Review
Immunology
Alessandra Vultaggio, Margherita Perlato, Francesca Nencini, Emanuele Vivarelli, Enrico Maggi, Andrea Matucci
Summary: Biologicals are commonly used for rheumatologic diseases, cancers, and chronic inflammatory conditions, but they may lead to the development of anti-drug antibodies (ADA), limiting their clinical usage due to safety concerns. Strategies such as concomitant immunosuppressive treatment and regular infusion regimens can help reduce the risk of immediate hypersensitivity reactions (HSRs) associated with ADA. Drug desensitization (DD) may be considered for patients needing reintroduction of the biological culprit, especially in cases of IgE-mediated HSRs, potentially inhibiting mast cell degranulation and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Asger Sverrild, John Carruthers, Kavitha Garuna Murthee, Alice Moore, Robyn Elizabeth O'Hehir, Robert Puy, Mark Hew, Celia Zubrinich
Summary: This study evaluated a published algorithm based on tryptase and clinical presentation to identify appropriate individuals for further testing for IgE-mediated perioperative hypersensitivity (POH). The results showed that the algorithm was highly sensitive but less specific in identifying patients testing positive on skin testing and/or specific IgE. Cardiovascular symptoms had high sensitivity, while the combination of respiratory symptoms and increased tryptase had the highest specificity. Respiratory involvement was more common in neuromuscular blocking agent allergy, while urticaria/angioedema was more common in antibiotic allergy.
Article
Allergy
Melike Ocak, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel
Summary: This study aimed to investigate the outcomes of sesame and tahini oral food challenges and the accuracy of sesame-specific IgE and skin prick tests in predicting sesame allergy in children. The results suggest that tahini OFC emerged as a more optimal diagnostic tool to avoid false negatives, and high sesame and tahini SPT levels individually can help predict the diagnosis of sesame allergy.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Review
Allergy
Annick Barbaud, Julie Castagna, Angele Soria
Summary: Skin tests, including patch tests, prick tests, and intradermal tests, are valuable in identifying the causes of cutaneous adverse drug reactions and finding safer alternative drugs. Patch tests are useful in studying maculopapular exanthema and severe drug reactions, including acute generalized exanthematous pustulosis and drug reaction with eosinophilia and systemic symptoms. Prick tests are used to evaluate immediate-type hypersensitivity, while intradermal tests can be used for both immediate and delayed-type hypersensitivity reactions.
CONTACT DERMATITIS
(2022)
Article
Anesthesiology
Lu Che, Xu Li, Xiuhua Zhang, Yue Lun Zhang, Jie Yi, Xia Ruan, Shuang Ma, Yuguang Huang
Summary: The study investigated perioperative allergic reactions among Chinese anesthesiologists, finding that such reactions are common but patients are rarely referred for further investigation by allergy specialists. There is variation in institutional support and management practices for perioperative allergic reactions. More standardized recommendations based on Chinese patient data are needed.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Review
Immunology
Graham A. Mackay, Nithya A. Fernandopulle, Jie Ding, Jeremy McComish, Paul F. Soeding
Summary: Acute anaphylaxis to small molecule drugs is believed to be predominantly antibody-mediated with IgE and IgG involvement, along with activation of mast cells and neutrophils. The MRGPRX2 receptor has also been identified as a potential trigger for anaphylactic reactions to various drugs, independent of antibody recognition. Understanding the role of MRGPRX2 in anaphylaxis could be crucial for future drug development and exploration as a potential drug target in broader clinical settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Sevim Bavbek, Secil Kepil Ozdemir, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolaci, Carla Lombardo, Maria J. Torres
Summary: This paper provides evidence-based recommendations for the diagnosis and management of hypersensitivity reactions (HSRs) to proton pump inhibitors (PPIs), and calls for further in-depth research.
Review
Biochemistry & Molecular Biology
Jan Romantowski, Aleksandra Gorska, Marek Niedoszytko, Theo Gulen, Marta Gruchala-Niedoszytko, Boguslaw Nedoszytko, Magdalena Lange, Knut Brockow, Michel Arock, Cem Akin, Peter Valent
Summary: MCAS and mastocytosis are two disorders related to mast cell activation, with the former characterized by massive systemic activation of mast cells and the latter by clonal accumulation of mast cells in various organ systems. Mast cells are crucial effector cells in allergic diseases, and proper diagnosis and management are essential for patients with mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jesper Jarkvist, Theo Gulen
Summary: This study investigates the prevalence and clinical features of hypersensitivity reactions to antibiotics in mastocytosis patients. The results suggest a similar prevalence of antibiotic hypersensitivity in these patients compared to the general population, and antibiotics appear to rarely cause anaphylaxis in this population. Therefore, mastocytosis patients without a history of antibiotic hypersensitivity may be safely treated with these drugs.
Article
Medicine, General & Internal
Yeonjoo Choi, Ja Min Byun, Inho Kim, Jin Hyun Park, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Min-Suk Yang, Hyunkyung Park
Summary: The case suggests that omalizumab is a good candidate for the management of severe allergic transfusion reactions, especially in cases of platelet-induced anaphylaxis. Early administration of omalizumab prior to transfusion may help prevent anaphylactic reactions, allowing patients to continue receiving necessary blood transfusions.
Article
Materials Science, Multidisciplinary
Edyta Jura-Szoltys, Lesia Rozlucka, Radoslaw Gawlik, Joanna Gluck
Summary: According to the analysis, the use of paraformaldehyde as a dental material can cause delayed hypersensitivity reactions, which can be life-threatening. Approximately 50% of patients treated with paraformaldehyde had positive specific IgE levels. Compared to the control group, the level of certainty of anaphylactic reaction after paraformaldehyde application was significantly higher in the PF-positive group according to the Brighton criteria.
Review
Allergy
Rosalaura Virginia Villarreal-Gonzalez, Sandra Gonzalez-Diaz, Oscar Vidal-Gutierrez, Alejandra Canel-Paredes, Carlos de la de la Cruz, Mariano Garcia-Campa, Alfonso Lopez-Mendez, Sofia Alvarado-Ruiz, Mariana Castells
Summary: Taxanes in cancer treatment often cause hypersensitivity reactions, limiting their use. Drug desensitization has allowed the reintroduction of taxanes in highly allergic patients. A systematic review was conducted to assess the safety and efficacy of rapid drug desensitization (RDD) for taxanes hypersensitivity reactions (HSR). The study identified 25 studies involving 976 patients with initial HSR to paclitaxel and docetaxel, and found that RDD was a safe and effective procedure with high success rates. Standardized protocols should be implemented for widespread use.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Allergy
Pedro Gamboa, Javier Sanchez de Vicente, Cristina Galan, Ignacio Jauregui, Aritza Segurola, Eduardo Garcia-Lirio, Yolanda Seras, Ma Dolores Martinez-Anton, Angel Arrien de Lecea
Summary: Skin tests had a sensitivity of less than 50% for patients with NIHRs due to iomeprol, while the negative predictive value of skin tests in patients who tolerated challenges with alternative contrasts (mainly iopamidol) was 53%. The cross-reactivity between iomeprol and iopamidol is high.
Article
Medicine, General & Internal
Silvia Pagani, Niccolo Lombardi, Giada Crescioli, Violetta Giuditta Vighi, Giulia Spada, Paola Andreetta, Annalisa Capuano, Alfredo Vannacci, Mauro Venegoni, Giuseppe Danilo Vighi
Summary: The aim of this study is to describe the pharmacological characteristics of drug-related allergies and anaphylaxis leading to emergency department visits. Male sex and age classes younger than 65 years were found to have a higher risk of drug-related allergies, while females and adults had a higher risk of anaphylaxis. Antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Cheng Wang, Yajing Hou, Shuai Ge, Jiayu Lu, Xiangjun Wang, Yuexin Lv, Nan Wang, Huaizhen He
Summary: This study demonstrates for the first time that synthetic imperatorin derivatives are effective in inhibiting MRGPRX2-induced allergic reactions and exhibit anti-allergic properties in a mouse model. These findings provide evidence for the development of drugs for the treatment of allergic diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Letter
Allergy
Aleksandra Wardzynska, Malgorzata Pawelczyk, Joanna Rywaniak, Joanna S. Makowska, Joanna Jamroz-Brzeska, Marek L. Kowalski, Maciej Chalubinski
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra H. Opinc, Joanna S. Makowska
Summary: This article summarizes the latest research on the association between idiopathic inflammatory myopathies and malignancy, the understanding of its pathogenesis. It analyzes the potential risk and protective factors for developing cancer-associated myositis (CAM), and proposes management recommendations and a new cancer screening scheme.
Article
Food Science & Technology
Hanna Steigerwald, Frank Blanco-Perez, Melanie Albrecht, Caroline Bender, Andrea Wangorsch, Hans-Ulrich Endress, Mirko Bunzel, Cristobalina Mayorga, Maria Jose Torres, Stephan Scheurer, Stefan Vieths
Summary: Pectin, a commonly used gelling agent in the food industry, is found to have prebiotic and immunomodulatory effects. This study analyzed the residual nsLTP content in two commercial pectins and found that the potential allergen content is below the threshold for inducing allergic reactions. Therefore, consumption of these pectin products poses no significant risk for nsLTP-allergic patients.
Article
Medicine, Research & Experimental
Monika E. Lysakowska, Malgorzata Szybka, Brzezinska Olga, Sylwia Moskwa, Magdalena Konieczka, Joanna Makowska, Dorota Pastuszak-Lewandoska
Summary: This study compared the immune response in rheumatology clinic patients with musculoskeletal symptoms and healthy blood donors, finding significant differences in mRNA levels of tested cytokines, indicating a potential suppressive influence of Bartonella spp. on the immune system.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Allergy
Didier G. Ebo, Jessy Elst, Nele Moonen, Marie-Line M. van der Poorten, Athina L. Van Gasse, Lene H. Garvey, Chris H. Bridts, Christel Mertens, Margo M. Hagendorens, Vito Sabato
Summary: This study explored cross-reactivity between chlorhexidine (CHX) and structurally similar compounds using a passive mast cell activation test (pMAT). Results showed that some CHX-allergic patients exhibited mast cell degranulation responses to alexidine (ALX) and octenidine (OCT), while polyhexamethylene biguanide (PHMB) directly activated mast cells via occupation of MRGPRX2.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Canas, Natalia Perez-Sanchez, Leticia Lopera-Doblas, Francisca Palomares, Ana Molina, Joan Bartra, Maria J. Torres, Francisca Gomez, Cristobalina Mayorga
Summary: Plant-food allergy, triggered by nonspecific lipid transfer proteins (nsLTPs), is a growing problem. The basophil activation test (BAT), which identifies specific IgE related to the allergic response, can be used as a diagnostic tool for precise diagnosis of LTP-allergic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adriana Ariza, Cristobalina Mayorga, Gador Bogas, Francesco Gaeta, Maria Salas, Rocco L. Valluzzi, Marina Labella, Natalia Perez-Sanchez, Cristiano Caruso, Ana Molina, Tahia D. Fernandez, Maria Jose Torres, Antonino Romano
Summary: This study analyzed the utility of ImmunoCAP (R) for detecting sIgE to penicillin G (PG) and amoxicillin (AX) in patients with confirmed penicillin allergy. The results showed limitations of ImmunoCAP (R) in evaluating individuals with type I hypersensitivity reactions to penicillins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Filip Styrzynski, Damir Zhakparov, Marco Schmid, Damian Roqueiro, Zuzanna Lukasik, Julia Solek, Jakub Nowicki, Milosz Dobrogowski, Joanna Makowska, Milena Sokolowska, Katja Baerenfaller
Summary: This study provides a set of easily obtainable parameters that can be used to rapidly identify SARS-CoV-2 positive patients, assess the risk of death during hospitalization, and predict the disease outcome.
INFECTIOUS DISEASES AND THERAPY
(2023)
Letter
Allergy
Jessy Elst, Marie-Line M. van der Poorten, Alessandro Toscano, Athina L. Van Gasse, Christel Mertens, Michiel Beyens, Margo M. Hagendorens, Didier G. Ebo, Vito Sabato
Letter
Allergy
Didier G. Ebo, Jessy Elst, Christel Mertens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Michel Van Houdt, Margo M. Hagendorens, Vito Sabato
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Budlewski, Joanna Sarnik, Grzegorz Galita, Grzegorz Dragan, Olga Brzezinska, Marta Poplawska, Tomasz Poplawski, Joanna Makowska
Summary: The polymorphisms of PADI4, PTPN22, and STAT4 genes have been detected in the Polish population, which are also known risk factors for rheumatoid arthritis (RA) in various other populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Grzegorz Galita, Joanna Sarnik, Olga Brzezinska, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Ireneusz Majsterek, Tomasz Poplawski, Joanna S. S. Makowska
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic arthritis and joint deformities. The risk of malignant neoplasms among patients with RA is being studied due to the autoimmune nature of RA and the use of immunomodulatory therapy. Impaired DNA repair efficiency in individuals with RA may contribute to this risk. In our study, we evaluated genetic variation in DNA damage repair genes and found associations between RA occurrence and certain polymorphisms. These findings suggest that DNA damage repair gene polymorphisms may play a role in RA pathogenesis and can potentially serve as markers of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Cristobalina Mayorga, Adriana Ariza, Rosa Munoz-Cano, Vito Sabato, Inmaculada Dona, Maria J. Torres
Summary: Immediate drug hypersensitivity reactions (IDHRs) are burdensome and diagnosing the right phenotype and endotype at early stages is crucial due to the diverse mechanisms involved in drug-immune system interactions.
Article
Allergy
D. G. Ebo, H. P. Rihs, C. H. Mertens, A. L. Van Gasse, M. L. van Der Poorten, M. M. Hagendorens, V. Sabato, J. Elst
Review
Rheumatology
Alaa Sherri, Mohamad Mahdi Mortada, Joanna Makowska, Anna Lewandowska-Polak
Summary: This article compares the similarities between central nervous system vasculitis and ANCA-associated vasculitis in terms of pathogenesis, clinical presentation, diagnosis, and treatment, and highlights the importance of brain biopsy in differentiation.
RHEUMATOLOGY INTERNATIONAL
(2023)