Review
Psychiatry
Hong Qian, Chang Shu, Ling Xiao, Gaohua Wang
Summary: This article explores the impact of the histaminergic system on depression, highlighting the involvement of histamine and its receptors in the occurrence and immune regulation of depression. The findings suggest that histamine receptors can be potential targets for the development of new antidepressant drugs.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Clinical Neurology
Manish Kumar Jha
Summary: There is a significant unmet need for effective treatment of major depressive disorder, often resorting to augmentation approaches. Seltorexant shows promise as a potential new treatment option for individuals with depression and insomnia symptoms.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Genetics & Heredity
Muhammad Kamran, Farhana Bibi, Asim Ur Rehman, Derek W. Morris
Summary: Major depressive disorder (MDD) is a common mental disorder characterized by symptoms associated with mood, pleasure and daily life activities. The pathogenesis of MDD is complex and not fully understood. Utilizing genetic data to understand the molecular mechanism of MDD, large genome-wide association studies have identified hundreds of loci, providing important information on the risk genes for MDD.
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Adam Savitz, Ewa Wajs, Yun Zhang, Haiyan Xu, Mila Etropolski, Michael E. Thase, Wayne C. Drevets
Summary: The study showed that seltorexant 20 mg as an adjunct once daily can significantly improve depressive symptoms in patients with MDD. In patients with sleep disturbances, seltorexant 20 mg showed a more significant effect compared to placebo, warranting further investigation. No new safety signals were identified in this study.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang
Summary: This study reveals that antidepressants can improve abnormal blood metabolism and have a weak inhibitory effect on the gut microbiota. The gut microbiota is associated with changes in plasma metabolites and clinical remission in patients with major depressive disorder (MDD). Furthermore, the presence of sporulation genes can predict the efficacy of antidepressant treatment.
Review
Cell Biology
Miguel Perez de la Mora, Dasiel O. Borroto-Escuela, Minerva Crespo-Ramirez, Jose del Carmen Rejon-Orantes, Daniel Alejandro Palacios-Lagunas, Magda K. Martinez-Mata, Daniela Sanchez-Luna, Emiliano Tesoro-Cruz, Kjell Fuxe
Summary: Major depressive disorder (MDD) and anxiety are highly prevalent mental diseases with negative impacts on society and patients. Finding effective treatments with limited side effects is an important goal. This review focuses on the role of G-protein coupled receptors (GPCRs), such as serotonin, dopamine, galanin, and opioid heteroreceptor complexes, in regulating synaptic transmission in the limbic networks of the brain, and how understanding these mechanisms can contribute to the development of new treatments for MDD and anxiety disorders.
Article
Biotechnology & Applied Microbiology
Jing Zhang, Shujun Xie, Rong Xiao, Dongrong Yang, Zhi Zhan, Yan Li
Summary: This study aimed to identify potential mitophagy-related biomarkers for Major Depressive Disorder (MDD) and characterize the underlying molecular mechanisms. Through analysis of gene expression profiles, 315 differentially expressed genes related to mitophagy in MDD were identified. Functional enrichment analysis showed that these genes were mainly involved in mitophagy-related biological processes and multiple neurodegenerative disease pathways. Additionally, two distinct molecular subtypes associated with mitophagy gene signatures were identified in MDD.
Article
Chemistry, Multidisciplinary
Shu Liu, Abdel Abdellaoui, Karin J. H. Verweij, Guido A. van Wingen
Summary: This study investigates the impact of gene expression on brain structural and functional abnormalities in MDD. By comparing gray matter volume and resting-state functional measures in a Chinese sample, the study finds that whole gene expression is positively associated with structural abnormalities while negatively associated with functional abnormalities. Furthermore, the study identifies individual genes with opposite relationships between expression levels and brain abnormalities in MDD patients. The MDD-related genes are enriched in brain tissue, cortical cells, and biological pathways.
Article
Immunology
Ting- Chiang, Yi-Yung Hung, Ming-Kung Wu, Ya-Ling Huang, Hong-Yo Kang
Summary: This study identified the abnormal expression of the GRβ/TNIP2/TNF-α axis in patients with MDD, which may lead to inflammation in depression. Inhibiting TNIP2 could potentially reduce the promoting effect of GRβ on TNF-α levels.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Rizwan Qazi, Muhammad Irfan, Zoobia Ramzan, Muhammad Jahanzaib, Maleeha Zaman Khan, Mahrukh Nasir, Muhammad Shakeel, Ishtiaq Ahmad Khan
Summary: This study identified both common and rare variants associated with the pathogenesis of MDD in Pakistani patients through whole exome sequencing. The genetic variations in BCR, RELN, and stress-associated PABPC1 suggest potential roles in the development of MDD.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Clinical Neurology
Song Yue, Linlin Luo, Yutao Feng, Debiao Liu, Fengting Wang, Rongbo Che, Jin Zhu, Ximing Duan, Yunfeng Tang, JianLi Wang, Yan Liu
Summary: This study provides evidence that the combined effect of rs768705 (TMEM161B) and rs35936514 (LHPP) may modulate the risk of MDD. The study also finds that the 2-year incidence of MDD in Chinese college students is 3.75%.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Genetics & Heredity
Bao Zhao, Qingyue Fan, Jintong Liu, Aihua Yin, Pingping Wang, Wenxin Zhang
Summary: This study used weighted gene co-expression network analysis to identify the relationship between co-expression modules and major depressive disorder in adolescents. The results showed that inflammation, stress, and immune responses were significantly associated with MDD. Key genes related to these processes were identified. These findings contribute to a better understanding of the molecular mechanism behind adolescent depression and provide potential biomarkers for diagnosis and treatment.
Article
Medicine, General & Internal
Yerik Junusbekov, Burcu Bayoglu, Mujgan Cengiz, Ahmet Dirican, Caner Arslan
IRISH JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Medicine, General & Internal
Ozge Pasin, Ahmet Dirican, Handan Ankarali, Rian Disci, Hasan Karanlik
SAUDI MEDICAL JOURNAL
(2020)
Article
Gastroenterology & Hepatology
Yusuf Erzin, Gurhan Sisman, Ibrahim Hatemi, Bilgi Baca, Ismail Hamzaoglu, Ahmet Dirican, Ugur Korman, Aykut F. Celik
TURKISH JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Endocrinology & Metabolism
Derya Metin Armagan, Ayse Seda Akdemir, Hande Mefkure Ozkaya, Ozge Polat Korkmaz, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover, Fatma-Kaya Dagistanli, Ahmet Dirican, Melek Ozturk
Summary: In this study, we investigated the genotype distributions of SNPs in miR-107 and miR-23b genes related to acromegaly, finding a significant association of the T-allele with certain clinical features in patients. Additionally, patients who responded to SSA treatment showed higher Ki-67 index. No polymorphisms were observed in the miR-23b and miR-107 genes in the Turkish population.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Irmak Sah, Emel Hulya Yukseloglu, Nese Kocabasoglu, Burcu Bayoglu, Emre Cirakoglu, Mujgan Cengiz
Summary: The study investigated the relationship between 5-HTTLPR gene variants and ASPD among criminals in the Turkish population, as well as differences in SLC6A4 gene expression levels. Results showed a significant association between SLC6A4 expression levels and ASPD in Turkish society, although the distributions of 5-HTTLPR polymorphisms were not different. This study provides valuable insights for future research in this field.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Psychiatry
G. Karacetin, B. Bayoglu, T. Eseroglu Soylemez, M. Topal, E. Bulanik Koc, M. Tekden, C. Ermis, T. Demir, M. Elagoz Yuksel, E. S. Ercan, M. Erkiran, S. B. Aksoyer Sezgin, M. Cengiz
Summary: This study investigated the clinical characteristics of adolescents with early-onset full psychotic disorders and their association with BDNF Val66Met and DRD2/ANKK1 Taq1A gene polymorphisms. The results showed no significant differences between patients and healthy controls in terms of these gene polymorphisms. However, patients with the A1A2 allele reported higher rates of substance use, and those with the Val66Met heterozygote allele had lower levels of negative symptoms.
EUROPEAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
M. Cengiz, G. Karacetin, M. Topal, M. E. Yuksel, T. Eseroglu, G. B. Akdeniz, T. Demir, M. Erkiran, A. Dirican, B. Bayoglu
Summary: This study aimed to explore the relationship between DRD2 and COMT gene variants and the clinical development of early-onset bipolar disorder (EOBD). The results showed that TT carriers of the DRD2 rs6275 genotype had significantly increased YMRS scores, while there was no significant difference between the COMT Val158Met genotypes and YMRS scores. Therefore, the DRD2 rs6275 TT variant may be associated with symptom severity in EOBD.
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Eymen Recep, Burcu Bayoglu, Caner Arslan, Deniz Goksedef, Gokhan Ipek
Summary: This study investigates the role of OLR1 and IL17A variants in the etiology and prognosis of CAD. The results suggest that the OLR1 rs11053646 CG+GG genotype is associated with a higher frequency of multi-vessel stenosis and significant risk factors for CAD development.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Biochemistry & Molecular Biology
Saadet Busra Aksoyer Sezgin, Burcu Bayoglu, Feyzullah Ersoz, Murat Sarici, Mutlu Niyazoglu, Ahmet Dirican, Mujgan Cengiz
Summary: IL-10, MMP-2, and MMP-9 play important roles in obesity development and its related clinical phenotypes. The gene expression of MMP-2 and MMP-9 was significantly downregulated in obesity patients, while IL-10 levels were elevated. MMP-2 was positively correlated with fasting blood glucose levels and negatively correlated with BMI and weight in the obesity group.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
