Review
Reproductive Biology
Erin K. Klein, Aleona Swegen, Allan J. Gunn, Cyril P. Stephen, Robert John Aitken, Zamira Gibb
Summary: This paper reviews the proteins, transcripts, and metabolites identified in spermatozoa and seminal plasma, with a focus on molecular factors correlated with high or low fertility bulls. The study aims to evaluate if these factors can be used as predictive biomarkers in the future. Understanding the molecular factors influencing fertility in cattle will have significant implications for livestock production.
BIOLOGY OF REPRODUCTION
(2022)
Article
Agriculture, Dairy & Animal Science
M. Kinukawa, M. Ito, Y. Uemoto, A. Ogino, S. Haruta, K. Kurogi, T. Watanabe, S. Sasaki, Y. Naniwa, K. Uchiyama, K. Togashi
Summary: There is considerable variation in the bull conception rate (BCR) of Japanese Black cattle, and some bulls with a low BCR have been identified. In this study, a genome-wide association study with whole-exome sequencing was conducted to identify single-nucleotide polymorphisms (SNPs) for predicting low BCR. The g.116408653G > A SNP in Bos taurus autosome 5 was found to have a significant effect on BCR.
Article
Agriculture, Dairy & Animal Science
Manish Kumar Sinha, Arumugam Kumaresan, Thirumala Rao Talluri, John Peter Ebenezer Samuel King, Mani Arul Prakash, Pradeep Nag, Nilendu Paul, Kathan Raval, Elango Kamaraj, V Aranganathan
Summary: In this study, high-throughput next-generation sequencing was used to identify important SNPs and novel variants associated with fertility in high-fertile (HF) and low-fertile (LF) breeding bulls. The results showed a higher number of SNPs in HF bulls compared to LF bulls. GO analysis revealed the involvement of genes with significant variations in oxidative phosphorylation and metabolic pathways in HF bulls, while genes related to Ca2++ ion binding, ribosomal structure, translation, and ribosomal small subunit assembly were found to have significant variations in LF bulls. Several candidate genes including TPT1, BOLA-DRA, CD74, RPS17, RPS28, RPS29, RPL14, RPL13, and RPS27A were identified, which are associated with sperm functionality, survival, oxidative stress, and bull fertility.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Isis da Costa Hermisdorff, Iara Del Pilar Solar Diaz, Gregorio Miguel Ferreira de Camargo, Lucia Galvao de Albuquerque, Raphael Bermal Costa
Summary: This study identified eight regions on chromosome X associated with scrotal circumference, explaining 28.52% of the genetic variance for this trait. Genes with potential functions in reproduction and fertility regulation were highlighted as candidates for sexual precocity rates in Nelore cattle, along with 10 genes not previously associated with sexual precocity traits in cattle. These findings will contribute to our understanding of the genetic architecture for reproductive traits in indicine cattle and enhance genomic prediction in beef cattle.
JOURNAL OF APPLIED GENETICS
(2021)
Article
Genetics & Heredity
Vikas Vohra, Supriya Chhotaray, Gopal Gowane, Rani Alex, Anupama Mukherjee, Archana Verma, Sitangsu Mohan Deb
Summary: The study used genome-wide association studies to identify genomic variations associated with lactation and fertility traits in Murrah buffaloes, offering prospects for systematic improvement. The identification of potential genomic regions may help in early selection of high-yielding persistent Murrah buffaloes and shape future genetic improvement programs.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Buddhika A. Dahanayaka, Lisle Snyman, Niloofar Vaghefi, Anke Martin
Summary: This study identified quantitative trait loci (QTL) associated with virulence and leaf symptoms in the net blotches caused by Pyrenophora teres. The accumulation of QTL in hybrid isolates may result in enhanced virulence.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Magnus Alm Rosenblad, Anna Abramova, Ulrika Lind, Pall Olason, Stefania Giacomello, Bjorn Nystedt, Anders Blomberg
Summary: This study characterized the genome of the bay barnacle Balanus improvisus, revealing its haploid genome size of approximately 740 Mbp and highly fragmented assembly due to high nucleotide diversity and repeat content. These genomic features can guide the development of a high-quality reference genome for further exploration of barnacle biology and antifouling strategies.
MARINE BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zixue Xuan, Yiwen Zhang, Jinying Jiang, Xiaowei Zheng, Xiaoping Hu, Xiuli Yang, Yanfei Shao, Guobing Zhang, Ping Huang
Summary: This study identified m(6)A-SNPs associated with breast cancer and explored their potential functions. The SNPs rs4829 and rs9610915 were found to potentially be associated with breast cancer due to having eQTL signals, altered gene expression, and proximity to m(6)A modification sites. Further research is needed to clarify how genetic variation affects epigenetic modification and its functions in breast cancer pathogenesis.
Article
Veterinary Sciences
Akansha Singh, Amit Kumar, Cedric Gondro, A. K. Pandey, Triveni Dutt, B. P. Mishra
Summary: In this study, GWAS was conducted to identify SNPs associated with milk protein and minerals in crossbred cows. Several significant SNPs were found, and candidate genes and related biological processes were identified.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Ruiqi Zhang, Xinghua Li, Ying Ma, Yuchen Liu, Yalan Zhang, Xue Cheng, Zhonghua Ning
Summary: This study aimed to identify significant single nucleotide polymorphism (SNP) sites and candidate genes related to thermogelled yolk texture in Hetian Dahei chicken (HTHD) flocks that can be used as genetic markers. The study found that 10 genes and some SNPs were associated with hardness of the thermogelled egg yolks, including RELCH gene participating in cholesterol transport and LRRK2 gene associated with gumminess. Moreover, 8 SNPs associated with resilience, 208 SNPs associated with chewiness, and 159 candidate genes were identified. The results provide a theoretical basis for breeding high-quality egg yolks using molecular marker-assisted selection.
Article
Plant Sciences
Jeewan Pandey, Douglas C. Scheuring, Jeffrey W. Koym, M. Isabel Vales
Summary: This study identified key genomic regions associated with tuber traits in potato using high-throughput genotyping and phenotyping, and obtained genomic estimated breeding values to improve breeding efficiency.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
J. M. D. R. Jayawardana, Nicolas Lopez-Villalobos, Lorna R. McNaughton, Rebecca E. Hickson
Summary: The aim of this study was to identify genomic regions and genes associated with milk composition and fertility traits in spring-calved dairy cows in New Zealand. Phenotypic data from two dairy herds at Massey University were analyzed, and 73 SNPs associated with 58 candidate genes were identified. Four SNPs on chromosome 14 were highly significant for fat and protein percentages, and genes DGAT1, SLC52A2, CPSF1, and MROH1 were found to be associated. Gene Ontology analysis revealed 10 candidate genes related to fertility traits, which are involved in reducing metabolic stress, increasing insulin secretion, embryonic development, and maternal lipid metabolism during pregnancy.
Article
Obstetrics & Gynecology
Sumeshree Govender, Nihar R. Nayak, Louansha Nandlal, Thajasvarie Naicker
Summary: This study investigates the association of C1q gene polymorphisms in HIV infected and uninfected preeclamptic women of African ancestry. The results suggest that these polymorphisms of the C1q gene are not associated with the pathogenesis of preeclampsia development in women of African ancestry.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Immunology
Ding-Ping Chen, Tang-Her Jaing, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu
Summary: This study identified specific SNPs in non-HLA genes associated with the effectiveness of unrelated CBT, which can aid in selecting the best donor and predicting the risk of CBT adverse reactions, further suggesting the important role of SNPs in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jihye Cha, Daehyeok Jin, Jae-Hwan Kim, Seung-Chang Kim, Jin A. Lim, Han-Ha Chai, Seul A. Jung, Jun-Heon Lee, Seung-Hwan Lee
Summary: Skin color in chickens is an economically important trait that affects consumer choice. Identifying genomic regions associated with skin color is crucial for increasing sales value.
