Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Magdalena Krauze, Jerzy Juskiewicz, Bartosz Fotschki, Katarzyna Ognik
Summary: The aim of this study is to evaluate the effect of different forms and dosages of copper on neurodegenerative markers in the brain and jejunum. The experiment involved feeding male Wistar rats a rat diet with two CuCO3 dosages and two CuNP dosages. Nanoparticles reduced the level of GAChE, increased the levels of AChE and LRP1, and decreased β-amyloid and Tau protein in both the brain and intestine of rats. The highest levels of beneficial markers and lowest levels of toxic markers were observed in rats receiving a standard dose of Cu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ewelina Cholewinska, Jerzy Juskiewicz, Michal Majewski, Radoslaw Smagiel, Piotr Listos, Bartosz Fotschki, Irena Godycka-Klos, Katarzyna Ognik
Summary: The aim of this experiment was to investigate the impact of replacing traditional CuCO3 with copper nanoparticles (CuNPs) on the biochemical parameters, redox status, and histomorphometry of rat tissues. The results showed that the substitution of CuCO3 with CuNPs exacerbated the negative changes induced by hypertension, particularly in the heart, liver, and intestines.
Article
Multidisciplinary Sciences
R. Gaikwad, P. R. Thangaraj, A. K. Sen
Summary: The study introduces a new method for fast measurement of H2O2 levels in blood using a microfluidic device, highlighting the significant impact of blood cells and soluble proteins on measurement accuracy. The new method enables reliable measurements with high sensitivity and rapid detection time.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Huajuan Fang, Xingping Zhang, Dongxu Gao, Yao Xiao, Liyuan Ma, Hualin Yang, Yu Zhou
Summary: A rapid and convenient fluorescence glyphosate biosensor based on DNA-templated copper nanoparticles was developed. The biosensor showed good selectivity and detection performance, and the whole detection process could be completed quickly.
Article
Fisheries
Rouhollah Sheikh Veisi, Aliakbar Hedayati, Mohammad Mazandarani, Ali Jafar Nodeh, Tahereh Bagheri
Summary: The study showed that adding molasses could alleviate the negative effects of copper nanoparticles exposure on the immunity indices of common carp. Therefore, using molasses in rearing aquatic species diets could be suggested as a protective solution.
AQUACULTURE REPORTS
(2021)
Article
Electrochemistry
Salma Khatun, Miguel A. Andres, Sidney R. Cohen, Ifat Kaplan-Ashiri, Olga Brontvein, Irit Rosenhek-Goldian, Robert S. Weatherup, Baran Eren
Summary: This study investigates the stability of Cu nanoparticles (NPs) attached to a single-layer graphene (SLG) membrane in a micro-electrochemical cell. The interfacial electronic interactions between Cu NPs and SLG are examined under different electrochemical potentials. The results show that Cu NPs can be oxidized and detached from SLG at anodic potentials, while they remain adhered to SLG at cathodic potentials.
ELECTROCHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Dicle Kargin
Summary: The study showed that zinc oxide and copper oxide nanoparticles, especially at higher doses, had negative effects on the blood physiological and biochemical responses in male Swiss albino mice. When used together, the impact was more significant compared to using zinc oxide or copper oxide nanoparticles alone. Blood serum profiles could be used as indicators to assess nanoparticle toxicity on various physiological functions in animals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Mostafa A. Askar, Mona S. Guida, Seham M. AbuNour, Essam A. Ragab, Eiman N. Ali, Nadia Abdel-Magied, Nahla A. Mansour, Samir A. Elmasry
Summary: Zinc coumarate and zinc caffeinate nanoparticles can mitigate liver damage induced by gamma rays by increasing antioxidant levels and reducing oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Analytical
Shuo Li, Qian Dong, Ying Yu, Bixia Lin, Li Zhang, Manli Guo, Yujuan Cao, Yumin Wang
Summary: In this study, a highly sensitive and label-free fluorescence biosensing strategy for the determination of alkaline phosphatase (ALP) activity was introduced using cobalt oxyhydroxide (CoOOH) nanoflakes and nonenzymatic cascade recycling amplification (CRA). The method exhibits excellent specificity and a low detection limit, making it suitable for evaluating ALP activity in complex human serum samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Nazim Husain, Samra Hasan, Aijaz Ahmed Khan, Riaz Mahmood
Summary: Oral administration of copper chloride in rats led to significant oxidative damage in the intestine, affecting cellular metabolism, cell membrane, and DNA damage, which in turn can impair digestive and absorptive functions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Rui A. Goncalves, Joanne W. K. Ku, Hao Zhang, Teddy Salim, Guodong Oo, Alfred A. Zinn, Chris Boothroyd, Richard M. Y. Tang, Chee Lip Gan, Yunn-Hwen Gan, Yeng Ming Lam
Summary: This study reports copper nanoparticle coatings with extremely fast and sustained antibacterial activity. Coating with cuprous oxide (Cu2O) nanoparticles and metallic copper nanoparticles on commonly used fabrics can kill bacteria within a short time, and both copper and Cu2O nanoparticles rapidly induce oxidative stress. Detailed physical and chemical analysis of the nanoparticles and the interaction between bacteria and the coated substrate help establish the parameters for achieving speedy and robust antibacterial properties in Cu2O-coated fabrics.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Shuofeng Li, Fangfang Wang, Chun Wang, Zhi Wang, Qiuhua Wu
Summary: By combining the CRISPR/Cas13a system with a simple and efficient signal amplification strategy triggered by TdT, a highly specific and sensitive method (Cas13a-TFCN) was developed for miRNA detection. The Cas13a-TFCN method showed high sensitivity and was able to accurately quantify miRNA in complex biological samples, demonstrating its practical application ability.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Environmental Sciences
Safa Hidouri, Ines Karmous, Oumaima Kadri, Oussama Kharbech, Abdelilah Chaoui
Summary: This study provides new evidence of the successful use of metal oxide nanoparticles in the remediation of heavy metals. Zinc oxide nanoparticles (ZnO NP) and copper oxide nanoparticles (CuO NP) were found to alleviate cadmium (Cd) toxicity in Phaseolus vulgaris L. seedlings and plants. The physiological and metabolic parameters were monitored to elucidate the mechanism and process of Cd-induced phytotoxic effects on bean. The NP dose-dependent response of P. vulgaris seedlings and the differential response of growing plants in terms of length and biomass were observed. Both ZnO NP and CuO NP were able to reduce the hypergeneration of hydrogen peroxide (H2O2) and enhance ROS scavenging enzymatic capacity, while inhibiting the activity of ROS producing enzymes. The modulation of redox enzymes involved in cellular homeostasis and maintaining reduced status in cells was also observed. ZnO NP triggered more significant metabolic regulations allowing to mitigate the oxidative damage caused by Cd.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Multidisciplinary
Merve Firat Ayyildiz, Elif Yazici, Meltem Saylan, Dotse Selali Chormey, Sezgin Bakirdere
Summary: In this study, an effective Fenton digestion procedure utilizing UV irradiation was developed for copper determination in human blood serum. The method involved the degradation of blood serum samples using free hydroxyl radicals generated from a mixture of iron magnetic nanoparticles and hydrogen peroxide under UV irradiation. The digestion process was carried out with a lab-made UV irradiation reactor, achieving satisfactory recovery rates and high repeatability.
Article
Pharmacology & Pharmacy
Lan Huang, Yaoxun Zeng, Yongliang Li, Yingshan Zhu, Yan He, Yan Liu, Anne Robert, Bernard Meunier
Summary: The study demonstrates that TDMQ20 effectively crosses the blood-brain barrier and accumulates in the brain, indicating its potential as a relevant drug-candidate for the treatment of AD.
Article
Biochemistry & Molecular Biology
Bartosz Fotschki, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Magdalena Krauze, Jerzy Juskiewicz
Summary: The study investigated the effects of chromium supplementation and switching dietary habits on lipid metabolism, inflammation, and oxidative stress in Wistar rats. The combination of chromium nanoparticles and dietary changes showed the strongest reduction in fat content and cholesterol in the liver. This combination also had favorable antioxidative effects. Supplementation with chromium nanoparticles alone also improved lipid metabolism and oxidative stress, although to a lesser extent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Bartosz Fotschki, Ewelina Cholewinska, Katarzyna Ognik, Michal Sojka, Joanna Milala, Joanna Fotschki, Wieslaw Wiczkowski, Jerzy Juskiewicz
Summary: The required amount of berry polyphenols for health benefits is difficult to achieve through fresh fruit consumption, suggesting polyphenol-rich extracts as a dietary alternative. This study fed rats high-fat diets supplemented with 0.1 or 0.3% raspberry polyphenols and found that the higher dose of extract had more noticeable health-promoting effects, including reduced white adipose tissue weight, hepatic triglyceride content, and plasma IL-6 concentration, as well as increased acetic acid concentration in the cecal digesta. The enhanced content of ellagitannin and anthocyanin metabolites in the blood plasma of rats administered the high dose extract may partially explain these effects.
Review
Biochemistry & Molecular Biology
Joanna Fotschki, Anna M. M. Ogrodowczyk, Barbara Wroblewska, Jerzy Juskiewicz
Summary: The vegetable processing industry generates large amounts of by-products that are susceptible to microbial degradation. Inadequate management leads to the loss of valuable compounds in vegetable by-products. Scientists are exploring the possibility of reusing discarded biomass to create higher value products. The by-products contain bioactive compounds with health-promoting properties. This review emphasizes the importance of these by-products in promoting health through their impact on the microbiota, immune system, and gut milieu.
Article
Nutrition & Dietetics
Ewelina Cholewinska, Aleksandra Marzec, Przemyslaw Solek, Bartosz Fotschki, Piotr Listos, Katarzyna Ognik, Jerzy Juskiewicz
Summary: The aim of this study was to investigate the effects of different types of dietary fibre (cellulose, inulin, pectin, and psyllium) in combination with recommended or enhanced levels of CuNPs on selected biological parameters of intestinal integrity in rats. The results showed that replacing CuCO3 with CuNPs in the diet reduced lactic acid and apoptosis markers levels in the small intestine, but it also increased DNA oxidation. Inulin had the most beneficial effect on DNA repair mechanisms, while pectin had the highest ability to inhibit inflammatory processes and apoptotic cell death in the small intestine. These findings suggest that dietary fibre supplementation can protect the small intestine against oxidative effects of CuNPs by enhancing the intestinal barrier.
Article
Biochemistry & Molecular Biology
Magdalena Szydlowska-Tutaj, Urszula Szymanowska, Krzysztof Tutaj, Dorota Domagala, Urszula Zlotek
Summary: The study investigated the effects of adding 2.5% and 5% dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta. The results showed that the samples subjected to gastrointestinal digestion had significantly higher levels of phenolic compounds and exhibited increased antioxidant, anti-inflammatory, and antiproliferative properties. The analysis of phenolic compounds using LC-MS/MS technique revealed that Reishi-enriched pasta had a higher content of syringic acid, while Lion's Mane supplemented pasta had a higher content of vanillin compared to the control pasta. Ethanol extracts of the Reishi-enriched samples showed higher ABTS antiradical properties and reducing power, while Lion's Mane supplemented samples exhibited stronger lipoxygenase inhibition ability. These findings suggest that Reishi and Lion's Mane mushroom powder can be used to fortify semolina pasta, imparting slightly healthier characteristics to the product.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Magdalena Krauze, Jerzy Juskiewicz, Bartosz Fotschki, Katarzyna Ognik
Summary: The aim of this study is to evaluate the effect of different forms and dosages of copper on neurodegenerative markers in the brain and jejunum. The experiment involved feeding male Wistar rats a rat diet with two CuCO3 dosages and two CuNP dosages. Nanoparticles reduced the level of GAChE, increased the levels of AChE and LRP1, and decreased β-amyloid and Tau protein in both the brain and intestine of rats. The highest levels of beneficial markers and lowest levels of toxic markers were observed in rats receiving a standard dose of Cu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michal Majewski, Leszek Gromadzinski, Ewelina Cholewinska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of dietary fiber supplementation with different types of nanoparticles on the cardiovascular system in rats. The results showed that compared to pectin, inulin and psyllium supplementation with a standard dose of copper nanoparticles improved antioxidant capacity and reduced heart malondialdehyde levels. Furthermore, with an enhanced dose of copper nanoparticles, inulin and psyllium enhanced vasodilation through up-regulation of COX-2-derived vasodilator prostanoids.
Article
Nutrition & Dietetics
Jerzy Juskiewicz, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Magdalena Krauze, Bartosz Fotschki
Summary: This study assessed the changes in faecal microbial activity in obese rats fed high-fat or low-fat diets supplemented with different forms of chromium. The results showed that switching from a high-fat to a low-fat diet had beneficial effects, and supplementing with chromium nanoparticles further modulated microbial activity.
Article
Nutrition & Dietetics
Bartosz Fotschki, Michal Sojka, Monika Kosmala, Jerzy Juskiewicz
Summary: Previous studies have shown that dietary supplementation with prebiotic fructooligosaccharides (FOSs) and polyphenols can alleviate disorders related to the early stage of nonalcoholic fatty liver disease (NAFLD). This experiment aimed to investigate whether raspberry polyphenols together with FOSs can regulate advanced-stage NAFLD in genetically obese Zucker rats. The results showed that the addition of FOSs and raspberry polyphenolic extract to the diet reduced liver fat accumulation, improved antioxidant potential, lowered plasma enzyme activities, and increased insulin sensitivity. These effects may be attributed to the upregulation of specific receptors in the liver responsible for regulating lipid metabolism and glucose and bile acid synthesis.
Article
Nutrition & Dietetics
Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Kamil Myszczynski, Magdalena Krauze, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of supplementation with chromium nanoparticles (Cr-NPs) on the gut microenvironment in rats fed a high-fat diet. The results showed that Cr-NPs mainly acted by altering the activity of gut microbiota, leading to decreased concentration of short-chain fatty acids and increased level of cecal lithocholic acid. Switching to a low-fat diet had a more significant impact on obesity-related disorders, improving microbial activity, composition, and the production of short-chain fatty acids.
