Article
Clinical Neurology
Wanying Shan, Liang Xu, Zhuoyin Qiu, Jingwen Wang, Jiaxing Shao, Jie Feng, Jie Zhao
Summary: This study aimed to investigate whether high-mobility group box 1 (HMGB1) levels could predict post-stroke depression (PSD) at 3 months after acute ischemic stroke. The results demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with an increased risk of PSD, with an optimal cutoff point of 8.6 ng/mL showing good sensitivity and specificity for predicting PSD.
NEUROLOGICAL SCIENCES
(2022)
Article
Virology
Daniele C. P. Rocha, Thiara Manuelle Alves Souza, Priscila Conrado Guerra Nunes, Ronaldo Mohana-Borges, Marciano Paes, Gabriel M. C. Guimaraes, Juan C. S. Arcila, Iury Amancio Paiva, Elzinandes Leal de Azeredo, Paulo Vieira Damasco, Luiz Jose de Souza, Flavia B. dos Santos, Diego Allonso
Summary: This study found increased serum levels of HMGB1 in CHIKV-infected patients and its positive correlation with virus titer, suggesting its potential use as a biomarker for diagnosis and treatment of chikungunya fever.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilijana Grigorov, Snezana Pejic, Ana Todorovic, Dunja Drakulic, Filip Veljkovic, Jadranka Miletic Vukajlovic, Katarina Bobic, Ivan Soldatovic, Sinisa Durasevic, Nebojsa Jasnic, Sanja Stankovic, Sofija Glumac, Violeta Mihailovic-Vucinic, Branislava Milenkovic
Summary: Careful monitoring of mild/moderate COVID-19 patients is crucial due to the rapid progression of complications. This study identified HMGB1 and HO-1 as potential biomarkers for COVID-19 management, based on their serum concentrations at hospital admission. The increase in HO-1 may provide protection against oxidative stress and inflammation, while the level of HMGB1 reflects the activity of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Article
Nutrition & Dietetics
Laura Kate Gadanec, Ulf Andersson, Vasso Apostolopoulos, Anthony Zulli
Summary: High levels of HMGB-1 have been found in patients with Hyperhomocysteinemia (HHcy), which worsens cardiovascular outcomes. Targeting HMGB-1 may be a potential therapy for improving HHcy-induced cardiovascular pathologies.
Review
Multidisciplinary Sciences
Zhiwu Wu, Liping Liang, Qianliang Huang
Summary: HMGB1 is a cytokine that serves as a marker of inflammation and has multiple functions depending on its subcellular location. CSF HMGB1 may play a role in the pathological mechanisms underlying complications associated with CNS diseases. Measuring the level of HMGB1 in the CSF can help predict disease progression and contribute to pathological alterations in distant areas.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Shuhua Wu, Yangyang Yu, Zhong Zheng, Qi Cheng
Summary: This article elaborates on the role and mechanism of HMGB1 in allergic rhinitis (AR), highlighting its potential value as a new target for clinical research on AR treatment. AR is a prevalent chronic inflammatory disease and current management focuses on symptom control.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wataru Takaki, Hirotaka Konishi, Daiki Matsubara, Katsutoshi Shoda, Tomohiro Arita, Satoshi Kataoka, Jun Shibamoto, Hirotaka Furuke, Kazuya Takabatake, Hiroki Shimizu, Shuhei Komatsu, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji
Summary: This study reveals that extracellular HMGB1 promotes the progression and metastasis of gastric cancer, and plasma HMGB1 concentrations can serve as a prognostic marker in gastric cancer patients. Recombinant human soluble thrombomodulin (rTM) targeting HMGB1 shows potential therapeutic effects in gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
E. Yan, Qiwen Deng, Guomei Shi, Zhongyuan Li, Chengfang Liu, Siyu Wang, Huiwen Lian, Haiming Cao, Xiaohao Zhang, Yingdong Zhang, Pengyu Gong, Teng Jiang
Summary: The study suggests that high-mobility-group box 1 (HMGB1) may serve as a potential biomarker for stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients.
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Jie Zhao, Fang Xu, Wanying Xu, Rong Lv, Juan Wang, Xufeng Yang
Summary: This study found an association between elevated HMGB1 levels and the severity of white matter lesions (WMLs) in stroke patients, particularly in the periventricular region.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Environmental Sciences
Jixuan Ma, Yujia Xie, Yiju Xu, Pei Gu, Yingdie Zhang, Lieyang Fan, Yun Zhou, Haijiao Wang, Ting Zhou, Jintong He, Dongming Wang, Weihong Chen
Summary: Environmental exposure to crystalline silica particles can cause serious pulmonary interstitial fibrosis called silicosis, but the underlying mechanism is unclear and effective treatments are lacking. This study explores the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung inflammation and fibrosis. The researchers found that IL-11 expression in mouse lungs significantly increased after silica exposure and remained high during inflammation and fibrosis. Blocking IL-11 effectively reduced the overexpression of pro-inflammatory cytokines and fibrotic proteins induced by silica particles. The study suggests that IL-11 may be a promising therapeutic target for lung inflammation and fibrosis caused by silica particle exposure.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Environmental Sciences
Wei Liu, Shuting Cao, Jixuan Ma, Da Shi, Linling Yu, Zi Ye, Meng Yang, Bin Wang, Weihong Chen
Summary: This study aimed to investigate the relationships between exposures to volatile organic compounds (VOCs) and vitamin D levels and kidney function. The results indicate that exposure to VOCs is associated with a decline in kidney function and serum vitamin D levels, and there may be interaction effects between vitamin D and VOCs on kidney function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ge Mu, Xiuquan Nie, Shijie Yang, Zi Ye, Man Cheng, Lieyang Fan, Weihong Qiu, Qiyou Tan, Min Zhou, Yanjun Guo, Weihong Chen
Summary: This study evaluated the associations between personal PM2.5 concentrations and DNA methylation, and investigated how PM2.5-related DNA methylation affects lung function. The results showed significant associations between PM2.5-related DNA methylation and lung function, indicating the potential role of DNA methylation in the link between PM2.5 exposure and lung function alteration.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Xiuyu Cao, Xiaojie You, Dongming Wang, Weihong Qiu, You Guo, Min Zhou, Weihong Chen, Xiaokang Zhang
Summary: A study in Ganzhou, China found that there are significantly positive associations between ambient ozone levels and hospitalizations for circulatory diseases, including hypertension, coronary heart disease, cerebrovascular disease, and heart failure. The risk of hospitalization increased with each 10 mu g/m3 increase in ozone concentration. These associations remained significant after adjusting for other air pollutants and varied in different seasons, genders, and age groups.
Article
Environmental Sciences
Zi Ye, Man Cheng, Lieyang Fan, Jixuan Ma, Yingdie Zhang, Pei Gu, Yujia Xie, Xiaojie You, Min Zhou, Bin Wang, Weihong Chen
Summary: In this study, the potential role of miRNAs in zinc-related hyperglycemia and type 2 diabetes mellitus (T2DM) was explored through population-based studies and in vitro experiments. MiR-144-3p was found to be positively associated with urinary zinc, hyperglycemia, and the risk of T2DM. In vitro experiments confirmed that zinc-induced increase in miR-144-3p expression suppressed the target gene Nrf2 and downstream antioxidant enzymes, and aggravated insulin resistance.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jiahao Song, Man Cheng, Bin Wang, Min Zhou, Zi Ye, Lieyang Fan, Linling Yu, Xing Wang, Jixuan Ma, Weihong Chen
Summary: This study aimed to explore the potential role of miR-4301 in PM2.5 exposure-associated lung function reduction. The results showed that personal PM2.5 exposure was negatively associated with lung function and plasma miR-4301 expression. Additionally, miR-4301 partially mediated the lung function reduction associated with PM2.5 exposure, possibly through regulating the Wnt signaling pathway.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ruyi Liang, Xiaobing Feng, Da Shi, Linling Yu, Meng Yang, Min Zhou, Yongfang Zhang, Bin Wang, Weihong Chen
Summary: This study investigated the associations between the chemical compound 1,3-butadiene (BD) exposure and glucose dyshomeostasis and diabetes in the general population. The results showed that BD exposure was positively associated with an increased risk of glucose dyshomeostasis, prediabetes, and diabetes, and serum alkaline phosphatase (ALP) mediated these associations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Xiuquan Nie, Ge Mu, Yanjun Guo, Shijie Yang, Xing Wang, Zi Ye, Qiyou Tan, Mengyi Wang, Min Zhou, Jixuan Ma, Weihong Chen
Summary: This study found that urinary selenium concentration was positively associated with total cholesterol and low-density lipoprotein, but not with triglycerides and high-density lipoprotein. Methylation sites cg06964030 and cg15824094 partly mediated the association between selenium and total cholesterol. These findings provide insights into the effects and mechanisms of selenium exposure on lipid metabolism and highlight the importance of controlling selenium exposure and intake to prevent high blood lipids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Xuedan Xu, Jixuan Ma, Wending Li, Yutong You, Qin Jiang, Pinpin Long, Kang Liu, Tingting Mo, Jing Jiang, Wei Wang, Yanshou Lei, Tingyue Diao, Shuping Ruan, Xiaozheng Wang, Huan Guo, Weihong Chen, Tangchun Wu
Summary: In this study, associations between polycyclic aromatic hydrocarbons (PAHs) exposure and long non-coding RNA (lncRNA) were explored. The levels of urinary PAHs metabolites and plasma lncRNAs were measured, and several PAHs-related lncRNAs were identified. Tissue specificity analysis revealed that these lncRNAs might specifically express in organs targeted by PAHs exposure. Moreover, the associations between plasma levels of certain lncRNAs and their levels in leukocytes were also investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Xiaojie You, Xiuyu Cao, You Guo, Dongming Wang, Weihong Qiu, Chuanfei Zhou, Min Zhou, Weihong Chen, Xiaokang Zhang
Summary: A time series study in Ganzhou found positive associations between both short-term and long-term exposure to PM2.5 and hospital admissions for circulatory system diseases (CSD). The study provides valuable insights into the adverse effects of PM2.5 on CSD.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Ruyi Liang, Xiaobing Feng, Da Shi, Bin Wang, Yongfang Zhang, Wei Liu, Linling Yu, Zi Ye, Min Zhou, Weihong Chen
Summary: This study aimed to assess the association between pyrethroid exposure and glucose homeostasis, as well as the interaction between obesity and pyrethroid exposure. The findings indicated that pyrethroid exposure was associated with glucose dyshomeostasis, and the association between pyrethroid exposure and increased fasting plasma glucose (FPG) level was enhanced by general obesity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Mengyi Wang, Min Zhou, Qiyou Tan, Linling Yu, Chaoqian Dong, Ruyi Liang, Wei Liu, Yongfang Zhang, Minjing Li, XiuQuan Nie, Tao Jing, Weihong Chen
Summary: This study aimed to assess the associations between triazine herbicides and glycemia-related risk indicators in general adults. The results showed that triazine herbicides exposure was positively associated with abnormal glucose metabolism, and decreasing serum IgM partly mediated these associations among uninfected participants.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Qiyou Tan, Bin Wang, Zi Ye, Ge Mu, Wei Liu, Xiuquan Nie, Linling Yu, Min Zhou, Weihong Chen
Summary: Ozone pollution has adverse health effects and this study aimed to investigate the association between ozone exposure and glucose homeostasis. The results showed a positive association between ozone exposure and fasting plasma glucose, insulin, and insulin resistance, and a negative association with beta cell function. Ozone exposure was also related to increased C-reactive protein, oxidative DNA damage, and lipid peroxidation in a dose-response manner. The findings suggest that ozone exposure can damage glucose homeostasis and obese individuals may be more susceptible. Systemic inflammation and oxidative stress may be potential pathways in the glucose homeostasis damage induced by ozone exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Yongfang Zhang, Min Zhou, Ruyi Liang, Linling Yu, Man Cheng, Xing Wang, Bin Wang, Weihong Chen
Summary: The associations and potential mechanisms of low to moderate arsenic exposure with fasting plasma glucose (FPG) and type 2 diabetes mellitus (T2DM) were investigated in a cohort study. The results showed a significant association between arsenic exposure and increased FPG levels and risks of IFG, T2DM, and AGR among general Chinese adults.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Weihong Qiu, Heng He, Lieyang Fan, Xiaobing Feng, Minjing Li, Chaoqian Dong, Zhenzhen Li, Wei Liu, Ruyi Liang, Yingdie Zhang, Yongfang Zhang, Pei Gu, Bin Wang, Weihong Chen
Summary: Non-optimal ambient temperatures can affect lung function, leading to inflammation and oxidative damage, especially under low temperatures.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)