Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation

New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration

(2018) Metello Innocenti   Cell Adhesion & Migration

Modulation of formin processivity by profilin and mechanical tension

(2018) Luyan Cao et al.   eLife

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

FiloQuant reveals increased filopodia density during breast cancer progression

(2017) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

(2017) Juan R. Hernandez-Fernaud et al.   Nature Communications

Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors

(2017) Daniela Leyton-Puig et al.   Nature Communications

New nuclear and perinuclear functions of formins

(2016) T. Isogai et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Profilin1 biology and its mutation, actin(g) in disease

(2016) Duah Alkam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapid Remodeling of Invadosomes by Gi-coupled Receptors

(2016) Katarzyna M. Kedziora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging biological roles of Cl−intracellular channel proteins

(2016) Elisabetta Argenzio et al.   JOURNAL OF CELL SCIENCE

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome

(2016) Tadamoto Isogai et al.   JOURNAL OF PROTEOME RESEARCH

CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

(2016) Szu-Yi Chou et al.   Nature Communications

PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteins

(2016) Daniela Leyton-Puig et al.   Biology Open

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

(2015) Jeremy D. Rotty et al.   DEVELOPMENTAL CELL

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex

(2015) T. Isogai et al.   JOURNAL OF CELL SCIENCE

Proteomic Analyses Uncover a New Function and Mode of Action for Mouse Homolog of Diaphanous 2 (mDia2)

(2015) Tadamoto Isogai et al.   MOLECULAR & CELLULAR PROTEOMICS

SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton

(2015) Tadamoto Isogai et al.   Scientific Reports

Members of the Chloride Intracellular Ion Channel Protein Family Demonstrate Glutaredoxin-Like Enzymatic Activity

(2015) Heba Al Khamici et al.   PLoS One

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

(2014) Martin Ovesný et al.   BIOINFORMATICS

CLIC4 regulates cell adhesion and  1 integrin trafficking

(2014) E. Argenzio et al.   JOURNAL OF CELL SCIENCE

CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?

(2013) Lele Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Spontaneous Skin Erosions and Reduced Skin and Corneal Wound Healing Characterize CLIC4NULL Mice

(2012) V.C. Padmakumar et al.   AMERICAN JOURNAL OF PATHOLOGY

A Flexible, Grid-Enabled Web Portal for GROMACS Molecular Dynamics Simulations

(2012) Marc van Dijk et al.   Journal of Chemical Theory and Computation

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Interplay between N-WASP and CK2 optimizes clathrin-mediated endocytosis of EGFR

(2011) M. Galovic et al.   JOURNAL OF CELL SCIENCE

The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

(2010) Dene R. Littler et al.   FEBS LETTERS

Chloride Intracellular Channel Protein-4 Functions in Angiogenesis by Supporting Acidification of Vacuoles Along the Intracellular Tubulogenic Pathway

(2009) Barbara Ulmasov et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

(2009) Syed A. Rizvi et al.   CHEMISTRY & BIOLOGY

Spatiotemporal Regulation of Chloride Intracellular Channel Protein CLIC4 by RhoA

(2009) Bas Ponsioen et al.   MOLECULAR BIOLOGY OF THE CELL

TGF-β signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3

(2009) Anjali Shukla et al.   NATURE CELL BIOLOGY

Unleashing formins to remodel the actin and microtubule cytoskeletons

(2009) Melissa A. Chesarone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2

(2008) Petra Beli et al.   NATURE CELL BIOLOGY

Fluorescence nanoscopy by ground-state depletion and single-molecule return

(2008) Jonas Fölling et al.   NATURE METHODS

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures ofCaenorhabditis elegans EXC-4 andDrosophila melanogaster DmCLIC

(2007) Dene R. Littler et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS