Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Allergy
Xinran O. Zhao, Maria Lampinen, Ola Rollman, Christian P. Sommerhoff, Aida Paivandy, Gunnar Pejler
Summary: MC proteases can influence the functionality of human lung fibroblasts, with chymase having a major impact on cellular morphology, extracellular matrix composition, and proinflammatory phenotype.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Premkumar Siddhuraj, Jimmie Jonsson, Manar Alyamani, Pavan Prabhala, Mattias Magnusson, Sandra Lindstedt, Jonas S. Erjefaelt
Summary: This study investigates the dynamics and spatial distribution of mast cell CPA3 expression in lung diseases, revealing complex and markedly upregulated CPA3 expression profiles in patients with chronic obstructive pulmonary disease (COPD) and idiopathic lung fibrosis (IPF). These alterations are likely to have clinical consequences due to the proposed roles of CPA3 in tissue homeostasis, remodeling, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Meitong Liu, Jing Lu, Yuelin Chen, Xiaolei Shi, YaZhuo Li, Shuting Yang, Jing Yu, Shuang Guan
Summary: The study revealed that sodium sulfite triggers pyroptosis, an inflammatory form of programmed cell death, in mast cells, leading to cell membrane rupture and degranulation. Reactive oxygen species and NLRP3 play crucial roles in this process.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pathology
Matthew J. Hamilton, Melissa Zhao, Matthew P. Giannetti, Emily Weller, Raied Hufdhi, Peter Novak, Lybil B. Mendoza-Alvarez, Jason Hornick, Jonathan J. Lyons, Sarah C. Glover, Mariana C. Castells, Olga Pozdnyakova
Summary: This study found that patients with the H alpha T mutation have increased numbers of MCs in the duodenum, which may contribute to the prevalent gastrointestinal manifestations seen in individuals with this genetic trait.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Lulu Zhang, Hongfang Jin, Yunjia Song, Selena Ying Chen, Yi Wang, Yan Sun, Chaoshu Tang, Junbao Du, Yaqian Huang
Summary: The study revealed the presence of an endogenous SO2/AAT pathway in MCs, where SO2 serves as an MC stabilizer by upregulating the cAMP pathway under hypoxic conditions.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth Proano-Perez, Laia Olle, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Munoz-Cano, Margarita Martin
Summary: Activating mutations in KIT (CD117) are associated with various diseases, and recent research found that the SH3BP2 pathway regulates MITF through miR-1246 and miR-5100, suggesting that MITF may be a potential therapeutic target for gastrointestinal stromal tumors and mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Yu-Na Wang, Yun-Fa Zhang, Xue-Fang Peng, Hong-Han Ge, Gang Wang, Heng Ding, Yue Li, Shuang Li, Ling-Yu Zhang, Jing-Tao Zhang, Hao Li, Xiao-Ai Zhang, Wei Liu
Summary: This study reveals the pathogenic role of mast cells (MCs) in response to severe fever with thrombocytopenia syndrome virus (SFTSV) infection. It also identifies potential biomarkers to differentiate SFTS patients with fatal outcomes and suggests novel therapeutic targets for the clinical management of SFTS. These findings shed light on the potential of MCs as a drug target in other viral hemorrhagic fever diseases with similar host pathology as SFTS.
MICROBIOLOGY SPECTRUM
(2022)
Article
Physiology
I. T. Parsons, M. J. Stacey, L. Faconti, N. Hill, J. O'Hara, E. Walter, B. Farukh, R. McNally, H. Sharp, A. Patten, R. Grimaldi, N. Gall, P. Chowienczyk, D. R. Woods
Summary: Heat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to exertion-related incapacity. This study found that mast cell degranulation may be a vasodilatory mechanism underlying PEH and exercise associated collapse.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Allergy
Matthew P. Giannetti, Grace Godwin, Emily Weller, Joseph H. Butterfield, Mariana Castells
Summary: Patients with hereditary alpha-tryptasemia (H alpha T) and symptoms of mast cell activation do not have elevated levels of mast cell urinary metabolites, suggesting that granule- and membrane-derived mediators may not play a role in driving symptoms in H alpha T.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Isao Matsuoka, Kazuki Yoshida, Masa-aki Ito
Summary: Adenosine triphosphate (ATP) is a neurotransmitter and an energy currency in cells, and it also acts as an extracellular signaling molecule in regulating immune cell functions. This article focuses on the unique features of ionotropic P2X4 receptor signals in mast cell functions, providing insights into the potential effects of purinergic signaling.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shuqi Meng, Xiaotong Sun, Zhaodong Juan, Mingling Wang, Ruoguo Wang, Lina Sun, Yaozu Li, Anran Xin, Shuping Li, Yao Li
Summary: This study demonstrates that clemastine fumarate attenuates myocardial ischemia reperfusion injury by inhibiting mast cell degranulation. Pretreatment with CLE significantly improves cardiac function and reduces cytotoxicity, reversing the damage caused by I/R.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Chuda Rujitharanawong, Sunisa Yoodee, Kanyarat Sueksakit, Paleerath Peerapen, Papapit Tuchinda, Kanokvalai Kulthanan, Visith Thongboonkerd
Summary: Mast cell activation is crucial in allergic diseases and anaphylaxis. This study systematically compared different markers for mast cell activation and recommended reliable markers for in vitro studies.
CELL AND TISSUE RESEARCH
(2022)
Article
Immunology
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus
Summary: Aberrant mast cell responses and complement activation both contribute to allergic diseases. IL-33 plays a critical role in regulating mast cell responses to complement anaphylatoxins, enhancing mast cell reactivity to C3a and C5a. This cross-regulation may aggravate Th2 immune responses and targeting anti-IL33 therapeutically could provide a rationale in allergic diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dmitri Atiakshin, Olga Patsap, Andrey Kostin, Lyudmila Mikhalyova, Igor Buchwalow, Markus Tiemann
Summary: The roles of mast cell tryptase and carboxypeptidase A3 in the development of ovarian endometriomas have been investigated. The formation of endometrioid cysts is associated with increased mast cell population in the ovarian medulla and cortex. Specific proteases in the ovarian local tissue microenvironment suggest novel mechanisms for the regulatory effects of mast cells. Targeting MC tryptase and CPA3 may have potential therapeutic value for ovarian endometriomas in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Juyoung K. Shim, Molly A. Caron, Lisa M. Weatherly, Logan B. Gerchman, Suraj Sangroula, Siham Hattab, Alan Y. Baez, Talya J. Briana, Julie A. Gosse
JOURNAL OF APPLIED TOXICOLOGY
(2019)