Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

Published 2016 View Full Article

Authors

Keywords

ado-trastuzumab emtansine, antibody tissue penetration, drug-antibody ratio (DAR), Herceptin, Kadcyla, Krogh cylinder

Journal

AAPS Journal

Volume 18, Issue 5, Pages 1117-1130

Publisher

American Association of Pharmaceutical Scientists (AAPS)

Online

2016-06-11

DOI

10.1208/s12248-016-9940-z

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