Review
Obstetrics & Gynecology
Janice de Miranda Vasconcellos Vilela, Marie-Madeleine Dolmans, Christiani Andrade Amorim
Summary: The practice of transporting ovarian tissue over long periods has been growing rapidly, but more clinical validation is needed despite reported successes. Current research is mainly focused on animal models, providing valuable insights for future studies involving humans.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Engineering, Biomedical
Daniel J. Portillo, Jose Gonzalez, Carorina Villarreal, Sophia J. Salazar, Anjelyka Fasci, Brandt Wearden, Jessica Oseghale, Anis Khalil, Thomas Perillo, Leslie Muenchow, Robert De Lorenzo, R. Lyle Hood
Summary: This study presents a novel, portable, and nonelectronic device that is capable of delivering oxygenated machine perfusion to different organs. Through an innovative pneumatic circuit system and silicone tube design, the device achieved perfusion parameters consistent with previous kidney preservation studies.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Gastroenterology & Hepatology
Riccardo De Carlis, Paolo Muiesan, Burcin Taner
Summary: DCD grafts pose risks of complications and graft loss after liver transplantation due to prolonged functional donor warm ischaemia time. Improved outcomes have been achieved through stringent donor selection criteria and utilization of organ perfusion technologies. These technologies also enable liver function assessment and precise graft-recipient selection.
JOURNAL OF HEPATOLOGY
(2023)
Article
Ethics
Katrina A. Bramstedt
Summary: This report presents the global issue of donor corneal tissue shortage for transplantation and suggests a potential solution by modifying the language used. It highlights that the term "eye donation" can discourage ocular tissue donation due to the "ick factor" it may generate. Instead, using terms like "ocular (eye tissue)" could provide less emotive terminology. The report emphasizes the importance of terminology shifts in the transplantation field and suggests that using "ocular" terminology could enhance the informed consent process, improve donation rates, and optimize patient quality of life for those with treatable blindness.
JOURNAL OF MEDICAL ETHICS
(2022)
Article
Ethics
G. M. Qurashi
Summary: This paper examines the ethical justifiability of the opt-out organ donor register introduced in England in 2019, questioning whether such paradigms for deceased organ donation are ethically sound. The author ultimately challenges the justification of opt-out systems for organ procurement, suggesting that ethical solutions to organ shortage lie elsewhere.
JOURNAL OF MEDICAL ETHICS
(2021)
Article
Surgery
Damiano Patrono, Davide Cussa, Veronica Sciannameo, Elena Montanari, Rebecca Panconesi, Paola Berchialla, Mirella Lepore, Alessandro Gambella, Giorgia Rizza, Giorgia Catalano, Stefano Mirabella, Francesco Tandoi, Francesco Lupo, Roberto Balagna, Mauro Salizzoni, Renato Romagnoli
Summary: Dual hypothermic oxygenated machine perfusion (D-HOPE) improves preservation and outcomes in liver transplantation, especially when utilizing donors after neurological determination of death (DBD). D-HOPE reduces early graft failure, complications, and improves survival for both patients and grafts, including elderly donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Engineering, Biomedical
Daniel J. Portillo, Lauren Bayliss, Stephen Rivas, Gabriela Pineda, Sukhwinder Kaur, Leonid Bunegin, R. Lyle Hood
Summary: The study introduced a novel and portable device that provided oxygenated and pulsatile perfusion, demonstrating its capability to achieve various perfusion parameters under simulated vascular resistance of kidneys, livers, and hearts. The device showed potential value in tissue preservation and physiological studies.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Laurie J. Morrison, Claudio Sandroni, Brian Grunau, Michael Parr, Finlay Macneil, Gavin D. Perkins, Mayuki Aibiki, Eileen Censullo, Steve Lin, Robert W. Neumar, Steven C. Brooks
Summary: Improving rates of organ donation among patients with out-of-hospital cardiac arrest is crucial. This scientific statement identifies the opportunities and challenges associated with organ donation in this population and provides strategies to increase donation rates.
Article
Medicine, General & Internal
Dong Eun Lee, Hyun Kim, Kwi Hwa Park, Song Yi Park, Seung Min Park, Yong Hun Jung, Wonjoon Jeong, Kyung Hye Park
Summary: The study found that specialists and individuals willing to donate organs have higher knowledge and attitude scores towards deceased organ and tissue donation. Those who have received education on organ donation also have higher knowledge scores. People with more experience in recommending organ and tissue donation had higher knowledge and attitude scores.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Olivier Aubert, Daniel Yoo, Dina Zielinski, Emanuele Cozzi, Massimo Cardillo, Michael Durr, Beatriz Dominguez-Gil, Elisabeth Coll, Margarida Ivo Da Silva, Ville Sallinen, Karl Lemstrom, Karsten Midtvedt, Camilo Ulloa, Franz Immer, Annemarie Weissenbacher, Natalie Vallant, Nikolina Basic-Jukic, Kazunari Tanabe, Georgios Papatheodoridis, Georgia Menoudakou, Martin Torres, Carlos Soratti, Daniela Hansen Krogh, Carmen Lefaucheur, Gustavo Ferreira, Helio Tedesco Silva, David Hartell, John Forsythe, Lisa Mumford, Peter P. Reese, Francois Kerbaul, Christian Jacquelinet, Serge Vogelaar, Vassilios Papalois, Alexandre Loupy
Summary: The study evaluated the impact of the COVID-19 pandemic on worldwide organ transplantation activities and found an overall decrease in transplant activity in all countries studied. Kidney transplantation was most affected, followed by lung, liver, and heart transplants. There was a marked reduction in transplant activity during the first 3 months of the pandemic, with losses stabilizing after June 2020 but decreasing again from October to December 2020.
LANCET PUBLIC HEALTH
(2021)
Article
Gastroenterology & Hepatology
Nikole A. Neidlinger, Christopher Brown, Patrick Wood, Jeff Traseger, Dan Lebovitz, Roxane Cauwels, Shareef Syed, Justin R. Parekh, Garrett R. Roll
Summary: Declining a liver offer during organ procurement may raise the risk of discard, but the details of late reallocation are still unclear. A study found that only 49% of livers declined during surgery were successfully transplanted, with varying success rates based on the timing of the decline.
LIVER TRANSPLANTATION
(2021)
Article
Surgery
Raymond J. Lynch, Brianna L. Doby, David S. Goldberg, Kevin J. Lee, Arielle Cimeno, Seth J. Karp
Summary: Research indicates that understanding performance across decedents and hospital types can help organ procurement organizations meet new Centers for Medicare and Medicaid Services metrics. Differences in recovery of organ donors exist between different OPOs, but are not apparent in SDRR rankings. Real-time recognition of underperformance across hospitals may provide important data for regulators and OPOs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Tal T. Klein, Michael J. O'Leary, Lukas Staub, Elena Cavazzoni
Summary: A retrospective observational study analyzed organ donation data in Australia from 2000 to 2019 and found that the 2009 National Reform Program did not significantly impact the number and characteristics of organ donors under 16 years of age.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Surgery
B. L. Kasiske, K. L. Lentine, Y. Ahn, M. A. Skeans, T. Eberhard, C. Folken, J. Wainright, L. Larkin, C. Nystedt
Summary: Living donor transplantation is an important source of organs, but there has been little growth in the number of living donor transplants in the past decade. To better understand the barriers and risks associated with living donation, a national registry has been established.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Dermatology
Hanlin Zhang, Keyun Tang, Yuchen Wang, Rouyu Fang, Qiuning Sun
Summary: This study reviewed the use of botulinum toxin in treating Hailey-Hailey disease, showing promising results in most patients with good efficacy and safety. However, there were also cases where botulinum toxin had limited effectiveness, indicating it may not work for all patients with this disease.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Oncology
Hanlin Zhang, Yuanzhuo Wang, Qingyue Zheng, Keyun Tang, Rouyu Fang, Yuchen Wang, Qiuning Sun
Summary: Over the past few years, research on melanoma has mainly focused on immunotherapy, omics, and the microbiome, while public interest in melanoma has mainly focused on related diseases or manifestations, treatment options, risk factors, diagnostic tools, and prognosis. The study found that the topics revealed by Google Trends and bibliometric analysis were mostly consistent, but there were differences in issues related to melanoma molecular biology.
FRONTIERS IN ONCOLOGY
(2021)
Review
Dermatology
Hanlin Zhang, Menglu Zhang, Yuanzhuo Wang, Qingyue Zheng, Keyun Tang, Runzhu Liu, Xianmei Li, Rouyu Fang, Qiuning Sun
Summary: Rosacea is characterized by facial flushing, erythema, telangiectasia, papules, and pustules, and its pathogenesis is not fully understood. The ROSacea COnsensus panel updated the diagnosis, classification, and assessment in 2017, recommending phenotype-based treatments and long-term managements. Murine models, including LL-37 injection model, have been used to study the pathophysiological and clinical features of rosacea, but there is still a need for improved and new models in future research.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Health Policy & Services
Zhun Xiang, Han Liu, Xuecheng Gao, Qianying Jin, Kun Qiao, Xingming Li, Xinran Qi, Hanlin Zhang, Keyun Tang
Summary: The public's understanding of patient safety and attitude towards safety reporting significantly impact their willingness to participate in spontaneous reports. Efforts to educate the public and develop reporting systems are expected to promote patient safety in China.
HEALTH POLICY AND TECHNOLOGY
(2021)
Review
Cell Biology
Keyun Tang, Hanlin Zhang, Yaqi Li, Qiuning Sun, Hongzhong Jin
Summary: This systematic review explored the functional, prognostic, and predictive roles of circRNAs in melanoma, shedding light on the potential clinical value and future directions for studies on melanoma-associated circRNAs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Hanlin Zhang, Keyun Tang, Rouyu Fang, Hongzhong Jin, Qiuning Sun
Summary: This study analyzed dermatology consultations provided to hospitalized patients in a general surgery ward at Peking Union Medical College Hospital. Results showed that consultations were categorized into preoperative, postoperative, and unrelated to general surgery diseases or treatments, with common skin diseases including drug eruption, dermatitis/eczema, infectious skin disorders, and urticaria. Surgical residents had difficulty distinguishing certain skin diseases, highlighting the importance of dermatologist input in managing inpatient skin conditions.
DERMATOLOGY AND THERAPY
(2021)
Review
Dermatology
Hanlin Zhang, Keyun Tang, Yuanzhuo Wang, Rouyu Fang, Qiuning Sun
Summary: Botulinum toxin treatment for rosacea shows some effectiveness and safety in studies, but is limited by small sample sizes, imperfect study designs, and short follow-up periods.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chaoyang Yan, Jing-Jing Lu, Kang Chen, Lei Wang, Haoda Lu, Li Yu, Mengyan Sun, Jun Xu
Summary: The research introduces a new S2aNet model for 3D dense segmentation of 54 organs and musculoskeletal structures in female pelvic MRI images, demonstrating superior performance compared to other state-of-the-art models in terms of sensitivity, Dice similarity coefficient, and relative volume difference.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Dermatology
Hanlin Zhang, Leyan Yang, Yuchen Wang, Dingyue Zhang, Keyun Tang, Rouyu Fang, Qiuning Sun
Summary: Topical calcineurin inhibitors, pimecrolimus and tacrolimus, can have both beneficial and harmful effects on rosacea. While they may be effective in treating rosacea, they also have the potential to induce the condition. Larger randomized controlled studies are needed to further investigate their role in rosacea treatment and induction.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Kang Chen, Yong Yao, Xinxin Mao, Hui You, Linjie Wang, Lian Duan, Kan Deng, Wen Zhang, Xin Lian, Huijuan Zhu
Summary: This case report describes a patient with clinical features resembling IgG4-related hypophysitis that was later diagnosed as sellar germinoma. Poor response to glucocorticoid therapy can be used as a diagnostic criterion to exclude IgG4-related hypophysitis.
BMC ENDOCRINE DISORDERS
(2022)
Article
Infectious Diseases
Jie Ma, Qingyue Zheng, Hanlin Zhang, Yubing Wen, Wenling Ye, Wei Ye, Ke Zheng, Ruitong Gao, Limeng Chen, Taisheng Li, Xuemei Li, Yang Yu, Wei Lyu
Summary: This study retrospectively analyzed renal biopsy results of HIV patients in China and found that classic HIV-associated nephropathy (HIVAN) was uncommon, while HIV immune complex kidney (HIVICK) diseases such as membranous nephropathy or IgA nephropathy were more common and had better prognosis. Antiretroviral therapy, ACE inhibitors, and angiotensin II receptor blockers were effective in reducing proteinuria and preserving renal function.
Article
Public, Environmental & Occupational Health
Huiping Gao, Yongliang Niu, Qiang Wang, Guangliang Shan, Chao Ma, Haiying Wang, Yaoda Hu, Kai Guan, Jianqing Gu, Jing Wang, Tao Wang, Hongmei Zhao, Hui Han, Haiyuan Chen, Wenxia Ruan, Hanlin Zhang, Cong Cong, Lianglu Wang, Yonglin Liu
Summary: The study investigated the prevalence and risk factors of allergic rhinitis and asthma in different regions of Shenmu City in China. The results showed higher prevalence of allergic rhinitis and asthma in the plain lands compared to hilly areas. Genetic and environmental factors were found to be important risk factors for these conditions. The findings provide valuable data for the prevention and control of allergic rhinitis and asthma in the future.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Multidisciplinary
Hanlin Zhang, Kang Chen, Naili Wang, Di Zhang, Qing Zhang, Keyun Tang, Mengyao Wan, Changlin Gong, Xinyu Hong, Wenying Qiu, Lawrence J. Rizzolo, Chao Ma
Summary: This study analyzed the statistical data of the body donation program at Peking Union Medical College and found that neoplasms were the most common cause of death among donors. Age was also identified as a factor that influenced the donors' participation.
OMEGA-JOURNAL OF DEATH AND DYING
(2022)
