Article
Pharmacology & Pharmacy
Xin Guo, Min Wu, Yanping Deng, Yan Liu, Yanpeng Liu, Jianhua Xu
Summary: A redox-responsive lipidic prodrug nano-delivery system of curcumin derivative C210 was developed to improve its bioavailability and antitumor activity. The system effectively released C210 in cancer cells, resulting in strong cytotoxicity and improved pharmacokinetic behavior. The results highlight the potential clinical applications of curcumin and its derivatives.
Review
Chemistry, Medicinal
Na Qiu, Xiyou Du, Jianbo Ji, Guangxi Zhai
Summary: Polymeric micelles have gained attention as intelligent carriers for curcumin, improving solubility, targeting delivery, prolonging circulation time, and enhancing bioavailability. Research on tumor microenvironment enables the design of stimuli-responsive smart micelles for precise drug release.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Biophysics
Qiankun Sun, Ju Liang, Yang Lin, Yunyun Zhang, Fuqing Yan, Wenlan Wu
Summary: In this study, nano-sized multi-vesicular vesicles (MVVs) containing doxorubicin (DOX) and curcumin (CUR) (DOX/CUR@MVVs) were successfully prepared using a glass bead combined with a thin film dispersion method. The DOX/CUR@MVVs exhibited independent non-homocentric vesicle structures with homogeneous particle sizes. The experimental results showed high encapsulation rates of DOX and CUR in DOX/CUR@MVVs, and they demonstrated enhanced bioavailability and sustained release properties.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Roya Karimi Alavijeh, Kamran Akhbari, Jonathan M. White
Summary: A new nano bio-coordination polymer was synthesized using ultrasonic irradiation in water, which exhibited reversible structure changes under wet conditions. This polymer, named bio-CP 2, was thermodynamically stable and capable of improving the solubility of curcumin. Experimental results showed that loading curcumin onto bio-CP 2 enhanced its cytotoxicity, leading to increased apoptosis in cancer cells.
Article
Nanoscience & Nanotechnology
ZhongHua Qin, GuiPing Yu, Ran Li, Jun Zhao
Summary: In this study, folic acid modified polymer micelles were prepared to encapsulate triptolide and enhance its bioavailability and antitumor activity. The micelles exhibited good in vitro release properties, stability, and tumor targeting potential. Compared with free triptolide, the micelles showed prolonged half-life and increased bioavailability in vivo. Moreover, the micelles significantly improved the antitumor activity of triptolide and demonstrated high safety.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wenyou Fang, Dan Su, Wenjie Lu, Nan Wang, Rong Mao, Yuan Chen, Kunkun Ge, Aizong Shen, Rongfeng Hu
Summary: Systemic chemotherapy and radiotherapy have been widely used in clinics for decades, with their major drawbacks being systemic cytotoxicity and severe side effects. Recent research has focused on the impact of extracellular matrix components in tumor progression, leading to the development of extracellular matrix targeted nanomaterials as a promising strategy for tumor theranostics.
CURRENT DRUG TARGETS
(2021)
Article
Medicine, Research & Experimental
Morteza Kamali, Thomas J. Webster, Amir Amani, Mahmoud Reza Hadjighassem, Mohammad Reza Malekpour, Fatemeh Tirgar, Masood Khosravani, Mahdi Adabi
Summary: The study aimed to prepare folate-targeted Erlotinib loaded human serum albumin nanoparticles (FA-ERL-HSA NPs) and investigate their cytotoxic and apoptotic effects using cell lines and a rat glioma model. The average size of FA-ERL-HSA NPs prepared using a desolvation method was 135 nm. In vitro experiments showed that FA-ERL-HSA NPs had lower IC50 values and induced higher apoptosis rates compared to free ERL in both cell lines. TUNEL assay indicated that FA-ERL-HSA NPs had a higher apoptosis index and effectively reduced tumor size in the rat model, leading to increased median survival rate.
Article
Food Science & Technology
Li Ma, Hongxia Gao, Ce Cheng, Mengmeng Cao, Liqiang Zou, Wei Liu
Summary: This study aims to enhance the antioxidant activity and absorption performance of curcumin through stabilized emulsions. The results show that the emulsions stabilized with curcumin nanosuspensions have good thermal and centrifugal stability, and can reduce the oxidation degree of algal oil.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Nutrition & Dietetics
Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu
Summary: Glioblastoma (GBM) is the most malignant brain tumor with limited treatment options. Curcumin, a phytochemical, shows promise as a potential anticancer agent by targeting multiple pathways in GBM cells.
Article
Pharmacology & Pharmacy
Xi-xi Hou, Xiao-qing Gong, Long-fei Mao, Ge Sun, Jian-xue Yang
Summary: Erlotinib is a targeted therapy drug for non-small-cell lung cancer, but its efficacy is limited due to drug resistance. In this study, a series of erlotinib-based 1,2,3-triazole compounds were designed and found to have inhibitory effects on IDO1 activity. Compound 14b showed the strongest inhibitory effect.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ali Bagherian, Bostan Roudi, Nahid Masoudian, Hamed Mirzaei
Summary: The research showed that nanomicelle-curcumin alone or combined with erlotinib can inhibit the viability of U87 glioblastoma cells, decrease the levels of genes related to angiogenesis and the Wnt pathway, and regulate proteins associated with autophagy and apoptosis.
Article
Oncology
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Matsuda, Fumihiko Nishimura, Mitsutoshi Nakamura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Takahiro Tsujimura, Hiroyuki Nakase
Summary: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults with poor survival rates. Immunotherapy utilizing Natural killer (NK) cells shows promise in treating GBM by exerting a cytotoxic effect on tumor cells. Preclinical evaluation using an ex vivo 3D spheroid model derived from GBM cell lines showed that NK cells had an anti-tumor effect by inducing tumor cell death through apoptosis, providing valuable information for future NK cell-based immunotherapy for GBM patients.
Article
Andrology
Mohamad Reza Sadraei, Marziyeh Tavalaee, Mohsen Forouzanfar, Mohammad Hossein Nasr-Esfahani
Summary: The study found that both curcumin and nano-curcumin as natural antioxidants had significant effects on spermatogenesis and sperm function in varicocelised rats, with nano-curcumin showing more effectiveness. This suggests that nano-curcumin may be a preferable option for treating infertility in individuals with varicocele.
Article
Pharmacology & Pharmacy
Yuanyuan Li, Aiyang Tong, Peiyuan Niu, Wenjing Guo, Yangye Jin, Yi Hu, Pei Tao, Wenjun Miao
Summary: This study developed a near-infrared light-decomposable nanomicelle for controlled delivery of a hypoxia-activated bioreductive prodrug, which showed remarkable tumor cell-killing potential in breast cancer cells and significant tumor accumulation and inhibition of lung metastasis in mice, making it a promising strategy for hypoxia-enhanced phototherapies against metastatic breast cancer.
Review
Biochemistry & Molecular Biology
Louise Orcheston-Findlay, Samuel Bax, Robert Utama, Martin Engel, Dinisha Govender, Geraldine O'Neill
Summary: The life expectancy of patients with high-grade glioma (HGG) has not improved, highlighting the need for advanced models for future improvement. Currently, advanced models are crucial for identifying new targets and evaluating treatment modalities. While pediatric HGG (pHGG) models lag behind those of adults, there is hope to bring this to light and improve pGBM models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)