Article
Agriculture, Dairy & Animal Science
Kinga Orzechowska, Marta Kiezun, Edyta Rytelewska, Marlena Gudelska, Katarzyna Kisielewska, Grzegorz Kopij, Kamil Dobrzyn, Ewa Zaobidna, Karolina Szymanska, Tadeusz Kaminski, Nina Smolinska
Summary: This study aimed to evaluate the effects of orexin A (OXA) on mRNA abundance of enzymes involved in prostaglandin production and the concentrations of prostaglandin E2 (PGE2) and F-2 alpha (PGF(2 alpha)) in endometrial and myometrial explants. The results suggest that OXA may affect the synthesis and secretion of PGE2 and PGF(2 alpha) in the uterus by regulating the mRNA levels of enzymes involved in prostaglandin production.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes, Emily S. Barrett
Summary: This study found that cadmium exposure during pregnancy may lead to lower testosterone levels in pregnant women, while estrogen levels remain unchanged. This effect may be stronger in pregnancies carrying female fetuses. Further research is needed to understand how alterations in gestational testosterone activity may impact pregnancy and child health.
Review
Endocrinology & Metabolism
Natalin Jimena Valeff, Maria Silvia Ventimiglia, Lianghui Diao, Federico Jensen
Summary: Systemic lupus erythematosus is an autoimmune disease that primarily affects women, and female sex hormones play a crucial role in its onset and progression. Estradiol enhances the survival of autoreactive B cells and stimulates the production of autoantibodies associated with the disease. Increased levels of estradiol can exacerbate the symptoms and increase the risk of pregnancy complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Acacia Eduarda de Jesus Nascimento, Luciano Cardoso Santos, Bianca Reis Santos, Emilly Oliveira Santos, Maria Clara da Silva Galrao Cunha, Paola Pereira das Neves Snoeck, Mario Sergio Lima de Lavor, Juneo Freitas Silva
Summary: Sex steroids and antioxidant enzymes play crucial roles in regulating uterine and placental physiology. This study investigated the expression patterns of receptors for sex steroids and antioxidant enzymes in the maternal-fetal interface of domestic cats. The results showed that the expression of sex steroid receptors and antioxidant enzymes is increased in the uterus during pregnancy, while their expression in the placenta varies according to gestational age.
Article
Cell Biology
Kinga Orzechowska, Kamil Dobrzyn, Marta Kiezun, Agata Malinowska, Bianka Swiderska, Tadeusz Kaminski, Nina Smolinska
Summary: This study examined the effects of CHEM on differentially regulated proteins in porcine endometrial tissue during implantation. It was found that CHEM modulates protein expressions involved in endometrial cell growth, migration, immune response, sensitivity to P4, and formation of new blood vessels. CHEM also appears to play a role in endothelial cell dysfunction during preeclampsia.
Article
Reproductive Biology
Hwanhee Jang, Soohyung Lee, Inkyu Yoo, Yohan Choi, Jisoo Han, Yugyeong Cheon, Hakhyun Ka
Summary: S100A8, S100A9, and S100A12, calcium-binding proteins, are dynamically expressed in response to conceptus-derived signals at the maternal-conceptus interface, potentially playing a critical role in regulating endometrial epithelial cell function and conceptus implantation to support the establishment and maintenance of pregnancy in pigs.
BIOLOGY OF REPRODUCTION
(2022)
Article
Oncology
Lei Zhang, JinFeng Wu, QiuMei Wu, XiangJuan Zhang, ShuaiCai Lin, WanLi Ran, Li Zhu, ChengYan Tang, Xing Wang
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms behind male propensity in HCC incidence, prognosis, and treatment responses are complex and inconclusive. This review integrates current knowledge on how hormones regulate HCC development in a sexually dimorphic manner. Understanding the role of sex hormones in HCC may lead to personalized therapeutic strategies in high-risk populations.
Article
Cell Biology
Damian Tanski, Agnieszka Skowronska, Malgorzata Tanska, Ewa Lepiarczyk, Mariusz T. Skowronski
Summary: The research shows that estradiol, progesterone, and arachidonic acid regulate the expression of AQP1 and AQP5 in porcine luminal epithelial cells through the PKA and MAPK signaling pathways.
Article
Obstetrics & Gynecology
Megan C. Hansel, Hannah R. Murphy, Jessica Brunner, Christina Wang, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett, Zorimar Rivera-Nunez
Summary: The study found that neighborhood stressors were associated with higher levels of maternal testosterone, which may have implications for maternal and child health.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Grzesiak, Kinga Kaminska, Aleksandra Bodzioch, Ewa M. Drzewiecka, Anita Franczak, Katarzyna Knapczyk-Stwora
Summary: This study reveals the presence of vitamin D-3 metabolism in the uterus of pigs, with both endometrium and myometrium capable of synthesizing vitamin D-3, while only the endometrium is involved in its metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Marlena Gudelska, Kamil Dobrzyn, Marta Kiezun, Katarzyna Kisielewska, Edyta Rytelewska, Tadeusz Kaminski, Nina Smolinska
Summary: This study aimed to investigate the influence of steroid hormones on the expression of the chemerin system in the uterus of domestic pigs. The results showed that both estradiol and progesterone can modulate the expression of chemerin receptor genes and proteins, as well as the abundance of RARRES2 mRNA transcripts. Additionally, estradiol increased chemerin protein secretion during the maternal recognition of pregnancy and decreased its release during embryo implantation.
Review
Environmental Sciences
J. O. Ojoghoro, M. D. Scrimshaw, J. P. Sumpter
Summary: Steroid hormones are crucial natural hormones that regulate physiological processes in vertebrates; both natural and synthetic steroid hormones have been identified as widespread aquatic contaminants; experiments have shown that even at extremely low concentrations, steroid hormones can adversely affect reproduction in aquatic vertebrates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Jasper Dingemanse, Pascal Charef, Jed Black, Chris Gouws
Summary: This study found that a 4-week once daily administration of 200 mg almorexant did not have any treatment effects on tear film break-up time, spermatogenesis, hormone levels, or pancreatic elastase in stool in healthy male subjects. The drug was well tolerated and did not show any adverse effects on the variables assessed. Preclinical findings related to ophthalmology and testicular function did not translate to humans in this clinical study, indicating the need for larger clinical trials.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Stanimir Yotov, Ivan Fasulkov, Anatoli Atanasov, Elena Kistanova, Branimir Sinapov, Boyana Ivanova, Dobri Yarkov, Darina Zaimova
Summary: The use of sexed semen reduces the number of cows needed for progeny testing, speeds up the production of replacement dairy heifers, and shortens the herd renewal period. This study found that ultrasound examination of cows' ovaries on the day of artificial insemination can be a reliable tool for selecting candidates for sexed semen application based on the relationship between ovarian status, follicle size, and hormone concentrations.
Article
Agriculture, Dairy & Animal Science
Kinga Orzechowska, Marta Kiezun, Edyta Rytelewska, Marlena Gudelska, Katarzyna Kisielewska, Grzegorz Kopij, Kamil Dobrzyn, Ewa Zaobidna, Karolina Szymanska, Tadeusz Kaminski, Nina Smolinska
Summary: This study aimed to evaluate the effects of orexin A (OXA) on mRNA abundance of enzymes involved in prostaglandin production and the concentrations of prostaglandin E2 (PGE2) and F-2 alpha (PGF(2 alpha)) in endometrial and myometrial explants. The results suggest that OXA may affect the synthesis and secretion of PGE2 and PGF(2 alpha) in the uterus by regulating the mRNA levels of enzymes involved in prostaglandin production.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marlena Gudelska, Kamil Dobrzyn, Marta Kiezun, Katarzyna Kisielewska, Edyta Rytelewska, Tadeusz Kaminski, Nina Smolinska
Summary: This study found that Chemerin can affect steroid hormone synthesis in the porcine endometrium, particularly P-4 and E-2. Chemerin achieves this impact by regulating the expression levels of specific steroidogenic enzyme proteins at different stages of pregnancy and the estrous cycle. Additionally, Chemerin also influences hormone synthesis through the Erk and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Karol G. Makowczenko, Jan P. Jastrzebski, Lukasz Paukszto, Kamil Dobrzyn, Marta Kiezun, Nina Smolinska, Tadeusz Kaminski
Summary: Chemerin participates in the regulation of physiological and disorder mechanisms in mammals. This study investigates the influence of Chemerin on alternative mRNA transcription in porcine luteal cells, including differential expression of long non-coding RNAs (DELs) and their interactions with differentially expressed genes (DEGs), differences in alternative splicing of transcripts (DASs), and allele-specific expression (ASEs). The results provide new insights into the effects of Chemerin on the functions of the corpus luteum.
Article
Reproductive Biology
Kinga Orzechowska, Grzegorz Kopij, Lukasz Paukszto, Kamil Dobrzyn, Marta Kiezun, Jan Jastrzebski, Tadeusz Kaminski, Nina Smolinska
Summary: This study found that CHEM affects the gene expression profile of the porcine endometrium, especially genes related to cell migration and adhesion, angiogenesis, inflammation, and steroidogenesis. This suggests that CHEM plays an important role in the pig embryo implantation process.
BIOLOGY OF REPRODUCTION
(2022)
Article
Cell Biology
Kinga Orzechowska, Kamil Dobrzyn, Marta Kiezun, Agata Malinowska, Bianka Swiderska, Tadeusz Kaminski, Nina Smolinska
Summary: This study examined the effects of CHEM on differentially regulated proteins in porcine endometrial tissue during implantation. It was found that CHEM modulates protein expressions involved in endometrial cell growth, migration, immune response, sensitivity to P4, and formation of new blood vessels. CHEM also appears to play a role in endothelial cell dysfunction during preeclampsia.
Article
Cell Biology
Ewa Mlyczynska, Marta Kiezun, Patrycja Kurowska, Monika Dawid, Karolina Pich, Natalia Respekta, Mathilde Daudon, Edyta Rytelewska, Kamil Dobrzyn, Barbara Kaminska, Tadeusz Kaminski, Nina Smolinska, Joelle Dupont, Agnieszka Rak
Summary: In this review, we summarize the current knowledge about the expression and role of adipokines and neuropeptides in the physiological regulation of corpus luteum function, as well as their potential involvement in pathologies affecting the luteal cells that disrupt the estrous cycle.
Article
Reproductive Biology
Marlena Gudelska, Kamil Dobrzyn, Marta Kiezun, Katarzyna Kisielewska, Edyta Rytelewska, Tadeusz Kaminski, Nina Smolinska
Summary: This study aimed to investigate the influence of steroid hormones on the expression of the chemerin system in the uterus of domestic pigs. The results showed that both estradiol and progesterone can modulate the expression of chemerin receptor genes and proteins, as well as the abundance of RARRES2 mRNA transcripts. Additionally, estradiol increased chemerin protein secretion during the maternal recognition of pregnancy and decreased its release during embryo implantation.
Article
Biochemistry & Molecular Biology
Jacek Kiezun, Marta Kiezun, Bartlomiej Emil Krazinski, Lukasz Paukszto, Anna Koprowicz-Wielguszewska, Zbigniew Kmiec, Janusz Godlewski
Summary: This study found that the expression levels of GALR1 and GALR3 proteins were elevated in colorectal cancer tissue, and higher GALR3 expression was associated with better prognosis. The expression of GALR1 and GALR3 slightly decreased in myenteric plexuses close to the cancer, but showed no correlation with tumor progression. The expression levels of GALRs in submucosal plexuses did not significantly change between distal and close to the tumor. However, elevated GALR1 expression in submucosal plexuses close to the tumor correlated with poor prognosis, higher tumor grading, and shorter overall survival.
Article
Biochemistry & Molecular Biology
Karol G. Makowczenko, Jan P. Jastrzebski, Marta Kiezun, Lukasz Paukszto, Kamil Dobrzyn, Nina Smolinska, Tadeusz Kaminski
Summary: The aim of this study was to investigate the transcriptomic changes and mechanisms accompanying transcription and translation processes in the pituitary of the domestic pig. Through high-throughput sequencing of RNA, the study obtained information on gene expression changes, alternative splicing events, allele-specific expression sites, and RNA editing events. The study also confirmed the expression profiles of select phenomena and identified intracellular pathways that induce changes in transcription and translation regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)