Article
Substance Abuse
Alyssa Shell Tilhou, Eleanor Murray, Jiayi Wang, Benjamin P. Linas, Laura White, Jeffrey H. Samet, Marc Larochelle
Summary: The study revealed a decrease in buprenorphine dosage and days supplied for new treatment episodes from 2010 to 2019, along with a worsening trend in buprenorphine possession. Further investigation is needed to explore the relationship between buprenorphine dosage and retention in the early treatment period.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Substance Abuse
M. Eugenia Socias, Evan Wood, Bernard Le Foll, Ron Lim, Jin Cheol Choi, Wing Yin Mok, Julie Bruneau, Juergen Rehm, T. Cameron Wild, Nikki Bozinoff, Ahmed Hassan, Didier Jutras-Aswad
Summary: This study aimed to evaluate the impact of baseline fentanyl exposure on medication treatment engagement and discontinuation among individuals with prescription-type opioid use disorder. The results showed that both buprenorphine/naloxone and methadone may be appropriate treatment options regardless of fentanyl exposure. Other characteristics of fentanyl-exposed individuals appear to be driving the association with poorer treatment outcomes.
Article
Obstetrics & Gynecology
Kevin Y. Xu, Hendree E. Jones, Davida M. Schiff, Caitlin E. Martin, Jeannie C. Kelly, Ebony B. Carter, Laura J. Bierut, Richard A. Grucza
Summary: This study aimed to examine the relationship between pregnancy and the initiation and discontinuation of medications for opioid use disorder (MOUD) in reproductive-aged individuals with opioid use disorder (OUD) in the United States. The findings showed that pregnancy was associated with increased initiation of buprenorphine and methadone and reduced risk of medication discontinuation.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Max Jordan Nguemeni Tiako, Ari Friedman, Jennifer Culhane, Eugenia South, Zachary F. Meisel
Summary: This study found that although medication administration for OUD among pregnant women has increased in recent years, retention in treatment has decreased. Individuals with a history of at least one prior treatment episode were more likely to receive medication for OUD and remain in treatment.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Substance Abuse
Karli R. Hochstatter, Mishka Terplan, Shannon Gwin Mitchell, Robert P. Schwartz, Kristi Dusek, Kim Wireman, Jan Gryczynski
Summary: Many individuals with OUD prefer using fentanyl, and they exhibit different characteristics compared to those who prefer other opioids. These individuals tend to use less non-prescribed buprenorphine in the 30 days before treatment, are younger, and more likely to have severe mental illness. Understanding preferences for fentanyl can inform treatment and harm reduction interventions.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Medicine, General & Internal
Elizabeth J. Austin, Jessica Chen, Elsa S. Briggs, Lori Ferro, Paul Barry, Ashley Heald, Joseph O. Merrill, Geoffrey M. Curran, Andrew J. Saxon, John C. Fortney, Anna D. Ratzliff, Emily C. Williams
Summary: This study explores the experiences and perspectives of multidisciplinary primary care (PC) teams in initiating or expanding medication for opioid use disorder (MOUD). The results suggest that PC teams face challenges in providing rapid access to care and engaging patients with MOUD, as well as maintaining clinician confidence. Attitudes towards MOUD expansion vary among PC teams. The study highlights the need for flexibility in appointment scheduling, effective patient engagement, and ongoing training to address evolving opioid-related clinical issues.
Article
Toxicology
Megan E. Land, Martha Wetzel, Robert J. Geller, Alaina R. Steck, Jocelyn R. Grunwell
Summary: This study examined trends in opioid poisoning among adults in the United States from 2005 to 2018, revealing an increase in the severity of clinical effects and death rates, driven primarily by suicidal intent and illicit opioid cases. The study underscores the importance of developing strategies to address suicide prevention and combat opioid misuse disorders.
CLINICAL TOXICOLOGY
(2021)
Article
Substance Abuse
Carrie M. Mintz, Ned J. Presnall, Kevin Y. Xu, Sarah M. Hartz, John M. Sahrmann, Laura J. Bierut, Richard A. Grucza
Summary: The presence of co-occurring alcohol dependence in individuals with opioid use disorder may decrease the likelihood of receiving medication treatment and impact the choice of treatment type. Buprenorphine and methadone are associated with higher treatment retention rates, but are not prescribed enough for individuals with opioid and alcohol dependence.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Public, Environmental & Occupational Health
Kelly R. Peck, Nathaniel Moxley-Kelly, Gary J. Badger, Stacey C. Sigmon
Summary: This study found that a history of PTSD is prevalent among individuals seeking treatment for OUD in Vermont and is associated with worse treatment outcomes. Participants with PTSD history were less likely to have received prior OUD treatment but more likely to have a primary care physician and medical insurance compared to those without PTSD history.
PREVENTIVE MEDICINE
(2021)
Article
Psychiatry
Kelly E. Dunn, H. Elizabeth Bird, Cecilia L. Bergeria, Orrin D. Ware, Eric C. Strain, Andrew S. Huhn
Summary: In this study, 106 people with opioid use disorder were given naloxone, and it was found that within 60 minutes, most participants experienced severe withdrawal symptoms such as tearing, yawning, and runny nose. The study also identified that an increase of 10 points on the SOWS scale and 6 points on the COWS scale within this timeframe were clinically significant indicators of worsened withdrawal symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Julie M. Donohue, Marian P. Jarlenski, Joo Yeon Kim, Lu Tang, Katherine Ahrens, Lindsay Allen, Anna Austin, Andrew J. Barnes, Marguerite Burns, Chung-Chou H. Chang, Sarah Clark, Evan Cole, Dushka Crane, Peter Cunningham, David Idala, Stefanie Junker, Paul Lanier, Rachel Mauk, Mary Joan McDuffie, Shamis Mohamoud, Nathan Pauly, Logan Sheets, Jeffery Talbert, Kara Zivin, Adam J. Gordon, Susan Kennedy
Summary: The study found that the prevalence of medication use for the treatment of opioid use disorder among Medicaid enrollees in 11 states in the US increased from 2014 through 2018. Further research is needed to understand the situation in other states.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pediatrics
Micah Piske, Fahmida Homayra, Jeong E. Min, Haoxuan Zhou, Carolyn Marchand, Annabel Mead, Jennifer Ng, Megan Woolner, Bohdan Nosyk
Summary: The incidence of perinatal OUD tripled in British Columbia over a 20-year period. Sustained opioid agonist treatment during pregnancy reduced the risk of adverse birth outcomes.
Article
Public, Environmental & Occupational Health
Michelle R. Lofwall, Laura C. Fanucchi
Summary: The opioid epidemic is worsening, with treatment access issues, especially in rural areas. The development of new LAB injectables holds promise to improve treatment access and retention.
PREVENTIVE MEDICINE
(2021)
Article
Substance Abuse
Lewei A. Lin, Amy S. B. Bohnert, Frederic C. Blow, Adam J. Gordon, Rosalinda V. Ignacio, H. Myra Kim, Mark A. Ilgen
Summary: This study found that the majority of Veterans diagnosed with opioid use disorder in 2017 appeared to have at least one comorbid substance use disorder, and many also had multiple substance use disorders. Despite a higher likelihood of visiting a substance use disorder clinic, having a non-opioid substance use disorder was associated with a lower likelihood of receiving buprenorphine treatment, highlighting the importance of addressing polysubstance use in efforts to expand treatment for opioid use disorder.
Article
Obstetrics & Gynecology
Shree Sundaresh, Gouri B. Sadananda, Jennifer L. Bailit
Summary: The severity of opioid use disorder during pregnancy did not change over time, according to this study. However, there was an increase in women reporting high-dose use and a preference for buprenorphine. Additionally, the rate of full-term deliveries also increased.
JOURNAL OF PERINATOLOGY
(2022)