Article
Biotechnology & Applied Microbiology
Tehreem Khalid, Luis Soriano, Mark Lemoine, Sally-Ann Cryan, Fergal J. O'Brien, Cian O'Leary
Summary: Tracheal replacement efforts have been largely unsuccessful due to difficulties in re-vascularising and replicating the mechanical properties of native tissue. This study aimed to improve a collagen-hyaluronic acid scaffold and use 3D-printed polymer designs to optimize the tracheal replacement device. The results showed that the composite scaffolds exhibited angiogenic growth and the presence of blood vessels in vitro and ex vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Pengren Huang, Peng Yang, Keming Liu, Wei Tao, Jun Tao, Fanrong Ai
Summary: A solvent method was used to add high concentration bioglass into polycaprolactone to prepare 70% BG/PCL composite scaffolds with high ductility by 3D printing technology. The scaffold showed good mechanical properties, biocompatibility, and osteogenic activity, making it a promising option for personalized repair of bone defects.
BIOMEDICAL MATERIALS
(2023)
Article
Cell Biology
Yunlang She, Ziwen Fan, Long Wang, Yinze Li, Weiyan Sun, Hai Tang, Lei Zhang, Liang Wu, Hui Zheng, Chang Chen
Summary: The study introduces a biomimetic scaffold with a separated-ring structure, created using 3D printing and collagen sponge embedding to mimic the anatomy and mechanical behavior of a native trachea. In vitro and in vivo experiments confirmed the success of the biomimetic trachea, with a long-segment tracheal replacement in a rabbit model demonstrating satisfactory repair outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Ji-Won Baek, Ho Park, Ki-Su Kim, Sung-Kun Chun, Beom-Su Kim
Summary: This study successfully fabricated 3D-printed scaffolds using marine plankton-derived whitlockite powder, which showed improved mechanical properties and biocompatibility for enhancing cell proliferation and differentiation in bone tissue engineering applications.
Article
Oncology
Shu Pan, Ziqing Shen, Tian Xia, Ziyin Pan, Yibo Dan, Jianfeng Li, Hongcan Shi
Summary: Pluronic F127-based modification of 3D printing scaffold showed excellent biocompatibility, benefiting the attachment and proliferation of bone marrow mesenchymal stem cells. Furthermore, a hybrid graft was constructed by combining the modified scaffold with decellularized matrix, showing great potential in tracheal replacement and reconstruction.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Yong Sang Cho, Min-Soo Ghim, Myoung Wha Hong, Young Yul Kim, Young-Sam Cho
Summary: This study aimed to guide the endogenous regeneration of bone defects by designing collagen patterns loaded with bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) on a 3D-printed polycaprolactone/nano-hydroxyapatite scaffold. The results demonstrated that the polycaprolactone/nano-hydroxyapatite/collagen scaffold with a radial pattern promoted endogenous bone regeneration and angiogenesis compared to scaffolds with positive and edge patterns.
MATERIALS & DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Automation & Control Systems
Trung Kien Nguyen, Bang Thi Le, Minh Thi Hong Nguyen, Van-Sang Pham, Truong Do, Phuong Tran, Lan Xuan Phung
Summary: This research develops and optimizes a novel design of a direct powder mini-screw extruder (DPSE) through numerical modeling analysis, which enables the printing of PCL-based composite scaffolds by utilizing a combination of PCL powder and other biomaterials. The high potential of the DPSE printer head in fabricating high-quality PCL-based composite scaffolds with minimal wastage and prolonged printability is demonstrated.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Materials Science, Composites
Zhiyong Ma, Qifan Wang, Wenjia Xie, Wenjie Ye, Linna Zhong, Jile Huge, Ying Wang
Summary: In this study, a PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The composite scaffold showed good mechanical and cell test performance, indicating potential applications in the field of bone tissue engineering.
POLYMER COMPOSITES
(2021)
Article
Materials Science, Multidisciplinary
Yanyan Cao, Peng Cheng, Shengbo Sang, Chuan Xiang, Yang An, Xiaochun Wei, Yayun Yan, Pengcui Li
Summary: Cartilage injury is difficult to self-repair, but a biphasic scaffold consisting of cells-encapsulated GelMA hydrogel and macroporous PCL scaffold filled with cells-encapsulated GelMA hydrogel shows promising results for cartilage regeneration, especially when co-cultured with BMSCs and chondrocytes. The synergistic effect of the two cell types induces chondrogenesis and TGF-beta(3) supplement further enhances cartilage regeneration. In both in vitro and in vivo studies, the PCL/GelMA biphasic scaffold demonstrates excellent cartilage regenerative capability, paving a new way for clinical cartilage repair.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Santosh Kumar Parupelli, Sheikh Saudi, Narayan Bhattarai, Salil Desai
Summary: In this study, a composite scaffold of poly(epsilon-caprolactone) (PCL) and calcium magnesium phosphate (CMP) bioceramics was fabricated using 3D printing technology. The scaffolds mimic the rough textured architecture, porosity, and chemical composition of natural bone tissue matrices, and provide a favorable microenvironment for bone cell growth by releasing soluble calcium and magnesium ions. These 3D-printed scaffolds are a promising approach for bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biophysics
Fahimeh Tabatabaei, Alexandra Gelin, Morteza Rasoulianboroujeni, Lobat Tayebi
Summary: This study demonstrates a new collagen coating process that optimizes the hydrophilic property and cell attachment of scaffolds. The coated scaffolds show higher cell proliferation, water absorption, protein absorption, and bioactivity compared to non-coated samples.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Anatomy & Morphology
Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yassin Panahi
Summary: Tissue engineering research has focused on the characteristics and biocompatibility of decellularized sheep tracheal scaffolds, as well as the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. The prepared scaffolds show potential for engineering applications and provide a suitable environment for stem cell differentiation. This research serves as a foundation for future studies on tracheal decellularization scaffolds and paves the way for their use in organ regeneration and clinical medicine.
Article
Orthopedics
Zhiguo Yuan, Teng Long, Jue Zhang, Zhuocheng Lyu, Wei Zhang, Xiangchao Meng, Jin Qi, You Wang
Summary: This study constructed a porous PEEK scaffold via 3D printing and evaluated its physical and chemical characteristics. The results showed that the scaffold with a 30-second surface treatment had good micro/nanostructure, appropriate biomechanical properties, and superior biofunctionalities. Furthermore, it was found that the surface-treated scaffold could promote macrophage polarization and prevent macrophage-induced cartilage degeneration. Animal experiments demonstrated that the scaffold could promote tissue ingrowth, prevent cartilage degeneration, inhibit inflammatory cytokine secretion, and restore cartilage function.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Multidisciplinary
Seunghun S. Lee, Nicole Kleger, Gisela A. Kuhn, Helen Greutert, Xiaoyu Du, Thijs Smit, Andre R. Studart, Stephen J. Ferguson
Summary: Digital Light Processing is used to fabricate a hive-structured assemblable bespoke scaffold (HIVE) that can be manually assembled and customized for specific defect. It can be filled with different biological factors in different areas to provide site-specific treatments. Through in vitro and in vivo experiments, it has been shown to induce osteogenesis and angiogenesis in a controlled manner.
ADVANCED MATERIALS
(2023)
Article
Cell & Tissue Engineering
Yi Zhong, Ai Jiang, Fei Sun, Yuanfan Xiao, Ying Gu, Lei Wu, Yujie Zhang, Hongcan Shi
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Xue Zhang, Congcong Lin, Waikei Chan, Kanglun Liu, Aiping Lu, Ge Lin, Rong Hu, Hongcan Shi, Hongqi Zhang, Zhijun Yang
Review
Biochemistry & Molecular Biology
Kai Yuan, Yi-Miao Gong, Lin Liu, Yan-Kun Sun, Shan-Shan Tian, Yi-Jie Wang, Yi Zhong, An-Yi Zhang, Si-Zhen Su, Xiao-Xing Liu, Yu-Xin Zhang, Xiao Lin, Le Shi, Wei Yan, Seena Fazel, Michael V. Vitiello, Richard A. Bryant, Xin-Yu Zhou, Mao-Sheng Ran, Yan-Ping Bao, Jie Shi, Lin Lu
Summary: The prevalence of PTSD after large-scale pandemics globally is estimated at 22.6%, with healthcare workers having the highest rate. Risk factors, including individual, family, societal factors, pandemic-related factors, and specific factors in healthcare settings, were summarized to aid in post-pandemic mental health support and recovery efforts.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Kai Yuan, Xiao-Lin Huang, Wei Yan, Yu-Xin Zhang, Yi-Miao Gong, Si-Zhen Su, Yue-Tong Huang, Yi Zhong, Yi-Jie Wang, Ze Yuan, Shan-Shan Tian, Yong-Bo Zheng, Teng-Teng Fan, Ying-Jian Zhang, Shi-Qiu Meng, Yan-Kun Sun, Xiao Lin, Tian-Ming Zhang, Mao-Sheng Ran, Samuel-Yeung-Shan Wong, Nicolas Rusch, Le Shi, Yan-Ping Bao, Lin Lu
Summary: This study found that stigma is a significant public health concern during infectious disease epidemics, affecting populations including patients, community populations, and healthcare workers. The prevalence of stigma in low- and middle-income countries was slightly higher than in high-income countries. Individuals with lower education levels had higher rates of stigma compared to those with higher education levels.
MOLECULAR PSYCHIATRY
(2022)
Review
Psychiatry
Hui Li, Kai Yuan, Yan-Kun Sun, Yong-Bo Zheng, Ying-Ying Xu, Si-Zhen Su, Yu-Xin Zhang, Yi Zhong, Yi-Jie Wang, Shan-Shan Tian, Yi-Miao Gong, Teng-Teng Fan, Xiao Lin, Nina Gobat, Samuel Yeung Shan Wong, Emily Ying Yang Chan, Wei Yan, Si-Wei Sun, Mao-Sheng Ran, Yan-Ping Bao, Jie Shi, Lin Lu
Summary: This research conducted a meta-analysis on the prevention of respiratory infections and found that the use of facemasks has a significant protective effect. The majority of people perceive facemasks as effective and are willing to wear them.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Yan Song, Chunyan Huang, Yi Zhong, Xi Wang, Guangyuan Tao
Summary: This study explored the neuroimaging biomarkers for the diagnosis of major depressive disorder (MDD) using the support vector machine (SVM) method. The results showed abnormal regional neural activity in the left anterior cingulum cortex (ACC) and precentral gyrus (PG) in MDD patients. The combination of these regions' activity may serve as a neuroimaging biomarker for first-episode MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Kai Yuan, Yong-Bo Zheng, Yi-Jie Wang, Yan-Kun Sun, Yi-Miao Gong, Yue-Tong Huang, Xuan Chen, Xiao-Xing Liu, Yi Zhong, Si-Zhen Su, Nan Gao, Yi-Long Lu, Zhe Wang, Wei-Jian Liu, Jian-Yu Que, Ying-Bo Yang, An-Yi Zhang, Meng-Ni Jing, Chen-Wei Yuan, Na Zeng, Michael V. Vitiello, Vikram Patel, Seena Fazel, Harry Minas, Graham Thornicroft, Teng-Teng Fan, Xiao Lin, Wei Yan, Le Shi, Jie Shi, Thomas Kosten, Yan-Ping Bao, Lin Lu
Summary: Mental symptoms are common during epidemics with substantial variation across populations. Factors associated with increased prevalence for all three mental health symptoms include female sex, having physical or psychiatric disorders, COVID infection, colleagues or family members infected, frontline work experience, close contact with infected patients, high exposure risk, quarantine experience, and high concern about epidemics. Frequent exercise and good social support were associated with lower risk for these mental symptoms.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Chunyan Huang, Yang Zhou, Yi Zhong, Xi Wang, Yunhua Zhang
Summary: This study found that the network homogeneity (NH) of the default-mode network (DMN) is altered in patients with right temporal lobe epilepsy (rTLE), which affects their cognitive function. Furthermore, the bilateral precuneus (PCu) was identified as a neuroimaging diagnostic biomarker for distinguishing rTLE patients from healthy controls.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Yujun Gao, Xinfu Zhao, JiChao Huang, Sanwang Wang, Xuan Chen, Mingzhe Li, Fengjiao Sun, Gaohua Wang, Yi Zhong
Summary: The aim of this study was to explore neuroimaging biomarkers for predicting mild cognitive impairment (MCI) using support vector machine (SVM) classification. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 53 MCI patients and 68 healthy controls. The results showed decreased regional homogeneity (ReHo) in the right caudate of MCI patients compared to healthy controls. SVM classification achieved an overall accuracy of 68.6%, sensitivity of 62.26%, and specificity of 58.82%.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
JiChao Huang, Yi Zhong, Yu Duan, Jie Sun
Summary: Chronic pelvic pain syndrome (CPPS) is a condition characterized by persistent pain in the pelvic area for 3-6 months or longer. It can be constant or episodic and significantly impacts a person's daily life. Dysfunction in the central nervous system can lead to central sensitization, which exacerbates pain and other symptoms. Somatic symptom disorder (SSD) is a condition where individuals experience one or more somatic symptoms, causing distress and disruptions in their lives.
FRONTIERS IN PSYCHIATRY
(2023)
Letter
Psychiatry
Yi Zhong, Yu-jun Chen, Yang Zhou, Yan-Ao-Hai Lyu, Jia-Jun Yin, Yu-jun Gao
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Yi Zhong, Jichao Huang, Wen Zhang, Shuiqing Li, Yujun Gao
Summary: As of 11 Jan 2023, the Coronavirus has infected up to 900 million people in China Mainland, which is more than 60% of the population. The pandemic's sudden and unprecedented nature has led to various psycho-somatic issues among the population. Addressing these issues is crucial as they can have severe consequences for individuals' mental and physical health. The lifting of lockdown measures in China creates an opportunity to provide support and assistance to those who have been affected.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Yujun Gao, Xin Guo, Yi Zhong, Xiaoxin Liu, Shanshan Tian, Jiahui Deng, Xiao Lin, Yanpin Bao, Lin Lu, Gaohua Wang
Summary: This study aimed to explore the changes in brain network homogeneity (NH) in patients with major depressive disorder (MDD) and determine the role of this parameter in differentiating between MDD patients and healthy controls. The results showed reduced NH in the left supramarginal gyrus (SMG) in MDD patients compared to healthy controls. Support vector machine analysis revealed that the NH of the left SMG could effectively differentiate between MDD patients and healthy controls with high accuracy, specificity, and sensitivity. These findings suggest that NH changes in the dorsal attention network may serve as a neuroimaging biomarker for distinguishing MDD patients from healthy individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Psychiatry
Yi Zhong, Yan-Ao-Hai Lyu, Song Yu, Yu-jun Gao, Wei-Feng Mi, Jian-Feng Li
ASIAN JOURNAL OF PSYCHIATRY
(2023)
