Article
Cell Biology
Yan Lu, Yijia Shao, Yinping Xie, Huinan Qu, Da Qi, Yuan Dong, Qiu Jin, Liping Wang, Junyuan Wei, Chengshi Quan
Summary: Overexpression of CLAUDIN6 can inhibit the malignant behavior of breast cancer by suppressing cell proliferation, migration, and invasion. CLAUDIN6 achieves this effect by inhibiting the ERK/Sp1/cyclin D1 and ERK/IL-8 signaling pathways.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Catia Morelli, Chiara Chiodo, Marta Claudia Nocito, Alessandro Cormace, Stefania Catalano, Diego Sisci, Rosa Sirianni, Ivan Casaburi, Sebastiano Ando, Marilena Lanzino
Summary: Androgen receptor expression is associated with lower tumor grade and better clinical outcome in estrogen receptor-positive breast cancer. Activation of intracellular androgen receptor upregulates BAD, which is associated with better disease-free survival in ER+ BC. Androgens influence the cellular compartmentalization of BAD, enhancing its nuclear and mitochondrial levels, and contribute to the anti-proliferative effect of androgens in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Swapna Asuthkar, Sujatha Venkataraman, Janardhan Avilala, Katherine Shishido, Rajeev Vibhakar, Bethany Veo, Ian J. Purvis, Maheedhara R. Guda, Kiran K. Velpula
Summary: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and the standard of care for MB patients includes maximum safe resection, postoperative craniospinal irradiation, and chemotherapy. Recent research has identified SMYD3 as a crucial epigenetic regulator, which activates the transcription of cyclin D3 and drives the growth of Group 3 Myc+ MB cells.
Article
Chemistry, Multidisciplinary
Tianci Han, Liang Zhang, Wei Tong, Jian Zhao, Wei Wang
Summary: This study explores the interaction between cyclin D1 and calycosin and provides insights into their binding properties and potential structural changes. The results indicate that hydrogen bonding and van der Waals forces are involved in the binding of calycosin with cyclin D1, leading to structural alterations in cyclin D1. Additionally, calycosin inhibits lung cancer cell proliferation by arresting the cell cycle at the G1 phase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee
Summary: Cancer, a disease of inappropriate cell proliferation, is closely linked to the cell cycle, with multiple genetic alterations leading to cancer development. Both oncogenes and tumor suppressor genes regulate the cell cycle and play key roles in breast cancer progression. These components are tightly controlled in normal breast epithelial cells, but following mitogenic stimuli, their deregulation promotes neoplastic transformation. Numerous clinical studies have revealed prognostic significance in screening for these components, impacting patient outcomes and treatment responses. The review aims to summarize the roles of oncogenic and tumor-suppressive components in breast cancer progression and prognosis.
Article
Biotechnology & Applied Microbiology
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O. Ahmed, Nabil Siraji, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Summary: The study demonstrated that cyclin D1 over-expression in Middle Eastern breast cancers is associated with favorable prognostic features, serving as an independent predictor of overall survival and recurrence-free survival. Cyclin D1 expression was also found to be associated with phospho-Rb in luminal subtype of breast cancer, predicting luminal A breast cancer independently.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Junmei Hao, Wenfeng Zhang, Yan Lyu, Jiarui Zou, Yunyun Zhang, Jiahong Lyu, Jianbo Zhang, Shuishan Xie, Cuiping Zhang, Jiandi Zhang, Fangrong Tang
Summary: In this study, it was found that cyclinD1 can be an independent prognostic factor, and in combination with Ki67, plays an important role in prognosis analysis. Subgroups with both biomarkers below optimized cutoffs had significantly higher survival rates compared to those with both biomarkers above the cutoffs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jennifer P. Ditano, Nandini Sakurikar, Alan Eastman
Summary: CDK complexes play crucial roles in cell cycle regulation, with CDK2 being regulated by different cyclin partners. Changes in phosphorylation status of CDC25A affect CDK2 activity. Inhibition of CHK1 results in accumulation of CDC25A and activation of CDK2.
Article
Biochemistry & Molecular Biology
Chao-Ming Hung, Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Our research shows that sulforaphane (SFN) has chemopreventive and potential chemotherapeutic effects on breast adenocarcinoma. Further studies are needed to understand the mechanisms behind SFN's antitumor activity. Our experiments demonstrate that SFN inhibits the growth of cancer cells and induces apoptosis, suggesting it could be used as an anticancer agent.
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Oncology
Zhengyan Yang, Hongyun Xu, Yupo Yang, Chaoqun Duan, Pai Zhang, Yang Wang, Kai Fu, Yonghong Shen, Marvin Xuejun Xu
Summary: In this study, a new naphthalene derivative called SMY002 was synthesized, which showed potent inhibitory effects on the STAT3 signal in TNBC cells. SMY002 directly interacted with the SH2 domain of STAT3, leading to inhibition of phosphorylation, dimerization, nuclear distribution, transcriptional activity, and target genes expression of STAT3. SMY002 also suppressed migration, invasion, survival, growth, and metastasis of TNBC cells in vitro and in vivo by down-regulating the expression of Cyclin D1 and MMP9.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Ping Guo, Shijia Zu, Shilong Han, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin, Xinrui Zhao, Haibo Lu, Chunyu Hua, Xinyu Wan, Liyuan Ru, Ziyue Guo, Hanxiao Ge, Kuan Lv, Guohui Zhang, Wuguo Deng, Cheng Luo, Wei Guo
Summary: This study revealed that Bromodomain PHD Finger Transcription Factor (BPTF) promotes colorectal cancer (CRC) progression by targeting Cdc25A under the regulation of c-Myc. Inhibition of BPTF could be a promising strategy for CRC treatment, and the c-Myc/BPTF/Cdc25A signaling axis may serve as candidate biomarkers for CRC diagnosis and prognosis prediction.
Article
Cell Biology
Xiao-Kun Wang, Ya-Wei Zhang, Chun-Ming Wang, Bo Li, Tian-Zhi Zhang, Wen-Jie Zhou, Lyu-jia Cheng, Ming-Yu Huo, Chang-Hua Zhang, Yu-Long He
Summary: The study showed that METTL16 was highly expressed in gastric cancer and associated with prognosis. In vitro and in vivo experiments confirmed that METTL16 promoted proliferation of GC cells and tumor growth. Furthermore, METTL16 was found to enhance proliferation of GC cells by regulating the expression of cyclin D1.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hai-Zhou Wu, Lan-Ya Li, Shi-Long Jiang, Yi-Zhi Li, Xiao-Mei Shi, Xin-Yuan Sun, Zhuo Li, Yan Cheng
Summary: This study found that overexpression of RSK2 in melanoma leads to resistance to vemurafenib therapy and is associated with poor overall survival in melanoma patients. In addition, the inhibition of RSK2 can suppress melanoma cell proliferation and enhance sensitivity to vemurafenib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Elnaz Fazeli, Samira Piltan, Hossein Sadeghi, Milad Gholami, Ghasem Azizi-Tabesh, Fakhrolmolook Yassaee, Reza Mirfakhraie
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Plant Sciences
Zahra Soleimannejad, Hamid Reza Sadeghipour, Ahmad Abdolzadeh, Masoud Golalipour
ACTA PHYSIOLOGIAE PLANTARUM
(2020)
Article
Obstetrics & Gynecology
Elnaz Fazeli, Samira Piltan, Milad Gholami, Mojdeh Akbari, Zahra Falahati, Fakhrolmolook Yassaee, Hossein Sadeghi, Reza Mirfakhraie
Summary: This study investigated the expression level of CYP24A1 in uterine leiomyoma samples compared to adjacent tissues. Results showed that CYP24A1 gene was ectopically expressed in 18% of uterine leiomyoma tissues, independent of the MED12 mutation profile. This supports the idea that dysregulation of vitamin D signaling and metabolic pathways may be involved in some subtypes of ULMs.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Medical Laboratory Technology
Ehsan Gharib, Ehsan Nazemalhosseini-Mojarad, Kaveh Baghdar, Zahra Nayeri, Hossein Sadeghi, Sama Rezasoltani, Arezo Jamshidi-Fard, Pegah Larki, Amir Sadeghi, Mehrdad Hashemi, Hamid Asadzadeh Aghdaei
Summary: This study aimed to detect early CRC through the analysis of fecal colonocytes lncRNAs. The designed predictive panel showed high diagnostic performance in distinguishing CRC from healthy individuals and CRC from polyps.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Medical Laboratory Technology
Hossein Sadeghi, Zeeba Kamaliyan, Roohollah Mohseni, Unes Sahebi, Ehsan Nazemalhosseini-Mojarad, Naser Aghaei, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Reza Mirfakhraie, Arfa Moshiri
Summary: The study revealed that the CYP2R1 and CYP27B1 genes are overexpressed in colorectal cancer tissues, while the CYP2R1rs12794714 variant is associated with CRC risk.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Hossein Sadeghi, Mohammad Heiat
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Obstetrics & Gynecology
Sahra Esmkhani, Hossein Sadeghi, Majid Ghasemian, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Fakhrolmolouk Yassaee, Reza Mirfakhraie
Summary: The study identified a significant association between the HOTAIR rs920778 polymorphism and preeclampsia risk in Iranian women, with a pronounced increase in risk. Further research is needed to validate these findings.
HYPERTENSION IN PREGNANCY
(2021)
Article
Biochemistry & Molecular Biology
Hossein Sadeghi, Sahra Esmkhani, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Ghasem Azizi Tabesh, Mohammad Reza Ghasemi, Latif Gachkar, Reza Mirfakhraie
Summary: Preeclampsia is a major complication of pregnancy that is more common in mothers carrying a fetus with a mutation in the CREBBP gene. The expression level of CREBBP gene is higher in preeclampsia patients, with slightly higher expression in the fetal side of the placenta. This suggests a role for CREBBP in the pathogenesis of preeclampsia and potential as a target for future studies due to its involvement in angiogenesis and hypoxia.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Statistics & Probability
Mahnaz Khalafi, Ahmad Reza Soltani, Masoud Golalipour, Majid Azimmohseni, Farzad Najafiamiri
Summary: In this paper, a class of multivariate periodically correlated processes and their corresponding time-domain and spectral-domain characterizations are introduced. A spectral coherence measure based on the Hilbert-Schmidt inner product of the Fourier transforms is proposed to assess the dependence between two periodically correlated processes. An estimator for the spectral coherence is developed along with a hypothesis for significant dependence and a testing procedure. Numerical examples using simulated and real PC time series are presented to illustrate the performance of the spectral coherence and its estimator.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2022)
Article
Genetics & Heredity
Emad Khodadadi, Seyed Mostafa Mir, Mohammad Yousef Memar, Hossein Sadeghi, Meysam Kashiri, Mehri Faeghiniya, Zahra Jamalpoor, Mehdi Sheikh Arabi
Summary: Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play important roles in tumorigenesis. The shelterin complex, consisting of six telomere-specific proteins, protects telomeres, prevents the activation of repair systems, and regulates telomerase activity. Alteration in shelterin complex proteins may lead to tumorigenesis.
Article
Biology
Parisa Najari-Hanjani, Touraj Farazmandfar, Masoud Golalipour
Summary: This study found that the PER3P1 pseudogene may positively affect the expression of PER3 and other clock-related genes, while also modulating the expression level of clock genes.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Article
Medicine, Research & Experimental
Maryam Memar, Touraj Farazmandfar, Amir Sabaghian, Majid Shahbazi, Masoud Golalipour
Summary: In this study, a stable cisplatin-resistant TNBC cell line was developed by exposing MDA-MB-231 cells to different concentrations of cisplatin. RNA-sequencing analysis and quantitative PCR were used to identify key pathways and genes associated with cisplatin-resistant TNBC. The results revealed that these genes are mainly involved in drug resistance-related pathways, especially the PI3K-Akt signaling pathway. The most important genes identified were heme oxygenase 1 and TIMP metallopeptidase inhibitor 3.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Plant Sciences
Zahra Soleimannejad, Hamid Reza Sadeghipour, Ahmad Abdolzadeh, Masoud Golalipour, Mohammad Reza Bakhtiarizadeh
Summary: Transcriptome analysis revealed that Cd stress in radish leaves resulted in changes in biological regulation, photosynthesis, and secondary metabolite synthesis. Cd triggered ROS production, photosynthesis decline, and protein hydrolysis, leading to the re-mobilization of nitrogen and carbon stores. The downregulation of glucosinolate metabolism favored chelator synthesis, and the upregulation of dehydrins increased tolerance to ionic/osmotic imbalances caused by heavy metals.
Article
Biochemistry & Molecular Biology
Mahnaz Hashemi, Masoud Golalipour
Summary: The overexpression of the ABCC6P1 pseudogene induces drug resistance, possibly through activation of the ancestral gene.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Anatomy & Morphology
Fatemeh Ghasemzadeh, Masoud Golalipour, Kamran Haidari, Zahra Nazari, Mohammad Jafar Golalipour
Summary: This study found that the expression of BMP6 increased in embryos with induced diabetes, which may lead to heart malformations.
JOURNAL OF THE ANATOMICAL SOCIETY OF INDIA
(2021)