Article
Surgery
Gautier Gelly, Hugo Meunier, Adrien Lee Bion, Marion Zamparini, Anne-Lise Fiant, Veronique Savey, Arnaud Alves, Benjamin Menahem
Summary: Revisional bariatric surgery (RBS) is a challenging procedure and this study analyzed data from 252 patients who underwent RBS after laparoscopic adjustable gastric banding (LAGB) or laparoscopic sleeve gastrectomy (LSG). The study found that RBS after LSG had a higher overall morbidity rate, while RBS after LAGB had more perioperative issues.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Macarena Torrego-Ellacuria, Ana Barabash, Pilar Matia-Martin, Andres Sanchez-Pernaute, Antonio J. Torres, Alfonso L. Calle-Pascual, Miguel A. Rubio-Herrera
Summary: The pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. This study analyzed the association between single nucleotide polymorphisms (SNPs) of 13 genes encoding gastrointestinal peptides and long-term weight response in patients undergoing bariatric surgery. Eight genetic variants were identified that were independently associated with weight response, and the highest scoring category in each risk score was significantly associated with lower weight loss and greater weight regain at the end of the follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Andreea Ciudin, Enzamaria Fidilio, Liliana Gutierrez-Carrasquilla, Assumpta Caixas, Nuria Vilarrasa, Silvia Pellitero, Andreu Simo-Servat, Ramon Vilallonga, Amador Ruiz, Maricruz de la Fuente, Alexis Luna, Enric Sanchez, Mercedes Rigla, Cristina Hernandez, Eduardo Salas, Rafael Simo, Albert Lecube
Summary: By combining clinical variables and genetic testing, the study established a good predictive model for weight loss response after bariatric surgery, showing a higher predictability compared to using only clinical variables. This finding highlights the key role of personalized medicine in improving clinical practice cost-effectiveness.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Surgery
Sapana R. Gupta, Yingjie Zhou, Thomas A. Wadden, Robert Berkowitz, Ariana M. Chao
Summary: This systematic review synthesized research examining the relationship between genetic predictors and weight loss after bariatric surgery. Genetic variants and risk scores show potential for predicting weight loss after surgery and identifying at-risk patients.
Article
Surgery
Tarin Worrest, C. Cole Malibiran, Jill Welshans, Elizabeth Dewey, Farah Husain
Summary: This study aimed to investigate the impact of marijuana use on complication rates and weight loss outcomes after bariatric surgery. The results showed that patients with a history of marijuana use generally had higher preoperative BMI, but marijuana use was not associated with complications or percent weight loss.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Nutrition & Dietetics
Isabella Gastaldo, Rosa Casas, Violeta Moize
Summary: This narrative review summarizes the existing research on the clinical impact of a Mediterranean diet before and after bariatric surgery, focusing on its effects on weight loss and improvement in comorbidities. Although the current knowledge is limited, the findings suggest that adopting a Mediterranean diet before and after bariatric surgery is of significant value.
Review
Endocrinology & Metabolism
Darlene Larissa de Souza Vilela, Alessandra da Silva, Sonia Lopes Pinto, Josefina Bressan
Summary: This systematic review examined the relationship between macronutrient intake and weight loss after bariatric surgery (BS). Eight articles involving 2,378 subjects were included, and the results indicated that protein intake was positively associated with weight loss after BS. Prioritizing protein followed by carbohydrates and reducing lipid intake favored weight loss and weight stability after BS. The review suggests that a high-protein diet (>60 g to 90 g/day) may be beneficial for weight loss and maintenance after BS, but a balance of other macronutrients is also important.
Article
Medicine, General & Internal
Afnan Sameer Azhri, Asma Almuqati, Firas Azzeh, Nuha Alamro, Wedad Azhar, Alaa Qadhi, Khloud Ghafouri
Summary: A study was conducted on patients who underwent bariatric surgery to investigate the factors affecting weight loss and the effectiveness of prophylactic ursodeoxycholic acid against gallstone formation. It was found that weight loss was influenced by initial body weight, sex, and dietary intake. Rapid weight loss was associated with a higher incidence of cholelithiasis.
Article
Surgery
Grace F. Chao, Jeffrey T. Kullgren, Rachel Ross, Aaron J. Bonham, Amir A. Ghaferi
Summary: The study aimed to examine the effects of a financial incentives program on follow-up and weight loss after bariatric surgery. The results showed that the program significantly increased follow-up rates for up to 6 months, but did not have a significant effect on weight loss.
Article
Surgery
Lisa R. Miller-Matero, Kaitlin Ross, Eve DePascale, Camila Arellano, Logan Zelenak, Jordan M. Braciszewski, Leah M. Hecht, Erin N. Haley, Amy M. Loree, Arthur M. Carlin
Summary: This study examined the impact of cannabis use on weight loss outcomes in patients undergoing bariatric surgery. The results showed that pre-surgical cannabis use was not associated with weight loss, but post-surgical cannabis use was linked to poorer weight loss outcomes and increased risk of weight recurrence. Frequent cannabis use (i.e., weekly) was particularly problematic. Healthcare providers should screen patients for cannabis use and educate them about the potential effects of postoperative cannabis use on weight loss.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Emanuele Muraca, Alice Oltolini, Alberto Binda, Mattia Pizzi, Stefano Ciardullo, Giuseppina Manzoni, Francesca Zerbini, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Pietro Pizzi, Guido Lattuada, Gianluca Perseghin, Matteo Villa
Summary: This study found that the weight loss 12 months after LSG was associated with factors including patient age, blood glucose level, blood pressure, and psychological features, with a predictive accuracy of 31.5%, indicating a close relationship between baseline metabolic and psychological characteristics and weight loss after surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Urs Pfefferkorn, Sabrina Hort, Melika Beluli, Monica La Vista, Thomas Zuger
Summary: Weight loss after bariatric surgery may be reduced in older patients due to changes in metabolism. Some studies showed inferior weight loss in older patients compared to younger ones while others showed no such difference. Stratified recommendations by age are important for counseling patients about expected weight loss after bariatric surgery.
Article
Obstetrics & Gynecology
K. Johansson, A-k Wikstrom, J. Soderling, I Naslund, J. Ottosson, M. Neovius, O. Stephansson
Summary: A nationwide matched cohort study in Sweden involving over 843,000 singleton pregnancies found that gastric bypass surgery before pregnancy is associated with a reduced risk of pre-eclampsia, with the largest absolute risk reduction observed in nulliparous women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Surgery
Estella Y. Huang, Eduardo Grunvald, Rachel R. Blitzer, Arielle M. Lee, Ryan C. Broderick, Jonathan Z. Li, Joslin N. Cheverie, Bryan J. Sandler, Santiago Horgan, Garth R. Jacobsen
Summary: The coronavirus pandemic has had a significant impact on the behaviors and weight loss outcomes of bariatric surgery patients. Despite deterioration of lifestyle habits, 1-year weight loss outcomes after surgery remained the same before and after social distancing measures were implemented.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Steffane McLennan, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: Revisional bariatric surgery is an option for patients with weight regain or inadequate weight loss after primary elective procedures. However, the safety outcomes of revisional procedures are conflicting. This study aims to characterize the patient demographics, procedure types, and safety outcomes for those undergoing revisional compared to initial bariatric interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Immunology
Laura Boswell, Pedro Ventura-Aguiar, Aida Alejaldre, Judith Navarro-Otano, Frederic Cofan, Tonet Seres-Noriega, Adriana Pane, Enrique Montagud-Marrahi, Alicia Molina-Andujar, Montserrat Ruiz, David Cucchiari, Mireia Musquera, Joana Ferrer-Fabrega, Fritz Diekmann, Enric Esmatjes, Antonio J. Amor
Summary: This study found that diabetic neuropathy has an independent impact on outcomes after pancreas transplantation. Vibration perception thresholds and orthostatic hypotension were used to assess diabetic neuropathy, and it was found that pre- and post-transplant markers of neuropathy were associated with graft failure/dysfunction and incident cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Luis Ortega-Paz, Helena Cristobal, Jose Tomas Ortiz-Perez, Pablo Garcia de Frutos, Guiomar Mendieta, Elena Sandoval, Juan Jose Rodriguez, Emilio Ortega, Ana Garcia-Alvarez, Salvatore Brugaletta, Manel Sabate, Ana Paula Dantas
Summary: In-vitro experiments on myocardial fibroblasts from patients with HFrEF found that Dapagliflozin alone dose-dependently slowed migration of the fibroblasts, and the combination of Dapagliflozin + LCZ696 further reduced migration rate, while Dapagliflozin + spironolactone altered the effects of SGLT2i on biomarkers.
Letter
Cardiac & Cardiovascular Systems
Amanda Jimenez, Clara Vinals, Victoria Marco-Benedi, Pilar Gonzalez, Monica Domenech, Manuel Suarez-Tembra, Xavier Pinto, Emilio Ortega
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Juan Carlos Valerio-Rojas, Marc Izquierdo, Oriol de Diego, Emilio Ortega, Ignacio Conget, Rut Andrea
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Endocrinology & Metabolism
Didac Mauricio, Bogdan Vlacho, Emilio Ortega, Xavier Cos-Claramunt, Manel Mata-Cases, Jordi Real, Berta Fernandez-Camins, Josep Franch-Nadal
Summary: The aim of this study was to estimate the incidence and risk factors for fatal and non-fatal events among COVID-19 infected subjects with obesity or diabetes during the initial three epidemiological waves in the region. A retrospective cohort study was conducted using a primary care database to identify individuals with COVID-19, stratifying them based on diabetes mellitus or obesity. Results showed that fatal events were more common among individuals with diabetes, particularly during the first wave. The number of study events decreased in the second and third waves. Diabetes was found to be a risk factor for fatal events, while obesity was only a risk factor when adjusted for age, sex, diabetes, and COVID-19 waves. HIV, cancer, and autoimmune diseases were also identified as risk factors for mortality among subjects with COVID-19 in the fully-adjusted model.
PRIMARY CARE DIABETES
(2023)
Article
Endocrinology & Metabolism
Tonet Seres-Noriega, Emilio Ortega, Veronica Perea, Marga Gimenez, Laura Boswell, Karla Mariaca, Carla Font, Alex Mesa, Clara Vinals, Jesus Blanco, Irene Vinagre, Adriana Pane, Enric Esmatjes, Ignacio Conget, Antonio J. J. Amor
Summary: In this study, H-1 NMR-derived lipidomic parameters were found to be independently associated with preclinical atherosclerosis in individuals with T1D. Specifically, omega-6 fatty acids and linoleic acid seem to be promising for identifying those with higher plaque burden.
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tonet Seres-Noriega, Emilio Ortega, Marga Gimenez, Veronica Perea, Laura Boswell, Karla Mariaca, Carla Font, Alex Mesa, Clara Vinals, Jesus Blanco, Irene Vinagre, Adriana Pane, Enric Esmatjes, Ignacio Conget, Antonio J. Amor
Summary: This study evaluated the relationship between lipoprotein abnormalities and atherosclerosis in patients with type 1 diabetes. The results showed that patients with atherosclerosis were older, had longer diabetes duration, higher prevalence of hypertension, lower LDL and HDL particles, but higher VLDL particles compared to those without atherosclerosis. HDL particles, LDL particles, and total atherogenic particle number were independently associated with preclinical atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Francesc Bujosa, Zoe Herreras, Marta Catalan, Montse Pinyol, Rosa M. Lamuela-Raventos, Miriam Martinez-Huelamo, Rosa Gilabert, Amanda Jimenez, Emilio Ortega, Gemma Chiva-Blanch
Summary: This study analyzed the association between fruit and vegetable intake, measured by carotene plasma concentrations, and atherosclerotic burden. The results showed that dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might contribute to reduce the occurrence and progression of atherosclerosis.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Laura Boswell, Antonio J. Amor, Enrique Montagud-Marrahi, Gregori Casals, Daniela Diaz-Catalan, Elisenda Banon-Maneus, Maria Jose Ramirez-Bajo, Natalia Hierro, Fritz Diekmann, Mireia Musquera, Tonet Seres-Noriega, Enric Esmatjes, Joana Ferrer-Fabrega, Pedro Ventura-Aguiar, Felicia A. Hanzu
Summary: This study explored the levels of midnight cortisol and soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) in simultaneous pancreas-kidney transplant recipients. The findings suggest that lower midnight cortisol is associated with lower baseline systolic blood pressure, improvement in antihypertensive treatment after transplant, and a higher prevalence of diabetic neuropathy.
Article
Medicine, General & Internal
Adriana Pane, Maria Claro, Alicia Molina-Andujar, Romina Olbeyra, Barbara Romano-Andrioni, Laura Boswell, Enrique Montagud-Marrahi, Amanda Jimenez, Ainitze Ibarzabal, Judith Viaplana, Pedro Ventura-Aguiar, Antonio J. Amor, Josep Vidal, Lilliam Flores, Ana de Hollanda
Summary: Obesity increases the risk of developing chronic kidney disease (CKD), and bariatric surgery (BS) has shown to improve obesity-related comorbidities and renal function in CKD patients. This study aimed to investigate the safety and outcomes of BS in CKD patients and found that BS was safe and effective in terms of weight loss, resolution of obesity comorbidities, and improvement of renal function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Celia Martinez-Sanchez, Octavi Bassegoda, Hongping Deng, Xenia Almodovar, Ainitze Ibarzabal, Ana de Hollanda, Raquel-Adela Martinez Garcia de la Torre, Delia Blaya, Silvia Arino, Natalia Jimenez-Esquivel, Beatriz Aguilar-Bravo, Julia Vallverdu, Carla Montironi, Oscar Osorio-Conles, Yiliam Fundora, Francisco Javier Sanchez Moreno, Alicia G. Gomez-Valades, Laia Aguilar-Corominas, Anna Soria, Elisa Pose, Adria Juanola, Marta Cervera, Martina Perez, Virginia Hernandez-Gea, Silvia Affo, Kelly S. Swanson, Joana Ferrer-Fabrega, Jose Maria Balibrea, Pau Sancho-Bru, Josep Vidal, Pere Gines, Andrew M. Smith, Isabel Graupera, Mar Coll
Summary: This study reveals the correlation between the accumulation of pro-inflammatory adipose tissue macrophages (ATMs) and liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Modulation of ATMs improves liver inflammation and fibrosis in an experimental non-alcoholic steatohepatitis (NASH) model. These findings highlight the potential of ATMs as a therapeutic target for NAFLD.
