ size regulation and is frequently deregulated in cancer. This article reviews the relevance of the Hippo pathway in specific sarcoma subtypes and discusses its genetic alterations and other molecular mechanisms involved in its deregulation. It also explores the potential for targeted therapy in sarcoma based on these alterations.
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Review
Cell Biology
Xiaolei Zhao, Tram P. Le, Shannon Erhardt, Tina O. Findley, Jun Wang
Summary: Neural crest cells are a migratory stem cell population in vertebrate embryogenesis that play a crucial role in the development of various tissues and organs. Recent studies have highlighted the importance of the Hippo-Yap pathway in normal neural crest development, but further research is needed to fully understand its roles and mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yu-Ling Chung, Vincent Laiman, Po-Nien Tsao, Chung -Ming Chen, Didik Setyo Heriyanto, Kian Fan Chung, Kai-Jen Chuang, Hsiao-Chi Chuang
Summary: Prenatal exposure to traffic-related air pollution, specifically diesel exhaust particles (DEPs), inhibits lung development in mice fetuses. DEP exposure decreases lung branching morphogenesis and impairs the expression of lung development-related genes. DEPs disrupt the Hippo signaling pathway and induce early cellular senescence in fetal lung fibroblast cells. These findings highlight the adverse effects of air pollution on fetal lung development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Cell Biology
Mylene Zarka, Eric Hay, Martine Cohen-Solal
Summary: YAP and TAZ are key regulators in organ growth and bone biology, responding to mechanical and cytoskeletal cues to control cell fate. They play significant roles in bone and cartilage homeostasis and their precise functions have been investigated in mouse and cellular models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Fu-Long Li, Kun-Liang Guan
Summary: The Hippo signaling pathway is an important regulatory pathway that plays a vital role in animal development and tissue homeostasis. It regulates tissue growth and organ size and is associated with various diseases, particularly cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qin
Summary: With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in humans. A study found that the transcriptional coactivator TAZ could be a potential therapeutic target in PDAC. Through unbiased deubiquitinase (DUB) library screening, researchers identified USP14 as a key regulator of TAZ stabilization, and the USP14-TAZ loop was found to promote cancer progression and liver metastasis in PDAC models. Inhibition of USP14 with the small molecule inhibitor IU1 showed promising anti-cancer effects in PDAC models.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Oncology
Taruna Arora, Mohd Adnan Kausar, Shimaa Mohammed Aboelnaga, Sadaf Anwar, Malik Asif Hussain, Sadaf Sadaf, Simran Kaur, Alaa Abdulaziz Eisa, Vyas Murti Madhavrao Shingatgeri, Mohammad Zeeshan Najm, Abdulaziz A. Aloliqi
Summary: This review article discusses the impact of the hippo signaling pathway, miRNA biogenesis, and the crosslinks between miRNA and the hippo pathway on cancer. Understanding these processes can enhance the effectiveness of cancer treatment therapies.
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Multidisciplinary Sciences
Kepeng Che, Ajaybabu Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin
Summary: In this study, the researchers identified a pharmacologically active small molecule called aurintricarboxylic acid (ATA) that can disrupt the formation of the TAZ-TEAD complex. They found that ATA inhibits TC/TEAD transcriptional activity and prevents anchorage-independent growth associated with dysregulated TAZ/TEAD activity.
Article
Chemistry, Medicinal
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Koetzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Boepple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
Summary: The dysregulated Hippo pathway and hyperactivity of the YAP/TAZ-TEAD transcriptional complexes are associated with diseases like cancer. This study describes the discovery and optimization of a P-site binding fragment to target the TEAD transcription factors. The optimized in vivo tool, MSC-4106, exhibited desirable potency, mouse pharmacokinetic properties, and in vivo efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sidi Zhang, Qianming Chen, Chao Yang, Jiayu Shi, Yansong Lin, Shijun Duan, Bing Shi, Zhonglin Jia
Summary: This study identified new potential SNPs around IRF6 associated with non-syndromic orofacial cleft (NSOC) in Western Han Chinese, and found that these SNPs have different transmission patterns and parent-of-origin effects in different subtypes, indicating their potential importance in the development of the disease.
Article
Dentistry, Oral Surgery & Medicine
Wei-cheng Chan, Liangyu Tan, Jie Liu, Qin Yang, Jiajia Wang, Min Wang, Yuan Yue, Liang Hao, Yi Man
Summary: The study found that inhibition of Rgs10 in mice with both periodontitis and rheumatoid arthritis can aggravate the development of periodontitis, indicating the potential therapeutic role of Rgs10 in this condition.
Article
Dentistry, Oral Surgery & Medicine
Dikan Wang, Juan Fang, Shuqiong Wen, Qunxing Li, Jinming Wang, Lisa Yang, Wenxiao Dai, Huanzi Lu, Junyi Guo, Zhongyan Shan, Wenqiang Xie, Xiangqi Liu, Liling Wen, Jie Shen, Anxun Wang, Qianming Chen, Zhi Wang
Summary: The study explores two subsets of exhausted T cells, TCF1(+)Tex(prog) and TCF1(-)Tex(term), in head and neck squamous cell cancer (HNSCC). TCF1(-)Tex(term) represents a greater proportion of CD8(+)PD1(+)Tex and exhibits a polyfunctional phenotype associated with better survival. These cells are also accompanied by an increase in the proportion of regulatory T cells (Tregs) in the tumor immune microenvironment (TIME).
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Materials Science, Biomaterials
Tingting Ding, Jiajia Qi, Jingcheng Zou, Hongxia Dan, Hang Zhao, Qianming Chen
Summary: A novel hydrogel material with excellent antibacterial and adhesive properties was successfully synthesized in this study, which could be degraded within three days in vivo. The hydrogel also showed remarkable antioxidant capability, injectability, and good cytocompatibility, accelerating wound healing in mice.
BIOMATERIALS SCIENCE
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Yilong Hao, Yao Yuan, Yining Li, Qianming Chen
Article
Biotechnology & Applied Microbiology
Zhiwei Jiang, Na Li, Qin Shao, Danji Zhu, Yuting Feng, Yang Wang, Mengjia Yu, Lingfei Ren, Qianming Chen, Guoli Yang
Summary: This study successfully isolated a new population of mesenchymal stem cells (PMSCs) from rat hard palates and fabricated scaffold-free 3D cell aggregates using light-controlled cell sheet technology. Transplantation of the PMSC aggregates significantly enhanced bone formation and implant osseointegration in vivo, demonstrating their potential as a powerful tool for tissue engineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiaofei Yu, Yao Liu, Keqing Pan, Pei Sun, Jing Li, Lingyu Li, Qianming Chen, Zheng Sun
Summary: BRCA1 depletion increases oxidative damage and promotes the malignant phenotype in oral cancer. The NRF2-activator sulforaphane is a potential chemo-preventive agent for oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2022)
Correction
Oncology
Xi Wang, Yiqun Jia, Liling Wen, Wenxin Mu, Xianrui Wu, Tao Liu, Xiangqi Liu, Juan Fang, Yizhao Luan, Ping Chen, Jinlong Gao, Ky-Anh Nguyen, Jun Cui, Gucheng Zeng, Ping Lan, Qianming Chen, Bin Cheng, Zhi Wang
Article
Dentistry, Oral Surgery & Medicine
Maofeng Qing, Yu Zhou, Jiakuan Peng, Qianhui Shang, Jiaxin Deng, Xin Zeng, Hao Xu, Qianming Chen
Summary: This study aimed to investigate the expression of interleukin-6 (IL-6) family in local tissues of oral lichen planus (OLP) patients and its correlation with presentations and outcomes. The results showed that the expression of IL-6 family significantly increased in erosive type OLP patients. Additionally, IL-6 family factors were significantly increased in the recurrent erosion group compared to the persistent nonerosion group. Multiple regression analysis revealed that the increased expression of IL-6 family was closely related to clinical types and outcomes of OLP.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Infectious Diseases
Yufeng Wang, Haiwen Zhou, Wenmei Wang, Ning Duan, Zhixiao Luo, Hongbo Chai, Lu Jiang, Qianming Chen, Jinli Liu, Hong Hua, Zhimin Yan, Yuan Fan, Juanyong Xu, Xiaobing Guan, Hongjian Wang, Hongzhou Lu, Wenhui Lun, Wei Fei, Tong Zhang, Jizhi Zhao, Chunling Jia, Hui Kong, Xuemin Shen, Qing Liu, Weizhi Wang, Guoyao Tang
Summary: The study found that once-daily treatment with miconazole buccal tablets is as effective as systemic itraconazole capsules in Chinese patients with oropharyngeal candidiasis, and it has minimal side effects.
Article
Materials Science, Multidisciplinary
Tiannan Liu, Yuqi Du, Yujie Yan, Shaojuan Song, Jiajia Qi, Xin Xia, Xiaopei Hu, Qianming Chen, Jiang Liu, Xin Zeng, Hang Zhao
Summary: In this study, a pH-responsive dual-functional isoG-based supramolecular hydrogel with excellent stability and sustained release capability was successfully developed. Both in vitro and in vivo experiments demonstrated its biocompatibility, biodegradability, and significant inhibition of tumor growth. This is the first example of a pH-responsive dual-functional isoG-based supramolecular hydrogel integrating localized delivery and anti-cancer activity in one molecule.
Article
Dentistry, Oral Surgery & Medicine
Yansong Song, Ling Ren, Jiaxin Liu, Xin Zeng, Qianming Chen, Hongxia Dan
Summary: The core outcome set (COS) is a minimum set of outcomes that should be reported by all clinical trials in a specific health field. The use of COS in clinical studies can reduce heterogeneity, facilitate systematic review, and increase the utility of studies. The importance of COS in oral health has recently been recognized.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Review
Immunology
Xiaoting Deng, Ying Wang, Lu Jiang, Jing Li, Qianming Chen
Summary: Oral lichen planus (OLP) is a chronic immune inflammatory disease that affects the oral mucosa and has the potential to develop into oral squamous cell carcinoma (OSCC). The etiology of OLP is still unknown, but immune dysregulation may play a vital role in its pathogenesis. This review focuses on the relationship between OLP and its immune microenvironment, summarizing the current developments in immunology, functional cell types, crucial cytokines, and signaling pathways involved. The potential application of targeted immune microenvironment therapy for OLP is highlighted.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Surgery
You Zhang, Yuqi Wu, Dan Pan, Zhenyu Zhang, Lu Jiang, Xiaodong Feng, Yuchen Jiang, Xiaobo Luo, Qianming Chen
Summary: This study aimed to evaluate the diagnostic accuracy of narrow band imaging (NBI) for malignant transformations of potentially malignant disorders (OPMD) in the oral cavity. The results showed that defining IPCL II and above as a positive result demonstrated the highest diagnostic accuracy for OPMD malignant transformations.
FRONTIERS IN SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yahui Wang, Fan Tang, Zhiyong Li, Qianming Chen
Summary: This retrospective study investigated and compared the features of SBCs and ABCs of the jaw. The study found that SBCs and ABCs mostly occur in adolescents and young adults, are generally asymptomatic and found incidentally, and the final diagnosis depends on pathological examination. Curettage combined with bone grafting is the main treatment method.
