Journal
AAPS PHARMSCITECH
Volume 18, Issue 2, Pages 358-368Publisher
SPRINGER
DOI: 10.1208/s12249-016-0505-3
Keywords
colorectal cancer; controlled release; metformin; oral drug delivery; solid lipid nanoparticles
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Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid lipid nanoparticles (SLN) were designed, optimized, and characterized for particle size, zeta potential, drug entrapment, structure, crystallinity, thermal behavior, morphology, and drug release. Optimized SLN were 195.01 +/- 6.03 nm in size, -17.08 +/- 0.95 mV with regard to surface charge, fibrous in shape, largely amorphous, and release of metformin was controlled. The optimized size, charge, and shape suggest the solid lipid nanoparticles will migrate and accumulate in the colon tumor preventing its proliferation and subsequently leading to tumor shrinkage and cell death.
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