Review
Oncology
Marie Nelson, Jennifer Levine
Summary: Although fertility preservation is not fully integrated into comprehensive cancer care for pediatric and adolescent patients, recent advances and trends have been summarized in this review to guide healthcare professionals. Standardized infertility risk assessment guidelines provide consistency in clinical care and serve as a baseline for future research. Dissemination of information is critical for fertility preservation to become an integral part of comprehensive cancer care.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Oncology
Eleonora Porcu, Linda Cipriani, Maria Dirodi, Pierandrea De Iaco, Anna Myriam Perrone, Pier Luigi Zinzani, Mario Taffurelli, Claudio Zamagni, Patrizia Maria Ciotti, Leonardo Notarangelo, Nilla Calza, Giuseppe Damiano
Summary: This study demonstrates that oocyte cryopreservation is a feasible and efficient option for fertility preservation in cancer patients, based on the comparison with nononcological patients undergoing in vitro fertilization treatments. The results show that cancer patients who undergo oocyte cryopreservation have a high pregnancy rate and birth rate, indicating the effectiveness of this method in preserving fertility.
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Eline van Dulmen-den Broeder, Gwendolyn P. Quinn, Jill P. Ginsberg, Erik A. H. Loeffen, Melissa M. Hudson, Karen C. Burns, Hanneke M. van Santen, Claire Berger, Tamara Diesch, Uta Dirksen, Aleksander Giwercman, Clarisa Gracia, Sarah E. Hunter, Joanne F. Kelvin, James L. Klosky, Joop S. E. Laven, Barbara A. Lockart, Sebastian J. C. M. M. Neggers, Michelle Peate, Bob Phillips, Damon R. Reed, Eva Maria E. Tinner, Julianne Byrne, Margreet Veening, Marleen van de Berg, Chris M. Verhaak, Antoinette Anazodo, Kenny Rodriguez-Wallberg, Marry M. van den Heuvel-Eibrink, Ogechukwu A. Asogwa, Alexandra Brownsdon, W. Hamish Wallace, Daniel M. Green, Roderick Skinner, Riccardo Haupt, Lisa B. Kenney, Jennifer Levine, Marianne D. van de Wetering, Wim J. E. Tissing, Norbert W. Paul, Leontien C. M. Kremer, Julia Inthorn
Summary: Patients with childhood, adolescent, and young adult cancer treated with gonadotoxic therapies are at higher risk for infertility and may desire fertility preservation. A clinical practice guideline offers recommendations for ongoing communication to facilitate effective dialogue between patients and their families.
Article
Genetics & Heredity
Glory E. Mgboji, Christina N. Cordeiro Mitchell, Bronwyn S. Bedrick, Dhananjay Vaidya, Xueting Tao, Yisi Liu, Jacqueline Y. Maher, Mindy S. Christianson
Summary: The study found that among pediatric and adolescent patients at an academic center undergoing fertility preservation consultation, there were no socioeconomic or clinical barriers to FPT use in those who had not yet undergone gonadotoxic therapy. The only factor negatively associated with odds of pursuing FPT was prior chemotherapy exposure.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Obstetrics & Gynecology
Marie-Madeleine Dolmans, Michael von Wolff, Catherine Poirot, Cesar Diaz-Garcia, Luciana Cacciottola, Nicolas Boissel, Jana Liebenthron, Antonio Pellicer, Jacques Donnez, Claus Yding Andersen
Summary: The feasibility of freezing and thawing ovarian tissue is well-documented, but ovarian tissue transplantation is progressing at a slower pace with limited clinical experience. Results from five European centers show a low risk of relapse with ovarian tissue reimplantation and successful recovery of endocrine function in most patients, although in vitro fertilization efficacy needs improvement. Chemotherapy before ovarian tissue cryopreservation does not significantly affect success rates. Further research is needed to optimize the approach for ovarian tissue transplantation.
FERTILITY AND STERILITY
(2021)
Article
Pediatrics
Dehlia Moussaoui, Anna Surbone, Cecile Adam, Tamara Diesch-Furlanetto, Celine Girardin, Julie Benard, Isabelle Vidal, Fanette Bernard, Kanete Busiah, Therese Bouthors, Marie-Pierre Primi, Marc Ansari, Nicolas Vulliemoz, Fabienne Gumy-Pause
Summary: Testicular tissue cryopreservation is a feasible and safe option for fertility preservation in prepubertal and adolescent boys, with a high acceptance rate among families and patients. Although still considered experimental, this procedure has shown promising results and offers hope for future reproductive options.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Renee L. Mulder, Anna Font-Gonzalez, Melissa M. Hudson, Hanneke M. van Santen, Erik A. H. Loeffen, Karen C. Burns, Gwendolyn P. Quinn, Eline van Dulmen-den Broeder, Julianne Byrne, Riccardo Haupt, W. Hamish Wallace, Marry M. van den Heuvel-Eibrink, Antoinette Anazodo, Richard A. Anderson, Anke Barnbrock, Joern D. Beck, Annelies M. E. Bos, Isabelle Demeestere, Christian Denzer, Natascia Di Iorgi, Holly R. Hoefgen, Rejin Kebudi, Cornelis Lambalk, Thorsten Langer, Lillian R. Meacham, Kenny Rodriguez-Wallberg, Catharyn Stern, Eveline Stutz-Grunder, Wendy van Dorp, Margreet Veening, Saskia Veldkamp, Eline van der Meulen, Louis S. Constine, Lisa B. Kenney, Marianne D. van de Wetering, Leontien C. M. Kremer, Jennifer Levine, Wim J. E. Tissing
Summary: This study aims to develop clinical practice guidelines for fertility preservation in female patients diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger. By utilizing the Grading of Recommendations Assessment, Development and Evaluation methodology, transparent recommendations were formed to facilitate the care of high-risk female patients. Collaboration led to a comprehensive review of existing evidence, transparent reporting, and achievement of global interdisciplinary consensus.
Article
Endocrinology & Metabolism
Marcos Eiji Shiroma, Luciana Lamarao Damous, Fernanda Pereira Cotrim, Cristiane Lima Roa, Jose Cipolla-Neto, Russel Joseph Reiter, Edmund Chada Baracat, Jose Maria Soares Jr
Summary: Melatonin pretreatment improves the quality of rat ovarian grafts by promoting the restart of the estrous cycle, increasing the expression of various key proteins in the ovaries, and reducing apoptosis levels. Further studies on reproductive function enhancement are warranted based on these findings.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Francesca Filippi, Cristina Meazza, Edgardo Somigliana, Marta Podda, Chiara Dallagiovanna, Maura Massimino, Francesco Raspagliesi, Monica Terenziani
Summary: This study evaluated the potential benefits of oocyte cryopreservation for female childhood and adolescent tumor survivors, finding that ovarian reserve impairment is common and about 10% of eligible subjects underwent egg freezing, with most successfully achieving pregnancy afterwards.
FERTILITY AND STERILITY
(2021)
Article
Oncology
Ida Wikander, Frida E. Lundberg, Hanna Nilsson, Birgit Borgstrom, Kenny A. Rodriguez-Wallberg
Summary: This study followed a cohort of girls undergoing HSCT and found that fertility preservation treatments are crucial in preventing fertility loss, and can be performed both before and after HSCT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Aisha L. Siebert, Veronica Gomez-Lobo, Emilie K. Johnson, Leena Nahata, Kyle E. Orwig, Louise C. Pyle, Selma F. Witchel, Courtney Finlayson, Monica M. Laronda
Summary: Gonadal tissue cryopreservation (GTC) is offered at around 50% of the institutions surveyed in the US for patients with differences of sex development (DSD), but only a minority are preserving tissue for research purposes. GTC is offered for various DSD conditions. Future research will focus on examining the presence and quality of germ cells to support clinical decision making related to fertility preservation for patients with DSD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Alla Vash-Margita, Katarzyna Szymanska-Vandendriessche, Kathryn Gunther, David F. Rodriguez-Buritica, Emily Christison-Lagay, Saurabh Saluja, Kutluk H. Oktay
Summary: This article describes an approach to fertility preservation through ovarian tissue harvesting and cryopreservation for a toddler with galactosemia. The authors highlight the importance of intervention for early preservation of fertility in patients with progressive primary ovarian insufficiency associated with galactosemia. A multidisciplinary team is involved in the procedure, including reproductive endocrinology and infertility specialists, pediatric gynecologists and surgeons, and genetics experts.
FERTILITY AND STERILITY
(2022)
Review
Veterinary Sciences
Sevastiani Antonouli, Valentina Di Nisio, Christina Messini, Alexandros Daponte, Singh Rajender, George Anifandis
Summary: The broad concept of fertility preservation and restoration has gained significant attention in the modern western world due to its relevance in people's everyday lives. A variety of patients, driven by different health conditions and social reasons, rely on assisted reproductive technologies, particularly cryopreservation of gametes and gonadal tissues, to expand their reproductive lifespan.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ji Young Choi, Tae Jin Kim
Summary: The gender diverse and transgender community is increasingly encountered in clinical settings due to improved awareness and access to medical facilities. Gender-affirming therapy can have an impact on fertility potential, and transgender patients should be counseled on fertility preservation options prior to transitioning. However, there is limited data and clinical information on fertility preservation for transgender individuals. Understanding this clinical agenda and the processes involved is important for providing comprehensive and specific care for transgender individuals who need fertility counseling or treatment options.
Article
Endocrinology & Metabolism
Raffaella Fabbri, Rossella Vicenti, Valentina Magnani, Roberto Paradisi, Mario Lima, Lucia De Meis, Stefania Rossi, Diego Raimondo, Paolo Casadio, Stefano Venturoli, Michela Maffi, Renato Seracchioli
Summary: This study reports the 20-year experience of the Bologna clinical center in ovarian tissue cryopreservation and transplantation. The results show that ovarian tissue cryopreservation is an effective technique for preserving ovarian function in pediatric and adult patients, and it can help restore menstruation and achieve pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Nicole D. Ulrich, Nicholas Raja, Erin Ellman, Molly B. Moravek
Summary: This study reported consultation and treatment outcomes for 21 cancer survivors and 3 mosaic Turner syndrome patients. It found that ovarian stimulation for mosaic TS AYA and survivors is feasible even with diminished ovarian reserve. Further research is needed to establish guidelines for patient selection, treatment timing, and stimulation protocols.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Clementina Cantatore, Jenny S. George, Raffaella Depalo, Giuseppe D'Amato, Molly Moravek, Gary D. Smith
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Obstetrics & Gynecology
Nicholas Saleem Raja, Colin B. Russell, Molly B. Moravek
Summary: This study discusses fertility concerns specific to LGBTQ+ and single-parent-to-be populations and reviews special considerations for evaluating and treating these patients in reproductive medicine. It emphasizes the need for equitable treatment regardless of sexual orientation or partner status and the importance of healthcare providers being comfortable and confident in addressing the needs of these populations.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Erin R. Inman, Daniel C. Miranian, Micaela J. Stevenson, Emily K. Kobernik, Molly B. Moravek, Samantha B. Schon
Summary: Among infertile individuals, the presence of a subchorionic hematoma on early ultrasound does not increase the risk of miscarriage; however, the probability of miscarriage significantly increases when patients experience vaginal bleeding and cramping.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Public, Environmental & Occupational Health
Halley P. Crissman, Caleb Haley, Daphna Stroumsa, Anca Tilea, Molly B. Moravek, Lisa H. Harris, Vanessa K. Dalton
Summary: This study identified significant differences in contraceptive patterns between trans masculine individuals and cisgender women. Trans masculine individuals were less likely to be prescribed oral contraceptive pills and long-acting reversible contraceptives, and had a lower rate of contraception use overall compared to cisgender women.
Article
Oncology
Versha Pleasant, Nicole Ulrich, Mark D. Pearlman, Molly B. Moravek
Summary: Early-onset breast cancer poses challenges to reproductive health, but there are now multiple options for fertility preservation and reproductive services, offering hope to young breast cancer patients.
CURRENT BREAST CANCER REPORTS
(2022)
Article
Obstetrics & Gynecology
Molly B. Moravek, Laurie J. Legocki, Claudia Kraus Piper, Katie Bernard, Barbara D. Reed, Hope K. Haefner
Summary: This study evaluated the impact of a single session of psychosocial counseling on patients with vulvodynia. Results showed that patients who received the counseling intervention reported improved understanding and lessened emotional impact of their symptoms, compared to the control group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Correction
Genetics & Heredity
L. M. Ataman, M. M. Laronda, M. Gowett, K. Trotter, H. Anvari, F. Fei, A. Ingram, M. Minette, C. Suebthawinkul, Z. Taghvaei, M. Torres-Velez, K. Velez, S. K. Adiga, A. Anazodo, L. Appiah, M. T. Bourlon, N. Daniels, M. M. Dolmans, C. Finlayson, R. B. Gilchrist, V. Gomez-Lobo, E. Greenblatt, J. A. Halpern, K. Hutt, E. K. Johnson, K. Kawamura, M. Khrouf, D. Kimelman, S. Kristensen, R. T. Mitchell, M. B. Moravek, L. Nahata, K. E. Orwig, M. E. Pavone, D. Pepin, R. Pesce, G. P. Quinn, M. P. Rosen, E. Rowell, K. Smith, C. Venter, S. Whiteside, S. Xiao, M. Zelinski, K. N. Goldman, T. K. Woodruff, F. E. Duncan
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
L. M. Ataman, M. M. Laronda, M. Gowett, K. Trotter, H. Anvari, F. Fei, A. Ingram, M. Minette, C. Suebthawinkul, Z. Taghvaei, M. Torres-Velez, K. Velez, S. L. Adiga, A. Anazodo, L. Appiah, M. T. Bourlon, N. Daniels, M. M. Dolmans, C. Finlayson, R. B. Gilchrist, V. Gomez-Lobo, E. Greenblatt, J. A. Halpern, K. Hutt, E. K. Johnson, K. Kawamura, M. Khrouf, D. Kimelman, S. Kristensen, R. T. Mitchell, M. B. Moravek, L. Nahata, K. E. Orwig, M. E. Pavone, D. Pepin, R. Pesce, G. P. Quinn, M. P. Rosen, E. Rowell, K. Smith, C. Venter, S. Whiteside, S. Xiao, M. Zelinski, K. N. Goldman, T. K. Woodruff, F. E. Duncan
Summary: Since 2007, the Oncofertility Consortium has held an annual conference to disseminate emerging research findings in fertility preservation and facilitate scientific communication. In 2020, the pandemic forced a shift to a virtual meeting, which attracted over 700 participants and showcased global advances in oncofertility and fertility preservation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
Cynthia Dela Cruz, Hadrian M. Kinnear, Prianka H. Hashim, Abigail Wandoff, Likitha Nimmagadda, Faith L. Chang, Vasantha Padmanabhan, Ariella Shikanov, Molly B. Moravek
Summary: This study successfully developed a mouse model to investigate the reproductive consequences of testosterone therapy in transgender men. The model provides a tool for researchers to study the effects of gender-affirming hormone therapy in peripubertal transmasculine youth.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Molly B. Moravek, Marjorie Dixon, Samantha M. Pena, Juno Obedin-Maliver
Summary: Approximately 50% of transmasculine people use testosterone for gender affirmation, but little is known about its effects on reproductive capacity. The current practice of stopping testosterone prior to ovarian stimulation may have negative effects on mental health. Two case studies are presented to support the continuation of testosterone during stimulation.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
M. Salama, L. Nahata, Y. Jayasinghe, V Gomez-Lobo, M. M. Laronda, M. B. Moravek, L. R. Meacham, M. S. Christianson, M. Lambertini, A. Anazodo, G. P. Quinn, T. K. Woodruff
Summary: Purpose: To compare the oncofertility practices for childhood cancer in limited resource settings versus optimum resource settings based on data collected in the Repro-Can-OPEN Study Part I & II. Methods: Surveyed 39 oncofertility centers from different regions. Results: Showed higher oncofertility scores in optimum resource settings, frequent utilization of certain techniques, and rare utilization of advanced options. Conclusions: Presented a best practice model to optimize care for children with cancer in different resource settings.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Oncology
Nina Jackson Levin, Chiu Yi Tan, Daria Stelmak, Nicholas T. Iannarino, Anao Zhang, Erin Ellman, Lindsey A. Herrel, Emily B. Walling, Molly B. Moravek, Rashmi Chugh, Megan R. Haymart, Brad Zebrack
Summary: Financial concern is a significant issue for adolescent and young adult cancer patients, especially in terms of oncofertility. The lack of financial support for fertility preservation services has a negative impact on these patients' decision making and experiences.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2023)
Article
Reproductive Biology
Hadrian M. Kinnear, Prianka H. Hashim, Cynthia Dela Cruz, Faith L. Chang, Gillian Rubenstein, Likitha Nimmagadda, Venkateswaran Ramamoorthi Elangovan, Andrea Jones, Margaret A. Brunette, D. Ford Hannum, Jun Z. Li, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov
Summary: After pausing testosterone in a transgender mouse model, estrous cyclicity resumes but with ovarian stromal aberrations and upregulated inflammation. The impact of taking and pausing testosterone on the ovaries is not fully understood. This study utilized a mouse model to characterize the ovarian dynamics following testosterone cessation and found stromal changes, immune pathway upregulation, and the presence of multinucleated macrophages in the ovaries.
BIOLOGY OF REPRODUCTION
(2023)
Article
Psychology, Clinical
Caleb Haley, Anca Tilea, Daphna Stroumsa, Molly B. Moravek, Vanessa K. Dalton, Halley P. Crissman
Summary: The conflation of sex assigned at birth and gender has made it difficult to identify transgender and nonbinary people in large datasets. This study developed a method using diagnostic and procedural codes to determine the sex assigned at birth of these patients, with the aim of expanding available datasets for exploring sex-specific conditions in this population.
TRANSGENDER HEALTH
(2023)
