Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Leo Chen, Elizabeth H. X. Thomas, Pakin Kaewpijit, Aleksandra Miljevic, Rachel Hughes, Lisa Hahn, Yuko Kato, Shane Gill, Patrick Clarke, Felicity Ng, Tom Paterson, Andrew Giam, Shanthi Sarma, Kate E. Hoy, Cherrie Galletly, Paul B. Fitzgerald
Summary: This study is the largest accelerated bilateral TBS study to date, providing evidence of its effectiveness and safety in treating treatment-resistant depression. The accelerated application of TBS did not lead to faster antidepressant effects, and bilateral TBS did not show superior antidepressant effects compared to unilateral rTMS. There was no significant difference in antidepressant efficacy between sub- and supra-threshold accelerated bilateral TBS.
Article
Behavioral Sciences
Andrew M. Fukuda, Jee Won Diane Kang, Asi Polly Gobin, Eric Tirrell, Fatih Kokdere, Linda L. Carpenter
Summary: The study found that TMS treatment significantly improved anhedonia in depressed patients and that the severity of anhedonia was significantly correlated with other depressive symptoms. However, baseline severity of anhedonia was not a significant predictor of clinical outcome.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Cheng-Ta Li, Chi-Hung Juan, Hui-Ching Lin, Chih-Ming Cheng, Hui-Ting Wu, Bang-Hung Yang, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This study is the first to reveal the underlying molecular mechanisms of the fronto-limbic circuit in individuals with major depressive disorder and demonstrates the differential modulation of neurotransmitter systems by rTMS and iTBS.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Prabhjot Dhami, Sravya Atluri, Jonathan Lee, Yuliya Knyahnytska, Paul E. Croarkin, Daniel M. Blumberger, Zafiris J. Daskalakis, Faranak Farzan
Summary: The study found that cortical reactivity in the left DLPFC was associated with changes in depressive symptoms. TBS treatment was shown to alter cortical reactivity in the right IPL, distal to the treatment sites, and was correlated with baseline fMRI connectivity.
DEPRESSION AND ANXIETY
(2021)
Article
Clinical Neurology
Marta Cano, Erik Lee, Christopher Polanco, Tracy Barbour, Kristen K. Ellard, Blake Andreou, Sofia Uribe, Michael E. Henry, Stephen Seiner, Narcis Cardoner, Carles Soriano-Mas, Joan A. Camprodon
Summary: In this study, the authors compared the brain volumetric changes in patients with treatment-resistant depression (TRD) after receiving electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS). The results showed that patients who received ECT exhibited greater volumetric increase in certain brain regions compared to those who received rTMS. However, the changes in brain volume were not associated with clinical improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Hannah Ford, Lisa Hahn, Patrick Clarke, Shane Gill, Ben Carnell, Cherrie Galletly
Summary: In this study, it was found that 15-minute and 30-minute rTMS treatments showed no significant difference in partial response, response, and remission rates for treatment resistant depression, indicating that shorter treatment sessions were just as effective as longer sessions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Brenton Hordacre, Kristina Comacchio, Lindy Williams, Susan Hillier
Summary: The study demonstrated that active rTMS significantly improved depression in stroke survivors and was well tolerated. The mechanistic role of theta frequency functional connectivity may warrant further investigation.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Sofie Carrette, Paul Boon, Debby Klooster, Annelies Van Dycke, Evelien Carrette, Marijke Miatton, Robrecht Raedt, Jean Delbeke, Alfred Meurs, Kristl Vonck
Summary: This study investigated the efficacy of continuous TBS treatment in patients with neocortical drug-resistant epilepsy. The results showed that the treatment protocol was safe and feasible. Although the small sample size limits the ability to determine therapeutic effects, the results encourage further exploration of continuous TBS as an anti-epileptic treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Peter Stohrmann, Godber Mathis Godbersen, Murray Bruce Reed, Jakob Unterholzner, Manfred Klobl, Pia Baldinger-Melich, Thomas Vanicek, Andreas Hahn, Rupert Lanzenberger, Siegfried Kasper, Georg S. Kranz
Summary: This longitudinal study investigated the effect of bilateral sequential theta-burst stimulation (TBS) on functional connectivity (FC) in treatment-resistant depression (TRD). Results showed that both active and sham stimulation groups exhibited reductions in depression scores, with no significant difference between the two groups. Baseline FC between the left dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate cortex (sgACC) was correlated with changes in depression severity. TBS significantly reduced FC between the left stimulation target and bilateral anterior insula, highlighting the effect on the salience network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Qi Wang, Hongfei Huang, Dongdong Li, Yitong Wang, Na Qi, Yihong Ci, Tianchao Xu
Summary: This study investigated the antidepressant and antisuicidal effects of an intensive rTMS protocol for treatment-resistant depression patients with suicidal ideation. The results showed significant improvement in depression symptoms and a high response rate for suicidal ideation. The protocol also showed promise as a treatment for military veteran populations.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Jeanette Hui, Reza Zomorrodi, Pantelis Lioumis, Elnaz Ensafi, Daphne Voineskos, Aristotle Voineskos, Itay Hadas, Tarek K. Rajji, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: Altered interhemispheric connectivity is found in both schizophrenia and major depressive disorder patients, indicating disruptions of interhemispheric signaling processes. There was increased interhemispheric signal propagation in patient groups compared to healthy controls, but no difference between SCZ and MDD groups. These results enhance our understanding of physiological mechanisms underlying interhemispheric imbalances in SCZ and MDD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Daphne Voineskos, Daniel M. Blumberger, Nigel C. Rogasch, Reza Zomorrodi, Faranak Farzan, George Foussias, Tarek K. Rajji, Zafiris J. Daskalakis
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) can reduce neurophysiological markers of inhibition and excitability in treating treatment resistant depression (TRD), revealing potential important neurophysiological mechanisms of action for rTMS.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Yoshihiro Noda, Kyoshiro Fujii, Yu Mimura, Keita Taniguchi, Shinichiro Nakajima, Ryosuke Kitahata
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors. Neuromodulation therapies such as transcranial magnetic stimulation (TMS) have gained attention as potential treatments for ASD. This case series analyzed 18 ASD cases who had failed to improve depressive symptoms with pharmacotherapy and were treated with intermittent theta burst stimulation (iTBS) to the left dorsolateral prefrontal cortex (DLPFC). The results suggest that iTBS may have beneficial therapeutic effects on depressive symptoms in individuals with ASD, but further validation is needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Bhedita J. Seewoo, Jennifer Rodger, Mark A. Demitrack, Karen L. Heart, John D. Port, Jeffrey R. Strawn, Paul E. Croarkin
Summary: The neurobiology of treatment-resistant depression (TRD) in adolescents and the impact of treatment on this neurobiology is poorly understood. This study found that adolescents with TRD and major depressive disorder (MDD) had reduced amygdala volumes compared to healthy adolescents. However, six weeks of active transcranial magnetic stimulation (TMS) increased amygdala volumes and the volume of the stimulated dorsolateral prefrontal cortex in adolescents with TRD.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Psychiatry
Paul B. Fitzgerald, Saxby Pridmore
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Neil W. W. Bailey, Harry Geddes, Isabella Zannettino, Gregory Humble, Jake Payne, Oliver Baell, Melanie Emonson, Sung Wook Chung, Aron T. Hill, Nigel C. Rogasch, Jakob Hohwy, Paul B. Fitzgerald
Summary: This study aimed to investigate the neural activity related to performance monitoring and error-processing in experienced meditators. The results showed that meditators exhibited stronger neural responses after correct and incorrect responses compared to non-meditators.
Article
Psychiatry
Shane Gill, Salam Hussain, Subramanian Purushothaman, Shanthi Sarma, Alan Weiss, Suneel Chamoli, Matthew Fasnacht, Ashu Gandhi, Paul B. Fitzgerald, Brett Simpson, Colleen K. Loo
Summary: In the last century, the prescribing of electroconvulsive therapy involved considering unilateral versus bilateral treatment options. However, recent research has shown that various parameters of the therapy can significantly impact its effectiveness and cognitive side effects. The dose relative to seizure threshold and stimulus pulse width have been found to be particularly important factors in determining efficacy and side effects. This viewpoint aims to raise awareness among psychiatrists about the importance of considering these parameters when prescribing electroconvulsive therapy.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
N. W. Bailey, M. Biabani, A. T. Hill, A. Miljevic, N. C. Rogasch, B. McQueen, O. W. Murphy, P. B. Fitzgerald
Summary: This study aimed to provide a fully automated EEG cleaning pipeline to address non-neural artifacts and improve measurement of EEG outcomes. RELAX, a software developed in this study, used Multi-channel Wiener filtering and wavelet enhanced independent component analysis to clean the artifacts identified by ICLabel. The results showed that RELAX performed well in cleaning blink and muscle artifacts while preserving neural signal.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
N. W. Bailey, A. T. Hill, M. Biabani, O. W. Murphy, N. C. Rogasch, B. McQueen, A. Miljevic, P. B. Fitzgerald
Summary: This study tested the RELAX preprocessing pipeline for ERP data and found that RELAX, particularly when using Multi-channel Wiener Filtering and wavelet-enhanced independent component analysis with ICLabel, achieved high artifact cleaning performance and produced reliable ERP estimates.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Aleksandra Miljevic, Neil W. Bailey, Oscar W. Murphy, M. Prabhavi N. Perera, Paul B. Fitzgerald
Summary: The brain works as an organised, network-like structure of functionally interconnected regions, and disruptions to interconnectivity in certain networks have been linked to symptoms of depression and impairments in cognition. This systematic review aimed to synthesize evidence on EEG functional connectivity (FC) in depression. Fifty-two studies were identified, and while consistent findings were found in resting-state studies, no clear conclusions could be drawn about the direction of differences in FC due to inconsistencies in study design and methodology. More robust research is needed to understand the true differences in EEG FC in depression, as characterizing how FC differs in depression is essential for understanding its etiology.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
James C. Pang, Kevin M. Aquino, Marianne Oldehinkel, Peter A. Robinson, Ben D. Fulcher, Michael Breakspear, Alex Fornito
Summary: The anatomy of the brain imposes constraints on its function, but how exactly these constraints work is not well understood. The traditional view in neuroscience is that the interaction between different specialized cell populations connected by a complex network of axonal fibers drives neuronal dynamics. However, neural field theory suggests that the geometry of the brain may be a more fundamental constraint than interregional connectivity. In this study, we confirm these predictions by analyzing human MRI data and show that brain activity can be explained by excitations of the brain's geometric modes rather than complex interregional connectivity.
Article
Business
Buddhini Ginigaddara, Srinath Perera, Yingbin Feng, Payam Rahnamayiezekavat, Russell Thomson
Summary: This study presents prediction models for offsite construction (OSC) skills and outlines the model development process. The models aim to predict skills using a comparable measure, manhours/m(2). The study also reveals complex, non-linear relationships between OSC types and skill utilization.
CONSTRUCTION MANAGEMENT AND ECONOMICS
(2023)
Article
Neurosciences
Marie-Claire Davis, Paul B. Fitzgerald, Neil W. Bailey, Caley Sullivan, Julie C. Stout, Aron T. Hill, Kate E. Hoy
Summary: This study investigated the effects of transcranial alternating current stimulation (tACS) targeted to the medial pre-frontal cortex (mPFC) on resting electroencephalographic (EEG) indices in individuals with HD and neurotypical controls. Results showed that alpha-tACS enhanced excitatory tone in participants with HD and increased delta power in neurotypical controls.
Article
Psychology, Clinical
M. Prabhavi N. Perera, Neil W. Bailey, Oscar W. Murphy, Sudaraka Mallawaarachchi, Caley Sullivan, Aron T. Hill, Paul B. Fitzgerald
Summary: Individualized noninvasive brain stimulation technique tACS may improve OCD severity by modulating neural circuitry. A pilot clinical trial involving 25 OCD patients showed that a six-week home-based treatment course of individualized alpha-tACS significantly improved OCD severity.
DEPRESSION AND ANXIETY
(2023)
Review
Rehabilitation
Ellen E. R. Williams, Sabrina Sghirripa, Nigel C. Rogasch, Brenton Hordacre, Stacie Attrill
Summary: This review summarized the existing literature on non-invasive brain stimulation (NIBS) as a treatment for post-stroke aphasia and provided recommendations for future research. Quantitative analysis showed that ipsilesional anodal transcranial direct current stimulation and contralesional 1-Hz repetitive transcranial magnetic stimulation were the most commonly used forms of NIBS. Qualitative analysis revealed four key themes. The results highlighted systemic challenges in the field.
DISABILITY AND REHABILITATION
(2023)
Article
Nutrition & Dietetics
Kaniz Jannat, Kingsley Emwinyore Agho, Sarker Masud Parvez, Mahbubur Rahman, Russell Thomson, Mohammed Badrul Amin, Dafna Merom
Summary: The study aimed to assess the effects of yogurt supplementation and nutrition education on the linear growth of infants at risk of stunting. A three-arm randomized controlled trial was conducted, with one group receiving nutrition education for mothers, another receiving nutrition education and a daily yogurt supplement for the infants, and a control group. The results showed no statistically significant differences in linear growth between the groups, but the yogurt group showed slightly better results in terms of dietary diversity. Further research with larger samples and longer follow-ups is recommended.
Article
Psychiatry
Sidhant Chopra, Ashlea Segal, Stuart Oldham, Alexander Holmes, Kristina Sabaroedin, Edwina R. Orchard, Shona M. Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Jeggan Tiego, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Ben D. Fulcher, Kevin Aquino, Christos Pantelis, Stephen J. Wood, Mark Bellgrove, Patrick D. Mcgorry, Alex Fornito
Summary: This study investigated gray matter changes in different stages of psychotic illness and found that brain network architecture plays a crucial role in constraining these changes. The results suggest that white matter fibers are important conduits for the spread of pathology in psychiatric disorders, and the anterior hippocampus may serve as an epicenter of early brain pathology.
Meeting Abstract
Mathematical & Computational Biology
Marija Markicevic, Oliver Sturman, Johannes Bohacek, Markus Rudin, Valerio Zerbi, Ben Fulcher, Nicole Wenderoth
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)