Article
Plant Sciences
N. S. Mshenskaya, M. A. Grinberg, E. A. Kalyasova, V. A. Vodeneev, N. V. Ilin, N. N. Slyunyaev, E. A. Mareev, Y. V. Sinitsyna
Summary: Magnetic fields with a frequency of 14.3 Hz were found to have a protective effect on wheat plants under drought conditions, delaying harmful changes in transpiration and photosynthesis processes for several days.
Article
Neurosciences
Isabella Orienti, Monica Armida, Gabriella Dobrowolny, Rita Pepponi, Gabriella Sollazzini, Antonella Pezzola, Irene Casola, Antonio Musaro, Patrizia Popoli, Rosa Luisa Potenza
Summary: Fenretinide (FEN) shows potential in preventing and overcoming the toxicity of mutant SOD1 (mSOD1) in amyotrophic lateral sclerosis (ALS). Administration of a new nanomicellar fenretinide formulation (NanoMFen) can ameliorate disease progression in ALS, with its efficacy influenced by gender and showing better effects in female subjects.
Article
Biochemical Research Methods
Behnaz Rashidieh, Alireza Madjid Ansari, Mahdi Behdani, Behrad Darvishi, Mahdi Habibi-Anbouhi
Summary: The expression of proteins in bacterial host cells, particularly E.coli, has been a subject of interest. However, low expression outcome has limited its large-scale application in industry. This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on protein expression in E.coli, and found that specific ELF-MF conditions can enhance protein expression.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Physics, Applied
Xin Li, Qi Wang, Wei Gao, Ziyang Shi, Hao Guo, Zhengjie Luo, Zhonghao Li, Huanfei Wen, Zongmin Ma, Jun Tang, Jun Liu
Summary: This paper proposes a set of schemes to generate, detect, and identify multi-frequency magnetic fields in the extremely low-frequency range based on quantum sensors. The schemes utilize nitrogen-vacancy centers in diamond as magnetic sensitivity elements and employ closed-loop proportional-integral-differential locking and microwave modulation-demodulation techniques to obtain magnetic field information. By training and identifying with the DenseNet network structure, the recognition rate achieves a high level.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Marina Grinberg, Maxim Mudrilov, Elizaveta Kozlova, Vladimir Sukhov, Fedor Sarafanov, Andrey Evtushenko, Nikolay Ilin, Vladimir Vodeneev, Colin Price, Evgeny Mareev
Summary: Magnetic field oscillations may affect the growth and responses of plants to environmental factors. In this study, it was found that a low-frequency magnetic field can modulate the light-induced electric reactions of wheat. Fluorescent and inhibitory analysis revealed the involvement of calcium ions and plasma membrane H+-ATPase in the development of the reaction, with the magnetic field activating H+-ATPase through increased calcium influx.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Pharmacology & Pharmacy
Ivan A. Burmistrov, Maxim M. Veselov, Alexander V. Mikheev, Tatiana N. Borodina, Tatiana V. Bukreeva, Michael A. Chuev, Sergey S. Starchikov, Igor S. Lyubutin, Vladimir V. Artemov, Dmitry N. Khmelenin, Natalia L. Klyachko, Daria B. Trushina
Summary: Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development. In this study, the researchers developed microcapsules modified with magnetic iron oxide nanoparticles to trigger the release of fluorescently labeled dextran under a low frequency magnetic field. The findings provide new insights for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.
Article
Spectroscopy
Sherif S. Mahmoud, Amal A. Ibrahim, Eman M. Aly, Mervat A. Ali
Summary: The study shows that magnetic field treatment has positive effects on blood and erythrocytes of fibromyalgia patients, including enhanced energetic pathways, increased hemoglobin-oxygen affinity, improved erythrocyte elasticity and rehydration. In addition, magnetic field treatment is associated with changes in the erythrocyte protein structure, specifically the alpha-helix component.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Engineering, Electrical & Electronic
Feichi Lin, Huan Zheng, Bing Xiang, Rui Xu, Wei Jiang, Liang Lang
Summary: Extremely low frequency magnetic antennas are commonly used in geophysical exploration and other applications, but vibration can lead to additional electromagnetic noise. Experimental results show that vibration-induced noise is a major source of antenna electromagnetic noise, but it can be reduced to the level of ambient electromagnetic noise with proper vibration isolation technology.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2021)
Article
Geosciences, Multidisciplinary
Z. Nemecek, J. Safrankova, K. Grygorov, A. Mokry, G. Pi, M. Aghabozorgi Nafchi, F. Nemec, N. Xirogiannopoulou, J. Simunek
Summary: The position of the magnetopause is mainly influenced by the solar wind dynamic pressure and the north-south interplanetary magnetic field component. By comparing observations and model predictions, researchers found that the magnetopause position is well predicted for cases up to a certain distance, but larger discrepancies are found under certain conditions. These discrepancies are linked to transient magnetopause displacements caused by strong sunward flows in the magnetosheath.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Food Science & Technology
Swati Mahato, Zhiwei Zhu, Da-Wen Sun
Summary: This study examined the potential significance of extremely low-frequency electromagnetic fields (ELF-EMF) at frequencies ranging from 40 to 70 Hz in inducing biological effects during chilled storage of grass carp. The results showed that treatment with 50 and 60 Hz frequencies significantly increased Ca2+ATPase activity and pH, while reducing the total sulfhydryl content. The treatment at 50 Hz had the most pronounced effects, indicating a potential "window" effect in enhancing the quality of myofibrillar protein during chilled storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Anatomy & Morphology
Nicola delli Muti, Gianmaria Salvio, Alessandro Ciarloni, Michele Perrone, Giovanni Tossetta, Raffaella Lazzarini, Massimo Bracci, Giancarlo Balercia
Summary: This study examined the effects of extremely low frequency magnetic fields (ELF-MF) on sperm parameters. The findings showed that exposure to ELF-MF at a frequency of 50 Hz (1 mT) for two hours led to significant changes in progressive motility, morphology, and the production of reactive oxygen species in human spermatozoa, suggesting that ELF-MF plays a role in altering reproductive function.
Article
Reproductive Biology
Anita Franczak, Ewa Monika Drzewiecka, Wiktoria Kozlowska, Agata Zmijewska, Pawel Jozef Wydorski
Summary: Previous research has shown that the ELF-EMF can induce molecular alterations in the porcine myometrium. In this study, it was found that exposure to ELF-EMF increased DNMT1 expression, decreased DNMT3a expression, and increased genomic DNA methylation level in porcine myometrium. Moreover, the amplification level of methylated and unmethylated variants of the promoter region of selected genes was also affected by ELF-EMF radiation.
Article
Chemistry, Multidisciplinary
Zuzana Judakova, Roman Radil, Ladislav Janousek, Ivana Pobocikova
Summary: The presented work aims to experimentally verify the ion parametric resonance theory in relation to the biological reaction to an externally applied, extremely low-frequency magnetic field. The study focuses on the effect of calcium ions and the B-AC/B-DC ratio on biological responses. The results show that the frequency of 29.89 Hz and a B-AC/B-DC ratio of 1.8 exhibit bioactivity, and the sensitivity analysis identifies additional bioactive frequencies of 24.89 Hz and 34.89 Hz. This research contributes to a better understanding of the mechanisms by which low-frequency magnetic fields affect biological systems.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Electrical & Electronic
Xuan Sun, Jingen Wu, Xianfeng Liang, Yongjun Du, Yiwei Xu, Yuhan Qu, Mengmeng Guan, Hui Huang, Fuchao Li, Sujie Liu, Dengfeng Ju, Zhiguang Wang, Zhongqiang Hu, Jinghong Guo, Ming Liu
Summary: Magnetoelectric (ME) sensors based on piezoelectric/ferromagnetic composites have been extensively investigated for their resonance-enhanced ME coupling effect and high sensitivity for magnetic field. However, their sensitivity drops rapidly away from resonance, making them unsuitable for low-frequency applications. In this work, we study the optimized amplitude and frequency of the modulation field, which significantly improve the sensitivity at low frequency without increasing the noise level. A magnetic field of 200 pT is detected at 10 Hz with a near-flat frequency response in the range of 1-100 Hz, showing promising potential for low-frequency applications in smart grid and renewable energy.
IEEE SENSORS JOURNAL
(2023)
Article
Optics
Chen-Xi Zhu, Xingxiang Zhou, Guang-Can Guo, Zheng-Wei Zhou
Summary: In this study, a full sawtooth lattice model with simulated magnetic and electric fields is constructed using orbital angular momentum (OAM) modes in a degenerate optical cavity. The critical parameters can be adjusted by taking advantage of optical interference implemented with simple optical circuit designs, allowing a wide range of simulations. The results significantly extend photonic OAM quantum simulation by enabling a sophisticated model involving both electric and magnetic fields.
Article
Urology & Nephrology
Luigi Montano, Elisabetta Ceretti, Francesco Donato, Paolo Bergamo, Claudia Zani, Gaia Claudia Viviana Viola, Tiziana Notari, Sebastiana Pappalardo, Danilo Zani, Stefania Ubaldi, Valentina Bollati, Claudia Consales, Giorgio Leter, Marco Trifuoggi, Angela Amoresano, Stefano Lorenzetti
Summary: The study indicated that an intervention based on Mediterranean diet and regular physical activity can improve semen quality in healthy young men. The intervention group showed higher adherence to the diet and physical activity, as well as improvements in sperm concentration, motility, and morphology at t4, compared to the control group.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Biochemistry & Molecular Biology
Simonetta Pazzaglia, Barbara Tanno, Ilaria De Stefano, Paola Giardullo, Simona Leonardi, Caterina Merla, Gabriele Babini, Seda Tuncay Cagatay, Ammar Mayah, Munira Kadhim, Fiona M. Lyng, Christine von Toerne, Zohaib N. Khan, Prabal Subedi, Soile Tapio, Anna Saran, Mariateresa Mancuso
Summary: Cell communication via exosomes could influence cell fate under stress situations like ionizing radiation. Studies suggest that exosomes may play a role in radiation effects and resistance to radiotherapy by carrying signaling mediators of radiation damage. There is a lack of comprehensive understanding of exosomes and their regulation under radiation in intact mammalian organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Claudia Consales, Caterina Merla, Barbara Benassi, Tomas Garcia-Sanchez, Adeline Muscat, Franck M. Andre, Carmela Marino, Lluis M. Mir
Summary: This study found that extremely low levels of electric stimulation can cause transcriptional changes, demonstrating the safety of the electroporating pulses used in biomedical applications.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Alessio Butera, Micaela Roy, Carlotta Zampieri, Eleonora Mammarella, Emanuele Panatta, Gerry Melino, Angelo D'Alessandro, Ivano Amelio
Summary: The lipid metabolism plays a crucial role in cancer pathogenesis, and the tumor suppressor protein p53 is involved in cell metabolism. By analyzing pancreatic ductal adenocarcinoma cells, researchers discovered that p53 depletion significantly affects the lipidome, particularly the class of lysophospholipids. Lysophospholipids can function as signaling molecules and instruct the cancer microenvironment and immunity.
Article
Biochemistry & Molecular Biology
Arianna Casciati, Mirella Tanori, Isabella Gianlorenzi, Elena Rampazzo, Luca Persano, Giampietro Viola, Alice Cani, Silvia Bresolin, Carmela Marino, Mariateresa Mancuso, Caterina Merla
Summary: Glioblastoma multiforme (GBM) is the most common brain cancer in adults, and current therapies have limited effectiveness. Research has shown that high intensity ultra-short pulsed electric fields (PEFs) can affect the growth and differentiation of GBM cells and neurospheres, potentially providing a promising treatment option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Barbara Tanno, Flavia Novelli, Simona Leonardi, Caterina Merla, Gabriele Babini, Paola Giardullo, Munira Kadhim, Damien Traynor, Dinesh K. R. Medipally, Aidan D. Meade, Fiona M. Lyng, Soile Tapio, Luca Marchetti, Anna Saran, Simonetta Pazzaglia, Mariateresa Mancuso
Summary: Radiation exposure can lead to heart disease in mice, even when only a portion of the body is irradiated. The study suggests that miRNAs released from irradiated cells may play a role in damaging unirradiated cardiac cells. Understanding the effects of radiation exposure on non-cancer diseases is crucial for developing preventive measures.
Article
Cell Biology
Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Summary: Gene-environment interactions can lead to perturbations in the epigenome that contribute to cancer development. In this study, we found that the tumor suppressor p53 plays a role in maintaining genomic integrity by regulating the levels of the universal methyl donor S-adenosylmethionine (SAM). Loss of p53 results in disruptions in DNA methylation, leading to chromosomal abnormalities and replication stress associated with R-loops. Insufficient levels of SAM contribute to the inability of p53-deficient cells to cope with these disruptions.
Article
Biology
Emanuele Panatta, Alessio Butera, Ivana Celardo, Marcel Leist, Gerry Melino, Ivano Amelio
Summary: Nuclear organization and architecture are crucial for genomic integrity, epigenetic regulation, and gene expression. This study reveals that loss of p53 is associated with increased expression of nuclear pore complex and nuclear lamina members, and directly regulates the transcription of Lamin B1.
Review
Oncology
Sabrina Caporali, Alessio Butera, Ivano Amelio
Summary: Mutations in the BAP1 gene are associated with hereditary cancer predisposition syndrome and sporadic tumors. BAP1 functions in a tissue-specific manner and plays a role in the regulation of histone ubiquitination and protein degradation. Understanding the role of BAP1 in cancer prevention and maintaining genomic integrity is of great importance.
Article
Cell Biology
Alessio Butera, Ivano Amelio
Summary: The development of genomic technologies has allowed for the identification of genetic variants responsible for diseases, and occasionally protective rare variants are discovered. Verweij et al recently reported on protective genetic variants in the CIDEB gene that protect against liver injury. This summary briefly outlines the recent findings on the impact of CIDEB variants on liver disease and highlights how identifying protective mutations can guide the development of prevention and therapeutic strategies for common diseases.
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Editorial Material
Medicine, Research & Experimental
Alessio Butera, Lena Smirnova, Elisa Ferrando-May, Thomas Hartung, Thomas Brunner, Marcel Leist, Ivano Amelio
Summary: Human health is influenced by both genetics and environment. Different responses can be observed in groups of individuals exposed to the same environmental factors. The concept of gene-environment interactions is still not well defined, but examples of these interactions driving disease development are provided in this article. The cellular epigenome is suggested to hold the key to unravel these complex layers of regulation. Developing a method to decode epigenetic information could provide quantitative measures of disease risk, similar to the concept of an epigenetic clock for estimating biological age.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesca Camera, Eleonora Colantoni, Tomas Garcia-Sanchez, Barbara Benassi, Claudia Consales, Adeline Muscat, Leslie Vallet, Luis M. Mir, Franck Andre, Caterina Merla
Summary: In recent years, the application of nanosecond pulsed electric fields has been investigated for novel medical purposes. This study focused on examining molecular calcium fluxes induced by different fractionated protocols of short electric pulses. The researchers found that fractionated doses of nanosecond pulsed electric fields did not increase cell electrosensitization, but targeted activation of calcium-dependent genes was observed based on the duration of calcium flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
B. Tanno, G. Babini, S. Leonardi, I De Stefano, C. Merla, F. Novelli, F. Antonelli, A. Casciati, M. Tanori, E. Pasquali, P. Giardullo, S. Pazzaglia, M. Mancuso
Summary: One harmful effect of ionizing radiation is the development of cataracts, and microRNAs play a significant role in this process. This study investigates the microRNA signature of mouse lenses shortly after irradiation and reveals the influence of genetic background on the deregulated microRNAs. Furthermore, it identifies the interplay between p53 and TLR signaling pathways in radiation-induced cataractogenesis.
RADIATION RESEARCH
(2022)
