Article
Chemistry, Multidisciplinary
Joseph Rosenfeld, Francois Ganachaud, Daeyeon Lee
Summary: Flow-based nanoprecipitation, which involves rapid mixing of two miscible liquids, is a scalable strategy for manufacturing nanoparticles with various shapes and morphologies. However, controlling the size of nanoparticles in this process is often done through empirical variations in flow rate ratios or total flow rate. In this study, coprecipitation of oil and polymer to form nanocapsules was investigated using glass capillary microfluidics, revealing the importance of supersaturation in determining the average diameter of the fabricated capsules. The control over nanocapsule size by varying the extent of supersaturation provides a systematic approach to controlling the size of nanoparticles via continuous nanoprecipitation.
Article
Chemistry, Applied
Hongmin Dong, Qing Zhang, Jun Gao, Lingyun Chen, Thava Vasanthan
Summary: The study investigated methods for producing starch nanoparticles under different processing parameters and analyzed their properties. Batch nanoprecipitation (BNP) can achieve smaller particle size and narrower size distribution in a shorter time. Under optimized conditions, continuous methods (such as flash nanoprecipitation) can be potential for commercial scale-up production.
FOOD HYDROCOLLOIDS
(2022)
Article
Polymer Science
Ewa Rybak, Piotr Kowalczyk, Sylwia Czarnocka-Sniadala, Michal Wojasinski, Jakub Trzcinski, Tomasz Ciach
Summary: The nanoprecipitation method was used to successfully formulate fluorescent PCL nanoparticles with small average diameter and low polydispersity index. In vitro experiments showed controlled dye release from these nanoparticles. Furthermore, MTT assays confirmed the non-toxicity of the PCL nanoparticles to cells. Thus, PCL nanoparticles have the potential for developing new drug delivery systems.
Article
Pharmacology & Pharmacy
Ilaria Ottonelli, Jason Thomas Duskey, Arianna Rinaldi, Maria Vittoria Grazioli, Irene Parmeggiani, Maria Angela Vandelli, Leon Z. Wang, Robert K. Prud'homme, Giovanni Tosi, Barbara Ruozi
Summary: This study aimed to transfer the production protocol for hybrid NMeds (H-NMeds) from a benchtop nanoprecipitation method to a microfluidic device, showing that microfluidic technology is not a simple transfer of established parameters, with several variables to be taken into account and optimized.
Article
Chemistry, Multidisciplinary
Barbora Boltnarova, Jana Kubackova, Josef Skoda, Alzbeta Stefela, Monika Smekalova, Petra Svacinova, Ivona Pavkova, Milan Dittrich, Daniel Scherman, Jarmila Zbytovska, Petr Pavek, Ondrej Holas
Summary: In this study, various PLGA polymer nanospheres were prepared for macrophage-targeted drug delivery using nanoprecipitation and emulsification solvent evaporation methods. The larger nanospheres, prepared using nanoprecipitation, showed enhanced distribution into macrophages. The experimental PLGA nanoformulations surpassed the commercially available polymer in their capacity as macrophage-specific carriers, with no observed effects on cell viability or proinflammatory response.
Article
Agricultural Engineering
C. N. Bernardo, I. C. S. Kling, W. H. Ferreira, C. T. Andrade, R. A. Simao
Summary: Thermoplastic starch films with glycerol and nanoparticles were prepared from regular cornstarch in a single step, demonstrating the green chemical principle. The addition of starch nanoparticles improved the mechanical properties, while the presence of glycerol made the films more flexible.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Applied
Hongmin Dong, Lingyun Chen, Qing Zhang, Jun Gao, Thava Vasanthan
Summary: Field pea starch was thermally solubilized in water, ultrasonicated, and used to produce starch nanoparticles (SNPs) via a rapid nanoprecipitation method. Factors such as optimal antisolvent/solvent ratio and starch concentration were found to influence the particle size and distribution of SNPs. The formation of SNPs followed a nucleation-growth/aggregation mechanism, with processing parameters and techniques impacting the properties of the nanoparticles.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Fan Jiang, Chunwei Du, Ning Zhao, Wenqian Jiang, Xiuzhu Yu, Shuang-kui Du
Summary: Quinoa starch nanoparticles (QSNPs) prepared under optimal conditions as a carrier for quercetin showed smaller particle size and higher loading capacity compared to maize starch nanoparticles (MSNPs), resulting in more effective protection and prolongation of quercetin bioactivity.
Article
Food Science & Technology
Ana Paula Zapelini de Melo, Cleonice Goncalves da Rosa, Carolina Montanheiro Noronha, Michelle Heck Machado, William Gustavo Sganzerla, Natalia Veronez da Cunha Bellinati, Michael Ramos Nunes, Silvani Verruck, Elane Schwinden Prudencio, Pedro Luiz Manique Barreto
Summary: In this study, Vitamin D3 was nanoencapsulated in zein polymeric matrices to improve its stability and availability. The fortified jelly with NP-D3 showed high levels of bioactive compounds, antioxidant capacity, and microbiological stability, demonstrating a suitable shelf life. The zein nanoparticles can be a promising approach to prolong the residence time of Vitamin D3 under food processing and gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Sana Javaid, Nasir M. Ahmad, Azhar Mahmood, Habib Nasir, Mudassir Iqbal, Naveed Ahmad, Sundus Irshad
Summary: This study successfully achieved the encapsulation of a therapeutic agent for antifouling functionality using nanotechnology. The drug-loaded nanoparticles showed potential for in vitro drug release and antifouling applications after optimization.
Article
Chemistry, Applied
Xiaoxia Yan, Hongyuan Wei, Lvheng Kou, Lili Ren, Jiang Zhou
Summary: Amylose granules were hydrolyzed with hydrochloric acid to prepare amylose nanoparticles. The acid hydrolysis reduced the molecular weight of amylose and cut the macromolecular chains into shorter ones. The residual amylose macromolecular chains after hydrolysis influenced the size and crystallinity of the precipitated amylose nanoparticles.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Antoine Combes, Khanh-Nam Tang, Andrey S. Klymchenko, Andreas Reisch
Summary: The study investigates the assembly of mixed-charge polymer nanoparticles through nanoprecipitation of mixtures of oppositely charged polymers, examining the influence of charge fraction, polymer mixing ratio, and precipitation conditions on particle size and surface charge. The results show the potential of this method for designing nanoparticles with precisely tuned surface properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Austin D. Fergusson, Rui Zhang, Judy S. Riffle, Richey M. Davis
Summary: Flash nanoprecipitation (FNP) is a reliable method for producing polymer nanoparticles loaded with hydrophobic drugs. By incorporating ion pairing agents (IPs) into the FNP formulation, hydrophobic drug salts can be efficiently precipitated. In this study, we investigated the effects of two hydrophobic IPs, palmitic acid (PA) and hexadecylphosphonic acid (HDPA), on the loading and size of LY294002-loaded nanoparticles. HDPA resulted in well-defined colloidally stable particles, while PA resulted in ill-defined aggregates. This approach opens up possibilities for intravenous administration of previously unusable hydrophobic drugs.
Article
Pharmacology & Pharmacy
Jorge Loureiro, Sonia P. Miguel, Ines J. Seabra, Maximiano P. Ribeiro, Paula Coutinho
Summary: Zein and chitosan nanoparticles have been successfully prepared using an adapted anti-solvent nanoprecipitation method. Size-controlled zein-honey-chitosan nanoparticles were achieved through flash nanoprecipitation, which is a rapid and scalable self-assembly method. The size of the nanoparticles can be tuned by varying the formulation parameters.
Article
Chemistry, Physical
Henrique Trevisan, Kana Nishimori, Stefano Aime, Jean-Michel Guigner, Makoto Ouchi, Francois Tournilhac
Summary: The selection of monomer couples with close to zero reactivity ratios, along with the customization of solvent-monomer interactions, has been shown to induce spontaneous copolymerization into nanoparticles with self-assembly properties. The ouzo effect was utilized to study the formation of stable alternating copolymer nanoparticles in water, without the need for stabilizing agents. Characterization techniques such as light scattering and transmission electron microscopy confirmed the successful self-assembly of copolymer chains into nanoparticles, with the size affected by the lipophilicity of the copolymers and solvent properties.
Article
Integrative & Complementary Medicine
I. Chattopadhyaya, Sumeet Gupta, Asad Mohammed, N. Mushtaq, S. Chauhan, Saikant Ghosh
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Review
Pharmacology & Pharmacy
Biswajit Mukherjee, Ruma Maji, Samrat Roychowdhury, Saikat Ghosh
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Saikat Ghosh, Biswajit Mukherjee, Shreyasi Chaudhuri, Tanushree Roy, Alankar Mukherjee, Soma Sengupta
Review
Pharmacology & Pharmacy
Vivek Patel, Rohan Lalani, Denish Bardoliwala, Saikat Ghosh, Ambikanandan Misra
Review
Chemistry, Multidisciplinary
Saikat Ghosh, Rohan Lalani, Vivek Patel, Denish Bardoliwala, Kuntal Maiti, Shubhadeep Banerjee, Subhas Bhowmick, Ambikanandan Misra
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Pharmacology & Pharmacy
Samrat Chakraborty, Zewdu Yilma Dlie, Biswajit Mukherjee, Shila Elizabeth Besra, Soma Sengupta, Ramkrishna Sen, Alankar Mukherjee
Review
Pharmacology & Pharmacy
Saikat Ghosh, Rohan Lalani, Vivek Patel, Subhas Bhowmick, Ambikanandan Misra
EXPERT OPINION ON DRUG DELIVERY
(2019)
Article
Medicine, Research & Experimental
Samrat Chakraborty, Zewdu Yilma Dlie, Somdyuti Chakraborty, Somdatta Roy, Biswajit Mukherjee, Shila Elizabeth Besra, Saikat Dewanjee, Alankar Mukherjee, Probir Kumar Ojha, Vinay Kumar, Ramkrishna Sen
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Pharmacology & Pharmacy
Shilpa Das, Tanmoy Kumar Dey, Arnab De, Anurag Banerjee, Samrat Chakraborty, Bhaskar Das, Asish Kumar Mukhopadhyay, Biswajit Mukherjee, Amalesh Samanta
Summary: The gum odina and gelatin based biomimetic scaffold showed excellent biocompatibility and the ability to promote cutaneous healing in vitro studies. Results demonstrated significant deposition of collagen and formation of intact epidermis, indicating strong potential for wound treatment applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Saikat Ghosh, Pooja Mishra, Shubhadeep Banerjee, Kuntal Maiti, Ajay Khopade, Ambikanandan Misra, Krutika Sawant, Subhas Bhowmick
Summary: The study evaluated the critical factors affecting the properties of nanoliposomes and analyzed their impact through univariate and multivariate studies. The optimized nanoliposomes showed high encapsulation efficiency, appropriate particle size, surface charge, and controlled release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Denish Bardoliwala, Vivek Patel, Ankit Javia, Saikat Ghosh, Akanksha Patel, Ambikanandan Misra
THERAPEUTIC DELIVERY
(2019)
Article
Pharmacology & Pharmacy
Tanushree Roy, Indranil Banerjee, Saikat Ghosh, Ranjita Santra Dhali, Anuradha De Pati, Santanu Kumar Tripathi
INDIAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Tapan Kumar Shaw, Dipika Mandal, Goutam Dey, Murari Mohan Pal, Paramita Paul, Samrat Chakraborty, Kazi Asraf Ali, Biswajit Mukherjee, Amal Kumar Bandyopadhyay, Mahitosh Mandal