Article
Engineering, Biomedical
Sanaz Behtaj, Fereshteh Karamali, Samaneh Najafian, Elahe Masaeli, Mohammad-Hossein Nasr Esfahani, Maksym Rybachuk
Summary: Stem cell-based retinal ganglion cells (RGCs) replacement therapy shows potential for restoring vision in glaucoma by replacing degenerated RGCs and facilitating axonal regeneration. However, generating clinically safe and functional RGCs that can integrate into hosts' retinas remains a challenge. The use of PGS/PCL scaffold in differentiation of hESCs into RGC-like cells promotes cell differentiation and neurite growth, contributing to potential future clinical therapy for glaucoma treatment.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Jose A. Fernandez-Albarral, Juan J. Salazar, Rosa de Hoz, Eva M. Marco, Beatriz Martin-Sanchez, Elena Flores-Salguero, Elena Salobrar-Garcia, Ines Lopez-Cuenca, Vicente Barrios-Sabador, Marcelino Aviles-Trigueros, Francisco J. Valiente-Soriano, Juan A. Miralles de Imperial-Ollero, Manuel Vidal-Sanz, Alberto Trivino, Jose M. Ramirez, Meritxell Lopez-Gallardo, Ana I. Ramirez
Summary: Studies have shown that glaucoma leads to changes in cytokine levels after ocular hypertension, confirming the involvement of the immune system in glaucomatous neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Plant Sciences
Zahra Ayatollahi, Vaiva Kazanaviciute, Volodymyr Shubchynskyy, Kotryna Kvederaviciute, Manfred Schwanninger, Wilfried Rozhon, Michael Stumpe, Felix Mauch, Sebastian Bartels, Roman Ulm, Salma Balazadeh, Bernd Mueller-Roeber, Irute Meskiene, Alois Schweighofer
Summary: This study reveals the crucial role of different types of MAPK phosphatases in plant stress responses and the tight control of MAPK activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Environmental Sciences
Teng Hu, Di Li, TiePing Fan, XuSheng Zhao, ZhongJun Chen
Summary: Numerous studies have found that circular RNA (circRNA) plays an important role in cerebral ischemia-reperfusion (CIR) injury. A recent study discovered a novel circRNA, circCRIM1, which was highly expressed in a CIR model. This study aimed to investigate the role of circCRIM1 in CIR-induced neuronal apoptosis. The results showed that circCRIM1 was up-regulated, while miR-141-3p was down-regulated in the CIR model. Knocking down circCRIM1 reduced apoptosis and oxidative stress, while overexpression of circCRIM1 accelerated apoptosis and disrupted redox balance.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Engineering, Biomedical
Hina Raja, Taimur Hassan, Muhammad Usman Akram, Naoufel Werghi
Summary: This study introduces a novel strategy focusing on RGC atrophy for screening and grading the severity of glaucomatous pathologies. The proposed framework utilizes a hybrid convolutional network to extract specific regions in the retina, allowing for quantitative screening of glaucomatous subjects. The performance of this framework is rigorously tested and clinically validated, achieving high accuracy in diagnosing and grading glaucomatous progression.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Oncology
Junpeng Cui, Yang Ge, Wei Sun, Baolin Liu, Chaoliu Dai
Summary: This study investigated the expression and function of CgB in colonic neuroendocrine carcinoma (NEC). It was found that the expression of CgB was significantly upregulated in colonic NEC tissues and promoted cell invasion, migration, as well as epithelial mesenchymal transition (EMT) and stemness. Mechanistically, CgB overexpression activated p38 MAPK and ERK pathways. Overall, CgB contributes to the development of colonic NEC by activating p38 MAPK and ERK pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Shiliang Dong, Minrui Ma, Ming Li, Yuexin Guo, Xiaoxiao Zuo, Xiaobin Gu, Mingzhi Zhang, Yonggang Shi
Summary: MEG3 and RBMS3 are low-expressed in breast cancer, negatively correlated with miR-141-3p, and positively correlated with each other. MEG3 inhibits BC cell proliferation and promotes apoptosis by down-regulating miR-141-3p and up-regulating RBMS3.
Article
Oncology
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuan Xia, Xuewei Wen, Bin Cai, Yan Li
Summary: Acteoside alleviates RGC loss and oxidative stress by activating the PI3K/AKT signaling pathway through upregulation of Cav1.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka
Summary: The study examined the roles of Clock genes and BMP system in regulating gonadotropin secretion by GnRH using mouse L beta T2 cells. The results showed that LH beta mRNA expression in L beta T2 cells changed over time and was influenced by Bmal1 and Clock. ERK and BMPs were found to be involved in the regulation of LH beta mRNA expression at different stages after GnRH stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Wenli Jiao, Weichen Ding, Jeffrey A. Rollins, Jinliang Liu, Yanhua Zhang, Xianghui Zhang, Hongyu Pan
Summary: In this study, SsTOR was identified as a critical component of the TOR signaling pathway in S. sclerotiorum. Gene silencing of SsTOR resulted in decreased mycelial growth, disrupted sclerotia and compound appressoria formation, and reduced virulence. Additionally, SsTOR was found to regulate cell wall integrity through the phosphorylation of SsSmk3 and induce autophagy potentially through SsAtg1 and SsAtg13. Overall, this study highlights the importance of SsTOR as a global regulator of growth, stress responses, cell wall integrity, autophagy, and virulence in S. sclerotiorum.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Xiaolin Jia, Ming Yang, Wei Hu, San Cai
Summary: The study found that miR-22-3p expression was lower and MAPK14 expression was higher in serum from patients with OP, and the two were negatively correlated in these patients. Additionally, miR-22-3p expression decreased during CD14(+) peripheral blood mononuclear cells (PBMCs) osteoclastic differentiation, inhibiting cell proliferation and differentiation while promoting apoptosis by targeting MAPK14.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Ophthalmology
Yifan Feng, Liyang Wang, Chunqiong Dong, Xi Yang, Jing Wang, Xi Zhang, Yuanzhi Yuan, Jinhui Dai, Jinhai Huang, Fei Yuan
Summary: miR-376b-3p is a suppressor of glutamine metabolism in endothelial cells. It inhibits the expression of GLS1 by suppressing CEBPB, leading to the inhibition of proliferation, migration, tube formation, and the promotion of apoptosis in HRMECs. Ultimately, it restrains CNV formation and may serve as a therapeutic target for CNV-related diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)