Article
Cell Biology
Benheng Qian, Kexin Li, Xiaoying Lou, Ye Guo, Yidong Wang, Lianpin Wu, Donghong Zhang
Summary: This study found increased quantity and decreased integrity of cell-free DNA (cfDNA) in the serum of atherosclerosis (AS) patients, which was inversely correlated with the progression of cardiovascular diseases (CVDs). This discovery suggests that cfDNA and cfDI have the potential to serve as molecular biomarkers for detecting and monitoring AS.
Article
Nutrition & Dietetics
Alejandro Martinez-Rodriguez, Laura Miralles-Amoros, Manuel Vicente-Martinez, Nuria Asencio-Mas, Rodrigo Yanez-Sepulveda, Maria Martinez-Olcina
Summary: Research has shown that Ramadan intermittent fasting may have a negative impact on the performance of professional soccer players. However, personalized nutritional planning and appropriate supplementation and rest protocols can improve their body composition and performance.
Article
Oncology
Sofie H. Tolmeijer, Rutger H. T. Koornstra, Jan Willem B. de Groot, Maartje J. Geerlings, Dirk H. van Rens, Marye J. Boers-Sonderen, Jack A. Schalken, Winald R. Gerritsen, Marjolijn J. L. Ligtenberg, Niven Mehra
Summary: For patients with metastatic melanoma, rapid BRAF mutation assessment is crucial, with ctDNA proving to be a reliable alternative to tissue-based testing. Monitoring disease progression and treatment response through ctDNA levels is superior to other blood-based biomarkers, showing promise for diagnostic and monitoring purposes.
Article
Biotechnology & Applied Microbiology
Vadim Fedyuk, Nir Erez, Noa Furth, Olga Beresh, Ekaterina Andreishcheva, Abhijeet Shinde, Daniel Jones, Barak Bar Zakai, Yael Mavor, Tamar Peretz, Ayala Hubert, Jonathan E. Cohen, Azzam Salah, Mark Temper, Albert Grinshpun, Myriam Maoz, Aviad Zick, Guy Ron, Efrat Shema
Summary: This study developed a single-molecule imaging technique that can accurately and sensitively detect colorectal cancer in cell-free nucleosomes. By analyzing the epigenetics, DNA methylation, and cancer-specific protein biomarkers of plasma-isolated nucleosomes, the system allows for high-resolution detection of histone modifications and provides quantitative data on plasma proteins. The analysis showed high accuracy and sensitivity in detecting cancer, even at early stages, and could determine the tissue origin of tumors.
NATURE BIOTECHNOLOGY
(2023)
Review
Veterinary Sciences
Rose Whelan, Sina Toenges, Florian Boehl, Frank Lyko
Summary: Biomarkers for holistic animal welfare monitoring are urgently needed in veterinary medicine. Epigenetic modifications, like DNA methylation, have great potential for biomarker development as they provide valuable information about cellular states and environments. This review discusses animal DNA methylation patterns, the technologies for analyzing them, and key frameworks for developing compound DNA methylation biomarkers, DNA methylation clocks, and environment-specific DNA methylation signatures. Practical examples of applying these biomarkers for health and environmental exposure monitoring are also provided. This article provides an overview of the molecular and biological foundations for developing epigenetic biomarkers in veterinary science and their potential in animal welfare monitoring.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Physiology
Karim Saidi, Hassane Zouhal, Daniel Boullosa, Gregory Dupont, Anthony C. Hackney, Benoit Bideau, Urs Granacher, Abderraouf Ben Abderrahman
Summary: This study analyzed the changes in biochemical markers, wellness status, and physical fitness in elite soccer players during a congested period of match play. The results showed that the players experienced increased stress, fatigue, delayed onset of muscle soreness, and decline in wellness status during this period. However, biochemical changes did not reflect a decline in physical fitness. The findings highlight the importance of monitoring and managing the wellness status of elite soccer players during congested match play.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2022)
Article
Psychology, Multidisciplinary
David Garrido, Daniel R. Antequera, Roberto Lopez Del Campo, Ricardo Resta, Javier M. Buldu
Summary: This study analyzed the closeness between professional soccer players during matches, finding a high heterogeneity in interaction time and exposure among players of different positions. Defender-forward interactions were the most frequent pattern observed.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Stefan Altmann, Leon Forcher, Ludwig Ruf, Adam Beavan, Timo Gross, Philipp Lussi, Alexander Woll, Sascha Hartel
Summary: This study examined the physical match performance of 25 professional soccer players in different positions using data from the 2019/20 German Bundesliga season. It was found that players adapted or maintained their performance differently when playing in various positions, with large individual differences. Coaches and practitioners should take into consideration these differences in training and recovery processes.
Article
Sport Sciences
Akinori Kobayakawa, Hideki Hiraiwa, Shinya Ishizuka, Satoshi Yamashita, Hiroki Oba, Yusuke Kawamura, Takefumi Sakaguchi, Masaru Idota, Takahiro Haga, Takafumi Mizuno, Itaru Kawashima, Kanae Kuriyama, Shiro Imagama
Summary: Spontaneous pneumomediastinum is a rare clinical disorder that often occurs in young people. Diagnosis is typically made through chest X-ray and CT scanning, and symptoms can be resolved within approximately one week in most cases.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Blanca Iglesias, Juan M. Garcia-Ceberino, Javier Garcia-Rubio, Sergio J. Ibanez
Summary: This study aims to analyze the relationship between coaches' player substitution strategies and the results of UEFA Champions League matches. The findings suggest that player substitutions can impact the final result, particularly goals scored within 5-10 minutes of a substitution.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Ying Liu, Xiaoge Li, Xuehao Zhou, Jianxun Wang, Xiang Ao
Summary: This review summarizes the recent findings on the structure, functions, and regulatory mechanisms of FADD, focusing on its role in cancer progression. The dysregulation of FADD has been associated with the pathogenesis of various types of cancer, but the detailed mechanisms are not fully understood. The clinical implications of FADD as a biomarker and therapeutic target for cancer patients are also discussed, providing potential insight for the development of FADD-based therapeutic strategies.
MOLECULAR MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Isaac Jesus da Silva, Danilo Hernani Perico, Thiago Pedro Donadon Homem, Reinaldo Augusto da Costa Bianchi
Summary: This study investigates the use of Deep Reinforcement Learning (DRL) in the humanoid robot soccer environment, showing success in learning tasks related to roles such as goalkeeper and penalty taker. Experiments conducted in a simulator led to transferring learned experience to a real humanoid robot, demonstrating the feasibility of using DRL in complex robotic tasks.
JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS
(2021)
Article
Physiology
Chiara Milanese, Valentina Cavedon, Giuliano Corradini, Aiace Rusciano, Carlo Zancanaro
Summary: Changes in bone mineral density associated with soccer participation were studied in a longitudinal investigation of an elite player over 10 years. Findings suggest that aBMD tends to increase with age, the preferred leg has higher aBMD, seasonal changes are meaningful, and the off-season has no effect on aBMD. Further research is needed to clarify long-term and seasonal patterns of bone characteristics in soccer players.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Xuanmei Luo, Lili Zhang, Jian Cui, Qi An, Hexin Li, Zaifeng Zhang, Gaoyuan Sun, Wei Huang, Yifei Li, Chang Li, Wenzhuo Jia, Lihui Zou, Gang Zhao, Fei Xiao
Summary: This study found that small extrachromosomal circular DNAs (eccDNAs) have the potential to be cancer biomarkers. Compared with non-cancer tissues, cancer tissues showed a significantly higher number and larger size of small eccDNAs, along with different formation mechanisms. Despite differences in characteristics and genomic annotation between cancer tissues and paired plasma, small eccDNAs had similar formation mechanisms and cancer-related functions. These findings suggest that small eccDNAs in both tissues and plasma can be used as ideal biomarkers for cost-effective multi-cancer diagnosis and monitoring.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang
Summary: Lysine crotonylation is a reversible protein posttranslational modification that plays a crucial role in maintaining genome stability and responding to genotoxic stresses. It connects cellular metabolism with gene regulation and is involved in various cellular processes, including transcriptional repression induced by double-strand breaks, DNA repair, and the response to DNA replication stress.
Article
Biology
Katharina Bahr, Perikles Simon, Barbara Leggewie, Haralampos Gouveris, Joern Schattenberg
Summary: Obstructive sleep apnea syndrome (OSA) and non-alcoholic fatty liver disease (NAFLD) are closely related, and the snoring index is a valuable screening tool to identify patients with NAFLD in the OSA population.
Article
Medicine, General & Internal
Nils Haller, Aleksandar Tomaskovic, Thomas Stoeggl, Perikles Simon, Elmo Neuberger
Summary: Circulating, cell-free DNA (cfDNA) is a potential blood-based biomarker in exercise physiology that reflects important aspects of exercise load. Sampling cfDNA from the earlobe is feasible, but repeated sampling at rest may increase cfDNA.
Article
Rehabilitation
Thomas Leonhard Stoeggl, Julia C. Blumkaitis, Tilmann Strepp, Mahdi Sareban, Perikles Simon, Elmo W. Neuberger, Thomas Finkenzeller, Natalia Nunes, Lorenz Aglas, Nils Haller
Summary: This study aims to examine the effects of different types of HIIT shock microcycles on endurance performance variables, and to monitor stress, fatigue, recovery, and sleep using innovative biomarkers, questionnaires, and wearable devices.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2022)
Article
Health Care Sciences & Services
Christopher Seifen, Johannes Pordzik, Katharina Bahr, Lisa Grosse-Brueggemann, Katharina Ludwig, Berit Hackenberg, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Evidence suggests that the apnea-hypopnea index (AHI) increases with aging, especially in males. However, the impact of aging on sleep-related metrics, specifically AHI, has been less studied in different gender-specific subpopulations while considering confounding factors such as obstructive sleep apnea-related comorbidities and body mass index (BMI). A retrospective analysis of 186 first-time polysomnographic recordings and medical files was conducted, forming six groups based on age and gender. The older mixed-gender and female cohorts showed significantly higher AHI, apnea-index, and hypopnea-index values. Within the older male cohort, AHI and apnea-index were also significantly higher. No significant differences in BMI were found. The older male cohort had significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders. Conversely, the female subpopulation showed no significant differences in these comorbidities. In conclusion, sleep PSG-parameters increased in older subpopulations, possibly due to the accumulation of comorbidities in older males but not in females.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Sport Sciences
Nils Haller, Thomas Reichel, Philipp Zimmer, Michael Behringer, Patrick Wahl, Thomas Stoeggl, Karsten Krueger, Perikles Simon
Summary: Blood-based biomarkers, such as cytokines, chaperones, and enzymes, have shown potential for monitoring athlete training load. However, further research is needed to fully understand their effects and improve their convenience and cost-effectiveness. Strategies to enhance knowledge of acute and chronic biomarker responses and develop minimally invasive point-of-care devices are outlined to make biomarkers suitable for regular load monitoring.
Review
Sport Sciences
Nils Haller, Michael Behringer, Thomas Reichel, Patrick Wahl, Perikles Simon, Karsten Krueger, Philipp Zimmer, Thomas Stoeggl
Summary: Blood-based biomarkers can provide objective and individualized measurements for training load, recovery, and health status. However, there are challenges in using and interpreting these biomarkers due to confounding variables, inter-individual differences, and statistical considerations. The lack of universally applicable reference levels further complicates the interpretation and load management using biomarkers.
Article
Cell Biology
Benedict Herhaus, Elmo Neuberger, Ema Juskeviciute, Perikles Simon, Katja Petrowski
Summary: This study investigated the effects of acute stress on the dynamics of circulating cell-free DNA (cfDNA). The results showed that a brief psychological stressor was sufficient to rapidly increase cfDNA levels, with a stronger association observed in individuals with higher basal cfDNA levels. This rapid regulation of cfDNA may be attributed to the transient activation of immune cells caused by neuroendocrine-immune activation. Further research is needed to evaluate the reliability of cfDNA as a marker of neuroendocrine-immune activation.
Article
Medicine, General & Internal
Christopher Seifen, Johannes Pordzik, Tilman Huppertz, Berit Hackenberg, Cornelia Schupp, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Obstructive sleep apnea (OSA) is associated with inflammatory diseases and serum ferritin. However, little is known about the relationship between OSA severity and serum ferritin levels in healthy individuals. This retrospective study analyzed polysomnographic recordings and serum ferritin levels in 90 healthy individuals with suspected OSA. Results showed a positive correlation between serum ferritin levels and apnea-hypopnea index (AHI). Patients with severe OSA had higher serum ferritin levels compared to those without or with mild OSA, while serum C-reactive protein and hemoglobin levels did not differ significantly. Age and body-mass index (BMI) were also higher with increasing OSA severity.
Article
Biology
Katharina Ludwig, Sebastian Malatantis-Ewert, Tilman Huppertz, Katharina Bahr-Hamm, Christopher Seifen, Johannes Pordzik, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: This study investigates the frequency of occurrence of central apneas in REM and NREM sleep in patients suffering from OSA of varying severity. It was found that a significantly increased frequency of central apneas in NREM was only observed in severely affected OSA patients. This study is important for understanding the pathophysiological mechanisms of obstructive sleep apnea.
Review
Pediatrics
Mareike Kuehn, Lena Wypyrsczyk, Sandra Stoessel, Marie A. Neu, Lisa Ploch, Elias Dreismickenbecker, Perikles Simon, Joerg Faber
Summary: This systematic review investigated whether physical activity interventions can reduce cancer-related fatigue in paediatric patients undergoing cancer treatment. The analysis of 20 studies showed that physical activity interventions had significant positive effects on fatigue in some patients, but more high-quality studies are needed to verify these results.
Article
Psychology, Developmental
Alexandra Wuttke, Annika Steinmetz, Kristina Endres, Perikles Simon, Andreas Fellgiebel, Nils Haller
Summary: This study examined the potential of using wearable devices for behavioral activation in elderly inpatients with depression. Seventeen patients with late-life depression wore a GPS watch that either monitored their activity or had a disabled display. The results showed high acceptance and satisfaction. However, the impact of continuous feedback on activity levels in a crossover design needs further assessment due to short-term differential effects and a high number of missing values in the ambulatory assessment.
GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Thomas Leonhard Stoggl, Tilmann Strepp, Julia Blumkaitis, Anna Schmuttermair, Patrick Wahl, Nils Haller
Summary: This study investigated the effects of different endurance exercise modalities on metabolic, physiological, and subjective responses. The results showed that high-intensity interval training (HIIT) is a time-saving and enjoyable exercise option for individuals of all genders and physical fitness levels.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Medicine, General & Internal
Christopher Seifen, Johannes Pordzik, Katharina Ludwig, Katharina Bahr, Cornelia Schupp, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: This study aimed to investigate the association between OSA severity in obese individuals with sleep parameters, CRP, and HbA1c serum levels. The results showed that respiratory sleep-associated parameters were significantly higher in individuals with moderate and severe OSA compared to those with mild OSA. HbA1c serum levels were significantly higher in the moderate/severe OSA group. Therefore, OSA severity may significantly impact glycemic control in obese individuals, and it does not appear to be further associated with systemic inflammation in obese individuals.
MEDICINA-LITHUANIA
(2022)
Meeting Abstract
Sport Sciences
Nils Haller, Thomas Stoeggl, Tilmann Strepp, Julia Blumkaitis, Anna Schmuttermair, Francesca Kilzer, Hans-Peter Wiesinger
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Sport Sciences
Nils Haller, Erik Huebler, Thomas Stoeggl, Perikles Simon
Summary: This study reviewed the scientific evidence and practical approaches of recovery strategies for soccer players. Nutrition and rehydration were identified as strategies with the best evidence, while cold-water immersion, compression garments, foam-rolling/massage, and sleep were rated with moderate evidence to enhance recovery. Other strategies should be applied on an individual basis.
JOURNAL OF HUMAN KINETICS
(2022)
