Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Biochemistry & Molecular Biology
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li
Summary: RAGE, as a critical molecule in inflammatory response, binds to various ligands and initiates intracellular signal cascade. It plays a vital role in the occurrence and development of immune-related diseases and has crucial functions in different aspects of life activities. Therefore, targeted intervention in the RAGE signaling pathway may have significant therapeutic potential.
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha
Summary: This study evaluated the impact of glyoxal-lysine dimer (GOLD) on oxidative damage and inflammatory response in SV40 MES 13 mesangial cells. GOLD increased RAGE expression, reactive oxygen species production, and regulated NRF2 and GLO1 expression. Additionally, GOLD induced mitochondrial deterioration and inflammation through oxidative stress, and regulated MAPK and proinflammatory cytokines release. Inhibition of RAGE using RAGE siRNA suppressed the oxidative stress and inflammatory responses triggered by GOLD, highlighting the importance of the interaction between GOLD and RAGE in mesangial cell function.
Article
Chemistry, Applied
Hyun Hee L. Lee, Sang Keun Ha, Yoonsook Kim, Jinyoung Hur
Summary: A new pre-column derivatization method based on dansylation is proposed to overcome the analytical challenges in identifying and quantifying advanced glycation end products (AGEs). The method allows for the separation of different structural isomers of AGEs with low detection limits and wide linear ranges. The developed method shows potential applicability in various fields of food chemistry and biochemistry.
Article
Cell Biology
Lei Yang, Baozhu Liang, Jingxin Li, Xiaoyan Zhang, Hong Chen, Jia Sun, Zhen Zhang
Summary: Excessive accumulation of AGEs can impair autophagy on podocytes, while the SGLT2 inhibitor dapagliflozin effectively mitigates AGE-induced podocyte injury by promoting autophagy and regulating the AMPK-mTOR signal pathway.
CELLULAR SIGNALLING
(2022)
Article
Food Science & Technology
Qin Li, Leibing Li, Hanjian Zhu, Fan Yang, Ke Xiao, Lin Zhang, Menglin Zhang, Yongsheng Peng, Chao Wang, Dongsheng Li, Qian Wu, Mengzhou Zhou
Summary: This study investigated the inhibitory activity of lactic acid bacteria (LAB) on advanced glycation end-products (AGEs) during vinegar fermentation. The results showed that LAB strains can inhibit the formation of AGEs by accelerating substrate consumption, improving antioxidant activities, and inhibiting enzyme activities. Moreover, there was a negative correlation between fluorescent AGEs and carboxymethyl lysine (CML)/carboxyethyl lysine (CEL) with antioxidant activities, while enzyme activities were positively correlated with total phenolic content and total flavonoids.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Engineering, Biomedical
Andrey Zakharchenko, Christopher A. Rock, Tina E. Thomas, Samuel Keeney, Emily J. Hall, Hajime Takano, Abba M. Krieger, Giovanni Ferrari, Robert J. Levy
Summary: This study investigated the effects of several anti-advanced glycation end products (AGE) agents on bioprosthetic heart valves, and found that these agents could reduce the infiltration of AGE and serum protein in the valves. In addition, the use of these agents could alleviate the calcification of the valves.
Article
Orthopedics
Bin-Fei Zhang, Wei Song, Jun Wang, Peng-Fei Wen, Yu-Min Zhang
Summary: In this study, we investigated how HMGB1 mediated the apoptosis of AEC in a rat model. Our results showed that levels of HMGB1 and inflammatory cytokines were downregulated in the CS + EP, CS + FPS-ZM1, and CS + SP600125 groups compared to the CS group. Western blot and RT-qPCR analysis revealed a significant downregulation of HMGB1, RAGE, and phosphorylated-JNK in the CS + EP, CS + FPS-ZM1, and CS + SP600125 groups, indicating the involvement of the HMGB1/RAGE/JNK signaling axis in the apoptosis of AEC. TUNEL assay further confirmed the reduction of apoptotic cells in the CS + EP, CS + FPS-ZM1, and CS + SP600125 groups. These findings suggest that targeting the HMGB1/RAGE/JNK pathway may be a potential strategy to prevent AEC apoptosis after crush injuries.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Taro Miyagawa, Yasunori Iwata, Megumi Oshima, Hisayuki Ogura, Koichi Sato, Shiori Nakagawa, Yuta Yamamura, Yasutaka Kamikawa, Taito Miyake, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kengo Furuichi, Seiichi Munesue, Yasuhiko Yamamoto, Shuichi Kaneko, Takashi Wada
Summary: The study found that in acute kidney injury (AKI), the absence of both RAGE and sRAGE leads to more severe renal damage, while the addition of sRAGE can inhibit hypoxia-induced inflammation and promote cell viability in tubular epithelial cells.
Review
Chemistry, Medicinal
Amna Parveen, Razia Sultana, Seung Min Lee, Tae Hun Kim, Sun Yeou Kim
Summary: Research shows that advanced glycation end products play a crucial role in diabetes and its related complications, while natural products rich in bioactive constituents can control and prevent these diseases through various signaling cascades.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biology
Andrew J. Smith, Jayshree Advani, Daniel C. Brock, Jacob Nellissery, Jessica Gumerson, Lijin Dong, L. Aravind, Breandan Kennedy, Anand Swaroop
Summary: We identified a mitochondrial protein, GATD3A, with bacterial evolutionary affinities, that functions as a deglycase and restricts the formation of AGEs in mitochondria. GATD3A may play a role in maintaining the integrity of important biomolecules.
