Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms20010051
Keywords
anti-cancer drug-resistance; histone deacetylase-3; cancer; testis antigen CAGE; epidermal growth factor receptor; micro RNAs; molecular network
Funding
- National Research Foundation [2017R1A2A2A05001029, 2017M3A9G7072417]
- BK21 plus Program
- Kangwon National University [520170495]
- [2018R1D1A1B07043498]
- National Research Foundation of Korea [2017R1A2A2A05001029] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
