Article
Biochemistry & Molecular Biology
Ze-Zhong Yu, Bu-Qing Xu, Ying-Ying Wang, Peng-Wei Zhang, Yu-Bin Shu, Zhi Shi
Summary: ABCG2 overexpression leads to multidrug resistance in colorectal cancer. Finding new inhibitors can be an effective way to overcome drug resistance.
Article
Medicine, Research & Experimental
Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V. Ambudkar
Summary: The overexpression of ABC transporters in cancer cells is associated with multidrug resistance. In this study, SKLB610 is found to reverse ABCG2-mediated resistance and increase sensitivity to anticancer drugs in multidrug-resistant cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Tian -Tian Zhao, Tian-Jiao Zhou, Chen Zhang, Ying-Xuan Liu, Chengjun Li, Lei Xing, Hu -Lin Jiang
Summary: In this study, dual-drug nanoparticles were prepared to overcome the drug resistance and poor antimetastatic effects in osteosarcoma treatment. The AD@PLGA-PEG NPs, containing albendazole and doxorubicin, showed enhanced intracellular reactive oxygen species and apoptosis efficiency compared to free DOX. Importantly, ABZ also inhibited the expression of HIF-1α and VEGF, leading to effective inhibition of tumor metastasis. Overall, the AD@PLGA-PEG NPs delivery system provided promising antitumor and antimetastatic efficacy for osteosarcoma.
MOLECULAR PHARMACEUTICS
(2023)
Article
Plant Sciences
Chung-Pu Wu, Yan-Qing Li, Tai-Ho Hung, Yu-Tzu Chang, Yang-Hui Huang, Yu-Shan Wu
Summary: SFG, a compound derived from plants, has the potential to reverse ABCG2-mediated multidrug resistance in NSCLC cells, suggesting a possible therapeutic effect.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Oncology
Duoli Xie, Zhuqian Wang, Jie Li, De-an Guo, Aiping Lu, Chao Liang
Summary: Osteosarcoma is an aggressive bone cancer with unknown molecular pathways, making it difficult to improve patient survival. Conventional therapies have severe side effects due to the lack of selectivity for malignant tissue. Researchers are exploring targeted treatment methods by combining specific ligands and chemotherapeutic agents to treat tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
Hao Shu, Bin Yuan, Yao Huang, Lei Wang, Bing He, Qi Sun, Luning Sun
Summary: The study aimed to investigate the role of ABCG2 in chemotherapy resistance and prognosis of osteosarcoma. Results showed a significant association between ABCG2 expression level, chemotherapy resistance, and overall survival in OS patients, suggesting ABCG2 as a potential therapeutic target for OS patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Environmental Sciences
Hongyu Xu, Ting Liu, Wenjie Li, Qi Yao
Summary: The transcriptional regulator SMAR1 has been found to be lowly expressed in osteosarcoma tissues and its overexpression can attenuate the stemness of OS cells. This is achieved by increasing the deacetylation level of the drug efflux pump ABCG2 and decreasing its transcriptional activity, which in turn positively regulates the chemotherapeutic sensitivity of OS cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Jonina S. Gudmundsdottir, Elizabeth G. A. Fredheim, Catharina I. M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan Andersson, Orjan Samuelsen, Pal J. Johnsen
Summary: The study found that methotrexate may selectively promote the evolution of trimethoprim resistance determinants, and selectively acts on them when co-existing on a multi-drug resistance plasmid. These selective effects occur at concentrations below the minimal inhibitory concentration of methotrexate.
Article
Oncology
Yingfang Fan, Tian Tao, Zhixing Guo, Kenneth Kin Wah To, Da Chen, Shaocong Wu, Chuan Yang, Jinsui Li, Min Luo, Fang Wang, Liwu Fu
Summary: The study demonstrates that lazertinib effectively reverses MDR by inhibiting drug efflux activities of ABCB1 and ABCG2, leading to increased intracellular accumulation of transporter substrate anticancer drugs. Additionally, lazertinib competitively binds to the ATP-binding site of the transporters and stimulates their ATPase activity, showing potential for overcoming MDR in cancer cells overexpressing ABCB1/ABCG2.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Philipp Stockmann, Lydia Kuhnert, Lisa Zoerner, Walther Honscha, Evamarie Hey-Hawkins
Summary: The role of ATP-binding cassette (ABC) transporter-mediated multidrug resistance (MDR) in anti-cancer therapy is challenging, as cancer cells exploit efflux transporters like BCRP to secrete chemotherapeutic substances. In this study, a hybrid BCRP inhibitor was designed by combining a prominent scaffold N-phenylquinazolin-4-amine with a boron-carbon cluster. The resulting compound showed increased inhibitory activity towards human ABCG2 and the ability to reverse drug resistance.
Review
Biochemistry & Molecular Biology
Daniela Damiani, Mario Tiribelli
Summary: The prognosis of acute myeloid leukemia (AML) remains unsatisfactory due to poor response to therapy or relapse, which can be attributed to the over-expression of multidrug resistance (MDR) proteins. ABCG2, an efflux transporter responsible for inducing MDR in leukemic cells, has the ability to extrude many antineoplastic drugs, leading to AML resistance and/or relapse. This review focuses on the expression and role of ABCG2, as well as its regulation and potential inhibition to counteract drug resistance and improve outcomes in AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Chenliang Zhou, Yong Sun, Ziying Gong, Jieyi Li, Xiaokai Zhao, Quanjun Yang, Hongjie Yu, Jianwei Ye, Jinrong Liang, Linlan Jiang, Daoyun Zhang, Zan Shen, Shuier Zheng
Summary: This study identified key mutations or polymorphisms in genes that correlate with osteosarcoma prognoses, with two SNVs located in MSH2 and FAT1 genes strongly correlated with osteosarcoma prognosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rossitza N. Irobalieva, Ioannis Manolaridis, Scott M. Jackson, Dongchun Ni, Els Pardon, Henning Stahlberg, Jan Steyaert, Kaspar P. Locher
Summary: This study explores the potential of inhibitors targeting sites other than the substrate binding pocket of ABCG2 and develops novel nanobodies as inhibitors. The results show that these nanobodies allosterically bind to different regions of the nucleotide binding domains and prevent the transporter from undergoing conformational changes required for substrate transport.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Melanie Zechner, Claudia A. Castro Jaramillo, Nadine S. Zubler, Marco F. Taddio, Linjing Mu, Karl-Heinz Altmann, Stefanie D. Kramer
Summary: Breast cancer resistance protein (BCRP, ABCG2) is a crucial efflux transporter involved in multidrug resistance to antineoplastic drugs. Ko143, an analogue of fumitremorgin C, is a potent ABCG2 inhibitor but is rapidly metabolized in vivo. In order to find ABCG2 inhibitors with improved metabolic stability, a series of Ko143 analogues were evaluated for their ability to inhibit ABCG2-mediated transport in cells and assessed for stability in liver microsomes. The most promising analogues increased the distribution of [11C]tariquidar, an ABCG2/ABCB1 substrate, to the brain in animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Kuang-Yu Chou, An-Chen Chang, Chao-Yen Ho, Te-Fu Tsai, Hung-En Chen, Po-Chun Chen, Thomas I-Sheng Hwang
Summary: Research on TSP4 has shown its association with the prognosis of bladder cancer, indicating that TSP4 is related to the progression and prognosis of bladder cancer, and may regulate through promoting MMP2 expression and cell motility. These findings facilitate further investigation into TSP4 silencing-based therapeutic strategies for bladder cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Thomas I-Sheng Hwang, Po-Chun Chen, Te-Fu Tsai, Ji-Fan Lin, Kuang-Yu Chou, Chao-Yen Ho, Hung-En Chen, An-Chen Chang
Summary: This study suggests the potential use of hsa-miR-30a-3p as a therapeutic intervention in bladder cancer. By suppressing the expression of matrix metalloproteinase-2 and MMP-9 and improving the chemosensitivity of bladder cancer cells, hsa-miR-30a-3p may reduce invasive potential and enhance the effectiveness of chemotherapy.
CELL DEATH & DISEASE
(2022)
Correction
Cell Biology
Thomas I-Sheng Hwang, Po-Chun Chen, Te-Fu Tsai, Ji-Fan Lin, Kuang-Yu Chou, Chao-Yen Ho, Hung-En Chen, An-Chen Chang
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yueh-Chien Lin, Yuan-Li Huang, Ming-Hua Wang, Chih-Yu Chen, Wei-Min Chen, Yi-Cheng Weng, Pei-Yi Wu
Summary: Prostate cancer is a common and deadly cancer in aging men worldwide, and recent research suggests that calreticulin (CRT) plays an important role in its regulation. In this study, we investigated the effects of CRT on the expression of beta 1-integrin in prostate cancer cells and found that it affects beta 1-integrin expression through distinct regulatory mechanisms.
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Shan-Chi Liu, Hung-Lun Hsieh, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsi-Chin Wu, Sunny Li-Yun Chang, Chin-Jung Hsu, Chih-Hsin Tang
Summary: Osteoarthritis is associated with upregulation of CCN2 and IL-17 expression, with CCN2 promoting IL-17 synthesis and osteoclast formation, and affecting IL-17 production by reducing miR-655 expression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell Biology
Te-Fu Tsai, An-Chen Chang, Po-Chun Chen, Chao-Yen Ho, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Summary: The study found that autophagy inhibitors can regulate cancer-associated immunosuppression in bladder cancer cells by influencing the expression of miR-34a and PD-L1. Consequently, the combined use of autophagy inhibitors and PD-L1 immune checkpoint blockade may serve as a potential therapeutic approach for treating bladder cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Alvin Kai-Xing Lee, Tsung-Li Lin, Chin-Jung Hsu, Yi-Chin Fong, Hsien-Te Chen, Chun-Hao Tsai
Summary: Three-dimensional printing and fracture mapping technology can reduce surgical time and blood loss, decrease postoperative complications, and improve reduction outcomes in pelvic and acetabular fractures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Hsi-Yao Wu, Yen-Hong Lin, Alvin Kai-Xing Lee, Ting-You Kuo, Chun-Hao Tsai, Ming-You Shie
Summary: This study demonstrates the fabrication of porous titanium scaffolds with precise structural designs using selective laser melting technology, and the successful modification of the scaffold surface with polydopamine and copper ions. The modified scaffolds maintain their general appearances and microstructural characteristics, while exhibiting improved hydrophilicity and surface roughness, promoting cell behaviors. Additionally, the scaffolds release ions in a sustained manner, leading to the upregulation of osteogenic and angiogenic-related proteins.
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Biochemistry & Molecular Biology
Nguyen Thi Nha Trang, Chao -Yang Lai, Hsiao-Chi Tsai, Yuan-Li Huang, Shan -Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Huey -En Tzeng, Chih-Hsin Tang
Summary: In this study, higher levels of APLN expression were found in osteosarcoma tissue compared to normal tissue, along with upregulation of PLOD2 mRNA synthesis. APLN increased PLOD2 expression and cell migration in osteosarcoma cell lines through MST1, MOB1, and YAP cascades, as well as through hsa_circ_0000004 acting as a sponge for miR-1303. Knockdown of APLN antagonized lung metastasis in mice with osteosarcoma. These findings suggest that APLN may be a potential therapeutic target for osteosarcoma metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Po-Han Su, Yi-Hsun Huang, Chen-Wei Yeh, Chun-Yen Chen, Yuan-Shun Lo, Hsien-Te Chen, Chun-Hao Tsai
Summary: This study assessed the recovery process and radiographic parameters associated with the functional outcomes in patients with spinopelvic dissociation (SPD) treated by triangular osteosynthesis. The study found that a vertical reduction in SPD during surgery may lead to more satisfactory outcomes than a horizontal anatomical reduction. The EQ-5D-5L and EQ-VAS showed significant improvements postoperatively, with different results depending on the measurement unit.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Trung-Loc Ho, Chih-Hsin Tang, Sunny Li-Yun Chang, Chun-Hao Tsai, Hsien-Te Chen, Chen-Ming Su
Summary: Skeletal muscle atrophy is caused by muscle wasting or reductions in protein associated with aging, injury, and inflammatory processes. The study found an association between HMGB1 and IL-18 signaling in skeletal muscle atrophy, and the HMGB1/IL-18 axis may be a potential target for the treatment of this condition.
Article
Endocrinology & Metabolism
Kun-Hui Chen, Chen-Ming Su, Wei-Ju Liu, Huey-En Tzeng, Chia-Lin Lee, Chun-Hao Tsai
Summary: This study investigates the association between physical activity, sleep duration, and osteoporosis in Taiwanese adults. The findings emphasize the joint role of sleep duration and physical activity in the prevention of osteoporosis, with individuals who engage in high physical activity and have longer sleep hours showing the lowest risk of osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Shang-Yu Yang, Chi-Jung Fang, Yu-Wen Chen, Wan-Ping Chen, Li-Ya Lee, Chin-Chu Chen, Yen-You Lin, Shan-Chi Liu, Chun-Hao Tsai, Wei-Chien Huang, Yang-Chang Wu, Chih-Hsin Tang
Summary: Hericium erinaceus mycelium has therapeutic effects on knee osteoarthritis, including relieving pain, reducing articular cartilage degradation and bone erosion, and inhibiting the synthesis of proinflammatory cytokines. Therefore, it shows promise as a functional food for the treatment of osteoarthritis.