Article
Chemistry, Multidisciplinary
Sidra Saeed, Usama Sarwar, Masoom Yasinzai, Abida Raza
Summary: Researchers have developed a polymer-based nanotheranostic drug delivery system for ultrasound-mediated release of hydrophobic chemotherapeutic drug, doxorubicin. This system demonstrates efficient drug delivery and enhanced anticancer effects in vivo, while reducing side effects.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Thev Pol, Wunpen Chonkaew, Lalintip Hocharoen, Nakorn Niamnont, Namphueng Butkhot, Yaowaluck Maprang Roshorm, Suda Kiatkamjornwong, Voravee P. Hoven, Kornkanya Pratumyot
Summary: Amphiphilic chitosan derivative bPalm-CS-HTAP was synthesized and found to self-assemble into nanosized particles. It effectively condensed plasmid DNA and enabled gene expression in cells without causing cytotoxicity, making it a promising nonviral gene carrier.
Article
Chemistry, Medicinal
Yvonne Lerchbammer-Kreith, Michaela Hejl, Nadine S. Sommerfeld, Xian Weng-Jiang, Uchechukwu Odunze, Ryan D. Mellor, David G. Workman, Michael A. Jakupec, Andreas G. Schaetzlein, Ijeoma F. Uchegbu, Mathea S. Galanski, Bernhard K. Keppler
Summary: In this study, cytotoxic platinum(IV) conjugates of cisplatin, carboplatin and oxaliplatin were synthesized and coupled to quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymers. The conjugates showed significantly increased cytotoxic activity compared to their respective platinum(IV) complexes and outperformed the platinum(II) counterparts. Biodistribution experiment revealed an increased accumulation of an oxaliplatin-based GCPQ conjugate in lung tissue. These findings suggest promising opportunities for further studies on tumor activity, particularly in lung tissue.
Article
Biochemistry & Molecular Biology
Jaemin Shim, Jiseon Kang, Seok Il Yun
Summary: The novel chitosan-dipeptide hydrogel prepared exhibited excellent stability and drug release properties, making it a promising candidate for localized and controlled drug delivery in cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Li-Yuan Huang, Wen Li, Nan Du, Hai-Qin Lu, Li-Dan Meng, Ke-Yu Huang, Kai Li
Summary: In this study, novel green in situ quaternary-ammonium-functionalized magnetic chitosan microspheres (IQMCM) were synthesized and characterized. The IQMCMs showed spherical morphology, superior thermal stability, magnetic properties, and surface charges. The adsorption capacities of the IQMCM microspheres to Congo red dye were high, and the adsorption process was spontaneous, endothermic, and monolayer chemisorption. The magnetic adsorbent could be easily separated and reused with little capacity loss, indicating the potential application of IQMCMs in wastewater treatment.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Wanjing Zou, Jingwei Gu, Jianna Li, Yuanfang Wang, Shiguo Chen
Summary: The study successfully synthesized IQAS and ISB derivatives and systematically investigated the effects of their substitution degree, carbon chain length, and content ratio on water solubility, antibacterial activity, and cytotoxicity of CS derivatives, suggesting that the properties of CS derivatives can be tailored by adjusting the amount of grafted antibacterial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zonghua Tian, Xia Wu, Li Peng, Na Yu, Guojing Gou, Wenbao Zuo, Jianhong Yang
Summary: In this study, pH-responsive bufadienolides nanocrystals decorated by chitosan quaternary ammonium salt (HE BU NCs) were successfully constructed to improve the bioavailability, release characteristics, and intestinal transport ability of bufadienolides. In vitro studies showed that HE BU NCs could improve the internalization of bufadienolides, induce apoptosis, decrease mitochondrial membrane potential, and increase ROS levels in tumor cells. In vivo experiments demonstrated that HE BU NCs effectively targeted intestinal sites, increased retention time, and exerted antitumor activity through Caspase-3 and Bax/Bcl-2 ratio pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Liqiu Chu, Zhiyu Zhou, Zhipan Feng, Xinqi Zhao, Huimin Tan, Yu Chen
Summary: In this study, HTCC/Fe3O4/CdTe magnetic fluorescent nanoparticles (MFCNPs) that can be well dispersed in water were prepared via electrostatic interaction. The nanoparticles showed good biocompatibility and their properties were mainly influenced by the relative ratios of different components. The chitosan-based magnetic fluorescent composite may be a promising delivery carrier candidate.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Baiqing Song, Tianyi Zhang, Xinfeng Li, Kaili Yang, Jinyu Shan, Yunzhi Dang, Jianhua Ma
Summary: Smart and controllable antibacterial fabrics have great potential in textile, medical, and healthcare fields. In this study, a composite antimicrobial fiber with thermally responsive properties was created by synthesizing nano zinc oxide (ZnO) and combining it with quaternary ammonium chitosan (QAC). The addition of a copper sulphide (CuS) layer further enhanced the antibacterial properties of the materials. These smart responsive composite fibers show promise in medical dressings, special textiles, and healthcare materials.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan, Hongliang Yao
Summary: In this study, a compound with anti-inflammatory activity, 3J, was synthesized and incorporated into an intelligent composite hydrogel for the treatment of oral ulcers. The hydrogel exhibited a dense honeycomb structure for effective drug loading and wound ventilation, as well as biodegradability. It showed antibacterial effects, reduced inflammatory cytokine levels, and had excellent swelling and water retention properties, making it a promising treatment for oral ulcers.
Article
Biochemistry & Molecular Biology
Hongcai Zhang, Tingting Qiu, Yifei Bai, Bin Chen, Juan Yan, Jianxiong Xu
Summary: In this study, cellulose nanocrystals were used to stabilize Lysozyme encapsulated in quaternary ammonium chitosan nanoparticles. The CNC stabilized Lys loaded QC NPs showed potential implications in the food industry for food preservation and packaging, as well as demonstrated good antibacterial activity against Staphylococcus aureus and Vibrio parahaemolyticus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Energy & Fuels
Chenglong Li, Geng Liu, Shuang Wang, Di Wang, Fengxiang Liu, Yinghe Cui, Dan Liang, Xiaodong Wang, Zhipeng Yong, Yue Chi
Summary: A hydrogel electrolyte with excellent electrochemical and sensing performance was prepared. The hydrogel is composed of a highly cross-linked network formed by quaternary ammonium side chain chitosan and polyvinyl alcohol, and the device is assembled with activated carbon electrodes. After 5000 charge/discharge cycles, the capacitance retention rate of the supercapacitor device remained as high as 92.5%. Additionally, the gel exhibited outstanding sensing ability, with a sensing factor of 0.995 and a response time of 180 ms, which could still be maintained after multiple cycles.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Physical
Samantha E. Mackay, Francois Malherbe, Daniel S. Eldridge
Summary: Phosphate contamination from agricultural runoff is a major global issue that has severe environmental effects. This study presents a synthesized biopolymer that can effectively remediate phosphate in the environment. The modified-chitosan not only demonstrates a high adsorption capacity but also shows remarkable regenerability.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Biochemistry & Molecular Biology
Yanbing Song, Jin Xing, Li Ren, Xia Xu, Donghua Han, Hao Xu, Liang Zhao, Yang Yu, Shige Wang, Chaobo Liu
Summary: A multi-functional hydrogel with antibacterial properties, hemostasis, and the ability to promote wound healing is proposed in this study. The hydrogel is composed of surfactin, polyvinylpyrrolidone, and methacrylic anhydride grafted quaternary ammonium chitosan. The formation of the hydrogel is triggered by ultraviolet-initiated polymerization, while surfactin is complexed with the hydrogel through hydrogen bonding interaction. This adhesive hydrogel with shape adaptability can cover the wound surface, simulate the microenvironment of the primary extracellular matrix, and promote collagen deposition and inflammatory factor transformation.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biochemical Research Methods
Haroon Iqbal, Farid Menaa, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Kifayat Ullah, Robia Kamal, Muhammad Sohail, Gobika Thiripuranathar, Bushra Uzair, Nosheen Fatima Rana, Barkat Ali Khan, Bouzid Menaa
Summary: Natural bioactive compounds from cinnamon, such as 2-hydroxycinnaldehyde and 2benzoyloxycinnamaldehyde, show significant anti-carcinogenic activity and have immunomodulatory, anti-platelet, and anti-inflammatory effects. However, understanding their exact molecular mechanisms remains challenging.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Biochemistry & Molecular Biology
Sadia Nazer, Saiqa Andleeb, Shaukat Ali, Nazia Gulzar, Abida Raza, Habib Khan, Kalsoom Akhtar, Muhammad Naeem Ahmed
Summary: The study investigated the anti-diabetic and hepato-protective effects of green synthesized silver nanoparticles using Ajuga bracteosa. Results showed valuable potential in reducing blood glucose levels, improving liver function, and protecting the liver in diabetic and CCl4-induced mice. These findings suggest that ABaqu and ABAgNPs possess strong anti-diabetic and hepatoprotective properties.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Najma Bibi, Asim ur Rehman, Nosheen Fatima Rana, Hashaam Akhtar, Muhammad Ijaz Khan, Muhammad Faheem, Syed Babar Jamal, Naveed Ahmed
Summary: This study developed curcumin-loaded nanoparticles of Eudragit E100 using a nanoprecipitation method, which enhanced the water solubility, permeability, and bioactivity of curcumin for topical skin applications. In vitro and in vivo evaluations showed that these nanoparticles have potential for the local treatment of skin cancer.
APPLIED NANOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Adil Farooq, Arfa Iqbal, Nosheen Fatima Rana, Misha Fatima, Tuba Maryam, Farhat Batool, Zahra Rehman, Farid Menaa, Shabia Azhar, Afrah Nawaz, Faheem Amin, Zuhair M. Mohammedsaleh, Salma Saleh Alrdahe
Summary: Chronic liver disease (CLD) is a global threat to human population, mainly caused by alcohol-related liver disease (ALD) and non-alcohol fatty liver disease (NAFLD). NAFLD may progress to non-alcoholic steatohepatitis (NASH), leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Vitexin, a natural flavonoid, has been reported to inhibit NAFLD. However, its low bioavailability and efficacy due to hydrophobic nature limit its therapeutic potential. In this study, vitexin encapsulated liposomes with polyethylene glycol (PEG) coating were developed and showed promising results for the treatment of liver cirrhosis through oral drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maryam Arshad, Ishrat Mahjabeen, Abida Raza, Sumbal Javaid, Maria Fazal Ul Haq, Masroor Alam, Ahmat Khurshid
Summary: In this study, PLGA nanoparticles were synthesized and their application in Rhabdomyosarcoma cell culture was investigated. The results showed that PLGA nanoparticles had good biocompatibility, but photodynamic therapy alone had a more significant effect on cell death compared to combination therapy. In addition, gene expression analysis revealed the absence of apoptosis during cell death.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Polymer Science
Zubia Abid, Asad Abbas, Azhar Mahmood, Nosheen Fatima Rana, Sher Jamal Khan, Laurent Duclaux, Kashif Mairaj Deen, Nasir M. Ahmad
Summary: In this study, polyether sulfone ultrafiltration membranes were successfully fabricated by incorporating modified activated carbon. The membranes demonstrated improved hydrophilicity and porosity, resulting in higher flux and water retention. The membranes also exhibited antibacterial properties and showed better performance in filtering protein solutions, indicating their potential applications in protein isolation and concentration.
Article
Pharmacology & Pharmacy
Mirina Sakhi, Abad Khan, Zafar Iqbal, Ismail Khan, Abida Raza, Asmat Ullah, Fazli Nasir, Saeed Ahmad Khan
Summary: The aim of this study was to develop an antibody-mediated drug delivery system for the treatment of breast cancer. The results showed that the antibody-conjugated polymeric nanoparticles exhibited controlled and sustained drug release, improved cytotoxicity, and enhanced pharmacokinetic parameters compared to conventional nanoparticles and commercially available formulations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Shabia Azhar, Nosheen Fatima Rana, Amer Sohail Kashif, Tahreem Tanweer, Iqra Shafique, Farid Menaa
Summary: This study successfully synthesized DEAE-Dextran silver nanoparticles and modified composite resins with these nanoparticles, resulting in significant improvements in mechanical and antibacterial properties. The DEAE-Dextran silver nanoparticles exhibited better antibacterial activity compared to regular silver nanoparticles and had lower hemolytic properties.
Article
Chemistry, Multidisciplinary
Nashmia Zia, Zafar Iqbal, Abida Raza, Aadarash Zia, Rabia Shafique, Saiqa Andleeb, Gilbert C. Walker
Summary: This study proposes the use of stable polymeric micelles as high-radiotracer-payload carriers in specific regions for noninvasive hepatocyte function assessment and diagnosis of liver fibrosis. The modified micelles show excellent biocompatibility and stability, offering a promising platform for nanotheranostic applications.
Article
Biochemistry & Molecular Biology
Wafa Arif, Nosheen Fatima Rana, Iqra Saleem, Tahreem Tanweer, Muhammad Jawad Khan, Sohad Abdulkaleg Alshareef, Huda M. Sheikh, Fatima S. Alaryani, Manal Othman AL-Kattan, Hanan Ali Alatawi, Farid Menaa, Aroosa Younis Nadeem
Summary: A study synthesized a resin composite with antibacterial properties, containing ciprofloxacin-loaded silver nanoparticles. The results showed that this composite exhibited high antibacterial activity and compressive strength, as well as good biocompatibility.
Article
Biochemistry & Molecular Biology
Tahreem Tanweer, Nosheen Fatima Rana, Iqra Saleem, Iqra Shafique, Sultan M. Alshahrani, Hanadi A. Almukhlifi, Amenah S. Alotaibi, Sohad Abdulkaleg Alshareef, Farid Menaa
Summary: This study aimed to enhance the antibacterial potential of resin composite by using Magnesium-doped Zinc oxide (Mg-doped ZnO) nanoparticles (NPs) and test their effectiveness in a diabetes model. The results showed that composites with 1% Mg-doped ZnO had significantly improved antibacterial properties, without affecting the mechanical properties and biocompatibility. Moreover, Mg-doped ZnO composites prevented secondary caries formation in diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tuba Maryam, Nosheen Fatima Rana, Sultan M. Alshahrani, Farhat Batool, Misha Fatima, Tahreem Tanweer, Salma Saleh Alrdahe, Yasmene F. Alanazi, Ifat Alsharif, Fatima S. Alaryani, Amer Sohail Kashif, Farid Menaa
Summary: Wilson's disease is characterized by copper accumulation in the liver and other organs. Current therapies aim to lower copper levels but lack the ability to repair liver and brain tissue damage. This study examined the use of silymarin-encapsulated liposome nanoparticles (SLNPs) in treating copper toxicity in rats. SLNPs reduced cellular degeneration, improved liver enzymes, enhanced spatial memory, and reduced depression symptoms. The combination of zinc and SLNPs was more effective than traditional zinc therapy in reducing depression but not in improving spatial memory.
Article
Biotechnology & Applied Microbiology
Usama Sarwar, Muhammad Naeem, Farwa Nurjis, Shafqat Karim, Abida Raza
Summary: Folate-conjugated sorafenib-loaded liposomes exhibited lower IC50 concentration and longer circulation time in mice under ultrasound exposure.
Article
Chemistry, Multidisciplinary
Sidra Saeed, Usama Sarwar, Masoom Yasinzai, Abida Raza
Summary: Researchers have developed a polymer-based nanotheranostic drug delivery system for ultrasound-mediated release of hydrophobic chemotherapeutic drug, doxorubicin. This system demonstrates efficient drug delivery and enhanced anticancer effects in vivo, while reducing side effects.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Medicinal
Sadia Tabassam Arif, Muhammad Ayub Khan, Shahiq uz Zaman, Hafiz Shoaib Sarwar, Abida Raza, Muhammad Sarfraz, Yousef A. Bin Jardan, Muhammad Umair Amin, Muhammad Farhan Sohail
Summary: This study evaluated the potential of levosulpiride-loaded nanostructured lipid carriers (LSP-NLCs) for enhanced antidepressant and anxiolytic effects. The results showed that LSP-NLCs had an improved antidepressant effect on lipopolysaccharide-induced depression and exhibited superior anxiolytic activity compared to LSP dispersion. Fluorescently labeled LSP-NLCs demonstrated the presence of LSP in the brain, indicating its ability to produce therapeutic effects. Acute toxicity studies revealed the safety of LSP-NLCs in vivo.
