Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

Published 2016 View Full Article

Authors

Keywords

antibody-drug conjugate, cellular pharmacokinetics, global sensitivity analysis, mechanistic model, model-based drug development, T-DM1, tumor disposition, tumor pharmacokinetics

Journal

AAPS Journal

Volume 18, Issue 4, Pages 861-875

Publisher

American Association of Pharmaceutical Scientists (AAPS)

Online

2016-03-31

DOI

10.1208/s12248-016-9904-3

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