Article
Cell Biology
Sheng Li, Lina Wu, Hong Zhang, Xijuan Liu, Zilei Wang, Bin Dong, Guang Cao
Summary: The study found that GINS1 is highly expressed in HCC tumors, associated with tumor grades, and predicts poor patient survival. By regulating the HRAS signaling pathway, GINS1 enhances HCC progression and promotes the stem cell activity of tumor cells. In addition, knocking down GINS1 can increase the sensitivity of HCC cells to sorafenib.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Saieh Hajighasemlou, Mohsen Nikbakht, Saeedreza Pakzad, Abdolnaser Azadbakht, Samad Muhammadnejad, Milad Mirmoghtadaei, Safoora Gharibzadeh, Iman Seyhoun, Javad Verdi
Summary: This study investigated the anti-inflammatory effect of mesenchymal stem cell (MSC)-based cell therapy on hepatocellular carcinoma (HCC) xenografts. The results showed that MSC therapy can reduce inflammation in HCC xenograft mouse models.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hui-Zhou Li, Qing-Qing Liu, De-Hua Chang, Shu-Xian Li, Long-Tao Yang, Peng Zhou, Jiang-Bei Deng, Chang-Hao Huang, Yu-Dong Xiao
Summary: In this study, differential co-expressed genes and their prognostic correlation between HCC and normal samples were explored using the GEO and TCGA dataset. The mRNA levels of these genes were validated and an eight-gene model was found to effectively predict the prognosis of HCC patients. NOX4 was identified as a potential therapeutic target and a biomarker for predicting the response to sorafenib treatment in HCC.
Review
Pharmacology & Pharmacy
Yang Zhang, Yanqi Zhong, Li Zou, Xiaoxia Liu
Summary: Well-developed placenta plays a fundamental role in successful pregnancy, while defective placental development is the underlying cause of preeclampsia. Placenta-derived mesenchymal stem cells (PMSCs) have the ability to differentiate into vessel wall cells and improve placental vasculature, artery remodeling, and immunoregulation. Recent studies have shown that preeclamptic PMSCs disrupt the balance and development in the placenta. However, transplantation or exosome therapies of PMSCs tend to improve placental vascular network and trophoblastic functions, suggesting a potential therapeutic strategy for preeclampsia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Gong Zhang, Yufeng Wang, Bryan C. Fuchs, Wei Guo, David L. Drum, Derek J. Erstad, Baomin Shi, Albert B. DeLeo, Hui Zheng, Lei Cai, Liyuan Zhang, Kenneth K. Tanabe, Xinhui Wang
Summary: The combination of DSF/Cu and sorafenib can effectively treat HCC by targeting HCSCs both in vitro and in vivo. DSF/Cu enhances the sensitivity of HCC cells to sorafenib, inhibits proliferation of HCC cells, and decreases the stemness of HCC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yeonghoon Son, Na-Rae Shin, Sung-Ho Kim, Su-Cheol Park, Hae-June Lee
Summary: This study investigated the role of FGL1 in regulating sorafenib resistance in HCC cells, showing that high expression of FGL1 in HCC cells leads to greater sensitivity to sorafenib and knocking down FGL1 can reduce the inhibitory effects of sorafenib, possibly through modulation of ERK and autophagy signals. These findings suggest FGL1 as a potential biomarker for sorafenib resistance and a target for HCC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wei Wang, Qun Wang, Da-Bing Huang, Qi-Kai Sun, Shu-Sheng Wu, Ya-Jun Zhao, Wei Jia, De-Sheng Hu, Yi-Fu He
Summary: Tumor-associated MSCs accelerate HCC growth and metastasis through the DNM3OS/KDM6B/TIAM1 axis. High DNM3OS expression is associated with poor prognosis in HCC patients, and silencing DNM3OS can inhibit HCC cell proliferation and invasion.
Article
Cell Biology
Zhaochen Ma, Wenjia Chen, Yudong Liu, Lingxiang Yu, Xia Mao, Xiaodong Guo, Funeng Jiang, Qiuyan Guo, Na Lin, Yanqiong Zhang
Summary: This study found that artesunate may have a potential therapeutic effect on mitigating sorafenib resistance in advanced hepatocellular carcinoma by exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy.
Article
Biochemistry & Molecular Biology
Jin Seok, Hyeri Park, Dae-Hyun Lee, Jun Hyeong You, Gi Jin Kim
Summary: Oxidative stress causes various degenerative diseases, including infertility due to ovarian dysfunction. Stem cell therapy has been studied as a potential solution, but the appropriate number of cells needed for the therapy is still unclear. In this study, researchers focused on determining the suitable dose of placenta-derived mesenchymal stem cells (PD-MSCs) for transplantation in an animal model with ovarian dysfunction.
Article
Oncology
Yongrong Lei, Xishu Wang, Heng Sun, Yuna Fu, Yichen Tian, Ludi Yang, Jianhua Wang, Feng Xia
Summary: The study found a strong correlation between Nanog expression in CTCs and poor prognosis in HCC patients, suggesting that Nanog expression could be a valuable marker for tumor progression evaluation. The detection and analysis of CTC markers (EpCAM, CK8, 18, CD45, Vimentin, Twist, and 19) and CSCs markers (NANOG) are crucial in predicting HCC recurrence and prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Jialiang Luo, Lei Li, Zhengyumeng Zhu, Bo Chang, Fan Deng, Di Wang, Xiao Lu, Daming Zuo, Qingyun Chen, Jia Zhou
Summary: This study demonstrated that the combination of fucoidan and sorafenib could overcome sorafenib resistance in hepatocellular carcinoma cells by interacting with cell membrane EGFR and suppressing EGFR redistribution and downstream signaling. The simultaneous treatment of fucoidan and sorafenib might serve as a potential therapeutic strategy against sorafenib-resistant HCC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Li-Zhu Liao, Chih-Ta Chen, Nien-Chen Li, Liang-Chun Lin, Bo-Shih Huang, Ya-Hui Chang, Lu-Ping Chow
Summary: Hepatocellular carcinoma is a common type of cancer worldwide, with sorafenib being the preferred treatment for advanced stages. However, resistance to sorafenib is a major challenge. The study identified elevated phosphorylation of the transcription factor Y-box binding protein-1 (YB-1) in sorafenib-resistant cells, leading to increased cell migration and invasion. The findings suggest a potential role of YB-1 in promoting hepatocellular carcinoma metastasis and highlight the importance of understanding the specific mechanisms to develop effective strategies against resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yan Liao, Yue Yang, Di Pan, Youxiang Ding, Heng Zhang, Yuting Ye, Jia Li, Li Zhao
Summary: Hypoxia in solid tumors induces resistance to chemotherapy, and in this study, researchers established a hypoxia model to investigate Sorafenib resistance in Hepatocellular carcinoma (HCC). The study revealed that HSP90 alpha plays a crucial role in Sorafenib resistance under hypoxia by promoting chaperone-mediated autophagy degradation. The results suggest that HSP90 alpha inhibitor, Demethoxygeldanamycin (17-AAG), could potentially reverse Sorafenib resistance in liver cancer.
Review
Oncology
Zhonghao Jiang, Chaoliu Dai
Summary: Liver cancer is a highly malignant disease with low sensitivity to chemotherapy, and the prognosis for patients is poor. Sorafenib has been the only first-line therapeutic agent for advanced hepatocellular carcinoma (HCC) until the discovery of lenvatinib. However, many HCC patients are insensitive to sorafenib, and the overall efficacy of the drug is unsatisfactory. This study reviews the potential mechanisms of sorafenib resistance and summarizes combination therapies and potential drugs that can sensitize HCC cells to sorafenib based on previous studies and reports.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Oncology
Qinqin Liu, Nan You, Jing Li, Ke Wu, Xuehui Peng, Zheng Wang, Liang Wang, Yinan Zhu, Lu Zheng
Summary: The study found that the combination of camrelizumab and sorafenib significantly improved the overall response rate and progression-free survival of patients with advanced HCC, but had no significant impact on overall survival. The combination therapy group exhibited more adverse events in terms of efficacy, but most of these adverse events were easily controlled after treatment. Further prospective randomized trials are needed to confirm the potential clinical benefits of this combination therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Farideh Zafari Zangeneh, Samad Muhammadnejad, Mohammad Mehdi Naghizadeh, Mina Jafarabadi, Maryam Sarmast Shoushtari, Masoumeh Masoumi
Summary: In women with PCOS, the sympathetic nervous system is hyperactive, and clonidine can help modulate this activity. The study showed that clonidine can increase oocyte maturity and pregnancy rate in PCO women, both in vivo and in vitro. These findings have implications for the pharmacological treatment of anovulation and assisted reproductive technology.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Maryam Behfar, Samad Muhammadnejad, Shahrokh Abdolahi, Rashin Mohseni, Alireza Shoae-Hassani, Seyed Mostafa Monzavi, Amir Ali Himidieh
Summary: This study evaluated the efficacy of adoptive NK-cell transfer as a potential treatment for high-risk WT. The effects of cell source and ex vivo activation strategy on the therapeutic efficacy of NK-cell product were also assessed.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Engineering, Biomedical
Sareh Abolhassani, Mahdokht Hossein-Aghdaei, Bita Geramizadeh, Negar Azarpira, Farhad Koohpeyma, Mahnaz Gholami, Aliakbar Alizadeh
Summary: This study aimed to develop a controlled-shape hydrogel and apply conditioned-media of mesenchymal stromal cells (CM-MSCs) to improve primary hepatocyte functions. The patterned alginate hydrogel was produced using an electrodeposition method. The presence of CM-MSCs significantly increased urea synthesis in the patterned hydrogel alginate compared to 2D culture after 3 days.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Zahra Abpeikar, Mohsen Safaei, Ali Akbar Alizadeh, Arash Goodarzi, Gholamreza Hatam
Summary: Cutaneous leishmaniasis (CL) is a global health issue, and conventional treatments have drawbacks. Topical treatment is a cost-effective approach for CL, and electrospun fibers and hydrogels are promising drug release systems for treating skin lesions. Polymeric scaffolds, microneedle patches, and nanocarriers enhance drug delivery to the skin. Additionally, cell therapy shows potential in overcoming leishmaniasis. This study investigates various treatment options, such as tissue engineering scaffolds, nanotechnology, and cell therapy, for reducing CL complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Marzieh Nemati, Zahra Ebrahimi, Sareh Abolhassani, Fatemeh Nemati, Bahareh Ebrahimi, Aliakbar Alizadeh
Summary: Stem cells offer a new avenue for treating liver disorders. They have the potential to differentiate into various specialized cell types, and efforts have been made to enhance their differentiation into hepatocytes. However, the effectiveness of this differentiation process depends on factors such as cell-to-cell adhesion and biological changes. A comprehensive review of studies on stem cell differentiation revealed that most research focused on mesenchymal stem cells, with acute liver failure being the most investigated liver disorder. Tissue engineering methods were commonly used for differentiation, and functional parameters were frequently evaluated.
BIOMED RESEARCH INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Fatemeh Parsaee, Aliakbar Alizadeh, Mostafa Rezaee, Omid Alavi, Hamed Alipour
Summary: This study investigated the properties of the PRF scaffold with tricalcium phosphate nanoparticles in socket preservation and found that it promotes bone regeneration. The experimental results showed that PRF/TCP scaffold accelerates bone formation, resulting in a higher amount of bone tissue and collagen fibers. The mechanical and chemical tests also confirmed that the addition of TCP to the PRF scaffold reduces swelling and prolongs degradation time. In conclusion, the injectable PRF\TCP hydrogel is a promising candidate for bone repair and regeneration.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Zahra Abpeikar, Ali Akbar Alizadeh, Leila Rezakhani, Vahid Ramezani, Arash Goodarzi, Mohsen Safaei
Summary: Material engineering is crucial in medical applications of materials. Recognition sites on biomaterial surfaces play a key role in enhancing tissue engineering scaffolds' efficiency. Synthetic ligands like nucleic acid aptamers have advantages in terms of synthesis ease, minimal immunogenicity, specificity, and stability. This study reviews the advantages of nucleic acid aptamers in tissue engineering, such as attracting endogenous stem cells for tissue regeneration and improving controlled drug delivery.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Hengameh Dortaj, Ali Akbar Alizadeh, Negar Azarpira, Lobat Tayebi
Summary: The administration of stem cells in regenerative medicine has emerged as a potential treatment option for many diseases. Many questions remain about the survival and biology of SC after transplantation. Non-invasive SC monitoring has been updated to assess the viability and biology of SC transplantation, and the use of nanoparticles has become important in many aspects of SC tracking.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Seyed Mostafa Monzavi, Amir Ali Hamidieh, Mohammad Vasei, Jafar Ai, Naser Ahmadbeigi, Hamid Arshadi, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh
Summary: This study aimed to investigate the feasibility of isolating WT1-reactive T cells from PBMCs and assess their cytotoxicity against WiTu cells. The results showed higher proportions of WT1-reactive T cells were isolated from Wilms tumor patients compared to healthy donors. WT1-reactive T cells exhibited anti-tumoral activity in a dose-dependent manner and mediated significantly greater cytotoxicity than non-WT1-reactive PBMCs on WT1+ WiTu cells. The cytotoxicity of standard chemotherapy was significantly lower than that of WT1-reactive T cells.
Article
Neurosciences
Amin Firoozi, Aliakbar Alizadeh, Asadollah Zarifkar, Tahereh Esmaeilpour, Mohammad Reza Namavar, Omid Alavi, Farzaneh Dehghani
Summary: This study aimed to investigate the effects of conditioned medium of human umbilical cord mesenchymal stem cells and platelet-rich plasma on AD model rats. The results showed that CM improved learning and memory impairments as well as the structure of the hippocampus.
IBRO NEUROSCIENCE REPORTS
(2023)
Review
Medicine, Research & Experimental
Sanaz Dastghaib, Farhad Koohpeyma, Mesbah Shams, Forough Saki, Aliakbar Alizadeh
Summary: Compared to the well-studied regulation of calcium homeostasis, our understanding of phosphate homeostasis is limited. Fibroblast growth factor 23 (FGF23) has recently gained attention as a key regulator of phosphate homeostasis, and further research is needed to fully understand its functions and interactions with other factors involved in mineral homeostasis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mobin Haghdel, Mohammad Hadi Imanieh, Hamidreza Hosseinpour, Younes Ghasemi, Ali Akbar Alizadeh
Summary: The esophagus is an important organ in the digestive system, and its lesions can cause significant damage to nutrition and digestion. Tissue engineering using scaffold biomaterials has emerged as a promising approach for repairing damaged esophageal segments. However, current methods have limitations and further improvement is needed.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Mobin Haghdel, Mohammad Hadi Imanieh, Hamidreza Hosseinpour, Younes Ghasemi, Ali Akbar Alizadeh
Summary: Esophageal tissue engineering focuses on the treatment of esophageal lesions, aiming to repair damaged esophageal segments using suitable scaffold materials and fabrication techniques.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Entomology
Naeimeh Teymouri, Ali Alizadeh, Fateme Haghiralsadat, Mahdie Hemati
Summary: This study developed abamectin-containing nanoliposomes/nanoniosomes using the thin-film hydration method and evaluated their effects on T. urticae. The nanoniosomal form showed the highest toxicity and reduced the mite's performance. These stable and effective nanopesticides can be used for the management of this destructive mite.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Seyed Mostafa Monzavi, Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh
Summary: This study reports a serial occurrence of xenogeneic graft-versus-host disease (xGvHD) in consecutive passages of Wilms' tumor patient-derived xenografts (PDX) in severely immunocompromised NOG mice, and discusses potential solutions to prevent such complications.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2022)