Article
Pharmacology & Pharmacy
Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
Summary: The study showed that the polycomb protein BMI-1 plays a crucial role in colorectal cancer liver metastasis, and knocking down BMI-1 can reduce liver metastasis, suggesting it as a potential therapeutic target.
ACTA PHARMACEUTICA SINICA B
(2021)
Letter
Oncology
Chen Wang, Taiyang Ye, Wenjing Wang, Keqi Song, Jie Zhu, Lan Dai, Wen Di
Summary: In this study, it was found that SphK1 is over-expressed in omental metastases of EOC patients. The inhibition of SphK1 suppressed the metastatic ability of EOC induced by adipocytes. SphK1 modulates adipocyte-induced E/N-cadherin switch through Twist1, suggesting a new target for EOC therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Oncology
Yiming Liu, Xinyang Hu, Shiyao Liu, Sining Zhou, Zhi Chen, Hongchuan Jin
Summary: GP73, a glycosylated protein highly expressed in various cancer tissues, has been identified as a novel serum biomarker for cancer diagnosis, especially in hepatocellular carcinoma (HCC). Recent studies have shown that GP73 plays multifunctional roles in cancer progression, especially in promoting EMT and cancer metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Lungulescu, Valentina Ghimpau, Dan Ionut Gheonea, Daniel Sur, Cristian Virgil Lungulescu
Summary: This systematic review investigates the expression and function of neuropilin-2 (NRP-2) in colorectal cancer. The majority of studies suggest that NRP-2 is highly expressed in colorectal cancer cells compared to normal colonic mucosa. The presence of NRP-2 is associated with epithelial-mesenchymal transition and metastatic progression in cancer.
Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Article
Gastroenterology & Hepatology
Zhong-Yang Jiang, Xi-Mei Ma, Xiao-Hui Luan, Zhen-Yu Liuyang, Yi-Yang Hong, Yuan Dai, Qing-Hua Dong, Guan-Yu Wang
Summary: This study found that BMI-1 is overexpressed in CRC liver metastasis and activates HSCs to secrete prometastatic factors, thereby creating a conducive environment for metastasis in the liver. In addition, HSCs also promote proliferation, migration, and EMT in CRC cells through the TGF-beta/SMAD pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Genetics & Heredity
Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke, Wataru Takaki, Jun Kiuchi, Hiroki Shimizu, Yusuke Yamamoto, Shuhei Komatsu, Atsushi Shiozaki, Yoshiaki Kuriu, Eigo Otsuji
Summary: In this study, miR-4442 was identified as a potential biomarker for predicting early recurrence in colorectal cancer. The level of miR-4442 was associated with the risk of recurrence and increased with earlier recurrence dates. Furthermore, miR-4442 played a role in promoting the proliferative, migratory, and invasive activities of colorectal cancer cells by directly targeting the messenger RNA of RBMS1, thus regulating epithelial-mesenchymal transition (EMT) in colorectal cancer.
Review
Pharmacology & Pharmacy
Paula I. Escalante, Luis A. Quinones, Hector R. Contreras
Summary: The FOLFOX scheme is commonly used for metastatic colorectal cancer patients, but chemoresistance is a major challenge. EMT and overexpression of multiple genes may contribute to drug resistance.
Article
Medicine, Research & Experimental
Daniela Judith Romero, Lucila Gisele Pescio, Bruno Jaime Santacreu, Jazmin Maria Mosca, Norma Beatriz Sterin-Speziale, Nicolas Octavio Favale
Summary: Epithelial renal cells can adopt different cellular phenotypes through epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). Sphingosine-1-phosphate (S1P) plays a crucial role in cell migration and differentiation, and its functions vary depending on the stage of cell differentiation and activation of S1P receptor 2 (S1PR2). Activation of S1PR2 promotes migration in fully differentiated cells but inhibits migration in non-differentiated cells. These findings provide new insights into the modulation of renal epithelial cell plasticity and have implications for research in various diseases.
Review
Oncology
Saida Mebarek, Najwa Skafi, Leyre Brizuela
Summary: Prostate cancer is the second most common cancer in men worldwide, with the majority of patients being above 65. Sphingosine 1-phosphate (S1P) is a bioactive lipid that plays a crucial role in the oncogenesis of prostate cancer. S1P metabolism and its enzymes have been extensively studied in relation to prostate cancer development and potential therapeutic targets. This review summarizes the significant findings and the current progress in targeting S1P metabolism for prostate cancer treatment.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Biochemistry & Molecular Biology
Erfei Chen, Fangfang Yang, Qiqi Li, Tong Li, Danni Yao, Lichao Cao, Jin Yang
Summary: The function and role of C9orf9 in colorectal cancer (CRC) progression was investigated in this study. Loss of wild-type C9orf9 was found to contribute to the tumorigenesis of CRC. C9orf9 exerted its tumor suppressor role by inhibiting cancer cell migration and invasion and suppressing the expression of metastasis-related genes and pathways.
Article
Pharmacology & Pharmacy
Maha-Hamadien Abdulla, Aminah Ahmad Alzailai, Mansoor-Ali Vaali-Mohammed, Rehan Ahmad, Sabiha Fatima, Ahmed Zubaidi, Thamer bin Traiki, Amer Mahmood, Reem Hamoud Alrashoudi, Zahid Khan
Summary: This study investigated the impact of a novel platinum complex on the invasion and migration of colorectal cancer cell lines. The results showed that the complex reduced cell motility and the expression of EMT markers involved in cell invasion and migration. This complex can potentially be used as an effective treatment for reducing metastasis in colorectal cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hilal Arnouk, Gloria Yum, Dean Shah
Summary: Cripto-1 is a crucial protein involved in embryonic development, promoting cell motility through epithelial to mesenchymal transition. However, its upregulation in cancer can lead to detrimental effects by remodeling cancer cells for metastasis and promoting the survival of cancer stem cells, potentially causing relapse in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shi-Quan Liu, Chun-Yan Xu, Meng-Bin Qin, Lin Tan, Chun-Feng Zhuge, Ye-Bo Mao, Ming-Yu Lai, Jie-An Huang
Article
Oncology
Mengbin Qin, Shiquan Liu, Aimin Li, Chunyan Xu, Lin Tan, Jiean Huang, Side Liu
Article
Oncology
Chun-Yan Xu, Meng-Bin Qin, Lin Tan, Shi-Quan Liu, Jie-An Huang
MOLECULAR MEDICINE REPORTS
(2016)
Article
Medicine, Research & Experimental
Chun-Yan Xu, Shi-Quan Liu, Meng-Bin Qin, Chun-Feng Zhuge, Lin Qin, Nan Qin, Ming-Yu Lai, Jie-An Huang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Multidisciplinary Sciences
Mengbin Qin, Jinxiu Zhang, Chunyan Xu, Peng Peng, Lin Tan, Shiquan Liu, Jiean Huang
Article
Oncology
Zhen-Hua Fu, Shi-Quan Liu, Meng-Bin Qin, Jie-An Huang, Chun-Yan Xu, Wen-Hong Wu, Li-Ye Zhu, Nan Qin, Ming-Yu Lai
Article
Oncology
Chunyan Xu, Wenlu Zhang, Shiquan Liu, Wenhong Wu, Mengbin Qin, Jiean Huang
Article
Multidisciplinary Sciences
Chunyan Xu, Wenlu Zhang, Chengxia Liu
Summary: This study demonstrates that downregulation of FAK can inhibit the stem cell-like properties and migration of colorectal cancer cells partly through altered modulation of AKT phosphorylation.