Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Volume 36, Issue 8, Pages 1999-2005Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/bkcs.10386
Keywords
Lentinan; Folic acid; Doxorubicin; Antitumor; Targeted drug delivery
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Funding
- National Science Foundation of China [31271817]
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In order to develop the application of the natural polysaccharide lentinan (LNT) and decrease the side effects of doxorubicin, we successfully synthesized a novel folate-modified maleilated lentinan-doxorubicin (FA-M.LNT-DOX) polymer and used it for tumor-targeted drug delivery. The release efficiency and cytotoxicity of the prodrugs were evaluated in vitro. Although DOX release from FA-M.LNT-DOX was quite slow in a neutral buffer, it was particularly fast in an acidic solution with a pH of 5.0. Compared with DOX, FA-M.LNT-DOX showed higher cytotoxicity in HeLa cells and significantly lower cytotoxicity in normal cells. These results suggested that FA-M.LNT-DOX could be considered as a potential drug delivery candidate for folate receptor-positive cancer therapy.
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