Article
Plant Sciences
Zahra Tayarani-Najaran, Elham Hadipour, Seyed Mahdi Seyed Mousavi, Seyed Ahmad Emami, Leila Mohtashami, Behjat Javadi
Summary: The study demonstrated that Lavandula stoechas methanol extract showed protective effects on 6-hydroxydopamine-induced cytotoxicity and oxidative damage in PC12 cells, indicating its potential as a valuable source of active compounds with neuroprotective, anti-oxidant, and anti-apoptotic properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Minyan Li, Sha Wang, Chunmei Fu, Hongyu Chen, Yuxia Su, Peng Wu, Xinhao Yan, Juanjuan Gao
Summary: Parkinson's disease (PD) is characterized by oxidative stress and this study investigated the neuroprotective effects of salidroside (Sal) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal effectively regulated oxidative stress and prevented the transmission of pathologic α-synuclein in the cells. These findings provide insights into potential protective mechanisms against neurodegenerative diseases and synucleinopathies.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Applied
Yanjun Qiu, Hong Jiang, Linlan Fu, Fangfang Ci, Xiangzhao Mao
Summary: Porphyra is an economically important red algae, with functional components such as porphyrans having strong physiological activities. Porphyran and oligo-porphyran have potential applications in various fields, with antioxidation, anticancer, and immunomodulatory effects.
Article
Nanoscience & Nanotechnology
Hong Cheng, Ying Chen, Haifan Yang, Xin Tang, Weiyi Zhu
Summary: This study indicates that Maprotiline can improve ferroptosis in 6-OHDA-challenged SH-SY5Y cells by activating Nrf2.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Neurosciences
Mostofa Jamal, Ikuko Tsukamoto, Takata Maki, Sella Takei, Ryoji Konishi, Hiroshi Kinoshita
Summary: COA-Cl demonstrates protective effects against H2O2 and 6-OHDA-induced toxicity in PC12 cells, suggesting its potential as a therapeutic agent for Parkinson's disease.
NEUROTOXICITY RESEARCH
(2022)
Review
Chemistry, Applied
Biswajita Pradhan, Laxmidhar Rout, Jang-Seu Ki
Summary: Porphyran, a polysaccharide found in red seaweeds, has immunomodulatory, anti-inflammatory, and anti-cancer effects by boosting immunity and targeting apoptotic molecules, making it a potential chemotherapeutic or chemopreventive drug.
CARBOHYDRATE POLYMERS
(2023)
Article
Cell Biology
Jingjing Li, Renkai Li, Xiaoping Wu, Ruby Lai-Chong Hoo, Simon Ming-Yuen Lee, Timothy Man-Yau Cheung, Bryan Siu-Yin Ho, George Pak-Heng Leung
Summary: The study found that the extract of Amauroderma rugosum possesses antioxidant and neuroprotective effects, reducing the toxicity induced by 6-hydroxydopamine in PC12 cells, possibly through influencing multiple signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Genetics & Heredity
Ragesh Babu Manjima, Sennimalai Ramya, Krishnamoorthy Kavithaa, Manickam Paulpandi, Thiruvenkataswamy Saranya, Suresh Babu Harysh Winster, Vellingiri Balachandar, Narayanasamy Arul
Summary: The study demonstrated the neuroprotective property of spathulenol in neuronal cells by reducing oxidative stress and maintaining mitochondrial membrane integrity, showing its potential as a promising therapy for treating neurodegenerative diseases induced by 6-OHDA.
Article
Chemistry, Medicinal
Jingwangwei Liu, Yujia Lu, Min Tang, Fanghao Shao, Dongzi Yang, Shuchang Chen, Ziyi Xu, Leilei Zhai, Juanjuan Chen, Qian Li, Wei Wu, Haimin Chen
Summary: Fucoxanthin, extracted from seaweeds, has neuroprotective activity through its antioxidant properties. It can reduce cytotoxicity, inhibit cell apoptosis, and improve motor ability in Parkinson's disease patients with long-term l-DA administration.
Article
Chemistry, Applied
Lihua Geng, Quanbin Zhang, Qishan Suo, Jing Wang, Yingxia Wang, Cong Wang, Ning Wu
Summary: The oligo-porphyran OP145, isolated from Pyropia yezoensis, shows potential in inhibiting SARS-CoV-2. Through experiments and simulations, it is found that OP145 can bind to Spike glycoprotein and prevent viral infection.
CARBOHYDRATE POLYMERS
(2023)
Article
Cell Biology
Wen-Wen Wang, Ruiyu Han, Hai-Jun He, Jia Li, Si-Yan Chen, Yingying Gu, Chenglong Xie
Summary: Studies show that quercetin can improve mitochondrial quality control, reduce oxidative stress, increase levels of mitophagy markers PINK1 and Parkin, and decrease alpha-synuclein expression in 6-OHDA-treated cells. In vivo, quercetin also helps alleviate PD-like motor behaviors, decrease neuronal death, reduce mitochondrial damage, and control alpha-synuclein accumulation in PD rats. The neuroprotective effect of quercetin is compromised when either Pink1 or Parkin is knocked down.
Article
Biochemistry & Molecular Biology
Stephanie Cristine Hepp Rehfeldt, Joana Silva, Celso Alves, Susete Pinteus, Rui Pedrosa, Stefan Laufer, Marcia Ines Goettert
Summary: This study evaluated the neuroprotective, antioxidant, and anti-inflammatory activities of luteolin-7-O-glucoside (Lut7). The results suggest that Lut7 has neuroprotective effects and further studies should be conducted to validate its potential in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Farzaneh-Sadat Rezazadeh-Shojaee, Elham Ramazani, Jamal Kasaian, Zahra Tayarani-Najaran
Summary: The study demonstrated that 6-gingerol has antioxidative and anti-apoptotic effects in PC12 cells and may have beneficial effects on the progression of Parkinson's disease. Pretreatment with 6-gingerol can enhance cell viability and reduce apoptosis, while also increasing survivin protein levels.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Fisheries
Xiaoqing Wang, Maosheng Wei, Jing Wang, Jing Liu, Quanbin Zhang
Summary: Carbohydrate compounds derived from marine seaweeds have been found to enhance the immune system. The study shows that oligo-porphyran (OP) has anti-inflammatory effects, regulates intestinal immunity, and promotes growth in zebrafish.
AQUACULTURE INTERNATIONAL
(2023)
Article
Immunology
Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, Bojian Ye, Shoupeng Fu, Dianfeng Liu
Summary: Parkinson's disease is a neurodegenerative disorder that primarily affects middle-aged and elderly individuals. Despite its complex etiology, there is currently no effective treatment. This study found that limonin (LM), a natural compound found in citrus fruits, can ameliorate PD-related damage and symptoms by inhibiting neuronal autophagy and microglial inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)