Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 469-481Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S191504
Keywords
periprosthetic joint infections; osteomyelitis; Staphylococcus aureus; myeloid-derived suppressor cells
Funding
- Chang Gung Medical Research Program Foundation (Chang-Gung Memorial Hospital, Taiwan) [CMRPG6F0341, CMRPG6F0342, CMRPG6G0231, CMRPG6H0401]
- Ministry of Science and Technology (ROC) [NMRPG6G6011, NMRPG6G6012]
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Background: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation. Methods: In this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model. Results: CURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1 - and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo. Conclusion: This is the first study to demonstrate that CURN may be useful for treating PJIs.
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