Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model

Triple negative breast cancer in Asia: An insider’s view

(2018) Chao Wang et al.   CANCER TREATMENT REVIEWS

Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling

(2017) Ya-Rong Liu et al.   PHYTOTHERAPY RESEARCH

YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway

(2017) Zekun Chen et al.   Theranostics

Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

(2016) Junmin Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Alantolactone induces apoptosis of human cervical cancer cells via reactive oxygen species generation, glutathione depletion and inhibition of the Bcl-2/Bax signaling pathway

(2016) YAN JIANG et al.   Oncology Letters

Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress

(2016) Chaoran Dong et al.   Scientific Reports

The thioredoxin system in breast cancer cell invasion and migration

(2016) Maneet Bhatia et al.   Redox Biology

Alantolactone Induces Apoptosis and Cell Cycle Arrest on Lung Squamous Cancer SK-MES-1 Cells

(2015) Peng Zhao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A Peptide-Coated Gold Nanocluster Exhibits Unique Behavior in Protein Activity Inhibition

(2015) Deyi An et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Triple-negative breast cancer: new perspectives for targeted therapies

(2015) Silverio Tomao et al.   OncoTargets and Therapy

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase

(2014) Yi-Hua Jan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway

(2013) YU ZHANG et al.   Molecular Medicine Reports

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone

(2013) Azhar Rasul et al.   TheScientificWorldJOURNAL

Emerging targeted therapies in triple-negative breast cancer

(2012) J. Crown et al.   ANNALS OF ONCOLOGY

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up

(2012) L. Malorni et al.   BREAST CANCER RESEARCH AND TREATMENT

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Alantolactone induces activation of apoptosis in human hepatoma cells

(2012) Jia-Chuan Lei et al.   FOOD AND CHEMICAL TOXICOLOGY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

(2009) Markus Selenius et al.   ANTIOXIDANTS & REDOX SIGNALING