Article
Immunology
Rajeev Dhupar, Katherine E. Jones, Amy A. Powers, Seth H. Eisenberg, Kai Ding, Fangyuan Chen, Cecile Nasarre, Zhanpeng Cen, Yi-Nan Gong, Amanda C. LaRue, Elizabeth S. Yeh, James D. Luketich, Adrian V. Lee, Steffi Oesterreich, Michael T. Lotze, Robert M. Gemmill, Adam C. Soloff
Summary: Tumor-associated macrophages (TAMs) play a significant role in breast cancer progression, and the neuropilin-2 (NRP2) isoforms NRP2a and NRP2b have been found to regulate TAM functionality. The expression levels of NRP2a and NRP2b in TAMs are influenced by the location of the tumor, and they are closely associated with TAM infiltration in both primary and metastatic breast cancers. This study also demonstrates that NRP2a and NRP2b have distinct functionality in macrophages and are associated with different TAM subsets in breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
C. G. H. Ronnau, S. Fussek, F. P. Smit, T. W. Aalders, O. van Hooij, P. M. C. Pinto, M. Burchardt, J. A. Schalken, G. W. Verhaegh
Summary: This study identified several novel deregulated miRNAs in CRPC tissue, including two microRNAs potentially involved in tumor invasion. The data support the hypothesized involvement of miRNAs in PCa tumorigenesis and progression to CRPC. The applicability of these miRNAs as novel biomarkers for CRPC needs further investigation.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Yalan Dai, Xinyi Zhang, Yingjun Ou, Linglin Zou, Duoli Zhang, Qingfan Yang, Yi Qin, Xiuju Du, Wei Li, Zhanpeng Yuan, Zhangang Xiao, Qinglian Wen
Summary: Breast cancer has the highest global incidence among all tumor types and metastasis is a critical cause of poor prognosis. Anoikis, a form of apoptosis induced by cell detachment from the native environment, is a crucial process in tumor metastasis. Understanding the mechanisms of anoikis resistance can inform strategies for preventing and regressing metastatic breast cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Joshua Altschuler, Jennifer A. Stockert, Natasha Kyprianou
Summary: Prostate cancer mortality poses a significant public health challenge, with therapeutic resistance being a complex issue involving various biological mechanisms. Understanding the mechanisms of resistance is crucial for improving therapeutic outcomes and developing predictive biomarkers. Epithelial-to-mesenchymal transition, mesenchymal-to-epithelial transition, and long non-coding RNAs play important roles in therapeutic resistance and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jasmine S. Owen, Aled Clayton, Helen B. Pearson
Summary: The continuous remodeling of the tumor microenvironment (TME) is critical for prostate tumor growth, progression, and drug-resistance. Cancer-associated fibroblasts (CAFs) are key players in TME and mediate various oncogenic events. Understanding fibroblast heterogeneity, recruitment, and differential functions can help in developing new therapies and biomarkers for prostate cancer patients.
Article
Pharmacology & Pharmacy
Ying Zhang, Changjun Yin, Chao Wei, Shuai Xia, Zhu Qiao, Xue-Wen Zhang, Bin Yu, Jun Zhou, Rong Wang
Summary: The current study aimed to assess the role and potential mechanism of miR-625-3p released by cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) cells. The results indicated that miR-625-3p released by CAFs might promote the migration, invasion, epithelial-mesenchymal transformation (EMT), and chemotherapeutic resistance in CRC cells by inhibiting the CELF2/WWOX pathway.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Xiaoli Liu, Qingfeng Fu, Xuehai Bian, Yantao Fu, Jingwei Xin, Nan Liang, Shijie Li, Yishen Zhao, Li Fang, Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Hui Sun
Summary: The study revealed that downregulation of MAPK8IP1P2 in thyroid cancer tissues with lymphatic metastasis, while upregulation suppressed anoikis resistance and lymphatic metastasis of cancer cells. MAPK8IP1P2 activated Hippo signaling by sponging miR-146b-3p, consequently inhibiting the metastasis. This suggests MAPK8IP1P2 could be a potential biomarker or therapeutic target for lymphatic metastatic thyroid cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Funmilayo O. Adeshakin, Adeleye O. Adeshakin, Lukman O. Afolabi, Dehong Yan, Guizhong Zhang, Xiaochun Wan
Summary: Cancer cells develop mechanisms to resist anoikis, promoting invasion and metastasis. Understanding the mechanisms driving anoikis resistance is crucial for preventing tumor progression and metastasis, with metabolic pathways playing a key role in helping cells evade anoikis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Farzad Sattari Fard, Nazila Jalilzadeh, Amir Mehdizadeh, Fakhrosadat Sajjadian, Kobra Velaei
Summary: The development of effective cancer treatments requires a detailed understanding of cellular mechanisms involved in cancer progression and metastasis. Anoikis, a special type of apoptosis induced by loss of anchorage, is a driving mechanism in cancer metastasis. This review discusses the mechanisms of gaining anoikis/anoikis resistance phenotype in tumor cells and highlights the significance of anoikis in malignancies for cancer diagnosis and therapy development.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song-Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck
Summary: This study found that prostate cancer tumors with concomitant inhibition of PP2A and PTEN are particularly aggressive, with low patient survival rates. Overexpression of PME-1 inhibits anoikis in PTEN-deficient prostate cancer cells. The results suggest that PME-1 may be a candidate biomarker for particularly aggressive PTEN-deficient prostate cancer.
MOLECULAR ONCOLOGY
(2023)
Article
Immunology
Jiahua Pan, Zehua Ma, Bo Liu, Hongyang Qian, Xiaoguang Shao, Jiazhou Liu, Qi Wang, Wei Xue
Summary: In this study, two distinct subtypes of CAFs with different molecular characteristics and biological functions were identified in the prostate cancer microenvironment. Similar CAFs were also found in bone metastatic prostate cancer lesions. The transcriptional factor regulatory network associated with CAFs-C1 was found to be related to castration resistance and poor prognosis, as well as treatment resistance to immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiangyan Chen, Qiong Xia, Ningwei Sun, Hailei Zhou, Zhihao Xu, Xi Yang, Ran Yan, Ping Li, Tingting Li, Xiang Qin, Hong Yang, Chunhui Wu, Fengming You, Xiaoling Liao, Shun Li, Yiyao Liu
Summary: The study found that circulating tumor cells acquire enhanced anti-anoikis abilities after experiencing flow shear stress in the circulatory system, with redox signaling involved in the regulation of Cav-1 level and anoikis resistance in suspended cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Ying Yu, Yarong Song, Lulin Cheng, Liang Chen, Bing Liu, Dingheng Lu, Xuexiang Li, Yunxue Li, Fang Lv, Yifei Xing
Summary: This study demonstrates that circ_0004585 plays an oncogenic role in the invasion and metastasis of prostate cancer by targeting the miR-1248/TM9SF4 axis and promoting anoikis resistance. These findings provide new insights into therapeutic strategy development for metastatic prostate cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Nastaran Masoudi-Khoram, Mohammad Hasan Soheilifar, Shima Ghorbanifar, Sima Nobari, Maryam Hakimi, Mahmoud Hassani
Summary: Cancer-associated fibroblasts (CAFs) are crucial in tumor progression and therapy response, as they communicate with tumor cells and surrounding cells through secretion of exosomes containing various cargos. These exosomes have been shown to contribute to chemotherapy and radiotherapy resistance. This review specifically focuses on CAF-derived exosomes and their role in resistance to chemotherapy and radiotherapy in different types of tumors.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Margherita Correnti, Andrea Cappon, Mirella Pastore, Benedetta Piombanti, Giulia Lori, Douglas V. P. N. Oliveira, Patricia Munoz-Garrido, Monika Lewinska, Jesper B. Andersen, Cedric Coulouarn, Laurent Sulpice, Caterina Peraldo Neia, Giuliana Cavalloni, Santina Quarta, Alessandra Biasiolo, Matteo Fassan, Matteo Ramazzotti, Matteo Parri, Stefania Recalcati, Luca Tommaso, Claudia Campani, Pietro Invernizzi, Guido Torzilli, Fabio Marra, Patrizia Pontisso, Chiara Raggi
Summary: The study indicates a crucial role of SerpinB3 (SB3) in mediating the malignant phenotype of cholangiocarcinoma (CCA) and identifies it as a new therapeutic target. Overexpression of SB3 in the stem-like subset of tumor cells is associated with enhanced sphere-forming capacity, invasion ability, and poor prognosis in both mouse models and human CCA patients. These findings suggest SB3 as a potential target for future CCA therapies.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Luigi Ippolito, Giuseppina Comito, Matteo Parri, Marta Iozzo, Assia Duatti, Francesca Virgilio, Nicla Lorito, Marina Bacci, Elisa Pardella, Giada Sandrini, Francesca Bianchini, Roberta Damiano, Lavinia Ferrone, Giancarlo la Marca, Sergio Serni, Pietro Spatafora, Carlo V. Catapano, Andrea Morandi, Elisa Giannoni, Paola Chiarugi
Summary: This research reveals that lactate can promote lipid metabolism in prostate cancer cells through the regulation of gene expression, thus contributing to cancer progression and metastasis.
Review
Oncology
Erica Pranzini, Giovanni Raugei, Maria Letizia Taddei
Summary: Tumor recurrence is a major challenge for cancer patients, as cancer cells can enter a dormant state before re-emerging. The mechanisms behind this dormant state and subsequent awakening are largely unknown, but cancer metabolism is gaining attention as a critical driver of tumor progression. This review focuses on the metabolic adaptations of dormant cancer cells and their role in tumor re-growth. Understanding these metabolic pathways could lead to novel therapeutic approaches to prevent tumor recurrence.
Article
Gastroenterology & Hepatology
Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci, Rossano Lattanzio, Gianluca Sala, Paola Cappello, Francesco Novelli, Elisa Giovannetti, Caterina Vicentini, Silvia Andreani, Pietro Delfino, Vincenzo Corbo, Aldo Scarpa, Paolo Ettore Porporato, Andrea Morandi, Emilio Hirsch, Miriam Martini
Summary: This study reveals that loss of PI3K-C2 gamma in pancreatic ductal adenocarcinoma (PDAC) leads to hyperactivation of mTORC1 pathway and rewiring of glutamine metabolism, increasing tumor aggressiveness. Furthermore, PI3K-C2 gamma knockout tumors fail to adapt to metabolic stress induced by glutamine depletion, resulting in cell death. These findings suggest that targeting mTORC1 and glutamine metabolism may be a potential strategy for personalized treatment in PDAC with PI3K-C2 gamma loss.
Article
Biochemistry & Molecular Biology
Marta Peruzzi, Matteo Ramazzotti, Roberta Damiano, Marzia Vasarri, Giancarlo la Marca, Cinzia Arzilli, Raffaele Piumelli, Niccolo Nassi, Donatella Degl'Innocenti
Summary: This study performed quantitative analysis of oxidative biomarkers in the urine of congenital central hypoventilation syndrome (CCHS) patients and found that levels of urinary MDA were elevated in these patients, suggesting its relevance as a biomarker for systemic oxidative status in CCHS. The study highlights the importance of monitoring oxidative stress in CCHS patients and provides a useful tool for their management.
Article
Biochemistry & Molecular Biology
Elisa Pardella, Luigi Ippolito, Elisa Giannoni, Paola Chiarugi
Summary: Deregulated metabolism is a well-known feature of challenging diseases, and dietary nutrients and metabolic intermediates can act as hormone-like molecules through GPCRs to regulate pathophysiological processes.
Article
Biochemistry & Molecular Biology
Claudia Bello, Erica Pranzini, Emanuele Piemontese, Maximilian Schrems, Maria Letizia Taddei, Lisa Giovannelli, Mario Schubert, Christian F. W. Becker, Paolo Rovero, Anna Maria Papini
Summary: In this study, a panel of homogeneous O-glycosylated MUC1 peptides were prepared using a quantitative chemoenzymatic approach to investigate the impact of MUC1 glycosylation on cancer cell interactions and adhesion. Cell-adhesion experiments showed that different glycans significantly influenced adhesion, suggesting a distinct role for MUC1 glycosylation patterns in cancer cell migration and invasion. NMR spectroscopy studies revealed minor differences in peptide structure, linking the observed adhesion behavior to the type and number of glycans linked to MUC1.
Article
Biochemistry & Molecular Biology
Edda Russo, Leandro Di Gloria, Matteo Cerboneschi, Serena Smeazzetto, Gian Paolo Baruzzi, Francesca Romano, Matteo Ramazzotti, Amedeo Amedei
Summary: In this study, the variation in facial skin microbiome architecture through aging and its functional association with host genetic factors were investigated in a cohort of healthy women. The facial skin microbiota showed different composition in different age groups and between normal and dry skins. Functional variations associated with collagen biosynthesis and oxidative stress damage repair were observed in middle-aged women.
Article
Biology
Alberto Vassallo, Roberta Amoriello, Prandvera Guri, Lorenzo Casbarra, Matteo Ramazzotti, Marco Zaccaroni, Clara Ballerini, Duccio Cavalieri, Massimiliano Marvasi
Summary: This study investigates the molecular mechanisms of how E. coli adapts and survives in tomatoes. The researchers compare E. coli grown in tomatoes with those grown in laboratory conditions, identifying genes and molecular determinants involved in the bacteria's adaptation. The study also demonstrates the protective effects of adaptation in resisting toxic compounds.
Review
Oncology
Carlotta Becherini, Luca Visani, Saverio Caini, Indrani S. Bhattacharya, Anna M. Kirby, Gustavo Nader Marta, Gilberto Morgan, Viola Salvestrini, Charlotte E. Coles, Javier Cortes, Giuseppe Curigliano, Evandro de Azambuja, Nadia Harbeck, Clare M. Isacke, Orit Kaidar-Person, Elisabetta Marangoni, Birgitte Offersen, Hope S. Rugo, Andrea Morandi, Matteo Lambertini, Philip Poortmans, Lorenzo Livi, Icro Meattini
Summary: CDK4/6 inhibitors have become the standard treatment for HR+ and HER2- metastatic breast cancer, improving survival outcomes. Combining CDK4/6 inhibitors with endocrine therapy has shown significant benefits for high-risk HR+/HER2- early breast cancer. Each CDK4/6 inhibitor (palbociclib, ribociclib, and abemaciclib) has distinct toxicity profiles.
CANCER TREATMENT REVIEWS
(2023)
Review
Oncology
Viola Salvestrini, Kyubo Kim, Saverio Caini, Sara Alkner, Maria Ekholm, Tanja Skytta, Carlotta Becherini, Charlotte E. Coles, Orit Kaidar-Person, Birgitte Offersen, Evandro de Azambuja Luca Visani, Luca Visani, Javier Cortes, Nadia Harbeck, Hope S. Rugo, Clare M. Isacke, Elisabetta Marangoni, Andrea Morandi, Matteo Lambertini, Philip Poortmans, Lorenzo Livi, Icro Meattini
Summary: This study provides a summary of the safety profile of combining trastuzumab emtansine (T-DM1) with radiation therapy (RT) in breast cancer patients. The results indicate that the combination is safe and feasible for locoregional treatment in non-metastatic breast cancer, but caution is advised when irradiating intracranial sites.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Rania El-Botty, Ludivine Morriset, Elodie Montaudon, Zakia Tariq, Anne Schnitzler, Marina Bacci, Nicla Lorito, Laura Sourd, Lea Huguet, Ahmed Dahmani, Pierre Painsec, Heloise Derrien, Sophie Vacher, Julien Masliah-Planchon, Virginie Raynal, Sylvain Baulande, Thibaut Larcher, Anne Vincent-Salomon, Guillaume Dutertre, Paul Cottu, Geraldine Gentric, Fatima Mechta-Grigoriou, Scott Hutton, Keltouma Driouch, Ivan Bieche, Andrea Morandi, Elisabetta Marangoni
Summary: The study demonstrates that targeting oxidative phosphorylation (OXPHOS) using IACS-010759 can inhibit tumor growth in estrogen receptor positive breast cancer (ER + BC) patients resistant to endocrine treatments and palbociclib. The results indicate that OXPHOS is a promising target for the treatment of resistant ER + BC.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Nicoletta Nastasi, Amada Pasha, Gennaro Bruno, Angela Subbiani, Laura Pietrovito, Angela Leo, Lucia Scala, Lorena de Simone, Gabriella Casazza, Federica Lunardi, Maria Letizia Taddei, Angela Tamburini, Annalisa Tondo, Claudio Favre, Maura Calvani
Summary: Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Standard treatment includes surgery and chemotherapy, but the effectiveness is limited for metastatic or recurrent cases. This study investigates the efficacy of mifamurtide and identifies interleukin-10 as a possible target to improve its effectiveness. The synergistic use of mifamurtide and an anti-IL-10 antibody significantly increases cell death and reduces metastasis in a mouse model. The findings suggest that combining mifamurtide with an anti-IL-10 antibody may improve outcomes for osteosarcoma patients.
Article
Biochemistry & Molecular Biology
Gianluca Mattei, Zhuohui Gan, Matteo Ramazzotti, Bernhard O. Palsson, Daniel C. Zielinski
Summary: In this work, the authors present an algorithm, MetPath, that calculates pathways for condition-specific production and consumption of specific metabolites. These pathways take into account the condition-specific metabolic role of a gene product, are localized around defined metabolic functions, and weigh the importance of gene expression to a function based on flux contribution. The pathways elucidate network interactions between genes across different growth conditions and between cell types.
Article
Engineering, Environmental
C. Polizzi, T. Lotti, A. Ricoveri, R. Campo, C. Vannini, M. Ramazzotti, D. Gabriel, G. Munz
Summary: This study highlights the importance of controlling mineral precipitation on granular sludge systems treating wastewaters prone to inert precipitation to ensure long-term stability. Severe mineral precipitation on the granules' surface can lead to deteriorated reactor performance and biomass activity, with potential mechanisms including substrate diffusion limitation, insufficient mixing, and biofilm erosion. Gravimetric selection proved effective in restoring process performance affected by mineral precipitation.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)