Article
Oncology
Joseph M. Tuscano, Christina Poh, Paul Kaesberg, Guilluame Luxardi, Alexander Merleev, Alina Marusina, Ann Brunson, Aaron Rosenberg, Brian Jonas, Emanual Maverakis
Summary: Rituximab plus lenalidomide followed by continuous lenalidomide is effective with manageable toxicity in patients with previously untreated and R/R iNHL. This regimen produces durable remissions, even in heavily pretreated patients, with some lasting greater than 10 years. GranB(+) CD8(+) T cells and B cell levels may allow prediction of treatment response.
CLINICAL CANCER RESEARCH
(2021)
Article
Hematology
Adam Suleman, Suriya J. J. Aktar, Zharmaine Ante, Ning Liu, Kelvin K. W. Chan, Matthew C. C. Cheung, Anca Prica
Summary: Bendamustine with rituximab has become the preferred treatment regimen for patients with indolent lymphoma in Ontario, Canada, compared to rituximab with cyclophosphamide, vincristine, prednisone or cyclophosphamide, doxorubicin, vincristine, and prednisone.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Agronomy
Xun Xiao, Zeng Tai Liu, Ren Fang Shen, Xue Qiang Zhao
Summary: This study investigated the differential effects of ammonium (NH4+) and nitrate (NO3-) on rice growth, fertilizer nitrogen recovery efficiency, and rhizosphere bacterial community in acidic paddy soils. The results showed that lime application and NO3- significantly improved the growth and nitrogen utilization efficiency of Al-sensitive rice, and had a stronger impact on the rhizobacterial community compared to NH4+.
Article
Hematology
Samuel Yamshon, Gui Zhen Chen, Caitlin Gribbin, Paul Christos, Bijal Shah, Stephen J. Schuster, Sonali M. Smith, Jakub Svoboda, Richard R. Furman, John P. Leonard, Peter Martin, Jia Ruan
Summary: This study reports the 9-year follow-up results of lenalidomide plus rituximab (LR) as the initial treatment for mantle cell lymphoma. The LR doublet shows prolonged, durable responses and manageable safety as induction therapy.
Article
Medicine, General & Internal
Titas Banerjee, Myung Sun Kim, Alyson Haslam, Vinay Prasad
Summary: Idelalisib is a first-in-class phosphatidylinositol 3-kinase inhibitor that received accelerated approval for the treatment of relapsed follicular lymphoma and small lymphocytic lymphoma. However, serious adverse effects were reported in 2016, leading to the drug's voluntary withdrawal from the market in 2022. This study evaluated the regulation and evidence generation of idelalisib during different periods.
JAMA INTERNAL MEDICINE
(2023)
Article
Political Science
Signe Bock Segaard, Ulrik Kjaer, Jo Saglie
Summary: This study explores the reasons behind the higher representation of women in municipal councils in Norway compared to Denmark. It concludes that while institutional explanations are not relevant, the candidate selection process by parties plays a significant role in this difference.
WEST EUROPEAN POLITICS
(2022)
Article
Hematology
Chukwuka Eze, Isabelle Friedrich, Indrawati Hadi, Nina-Sophie Schmidt-Hegemann, Sarah Nindya Hartoyo, Richard Trauth, Daniel Reitz, Farkhad Manapov, Axel Siefert, Martin Dreyling, Claus Belka, Minglun Li
Summary: This study retrospectively analyzed the recurrence and toxicity of patients with early-stage orbital lymphoma treated with radiotherapy. The results showed that radiotherapy remains effective in treating early-stage lymphoma, but further research is needed to assess long-term sequelae.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Juan P. Alderuccio, Eduardo E. Saul, Sunil G. Iyer, Isildinha M. Reis, Alvaro J. Alencar, Joseph D. Rosenblatt, Izidore S. Lossos
Summary: The long-term combined results of two clinical trials implementing R-MACLO-IVAM induction followed by thalidomide or rituximab maintenance in untreated mantle cell lymphoma (MCL) patients showed a high rate of complete response and good progression-free and overall survival rates. This treatment regimen was effective for inducing long-term remission without the need for stem cell transplantation consolidation in MCL patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Oncology
Espen Basmo Ellingsen, Elin Aamdal, Tormod Guren, Wolfgang Lilleby, Paal F. Brunsvig, Sara M. Mangsbo, Steinar Aamdal, Eivind Hovig, Nadia Mensali, Gustav Gaudernack, Else Marit Inderberg
Summary: Therapeutic cancer vaccine UV1 has been studied in three phase I/IIa clinical trials for malignant melanoma, non-small cell lung cancer, and prostate cancer. The vaccine induced measurable T cell responses in 78.4% of treated patients, with superior response kinetics observed in the melanoma study. Long-term immunomonitoring showed persistent telomerase peptide-specific immune responses lasting up to 7.5 years after initial vaccination.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Health Care Sciences & Services
Xiaolin Zhang, Mangju Wang, Xinmin Liu
Summary: In this study, a rare case of small B cell lymphoma presenting as pleural effusion in an immunocompetent adult woman is reported. Flow cytometry was used effectively for diagnosis, leading to the decision of not pursuing further treatment by the patient. Follow-up showed symptom relief without thoracentesis, highlighting the value of flow cytometry in diagnosing unexplained pleural effusion.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Paul E. Sax, Jose R. Arribas, Chloe Orkin, Adriano Lazzarin, Anton Pozniak, Edwin DeJesus, Franco Maggiolo, Hans-Joergen Stellbrink, Yazdan Yazdanpanah, Rima Acosta, Hailin Huang, Jason T. Hindman, Hal Martin, Jared M. Baeten, David Wohl
Summary: This study evaluated the long-term efficacy and safety of B/F/TAF in HIV-1 treatment. The results showed that B/F/TAF maintained high rates of virologic suppression over 5 years, with no treatment-emergent resistance and rare drug discontinuations due to adverse events.
Article
Infectious Diseases
Niccolo Buetti, Stephane Ruckly, Bertrand Souweine, Olivier Mimoz, Jean-Francois Timsit
Summary: This study found that the risk of catheter infection increases after 10 days of insertion for central venous catheters (CVCs) and short-term dialysis catheters (DCs). Routine replacement is recommended for non-subclavian catheters after they have been in place for more than 10 days.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Hematology
Christian Winther Eskelund, Kostas Dimopoulos, Arne Kolstad, Ingrid Glimelius, Riikka Raty, Lise Mette Rahbek Gjerdrum, Kristina Sonnevi, Par Josefsson, Herman Nilsson-Ehle, Hans H. N. Bentzen, Unn Merete Fagerli, Outi Kuittinen, Jacob Haaber, Carsten Utoft Niemann, Lone Bredo Pedersen, Maria Torp Larsen, Christian Hartmann Geisler, Martin Hutchings, Mats Jerkeman, Kirsten Gronbaek
Summary: In patients with mantle cell lymphoma, early disease progression (POD24) significantly affects survival, and other biomarkers have independent prognostic value. Novel therapies are particularly important for patients with high-risk features.
Article
Oncology
Makoto Saito, Akio Mori, Shihori Tsukamoto, Takashi Ishio, Emi Yokoyama, Koh Izumiyama, Masanobu Morioka, Takeshi Kondo, Hirokazu Sugino
Summary: Treatment intervention in Stage IV D-FL patients has shown success, but long-term recurrence is possible. The study highlights the need for establishing treatment criteria for advanced D-FL based on more cases and emphasizes the importance of long-term follow-up examinations.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Oncology
Surbhi Sidana, Cristine Allmer, Melissa C. Larson, Amylou Dueck, Kathleen Yost, Rahma Warsame, Gita Thanarajasingam, James R. Cerhan, Jonas Paludo, S. Vincent Rajkumar, Thomas M. Habermann, Grzegorz S. Nowakowski, Yi Lin, Morie A. Gertz, Thomas Witzig, Angela Dispenzieri, Wilson Gonsalves, Stephen M. Ansell, Carrie A. Thompson, Shaji K. Kumar
Summary: Patients treated on CTs reported similar QoL and quality of care compared to the non-CT group, but both groups experienced increasing financial burden over time.
JCO ONCOLOGY PRACTICE
(2022)
Article
Hematology
Eva Kimby, Sandra Lockmer, Harald Holte, Hans Hagberg, Bjorn E. Wahlin, Peter Brown, Bjorn Ostenstad
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Letter
Hematology
Thomas Menter, Stefanie Hayoz, Emanuele Zucca, Eva Kimby, Stefan Dirnhofer, Alexandar Tzankov
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Hematology
Henna-Riikka Junlen, Sandra Lockmer, Eva Kimby, Bjorn Engelbrekt Wahlin
ANNALS OF HEMATOLOGY
(2020)
Article
Hematology
Alden Alberto Moccia, Saemi Schaer, Stefanie Hayoz, Maria Cristina Pirosa, Christian Taverna, Urban Novak, Eva Kimby, Michele Ghielmini, Emanuele Zucca
Summary: The relapse of follicular lymphoma within 24 months of chemoimmunotherapy is associated with poor survival, and the POD24 remains a prognostic factor even in patients treated without chemotherapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biophysics
R. Pettengell, R. Uddin, A. Boumendil, R. Johnson, B. Metzner, A. Martin, J. Romejko-Jarosinska, I Bence-Bruckler, P. Giri, C. U. Niemann, S. P. Robinson, E. Kimby, N. Schmitz, P. Dreger, A. H. Goldstone, S. Montoto
Summary: The study showed that rituximab maintenance therapy continues to benefit patients with relapsed follicular lymphoma undergoing autologous stem cell transplant by improving progression-free survival after 10 years, indicating that it enhances the curative potential of ASCT without significantly affecting overall survival.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Daniel Tesfa, Birgitta Sander, Henric Lindkvist, Christer Nilsson, Eva Kimby, Hans Hagglund, Bjorn E. Wahlin, Monika Klimkowska, Jan Palmblad
Summary: Late-onset neutropenia in NHL patients treated with rituximab is related to transient bursts of blood G-CSF and BAFF concentrations, suggesting a role for these growth factors in the emergence of LON, with inflammation potentially triggering G-CSF production during LON.
Article
Hematology
Lena Brandefors, Birgitta Sander, Kristina Lundqvist, Eva Kimby
Summary: The study revealed differences in clinical features between non-WM LPL and WM patients, such as age, prognostic factors, etc., but no significant difference in survival rate.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Chloe Steen, Bogdan Luca, Mohammad Esfahani, Armon Azizi, Brian Sworder, Barzin Nabet, David Kurtz, Chih Liu, Farnaz Khameneh, Ranjana Advani, Yasodha Natkunam, June Myklebust, Maximilian Diehn, Andrew Gentles, Aaron Newman, Ash Alizadeh
Summary: This study utilized the EcoTyper machine-learning framework to characterize cell states and ecosystems of DLBCL, identifying malignant B cell states with varying prognostic associations and diverse interactions in the tumor microenvironment. The results reveal the clinical heterogeneity captured within DLBCL ecosystems, extending beyond cell-of-origin subtypes and genotypic classes, providing opportunities for therapeutic targeting.
Article
Biochemistry & Molecular Biology
Bogdan A. Luca, Chloe B. Steen, Magdalena Matusiak, Armon Azizi, Sushama Varma, Chunfang Zhu, Joanna Przybyl, Almudena Espin-Perez, Maximilian Diehn, Ash A. Alizadeh, Matt van de Rijn, Andrew J. Gentles, Aaron M. Newman
Summary: This study introduced EcoTyper, a machine learning framework for identifying cell states and multicellular communities from gene expression data, and identified 69 transcriptionally defined cell states in 12 major cell lineages across 16 types of human carcinoma. By analyzing cell-state co-occurrence patterns, it discovered ten clinically distinct multicellular communities, including those linked to adverse survival.
Article
Biochemistry & Molecular Biology
Alexander X. Lozano, Aadel A. Chaudhuri, Aishwarya Nene, Antonietta Bacchiocchi, Noah Earland, Matthew D. Vesely, Abul Usmani, Brandon E. Turner, Chloe B. Steen, Bogdan A. Luca, Ti Badri, Gunsagar S. Gulati, Milad R. Vahid, Farnaz Khameneh, Peter K. Harris, David Y. Chen, Kavita Dhodapkar, Mario Sznol, Ruth Halaban, Aaron M. Newman
Summary: This study provides new insights into the immunological state prior to the development of immune-related adverse events (irAEs) in patients with melanoma treated with immune checkpoint inhibitors (ICIs). The abundance of activated CD4 memory T cells and T cell receptor diversity in the blood samples were found to be associated with severe irAEs, regardless of the affected organ system. The study also investigated the changes in T cell receptor clonality during combination therapy and linked them to the severity and timing of irAE onset. These findings have implications for improved diagnostics and clinical management of irAEs.
Article
Biotechnology & Applied Microbiology
Mohammad Shahrokh Esfahani, Emily G. Hamilton, Mahya Mehrmohamadi, Barzin Y. Nabet, Stefan K. Alig, Daniel A. King, Chloe B. Steen, Charles W. Macaulay, Andre Schultz, Monica C. Nesselbush, Joanne Soo, Joseph G. Schroers-Martin, Binbin Chen, Michael S. Binkley, Henning Stehr, Jacob J. Chabon, Brian J. Sworder, Angela B-Y Hui, Matthew J. Frank, Everett J. Moding, Chih Long Liu, Aaron M. Newman, James M. Isbell, Charles M. Rudin, Bob T. Li, David M. Kurtz, Maximilian Diehn, Ash A. Alizadeh
Summary: EPIC-seq is a method that predicts gene expression levels at individual genes from cfDNA. We demonstrate the potential of EPIC-seq in cancer subtype classification and prediction of clinical response.
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shaheen S. Sikandar, Gunsagar S. Gulati, Jane Antony, Isobel Fetter, Angera H. Kuo, William Hai Dang Ho, Veronica Haro-Acosta, Soumyashree Das, Chloe B. Steen, Thiago Almeida Pereira, Dalong Qian, Philip A. Beachy, Fredrick Dirbas, Kristy Red-Horse, Terence H. Rabbitts, Jean Paul Thiery, Aaron M. Newman, Michael F. Clarke
Summary: A minority population of immature tumor epithelial cells with angiogenic features, marked by the oncogene LMO2, has been identified in human breast tumor biopsies. Higher abundance of LMO2(+) basal cells is correlated with tumor endothelial content and predicts poor prognosis. LMO2 binds to STAT3 and is required for STAT3 activation, promoting breast cancer metastasis.
Article
Biotechnology & Applied Microbiology
Milad R. Vahid, Erin L. Brown, Chloe B. Steen, Wubing Zhang, Hyun Soo Jeon, Minji Kang, Andrew J. Gentles, Aaron M. Newman
Summary: CytoSPACE is an optimization method that maps individual cells from a reference single-cell RNA sequencing atlas to spatial transcriptomics data, enabling tissue cartography at single-cell resolution with improved noise tolerance and accuracy.
NATURE BIOTECHNOLOGY
(2023)
Review
Oncology
Kim M. Linton, Lena Specht, Astrid Pavlovsky, Carrie A. Thompson, Eva Kimby, Daphne de Jong, Loretta J. Nastoupil, Anne-Segolene Cottereau, Carla Casulo, Clementine Sarkozy, Jessica Okosun
Summary: Follicular lymphoma, the most common indolent lymphoma in western countries, has a favorable prognosis but includes high-risk groups with poor outcomes. This review discusses recent updates in risk stratification and treatment approaches, including upfront treatment for limited and advanced stage follicular lymphoma, as well as options for relapsed, refractory disease. It also highlights the need for precise and prospective selection of optimal treatment based on varying risks, which may be achieved through a better understanding of the biology of different phenotypes and improved imaging and biomarker-based tools.
HEMATOLOGICAL ONCOLOGY
(2023)
Letter
Hematology
Igor Aurer, Martin Dreyling, Massimo Federico, Herve Tilly, Kim Linton, Eva Kimby, Martine E. D. Chamuleau, Marie Jose Kersten