Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications

Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans

(2018) Paul Tuijnenburg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

(2018) Charlotte Schwab et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CVID enteropathy is characterized by exceeding low mucosal iga levels and interferon-driven inflammation possibly related to the presence of a pathobiont

(2018) Natalia Shulzhenko et al.   CLINICAL IMMUNOLOGY

Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies

(2017) Alain Fischer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

(2017) Tanya I. Coulter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD

(2017) Alina E. Dulau Florea et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Disturbed canonical nuclear factor of κ light chain signaling in B cells of patients with common variable immunodeficiency

(2017) Baerbel Keller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

(2017) Maria B. Olsen et al.   Cell Reports

Follicular T Cells from smB− Common Variable Immunodeficiency Patients Are Skewed Toward a Th1 Phenotype

(2017) Vanesa Cunill et al.   Frontiers in Immunology

A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency

(2016) Silje F Jørgensen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Indications to Epigenetic Dysfunction in the Pathogenesis of Common Variable Immunodeficiency

(2016) William Rae   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Gut Microbiome Associates With Lifetime Cardiovascular Disease Risk Profile Among Bogalusa Heart Study ParticipantsNovelty and Significance

(2016) Tanika N. Kelly et al.   CIRCULATION RESEARCH

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

(2016) Pauline Luczynski et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency

(2016) Johanna Schepp et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

(2016) Michel J. Massaad et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

(2016) S F Jørgensen et al.   Mucosal Immunology

Activating PI3Kδ mutations in a cohort of 669 patients with primary immunodeficiency

(2015) M. Elgizouli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation

(2015) Rebecca L. Tallmadge et al.   CLINICAL IMMUNOLOGY

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex

(2015) Sven Kracker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition

(2015) Virginia C. Rodríguez-Cortez et al.   Nature Communications

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

(2015) Jin Li et al.   Nature Communications

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Update on primary sclerosing cholangitis genetics

(2014) Eva K.K. Henriksen et al.   CURRENT OPINION IN GASTROENTEROLOGY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Clinical picture and treatment of 2212 patients with common variable immunodeficiency

(2014) Benjamin Gathmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders

(2014) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals

(2014) J F Vázquez-Castellanos et al.   Mucosal Immunology

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

(2013) Mora Murri et al.   BMC Medicine

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

(2012) Gabriela Lopez-Herrera et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia

(2012) J. Litzman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IgA synthesis: a form of functional immune adaptation extending beyond gut

(2012) Duncan B Sutherland et al.   CURRENT OPINION IN IMMUNOLOGY

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

Genomic modulators of the immune response

(2012) Julian C. Knight   TRENDS IN GENETICS

Morbidity and mortality in common variable immune deficiency over 4 decades

(2011) E. S. Resnick et al.   BLOOD

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

(2011) Min Wei et al.   NATURE IMMUNOLOGY

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut

(2011) Natalia Shulzhenko et al.   NATURE MEDICINE

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

How I treat common variable immune deficiency

(2010) C. Cunningham-Rundles   BLOOD

Enhanced generation of reactive oxygen species in monocytes from patients with common variable immunodeficiency

(2010) P. AUKKUST et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toward defining the autoimmune microbiome for type 1 diabetes

(2010) Adriana Giongo et al.   ISME Journal

Common variable immunodeficiency disorders: division into distinct clinical phenotypes

(2008) H. Chapel et al.   BLOOD

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE