Effective NY-ESO-1–specific MHC II–restricted T cell receptors from antigen-negative hosts enhance tumor regression

Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity

(2017) Xiaojing Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432

(2017) Tomohira Takeoka et al.   JOURNAL OF IMMUNOTHERAPY

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

(2016) Elisa Kieback et al.   IMMUNITY

Targeting human melanoma neoantigens by T cell receptor gene therapy

(2016) Matthias Leisegang et al.   JOURNAL OF CLINICAL INVESTIGATION

Isolation and Characterization of an HLA-DPB1*04

(2016) Xin Yao et al.   JOURNAL OF IMMUNOTHERAPY

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+T Cells after Intercellular Antigen Transfer

(2015) Jean Francois Fonteneau et al.   JOURNAL OF IMMUNOLOGY

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

(2015) Matthias Obenaus et al.   NATURE BIOTECHNOLOGY

NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

(2015) Aaron P Rapoport et al.   NATURE MEDICINE

Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses

(2015) Junko Matsuzaki et al.   Scientific Reports

Rapid generation of NY-ESO-1-specific CD4+THELPER1 cells for adoptive T-cell therapy

(2015) Simone Kayser et al.   OncoImmunology

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

(2014) P. F. Robbins et al.   CLINICAL CANCER RESEARCH

Both positive and negative effects on immune responses by expression of a second class II MHC molecule

(2014) Peggy P. Ni et al.   MOLECULAR IMMUNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-Specific CD8+ T Cells Induced by Melanoma Vaccines

(2013) J. Fourcade et al.   CANCER RESEARCH

Spleen Cells from Young but Not Old Immunized Mice Eradicate Large Established Cancers

(2012) K. Schreiber et al.   CLINICAL CANCER RESEARCH

MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer

(2012) C. Poli et al.   HAEMATOLOGICA

Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer

(2011) Kathleen Anders et al.   CANCER CELL

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Bystander killing of cancer requires the cooperation of CD4+and CD8+T cells during the effector phase

(2010) Andrea Schietinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transgenic mice with a diverse human T cell antigen receptor repertoire

(2010) Liang-Ping Li et al.   NATURE MEDICINE

Efficient Human Hematopoietic Cell Transduction Using RD114- and GALV-Pseudotyped Retroviral Vectors Produced in Suspension and Serum-Free Media

(2009) Karim Ghani et al.   HUMAN GENE THERAPY

Self-Tolerance Does Not Restrict the CD4+ T-Helper Response against the p53 Tumor Antigen

(2008) M. M. Lauwen et al.   CANCER RESEARCH

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

(2008) Matthias Leisegang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM