Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Review
Multidisciplinary Sciences
Won-Seok Choi, Young Sup Woo, Sheng-Min Wang, Hyun Kook Lim, Won-Myong Bahk
Summary: The prevalence of comorbid psychiatric disorders in adults with ADHD varies depending on the diagnostic tools used and the characteristics of the population. Standardization of ADHD diagnostic tools is necessary.
Article
Neurosciences
Jose Ramon Gutierrez-Casares, Cristina Segu-Verges, Juncal Sabate Chueca, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto, Javier Quintero
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric condition that can continue into adulthood and is often accompanied by other psychiatric comorbidities. Lisdexamfetamine (LDX) is a stimulant prodrug approved for treating ADHD and binge eating disorder (BED). Through a computational model, we evaluated the efficacy of a virtual model of LDX (vLDX) as ADHD treatment in improving five common ADHD psychiatric comorbidities in adults and children, and explored the molecular mechanisms underlying the predicted efficacy of LDX.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychiatry
Yi-Chun Liu, Vincent Chin-Hung Chen, Yao-Hsu Yang, Yi-Lung Chen, Michael Gossop
Summary: Male patients with ADHD, especially those comorbid with epilepsy, ODD/CD, or ID, were at high risk of transport accidents. Female patients, when comorbid with ASD or ID, also exhibited a higher risk of accidents. MPH treatment lowered the accident risk with a dose-response relationship.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Article
Psychiatry
Mariah K. Evans, Jeremy L. Grove, Tapan A. Patel, Molly Gromatsky, Patrick S. Calhoun, Jean C. Beckham, Nathan A. Kimbrel
Summary: This study aimed to explore the association between attention-deficit/hyperactivity disorder (ADHD) symptoms and nonsuicidal self-injury (NSSI) in veterans. Contrary to hypotheses, adult ADHD symptoms were not associated with NSSI history or disorder. Instead, disorders characterized by negative affect may have greater utility for predicting NSSI.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
Haoran Tao, Shujin Fan, Tianxin Zhu, Lili You, Dinghao Zheng, Li Yan, Meng Ren
Summary: The study suggests that there is a causal effect of ADHD and MDD on increasing the risk of T2DM, and T2DM also has an impact on ADHD. Factors such as smoking and obesity may play a role in mediating these effects.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson, Helga Zoega
Summary: Using a large nationwide study of Icelandic women, this research aims to provide evidence on the relationship between female attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic comorbidities. The study found that ADHD is overrepresented among women with cardiometabolic conditions and significantly contributes to other psychiatric comorbidities.
Review
Biochemistry & Molecular Biology
Aleksandra Goralczyk-Binkowska, Dagmara Szmajda-Krygier, Elzbieta Kozlowska
Summary: This article highlights the link between the intestinal microbiome and the brain, as well as the host response involving different pathways between the intestinal microbiota and the nervous system. It discusses microbiota alterations and their role in the development of psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Developmental
Maria C. Broletti, Christina Efthymiou, Aja Louise Murray, Emily McDougal, Sinead M. Rhodes
Summary: This study investigates the effects of ADHD and DCD on depression levels and the mediating role of executive function in adults. It finds distinct profiles of executive function across diagnostic groups, with higher depression symptoms in adults with ADHD + DCD. ADHD and DCD symptoms, as well as most executive function domains, predict depression symptoms. Overall executive function difficulties fully mediate the relationships between ADHD/DCD and depression symptoms, with several specific domains showing mediating effects. Targeting executive function may be important for preventing co-occurring depression in individuals with these neurodevelopmental conditions.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Judit Cabana-Dominguez, Barbara Torrico, Andreas Reif, Noelia Fernandez-Castillo, Bru Cormand
Summary: Psychiatric disorders exhibit clinical and genetic overlap, with dopaminergic and serotonergic neurotransmission playing important roles. This study assessed the genetic contribution of these systems to eight psychiatric disorders using GWAS analyses, identifying several associated genes and gene sets.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Eliane S. Sanches, Raquel Boia, Ricardo A. Leitao, Maria H. Madeira, Carlos A. Fontes-Ribeiro, Antonio Francisco Ambrosio, Rosa Fernandes, Ana Paula Silva
Summary: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that affects children, and it is associated with ophthalmologic abnormalities. The effects of methylphenidate (MPH) on retinal physiology in ADHD are still unclear. This study used animal models to investigate the structural, functional, and cellular alterations in the retina of ADHD, as well as the impact of MPH. The findings revealed deficits in retinal structure, function, and neurons in the ADHD animal model, and MPH had a beneficial effect on reducing inflammation and blood-retinal barrier dysfunction. However, MPH had opposite effects in the control animals, impairing retinal function and promoting inflammation.
Article
Environmental Sciences
Liheng Fan, Wenjing Qing, Yinling Wang, Meichen Zhan
Summary: This study aimed to explore the relationship between family socioeconomic status (SES) and attention deficit/hyperactivity disorder (ADHD) symptoms in preschool children, as well as the mediating role of executive function (EF). The results revealed that SES can affect preschoolers' ADHD both directly and through EF, especially through working memory and inhibitory ability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Pediatrics
O. Gizli Coban, A. Onder, A. Surer Adanir
Summary: Research shows that elimination disorders are associated with comorbid psychiatric disorders and emotional and behavioral symptoms. The most common diagnoses are attention-deficit/hyperactivity disorder and oppositional defiant disorder. Patients with enuresis + encopresis have the highest rate of comorbid psychiatric disorders.
ARCHIVES DE PEDIATRIE
(2021)
Article
Psychiatry
Sini Sulkama, Jenni Puurunen, Milla Salonen, Salla Mikkola, Emma Hakanen, Cesar Araujo, Hannes Lohi
Summary: Research indicates that higher levels of hyperactivity/impulsivity and inattention are more common in young, male dogs who spend more time alone at home. Additionally, different breeds of dogs show genetic differences in hyperactivity/impulsivity and inattention. Hyperactivity/impulsivity and inattention in dogs often co-occur with compulsive behavior, aggressiveness, and fearfulness.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Dermatology
C-K Wong, Y-L Chen, R. C. Hsiao, S. C-S Hu, C-F Yen
Summary: This study confirmed the heritability of alopecia areata (AA) and found that the transmission of AA from parents to offspring may occur in opposite directions depending on sex. Further studies with a larger sample size are warranted to examine the sex-specific heritability of AA.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Huey-Ling Chiang, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Shoou-Lian Hwang-Gu, Chi-Yung Shang, Susan Shur-Fen Gau
Summary: This study reveals the associations between intra-individual variability in reaction time and different brain regions in individuals with attention-deficit/hyperactivity disorder (ADHD), including the cingulate cortex, thalamus, and right inferior frontal gyrus. These brain regions are involved in motor function, salience processing, and multimodal information integration.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
Yi-Ling Chien, Wen-Che Tsai, Wen-Hao Chen, Chi-Liang Yang, Susan Shur-Fen Gau, Wei-Tsuen Soong, Elizabeth Laugeson, Yen-Nan Chiu
Summary: This study investigated the effectiveness of the PEERS intervention in Taiwanese young adults with ASD and found that it significantly improved social deficits, autism severity, social interaction anxiety, empathy, and social skills knowledge. The improvements were maintained at 3-month and 6-month follow-ups.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Yu-Ju Lin, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
Summary: This study followed up on ADHD/autistic symptoms and attentional performance in children/adolescents with ASD and TD over a period of 5-7 years. The results showed that ADHD symptoms, especially hyperactivity, and attentional functions significantly improved during follow-up, with greater improvement observed in children compared to adolescents, in both ASD and TD. More omission errors and perseverations were noted in ASD compared to TD throughout the follow-up. Children with ASD showed more improvement in reaction time, while adolescents with ASD showed less improvement in commission errors and detectability compared to TD. The lack of correlation between attentional functions and ADHD symptoms in ASD suggests different neural mechanisms of ADHD symptoms between ASD and ADHD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Correction
Psychology, Developmental
Yu-Ju Lin, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Neurosciences
Ming-Yen Hsieh, Li-Heng Tuan, Ho-Ching Chang, Yu-Chun Wang, Chia-Hsiang Chen, Horng-Tzer Shy, Li-Jen Lee, Susan Shur-Fen Gau
Summary: By studying Dlgap2 KO mice, it was found that hippocampal function is impaired and spatial memory is affected in the absence of DLGAP2. Aberrant expressions of postsynaptic proteins and changes in synaptic density and postsynaptic density were also observed. These structural changes might be linked to impaired hippocampus-related cognitive functions.
Article
Psychology, Developmental
Yi-Ling Chien, Yu-Jen Chen, Wan-Ling Tseng, Yung-Chin Hsu, Chi-Shin Wu, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau
Summary: This study examines the differences in white matter microstructural properties between autistic individuals and their non-autistic siblings. The findings suggest that there are similar microstructural properties in certain neural segments between autistic individuals and their siblings, indicating potential intermediate phenotypes of autism. The study also highlights the compensatory processes in unaffected siblings, which may be related to genetic predisposition for autism.
Article
Psychology, Clinical
Yi-An Hung, Shih-Cheng Liao, Chia-Ming Chang, Shu-Sen Chang, Albert C. Yang, Yi-Ling Chien, Chi-Shin Wu, Susan Shur-Fen Gau
Summary: This study aimed to estimate the population-attributable risk of psychiatric disorders associated with suicide among Taiwanese youth aged 10-24 years. The findings suggest that major depressive disorder, dysthymia, and sleep disorder are strongly associated with youth suicides.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neuroimaging
Hsing-Chang Ni, Yi-Ping Chao, Rung-Yu Tseng, Chen-Te Wu, Luca Cocchi, Tai-Li Chou, Rou-Shayn Chen, Susan Shur-Fen Gau, Chun-Hung Yeh, Hsiang -Yuan Lin
Summary: This study aimed to explore the impact of intermittent theta burst stimulation (iTBS) on white matter microstructure in intellectually able children and adolescents with autism. The results showed that iTBS had no effect on white matter measures after 4 weeks and 8 weeks.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychiatry
Huey-Ling Chiang, Wen-Yih Isaac Tseng, Wan-Ling Tseng, Yu-Hung Tung, Yung-Chin Hsu, Chang-Le Chen, Susan Shur-Fen Gau
Summary: In cross-sectional studies, white matter microstructure alterations are observed in children with ADHD, but not as prominent in adults with ADHD compared to typically-developing controls. Limited longitudinal imaging studies have made the developmental trajectories of white matter microstructures in ADHD unclear. This study used diffusion spectrum imaging to examine the longitudinal changes in white matter tracts in ADHD and found that participants with ADHD showed more rapid development in certain tracts. Furthermore, more rapid development in specific tracts was associated with slower decreases in inattention symptoms and greater improvement in attention performance.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Behavioral Sciences
Hsing-Chang Ni, Yi-Lung Chen, Yi-Ping Chao, Chen-Te Wu, Rao-Shayn Chen, Tai-Li Chou, Susan Shur-Fen Gau, Hsiang-Yuan Lin
Summary: Although previous open-label trials suggest the potential of inhibitory rTMS over the DLPFC in ASD, our double-blind sham-controlled trial did not find superior efficacy of cTBS over the left DLPFC in children, adolescents, and adults with ASD. Time effects of cTBS on symptoms and executive function were significant in both active and sham groups. These findings suggest the need for more rigorous rTMS/TBS studies in ASD.
Article
Psychology, Biological
Shu-Hui Lee, Seng Chia, Tai-Li Chou, Susan Shur-Fen Gau
Summary: Emerging evidence suggests deficits in executive functions in the fronto-striato-parietal network in individuals with ADHD. This study aimed to investigate whether these deficits are also present in women with ADHD by using functional magnetic resonance imaging. The results showed that compared to healthy controls, adults with ADHD exhibited reduced activation in the caudate nucleus and inferior frontal gyrus. Furthermore, women with ADHD showed greater difficulties in resolving interference compared to men with ADHD, as indicated by the increased differences in brain activation.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Neurosciences
Chun-Yi Lee, Joshua Oon Soo Goh, Susan Shur-Fen Gau
Summary: This study examined altered neural processing of stimuli values associated with risk-taking decision behavior in adults with ADHD. The results showed that adults with ADHD had slower response times and tended to accept more stakes with a middle-to-low probability of winning compared to healthy controls. Adults with ADHD also exhibited lower activity in the dorsolateral prefrontal cortex and reduced sensitivity in the ventromedial prefrontal cortex in response to linear changes in probability.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Heng-Ching Liao, Fang-Ju Lin, Chien-Ning Hsu, Susan Shur -Fen Gau, Chi-Chuan Wang
Summary: This study examined the use of methylphenidate and atomoxetine in patients diagnosed with attention deficit hyperactivity disorder (ADHD) in Taiwan between 2004 and 2017. The study investigated the initial treatment for ADHD, the time between diagnosis and prescription, and medication-switching patterns. The majority of patients (98.2%) received methylphenidate, while atomoxetine use increased over time. The study also found that the prevalence of pharmacotherapy for ADHD was relatively low.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Psychology, Developmental
Hsiang-Lin Chan, Yi-Hsuan Hsieh, Chiao-Fan Lin, Hsin-Yi Liang, Su-Shin Lee, Jun-Cheng Weng, Min-Jing Lee, Yi-Lung Chen, Vincent Chin-Hung Chen, Michael Gossop
Summary: Research has found that the risk of burn injury in children with autism spectrum disorder is age-dependent, with higher risk between the ages of 6 and 12.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)