Article
Endocrinology & Metabolism
J. P. van den Bergh, P. Szulc, A. M. Cheung, M. Bouxsein, K. Engelke, R. Chapurlat
Summary: HR-pQCT has been developed for imaging bone microarchitecture in peripheral skeletal sites, with increasing clinical research focusing on understanding skeletal fragility and improving fracture prediction. Differentiation and reference data for HR-pQCT variables by age, sex, and race/ethnicity have been provided, along with discussions on fracture risk prediction, monitoring response to anti-osteoporosis therapy, and novel applications in patients with metabolic bone disorders and secondary osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Orthopedics
Arastoo Nia, Natasa Jeremic, Domenik Popp, Lukas Schmoelz, Janina Patsch, Kevin Doering, Michael Weber, Alexander Synek, Dieter H. Pahr, Silke Aldrian
Summary: Recently, a study evaluated the feasibility of radiography-based bone mineral density (BMD) measurement using a graded aluminum phantom. Strong correlations were found between aluminum phantom radiography-based mean gray value (mGV) and DXA-derived BMD for the ultradistal radius, and a moderate correlation was found for the femoral neck. Aluminum phantom radiography could be a cost-efficient and low-radiation dose method for screening and diagnosing osteoporosis, especially in areas with limited DXA availability. Further investigation and assessment of specificity and sensitivity is needed.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Charles Ginsberg, Terri Blackwell, Jonathan H. Cheng, O. Alison Potok, Jane A. Cauley, Kristine E. Ensrud, Simon Hsu, Deborah M. Kado, Eric Orwoll, Peggy M. Cawthon, Joachim H. Ix
Summary: This study evaluated the impact of the ratio of 24,25-dihydroxyvitamin D3 to 25(OH)D3 (VMR) and 25(OH)D3 on vBMD and bone strength in the distal radius and tibia of older men. The results showed that higher VMR was associated with higher vBMD and bone strength, while 25(OH)D3 had no impact on these outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Rheumatology
Scott Cameron Brunet, Stephanie Finzel, Klaus Engelke, Steven Kyle Boyd, Cheryl Barnabe, Sarah Lynn Manske
Summary: HR-pQCT is sensitive in detecting bone surface changes in early inflammatory arthritis (EIA) patients. Gradual degradation of joint space width proportional to symptom duration was observed in the study. Patients with EIA need close monitoring for exacerbation of arthritis and progression of periarticular bone damage.
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Pia Nicolaisen, Maria Lohman Obling, Kristian Hillert Winther, Stinus Hansen, Anne Pernille Hermann, Laszlo Hegedus, Steen Joop Bonnema, Thomas Heiberg Brix
Summary: Hyperthyroidism is associated with lower volumetric bone mineral density, lower estimated bone strength, and compromised cortical microarchitecture in the radius. However, post-recovery from euthyroidism led to significant improvements in volumetric bone mineral density and cortical microarchitecture, emphasizing the importance of achieving and maintaining euthyroidism.
Article
Endocrinology & Metabolism
Shengyu Lu, Nicholas R. Fuggle, Leo D. Westbury, Micheal O. Breasail, Gregorio Bevilacqua, Kate A. Ward, Elaine M. Dennison, Sasan Mahmoodi, Mahesan Niranjan, Cyrus Cooper
Summary: By combining computer vision and machine learning techniques with clinical risk factors and bone density measurements, researchers found that the accuracy of fracture risk assessment can be improved. This approach has the potential to make the information offered by HR-pQCT more accessible and applicable to healthcare professionals.
Article
Endocrinology & Metabolism
Xiaolin Ni, Wenmin Guan, Qianqian Pang, Chenxi Jin, Yiyi Gong, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Yan Jiang, Weibo Xia
Summary: X-linked hypophosphatemia (XLH) patients have abnormal lumbar spine bone mass, but compromised microarchitecture and bone strength in the peripheral bone.
Article
Rheumatology
Rasmus Klose-Jensen, Josephine Therkildsen, Anne-Birgitte Garm Blavnsfeldt, Bente L. Langdahl, Anna Zejden, Jesper Thygesen, Kresten Krarup Keller, Ellen-Margrethe Hauge
Summary: This study compares the accuracy of HR-pQCT and CR in classifying patients as having erosive RA, and the results show that these two methods are comparable.
Article
Endocrinology & Metabolism
Arun S. Karlamangla, Albert Shieh, Gail A. Greendale, Elaine W. Yu, Sherri-Ann M. Burnett-Bowie, Patrick M. Sluss, Deborah Martin, Anthony Morrison, Joel S. Finkelstein
Summary: The decline in AMH levels in women during the menopause transition is associated with rapid bone loss, and measuring AMH can help identify women at risk for significant bone loss for early intervention.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
H. Jiang, D. L. Robinson, P. V. S. Lee, E. O. Krejany, C. J. Yates, M. Hickey, J. D. Wark
Summary: Prophylactic oophorectomy is recommended for women at high risk of ovarian cancer, but it may lead to substantial loss of bone density and strength. Postoperative hormone therapy can help alleviate bone loss, particularly in the spine, but may not fully prevent it.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Benedikt, Lukas Horling, Kerstin Stock, Gerald Degenhart, Johannes Pallua, Gernot Schmidle, Rohit Arora
Summary: The study aimed to investigate the feasibility of the visual grading system (VGS) and the influence of image quality on bone density and microarchitecture parameters for the scaphoid bone. The results showed that image quality had a minor influence on bone volume and trabecular bone mineral density, but significantly affected trabecular number, trabecular thickness, and trabecular separation. The high inter- and intraobserver variability limited the use of VGS.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Clinical Neurology
Stephan N. Salzmann, Ichiro Okano, Conor Jones, Eric Basile, Anthony Iuso, Jiaqi Zhu, Marie -Jacqueline Reisener, Erika Chiapparelli, Jennifer Shue, John A. Carrino, Federico P. Girardi, Frank P. Cammisa, Andrew A. Sama, Alexander P. Hughes
Summary: This study aimed to evaluate the reliability of thoracic QCT measurements, determine possible level-specific BMD variation throughout the thoracic spine, and assess the correlation between BMDs of the T1-T12 spinal levels. The results showed significant regional BMD variation in the thoracic spine depending on spinal level, which might contribute to several clinically relevant phenomena.
Article
Endocrinology & Metabolism
Tamara D. Rozental, Kempland C. Walley, Serkalem Demissie, Signe Caksa, Adriana Martinez-Betancourt, Amber M. Parker, Joy N. Tsai, Elaine W. Yu, Mary L. Bouxsein
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Deborah M. Mitchell, Signe Caksa, Amy Yuan, Mary L. Bouxsein, Madhusmita Misra, Sherri-Ann M. Burnett-Bowie
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Endocrinology & Metabolism
Ginu Unnikrishnan, Chun Xu, Kristin L. Popp, Julie M. Hughes, Amy Yuan, Katelyn I. Guerriere, Signe Caksa, Kathryn E. Ackerrnan, Mary L. Bouxsein, Jaques Reifman
Article
Endocrinology & Metabolism
Signe Caksa, Amy Yuan, Sara E. Rudolph, Elaine W. Yu, Kristin L. Popp, Mary L. Bouxsein
Article
Endocrinology & Metabolism
Deborah M. Mitchell, Signe Caksa, Taisha Joseph, Mary L. Bouxsein, Madhusmita Misra
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Taisha Joseph, Signe Caksa, Madhusmita Misra, Deborah M. Mitchell
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Sport Sciences
Sara E. Rudolph, Signe Caksa, Sarah Gehman, Margaret Garrahan, Julie M. Hughes, Adam S. Tenforde, Kathryn E. Ackerman, Mary L. Bouxsein, Kristin L. Popp
Summary: The study found that female athletes with a history of multiple bone stress injuries spent more time in physical activities during high school, engaged in more uniaxial loading activities, and had a higher proportion of cases with amenorrhea. This suggests that engaging in sports with multiaxial loading and maintaining normal menstrual status can reduce the risk of multiple bone stress injuries.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Cell Biology
Sheera R. Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, McKenna Glasheen, Danielle Pomante, Daniel Kotas, Inna Chervoneva, Andrew E. Aplin
Summary: The study reveals the role of SOX10 in regulating immune checkpoint protein expression and anti-tumor immunity in melanoma, with Sox10 knockout reducing tumor growth and having an impact on CD8+ T cells. This highlights the importance of developmental factors in cancer immune evasion.
Article
Gastroenterology & Hepatology
Jeffrey A. Rappaport, Ariana A. Entezari, Adi Caspi, Signe Caksa, Aakash V. Jhaveri, Timothy J. Stanek, Adam Ertel, Joan Kupper, Paolo M. Fortina, Steven B. McMahon, James B. Jaynes, Adam E. Snook, Scott A. Waldman
Summary: The study revealed the corepression of GUCY2C ligand transcription by beta-catenin/TCF signaling and provided genomic strategies to reestablish hormone expression. This mechanism reflects a novel pathophysiological step in tumorigenesis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Claudia Capparelli, Timothy J. Purwin, McKenna Glasheen, Signe Caksa, Manoela Tiago, Nicole Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W. Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, Andrew E. Aplin
Summary: Cellular plasticity plays a crucial role in tumor heterogeneity and phenotype switching. SOX10 is involved in the phenotypic switching of cutaneous melanoma, and cIAP1/2 inhibitors can selectively induce cell death in SOX10-deficient cells.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Sarah Gehman, Kathryn E. Ackerman, Signe Caksa, Sara E. Rudolph, Julie M. Hughes, Margaret Garrahan, Adam S. Tenforde, Mary L. Bouxsein, Kristin L. Popp
Summary: This study aimed to explore whether energy availability, menstrual function, measures of bone health, and a modified Female Athlete Triad Cumulative Risk Assessment (CRA) tool are associated with a history of multiple bone stress injuries (BSIs). The study found that compared to the control group, the multiBSI group had a higher incidence of prior low-energy fractures and higher modified Triad CRA scores. These preliminary findings suggest that women with a history of multiple BSIs have a higher risk for prior low-energy fractures and greater estimates of energy deficit, both historical and current, compared to controls.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Signe Caksa, Usman Baqai, Andrew E. Aplin
Summary: Melanoma, a growing cancer, is currently treated with targeted inhibitors in the MAPK pathway, but drug resistance limits its effectiveness. However, new applications and combinations with other therapies may provide hope for melanoma treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Kristin L. Popp, Julie M. Hughes, Adriana Martinez-Betancourt, Matthew Scott, Victoria Turkington, Signe Caksa, Katelyn I. Guerriere, Kathryn E. Ackerman, Chun Xu, Ginu Unnikrishnan, Jaques Reifman, Mary L. Bouxsein