Article
Biochemistry & Molecular Biology
Mehmet Ozcan, Duygu Aydemir, Merve Bacanli, Hatice Gul Anlar, N. Nuray Ulusu, Yasemin Aksoy
Summary: The study found that chlorophyllin has a significant anti-genotoxic effect in the short term and protects glutathione-related enzyme activities in the MNU-induced breast cancer model. Additionally, chlorophyllin treatment reversed the adverse effects of MNU on mineral and trace element levels in various organs and tumor tissues.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Oncology
Inga Bekes, Jens Huober
Summary: Seventy percent of breast cancer subtypes are hormone receptor-positive, and adjuvant endocrine therapy is crucial for these patients. Extending adjuvant endocrine therapy beyond 5 years has been shown to reduce the risk of late recurrence, but the optimal duration is still debated. Newer data suggest only marginal benefits beyond 7 to 10 years, and longer duration may result in more side effects. Therefore, it is important to select patients who qualify for extended therapy based on genomic tests and risk assessment.
Review
Chemistry, Medicinal
Tingting Liu, Shubin Song, Xu Wang, Jifu Hao
Summary: Breast cancer remains a challenging health issue and a top priority in biomedical research. Researchers are increasingly interested in studying breast cancer in young women. Common treatment options for breast cancer include chemotherapy, immunotherapy, hormone therapy, surgery, and radiotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Annemiek van Ommen-Nijhof, Judy N. Jacobse, Lars C. Steggink, Joop D. Lefrandt, Jourik A. Gietema, Flora E. van Leeuwen, Michael Schaapveld, Gabe S. Sonke
Summary: This study investigated the association between aromatase inhibitor (AI) exposure and early markers for cardiovascular disease in breast cancer survivors. The results showed no association between AI exposure and carotid intima media thickness (cIMT), advanced glycation end products (AGEs), or the presence of dyslipidemia.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Aram Ismail, Elizabeth Lewis, Birgitta Sjodin, Bengt Mannervik
Summary: The study successfully produced the canine enzyme CluGST P1-1, which showed potential as a marker for tumors and a target for enzyme-activated prodrugs. It exhibited high catalytic activity with substrates like benzyl isothiocyanate, but lower activity compared to the human homolog in activating the prodrug Telcyta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Michael Gnant, Florian Fitzal, Gabriel Rinnerthaler, Guenther G. Steger, Sigrun Greil-Ressler, Marija Balic, Dietmar Heck, Raimund Jakesz, Josef Thaler, Daniel Egle, Diether Manfreda, Vesna Bjelic-Radisic, Ursula Wieder, Christian F. Singer, Elisabeth Melbinger-Zeinitzer, Ferdinand Haslbauer, Paul Sevelda, Harald Trapl, Viktor Wette, Kerstin Wimmer, Simon P. Gampenrieder, Rupert Bartsch, Stephanie Kacerovsky-Strobl, Christoph Suppan, Christine Brunner, Christine Deutschmann, Lidija Soelkner, Christian Fesl, Richard Greil
Summary: This study showed that extending hormone therapy by 5 years in postmenopausal women with hormone-receptor-positive breast cancer who had received 5 years of adjuvant endocrine therapy provided no benefit over a 2-year extension but was associated with a greater risk of bone fracture.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Oncology
Niamh C. Cunningham, Nicholas C. Turner
Summary: CDK4/6 inhibitors have shown consistent efficacy in the treatment of metastatic breast cancer, but recent adjuvant trials for early stage breast cancer have produced conflicting results, highlighting the need for further research on their clinical utility and future trial design.
Article
Oncology
Jose P. Leone, Bernard F. Cole, Meredith M. Regan, Beat Thurlimann, Alan S. Coates, Manuela Rabaglio, Anita Giobbie-Hurder, Richard D. Gelber, Bent Ejlertsen, Vernon J. Harvey, Patrick Neven, Istvan Lang, Herve Bonnefoi, Andrew Wardley, Aron Goldhirsch, Angelo Di Leo, Marco Colleoni, Ines Vaz-Luis, Nancy U. Lin
Summary: Endocrine therapy resistance is a major cause of distant recurrence in hormone receptor-positive breast cancer. In the BIG 1-98 trial, different adjuvant endocrine therapy regimens did not affect survival after distant recurrence. Age, primary tumor size, nodal and PR status, and DFS were significant factors impacting post-distant recurrence survival.
Article
Oncology
Michael Gnant, Amylou C. Dueck, Sophie Frantal, Miguel Martin, Hal J. Burstein, Richard Greil, Peter Fox, Antonio C. Wolff, Arlene Chan, Eric P. Winer, Georg Pfeiler, Kathy D. Miller, Marco Colleoni, Jennifer M. Suga, Gabor Rubovsky, Judith M. Bliss, Ingrid A. Mayer, Christian F. Singer, Zbigniew Nowecki, Olwen Hahn, Jacqui Thomson, Norman Wolmark, Kepa Amillano, Hope S. Rugo, Guenther G. Steger, Blanca Hernando Fernandez de Aranguiz, Tufia C. Haddad, Antonia Perello, Meritxell Bellet, Hannes Fohler, Otto Metzger Filho, Anita Jallitsch-Halper, Kadine Solomon, Celine Schurmans, Kathy P. Theall, Dongrui R. Lu, Kathleen Tenner, Christian Fesl, Angela DeMichele, Erica L. Mayer
Summary: The addition of adjuvant palbociclib to standard endocrine therapy did not improve outcomes over endocrine therapy alone in patients with early hormone receptor-positive breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Yuxin Xie, Libo Yang, Yanqi Wu, Hong Zheng, Qiheng Gou
Summary: The study found that AI/T + AI combination endocrine therapy may be a reasonable treatment option for ER-low positive breast cancer patients, and treatment duration of more than 3 years is associated with better disease-free survival.
Review
Oncology
Emma E. Bright, Lauren B. Finkelstein, Madeline S. Nealis, Sarah R. Genung, Jordan Wrigley, Heng Chao J. Gu, Sarah J. Schmiege, Joanna J. Arch
Summary: This study aims to provide an up-to-date systematic review and meta-analysis of interventions to enhance AET adherence among breast cancer survivors. The results showed that lowering medication costs and a subgroup of psychosocial and reminder interventions showed the most promise, informing future research, policy, and clinical directions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Taruna Rajagopal, Arun Seshachalam, Krishna Kumar Rathnam, Arunachalam Jothi, Srikanth Talluri, Sivaramakrishnan Venkatabalasubramanian, Nageswara Rao Dunna
Summary: The study identified associations between genetic variants in CYP1A1-M1, GST-T1, and NQO1 with increased risk of breast cancer, and certain combinations of genotypes could result in significantly elevated breast cancer risk.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Yasemin Uslu, Vildan Kocatepe, Derya Subasi Sezgin, Cihan Uras
Summary: The purpose of this study was to investigate adjuvant tamoxifen adherence and associated factors in breast cancer survivors. The results showed that overall, breast cancer survivors in the study had moderate adherence to tamoxifen. Individual characteristics and treatment-related adverse effects influenced medication adherence. Healthcare professionals can increase adherence to this treatment by explaining its importance, addressing barriers to adherence, and providing evidence-based interventions.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Endocrinology & Metabolism
Sheng-Fan Wang, Yi-Sheng Lin, Wan-Yu Yeh, Yuh-Lih Chang, Chern-En Chiang, Chen-Huan Chen, Ling-Ming Tseng, Hsin-Chen Lee, Chun-Yu Liu, Hao-Min Cheng
Summary: This study summarizes the clinical effects of antiresorptive agents in patients with early breast cancer receiving endocrine therapy. The results show that antiresorptive agents have significant clinical benefits on disease recurrence and locoregional recurrence in these patients. However, there is a potential risk of osteonecrosis of the jaw with the use of these agents.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Hao Liao, Wendi Pei, Jianxin Zhong, Bin Shao, Xiaoran Liu, Yaxin Liu, Jiayang Zhang, Hope S. Rugo, Huiping Li
Summary: The study aimed to determine the optimal initial 5 years of adjuvant endocrine therapy for hormone receptor-positive postmenopausal early breast cancer patients. The results showed that sequential use of aromatase inhibitors may be the optimal treatment mode with the best curative effects and relatively mild side effects. The three types of aromatase inhibitors achieved roughly equal efficacy but caused different types of severe adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ece Tavukcuoglu, Utku Horzum, Kerim Bora Yilmaz, Gunes Esendagli
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Cheng Zhang, Elias Bjornson, Muhammad Arif, Abdellah Tebani, Alen Lovric, Rui Benfeitas, Mehmet Ozcan, Kajetan Juszczak, Woonghee Kim, Jung Tae Kim, Gholamreza Bidkhori, Marcus Stahlman, Per-Olof Bergh, Martin Adiels, Hasan Turkez, Marja-Riitta Taskinen, Jim Bosley, Hanns-Ulrich Marschall, Jens Nielsen, Mathias Uhlen, Jan Boren, Adil Mardinoglu
MOLECULAR SYSTEMS BIOLOGY
(2020)
Article
Oncology
Utku Horzum, Digdem Yoyen-Ermis, Ekim Z. Taskiran, Kerim Bora Yilmaz, Erhan Hamaloglu, Derya Karakoc, Gunes Esendagli
Summary: In cancer patients, a specific subpopulation of monocytes expressing CD66b was identified in the circulation. These monocytes displayed high phagocytic activity, matrix adhesion, and migration, and provided costimulation for T cell proliferation and IFN-gamma secretion without suppressing T cell responses. They represent a novel myeloid subpopulation which lacks immune regulatory influences and shows enhanced proinflammatory capacities.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Letter
Dermatology
Ayse Oktem, Utku Horzum, Pelin Ertop, Nihal Kundakci, Bengu Nisa Akay, Basak Yalcin, Gunes Esendagli
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Merve Karpuz, Mine Silindir-Gunay, A. Yekta Ozer, Suleyman Can Ozturk, Hamdullah Yanik, Murat Tuncel, Cisel Aydin, Gunes Esendagli
Summary: This study demonstrates that folate-targeted, co-drug encapsulating liposomal formulations exhibit higher therapeutic and diagnostic efficacy in inhibiting lung cancer tumor growth and preventing lung metastasis. Additionally, liposomal formulations show lower toxicity compared to free drug combinations.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Marine
Mostafa Beyramzadeh, Seyed Mostafa Siadatmousavi, Marzieh H. Derkani
Summary: The third generation wave models have improved wind energy input and whitecap dissipation terms over time. The research compared different model packages in the Persian Gulf and Gulf of Oman, showing significant differences in model performance. While ST3 package significantly underestimated wave height, ST6 package showed better results in the Gulf of Oman.
Article
Immunology
Utku Horzum, Hamdullah Yanik, Ekim Z. Taskiran, Gunes Esendagli
Summary: This study investigates the impact of immune checkpoint inhibitors on T-cell functions and suggests that modifying the timing and duration of the blockade can improve the efficacy of ICI therapy.
Article
Medicine, Research & Experimental
Occam Kelly Graves, Woonghee Kim, Mehmet Ozcan, Sajda Ashraf, Hasan Turkez, Meng Yuan, Cheng Zhang, Adil Mardinoglu, Xiangyu Li
Summary: This study identified potential therapeutic target genes for lung adenocarcinoma and repurposed existing drugs. The effectiveness of these target genes and drugs was validated through in vitro experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yaman Musdal, Aram Ismail, Birgitta Sjodin, Bengt Mannervik
Summary: Nobo is a crucial glutathione transferase (GST) in insects that contributes to their growth and the spread of diseases. It has been found to have efficient hydroxylase activity in insects containing the ketosteroid. Specific amino acid residues are essential for the catalytic activity of Nobo.
Article
Biochemistry & Molecular Biology
Ahmet Dumanli, Ersin Gunay, Suphi Aydin, Sule Cilekar, Adem Gencer, Emira Kurbasevic, Gurhan Oz, Sefa Celik, Aydin Balci, Mehmet Ozcan, Mujgan Ercan Karadag
Summary: This study investigated the usability of pleural pyruvate kinase (PK), total antioxidant status (TAS), and total oxidant status (TOS) as an alternative to Light's criteria in exudate-transudate differentiation. The levels of PK, TAS, and TOS in pleural fluids were found to be significantly higher in the exudate group. However, pleural TOS and TAS parameters could not be as sensitive and specific as Light's criteria.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Multidisciplinary Sciences
Sevim Ipek Acar-Comert, Mehmet Ozcan, Hakan Eskizengin, Nursel Gul
Summary: This study investigated the protective effects of vitamin E against spinosad-induced damage in rats. The results showed that vitamin E alleviated intestinal cell damage and affected glutathione and lipid peroxidation levels. Further studies on spinosad and antioxidants are needed.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Meeting Abstract
Clinical Neurology
Doruk Arslan, Zeynep Ergul-Ulger, Sibel Goksen, Gunes Esendagli, Sevim Erdem-Ozdamar, Ersin Tan, Can Ebru Bekircan-Kurt
Article
Multidisciplinary Sciences
Ece Tavukcuoglu, Hamdullah Yanik, Mubaida Parveen, Sila Uluturk, Mine Durusu-Tanriover, Ahmet Cagkan Inkaya, Murat Akova, Serhat Unal, Gunes Esendagli
Summary: This study evaluates the functional capacity of CD4(+) and CD8(+) memory T cells obtained from volunteers vaccinated with an aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine. The results show that memory T cells from vaccinated individuals significantly proliferate and secrete IFN-γ in response to S1 stimulation.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Nese Unver, Digdem Yoyen Ermis, Bahar Zehra Weber, Gunes Esendagli
TURKISH JOURNAL OF BIOLOGY
(2020)
Review
Materials Science, Biomaterials
Mehmet Ozcan, Ozlem Altay, Simon Lam, Hasan Turkez, Yasemin Aksoy, Jens Nielsen, Mathias Uhlen, Jan Boren, Adil Mardinoglu
ADVANCED BIOSYSTEMS
(2020)