Article
Environmental Sciences
Fanli Sun, Xuying Wang, Pinzheng Zhang, Ziyun Chen, Zhiyi Guo, Xuan Shang
Summary: Exposure to silica nanoparticles (SiNPs) during puberty significantly damages the structure and function of the testis and epididymis by inducing oxidative stress, cell apoptosis, and an inflammatory response. These findings highlight the need for a more careful assessment of SiNPs before their application in juvenile supplies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Huimiao Feng, Ping Zhou, Feixue Liu, Wei Zhang, Haitao Yang, Xueqing Li, Jingquan Dong
Summary: This study investigated the effects of abamectin exposure on the respiratory system of carp. It found that abamectin caused toxicity through oxidative stress, inflammation, apoptosis, and inhibition of autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Li Zhou, Chaoqin Zhang, Yu Qiang, Min Huang, Xiangmei Ren, Yuanhong Li, Jihong Shao, Lichun Xu
Summary: The study demonstrated that APSP can protect against lead-induced reproductive toxicity in male mice by attenuating testicular injury, improving sperm count and motility, reducing sperm abnormality rate, restoring antioxidant levels, inhibiting lipid peroxidation, and modulating the JNK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Environmental Sciences
Vishal Afreen, Kanza Hashmi, Rimsha Nasir, Ammara Saleem, Muhammad Imran Khan, Muhammad Furqan Akhtar
Summary: Microplastics (MPs) are polymers with a diameter of less than 5 mm, including polystyrene, polypropylene, and polyethylene. MPs come in various forms such as fragments, beads, fibers, and films, and are ingested by freshwater and land-based animals, entering their food chain and causing harmful effects on the female reproductive system, such as uterine toxicity, infertility, and neurotoxicity. This review explores the effects of polystyrene MPs (PS-MPs) on the female reproductive system and investigates the mechanisms by which they induce reproductive toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Emin Sengul, Volkan Gelen, Serkan Yildirim, Irfan Cinar, Emrah Hicazi Aksu
Summary: In this study, we aimed to investigate the protective effect of naringin against the damage of acrylamide on testicular tissue and the reproductive system in rats. The results showed that naringin alone did not cause tissue damage, and the co-administration of naringin with acrylamide significantly reduced acrylamide-induced testis toxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruonan Wang, Yuxiang Huang, Lu Yu, Siyu Li, Jiayi Li, Biqi Han, Xiaoyan Zheng, Zhigang Zhang
Summary: This study investigates the molecular mechanism of testicular toxicity induced by Cr(VI) exposure. The results demonstrate that Cr(VI) exposure disrupts mitochondrial dynamics and induces oxidative stress, leading to testis apoptosis and autophagy. The suppression of Sirt1/Pgc-1α pathway and downregulation of Nrf2 contribute to the observed effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Manal F. El-Khadragy, Wafa A. AL-Megrin, Suliman Alomar, Afrah F. Alkhuriji, Dina M. Metwally, Shahenda Mahgoub, Hatem K. Amin, Ola A. Habotta, Ahmed E. Abdel Moneim, Rasha S. Albeltagy
Summary: Arsenic is a major global environmental pollutant with reproductive toxicity. This study found that chlorogenic acid (CGA) protects against arsenic-induced testicular damage through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhang
Summary: Exposure to tri-n-butyl phosphate (TnBP) may reduce reproductive ability, increase germ cell apoptosis and DNA damage, and elevate oxidative stress levels in Caenorhabditis elegans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Zahra Rahmani, Abbasali Karimpour Malekshah, Mehryar Zargari, Fereshteh Talebpour Amiri
Summary: This study investigated the effects of prenatal exposure to BaP on ovarian toxicity and the protective role of ATV. Results showed that BaP induced oxidative stress and disrupted ovarian tissue structure, while ATV reduced ovarian damage and restored sex hormone levels.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Lina Joo, Hye Yun Jeong, Dong Hyuck Bae, Joo Hyun Jee, Woo Hee Choi, Hye-Youn Kim, Sejoong Kim, Dong-Ho Yang, Heon Yung Gee, Seonggyeong Jeon, Yun-Gil Roh, Jongman Yoo
Summary: In this study, we have identified bimatoprost, a prostaglandin F2 alpha analogue, as a drug that ameliorates colistin-induced nephrotoxicity. In vitro and in vivo experiments confirmed the protective effects of bimatoprost on colistin-induced kidney damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Qun Lu, Chao Huang, Zhiming Cui
Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the modulation of autophagy, oxidative stress, and apoptosis with Acai Berries in a rat model of endometriosis. The results showed that Acai Berry inhibited the phosphorylation of PI3K, AKT, and ERK1/2, promoting autophagy, and exerted regulatory effects on cell apoptosis and oxidative stress.
Review
Immunology
Jin-yan Dong, Hong-Lin Yin, Hao Hao, Yang Liu
Summary: Autophagy is a highly conserved process that maintains cell stability and function, and helps resist pathogen invasion. It plays a role in various diseases, including lung diseases like acute lung injury (ALI). Traditional Chinese medicine has been used to regulate autophagy and improve ALI symptoms. This paper introduces the molecular mechanism and common pathways of autophagy regulation, as well as the relationship between autophagy and ALI, and summarizes the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Li'E Hou, Tiantian Gu, Kaiqi Weng, Yu Zhang, Yang Zhang, Guohong Chen, Qi Xu
Summary: This study found that excessive granulosa cell apoptosis and autophagy occur during goose broodiness, which is caused by oxidative stress. Additionally, vitamin E treatment effectively protected granulosa cells from oxidative stress-induced apoptosis and autophagy, alleviating these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Sefa Kucukler, Fatih Mehmet Kandemir, Serkan Yildirim
Summary: This study investigated the potential gastroprotective effects of chrysin on indomethacin-induced gastric ulcers in rats. The results showed that chrysin exhibited antioxidant, anti-inflammatory, and anti-apoptotic activities, leading to gastroprotective effects.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Environmental Sciences
Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemir
Summary: In this study, it was found that hesperidin provided significant protection against chronic toxicity in testicular tissue caused by abamectin by exerting antioxidant, anti-inflammatory, antiapoptotic, and anti-autophagic effects, suggesting its potential as an alternative treatment option.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kerim Yesildag, Cihan Gur, Mustafa Ileriturk, Fatih Mehmet Kandemir
Summary: The study demonstrated that carvacrol exhibits antioxidant properties, reduces oxidative stress, inflammation, and apoptosis induced by cadmium chloride. Carvacrol also lowers the levels of proinflammatory cytokines, counteracting the effects of Cd. Additionally, carvacrol shows anti-apoptotic effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Behcet Varisli, Ekrem Darendelioglu, Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Aydin Genc, Ozge Kandemir
Summary: This study found that hesperidin (HSP) can alleviate the injury of rat heart tissue induced by sodium fluoride (NaF). HSP can increase the activities of SOD, CAT, and GPx, and levels of GSH, while suppressing lipid peroxidation. Additionally, HSP can reverse the changes in apoptotic, autophagic, and inflammatory parameters induced by NaF, as well as modulate the gene expression levels of the PI3K/Akt/mTOR signaling pathway and cardiac markers.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Adem Kara, Seda Yakut, Cuneyt Caglayan, Tugce Atcali, Aykut Ulucan, Fatih Mehmet Kandemir
Summary: This study evaluated the potential toxicological effects of favipiravir administration on the liver and kidney tissues of rats. The results showed that favipiravir caused damages to the liver and kidney, including elevated liver and kidney enzymes, oxidative damage, histopathologic changes, apoptotic cell death, and inflammation.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatih Mehmet Kandemir, Mustafa Ileriturk, Cihan Gur
Summary: This study investigated the effects of rutin on liver and kidney damage caused by valproic acid. The results showed that rutin treatment can protect against oxidative stress, ER stress, inflammation, apoptosis, and autophagy-induced damage in the liver and kidney.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Mustafa Onur Yildiz, Hamit Celik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gur, Ibrahim Bayav, Aydin Genc, Ozge Kandemir
Summary: Hesperidin has protective effects against NaF-induced neurotoxicity by reducing lipid peroxidation, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.
Article
Neurosciences
Ahmet Yardim, Cihan Gur, Selim Comakli, Selcuk Ozdemir, Sefa Kucukler, Hamit Celik, Fatih Mehmet Kandemir
Summary: This study investigated the potential protective effects of berberine (BBR) on bortezomib (BTZ)-induced peripheral neuropathy. The results showed that BBR could alleviate oxidative stress, inflammation, and neuropathic changes caused by BTZ, demonstrating its neuroprotective properties.
Article
Environmental Sciences
Fazile Nur Ekinci Akdemir, Serkan Yildirim, Fatih Mehmet Kandemir
Summary: This study aimed to investigate the potential beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration. The results showed that evodiamine could reduce lipid peroxidation and increase antioxidant activities induced by cisplatin, as well as attenuate the expression of apoptotic proteins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Mustafa Ileriturk, Ozge Kandemir, Fatih Mehmet Kandemir
Summary: This study found that the administration of quercetin could protect against oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, autophagy, and the IL-6/JAK2/STAT3/MAPK14 signaling pathway in lung tissue induced by CYP-induced toxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Cihan Gur, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of rutin against liver and kidney toxicity caused by malathion. The results showed that rutin exhibited antioxidant properties and protected liver and kidney tissues from oxidative damage. Furthermore, rutin alleviated endoplasmic reticulum stress and suppressed inflammation, apoptosis, and autophagy markers. It was observed that rutin treatment could alleviate the toxic effects of malathion on liver and kidney tissues.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Cihan Gur, Serkan Ali Akarsu, Nurhan Akaras, Sibel Cigdem Tuncer, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of carvacrol against testicular toxicity induced by sodium arsenite. The results showed that carvacrol improved sperm motility and reduced abnormal and dead sperm. It also reduced oxidative stress, inflammation, autophagy, and apoptosis induced by sodium arsenite.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hamit Emre Kizil, Cuneyt Caglayan, Ekrem Darendelioglu, Adnan Ayna, Cihan Gur, Fatih Mehmet Kandemir, Sefa Kucukler
Summary: This study reveals that morin can protect liver tissue from oxidative damage and apoptosis caused by methotrexate. Morin treatment reduces oxidative stress, apoptosis, and regulates liver function indicators and gene expressions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Esra Aktas Senocak, Necati Utlu, Seyda Kurt, Sefa Kucukler, Fatih Mehmet Kandemir
Summary: The research aims to investigate the protective effects of boron against APAP-induced toxicity in rats. Oral administration of boron reduced the harmful effects of APAP on the liver and kidneys, and exerted anti-inflammatory, antioxidant, and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Serkan Yildirim, Emin Sengul, Emrah Hicazi Aksu, Irfan Cinar, Volkan Gelen, Samet Tekin, Yusuf Dag
Summary: This study found that Selenium can prevent testis toxicity induced by Acrylamide in rats, reducing oxidative stress and inflammation, and maintaining normal reproductive function and sperm morphology.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manigandan Nagarajan, Gobichettipalayam Balasubramaniam Maadurshni, Jeganathan Manivannan
Summary: This study found that exposure to BPA exacerbates hypertension-induced pathological changes, including renal fibrosis, oxidative stress, elevated angiotensin-converting enzyme activity, dysfunction of antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities, and expression of inflammatory factors. In addition, high levels of BPA have dose-dependent effects on kidney cells, including oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Therefore, a precise investigation of BPA exposure in hypertensive populations is highly recommended during risk assessment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiping Bao, Qiang Zhang, Yu Li, Chen Nie
Summary: In this study, the role of circDLGAP4 in Parkinson's disease (PD) was investigated. The results showed that circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus alleviating neuronal injury in PD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Lina Yang, Tianwei He, Yanming Yu
Summary: This study found that uric acid induces kidney injury by inducing IL-17 expression, and treatment with anti-IL-17 antibody can alleviate uric acid-induced kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
