Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1592, Issue -, Pages 31-37Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2019.01.008
Keywords
Multi-phase extraction; Dual ionic liquid; Aristolochic acid; Isolation; Herbal
Funding
- National Natural Science Foundation of China [51503020, 51874046]
- program of China Scholarships Council [201808420038]
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A convenient, and efficient multi-phase extraction method was used to isolate aristolochic acid from real samples. To increase the efficiency, a new dual ionic liquid-immobilized silica was used as a sorbent and the effects of the adsorption conditions were investigated. IM-BIM@Sil in a methanol/water (60:40, v/v) solution at 60 degrees C extracted the highest amount of aristolochic acid (16.69 mg/g) compared to the other sorbents examined. The sorbent was then applied to the multi-phase extraction of aristolochic acid, After extraction eight times, 2.4-70.9 x 10(-3) mg/g of aristolochic acid was isolated from nine real samples after several washing and elution steps. The recoveries of aristolochic acid ranged from 70.0% to 110.6% with relative standard deviations of 3.5%-9.1%, highlighting the accuracy of this method. (C) 2019 Elsevier B.V. All rights reserved.
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