Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Shiyi Tan, Shi Chen
Summary: Silicosis is a pressing public health issue globally, with autophagy playing a crucial role in disease progression and potentially providing therapeutic targets through regulating macrophage apoptosis. Exogenous chemicals like lipopolysaccharides or natural product ingredients may have either detrimental or beneficial effects on silicosis fibrosis by modulating macrophage autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Juanhua Fu, Li Lu, Haining Wang, Yayi Hou, Huan Dou
Summary: The study revealed that Hirsutella sinensis mycelium (HSM) inhibited the autophagy of alveolar macrophages through the TLR4/NF-kappa B signaling pathway, leading to an anti-fibrotic effect.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Immunology
Yue Su, Wei Zhang, Ruoxi Zhang, Quan Yuan, Ruixia Wu, Xiaoxuan Liu, Jimusi Wuri, Ran Li, Tao Yan
Summary: This study found that activation of α7nAChR improves cerebral and cardiac dysfunction after ICH through autophagy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yue-Jiao Lan, Napoleon Bellua Sam, Ming-Han Cheng, Hai-Feng Pan, Jian Gao
Summary: Progranulin, a secretory glycoprotein, plays a protective role in the development of various immune-mediated diseases by regulating critical signaling pathways. Its immunological functions and role in disease pathogenesis, despite controversy in some diseases, provide new ideas for therapeutic strategies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Toxicology
Balasubramanyam Annangi, Zhuyi Lu, Jonathan Bruniaux, Audrey Ridoux, Vanessa Marques da Silva, Delphine Vantelon, Jorge Boczkowski, Sophie Lanone
Summary: Exposure to CeO2 NP in mice induces progressive and dose-dependent lung fibrosis in bronchiolar and alveolar walls, accompanied by autophagy activation. Inhibition of macrophagic autophagy provides protection against alveolar fibrosis, by modulating macrophage polarization towards M2 phenotype.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Environmental Sciences
Haiying Wei, Wanjun Yuan, Huan Yu, Hong Geng
Summary: PM2.5 can induce apoptosis in alveolar macrophages, causing cytotoxic effects, increasing levels of reactive oxygen species and intracellular calcium ions, and leading to lung injury diseases through a mitochondrial-mediated pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Pengbo Wu, Tian Tian, Jinbo Zhao, Qi Song, Xiaoman Wu, Yitian Guo, Yuanjie Yu, Shiyun Tan, Hongmiao Xia
Summary: During the initial phase of hepatic steatosis, aggravated lipid accumulation, increased autophagy, and no alteration of apoptosis were observed under increased ER stress. The activation of the IRE1 alpha-JNK pathway during ER stress promoted cell survival by enhancing autophagy. Targeting this signaling pathway may offer new insights into preventive strategies for hepatic steatosis.
Review
Immunology
Eva S. Vanamee, Denise L. Faustman
Summary: This review paper synthesizes key findings from recent studies on the tumor necrosis factor (TNF) receptor superfamily signaling, emphasizing the importance of clustering. The underlying molecular mechanisms of signaling, functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes are discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xuanyao Ren, Weilong Zhong, Wenting Li, Mindan Tang, Kaoyuan Zhang, Fenli Zhou, Xin Shi, Jun Wu, Bo Yu, Cong Huang, Xiaofan Chen, Wei Zhang
Summary: Psoriasis is a chronic, immune-mediated disease that affects a significant portion of the world population. Recent studies have shown that mesenchymal stem cells (MSCs) can be used to alleviate psoriasis, but the exact mechanisms are still unclear. This study found that MMP13, an enzyme involved in extracellular matrix remodeling, is upregulated in psoriasis skin lesions and downregulated after infusion of human umbilical cord MSCs (hUC-MSCs). Knockdown of MMP13 inhibited keratinocyte proliferation and arrested the cell cycle. The study also showed that hUC-MSCs reduced TNF-alpha levels through co-culture experiments, and TNF-alpha upregulated MMP13 in keratinocytes through the NF-kappa B pathway. Overall, this suggests that hUC-MSCs exert their therapeutic effects on psoriasis through the TNF-alpha/NF-kappa B/MMP13 pathway.
Article
Cell Biology
Shi Chen, Kun Tang, Peiwu Hu, Shiyi Tan, Shang Yang, Chang Yang, Gang Chen, Yixiao Luo, Hui Zou
Summary: The research found that ATL-III may inhibit autophagy in a mTOR-dependent manner, alleviating apoptosis of AMs in human silicosis; ATL-III could be a potentially protective ingredient for workers exposed to silica dust; Inhibition of autophagy may be an effective way to alleviate the apoptosis of AMs in silicosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Nan Zhang, Ying Bian, Lei Yao
Summary: The essential oils extracted from two gardenia varieties have anti-inflammatory effects on murine alveolar macrophages, inhibiting nitric oxide release and reducing the production of TNF-alpha and PGE2. Components such as linalool and alpha-farnesene in the gardenia flower essential oils have potential as anti-inflammatory agents.
Article
Biochemistry & Molecular Biology
Barbara Pesce, Carolina H. Ribeiro, Milton Larrondo, Veronica Ramos, Lilian Soto, Diego Catalan, Juan Carlos Aguillon
Summary: Tumor necrosis factor (TNF)-alpha regulates cytokine production by CD4+ T helper cells, and targeting TNFR2 may be an alternative strategy to normalize key cytokine levels that contribute to the pathogenesis of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jo Young Son, Jin Sook Ju, Yu Mi Kim, Dong Kuk Ahn
Summary: This study reveals that astroglial RIPK1, activated by the TNF-alpha pathway, plays a central role in neuropathic pain. Blocking the TNF-alpha-mediated RIPK1 pathway may be a potential therapeutic target for reducing neuropathic pain following nerve injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)