Article
Biochemistry & Molecular Biology
Irene Dervisi, Kosmas Haralampidis, Andreas Roussis
Summary: AtRD19c is a papain-like cysteine protease known for its participation in anther development and interaction with AtSBP1. Its gene expression is regulated by selenium and it localizes in the root tip, lateral roots, and leaf trichomes. The physical interaction with AtSBP1 was confirmed through BiFC in planta.
Article
Biochemistry & Molecular Biology
Soumen Bera, Alan M. Diamond
Summary: The contribution of selenium and selenoproteins in prostate cancer etiology is not well understood. This review highlights the role of two selenium-containing proteins, selenium binding protein 1 and selenoprotein F, in modulating the metabolic characteristics of prostate cancer, including oxidative phosphorylation and ATP synthesis, and their potential implications in growth advantage and therapeutic resistance.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Irene Dervisi, Orfeas Petropoulos, Adamantia Agalou, Varvara Podia, Nikolaos Papandreou, Vassiliki A. Iconomidou, Kosmas Haralampidis, Andreas Roussis
Summary: In this study, we investigated the role of AtSAH7, a member of the Ole e 1 domain-containing family, in Arabidopsis thaliana. We discovered a novel interaction between AtSAH7 and Selenium-binding protein 1 (AtSBP1). Our results showed that the minimal promoter for AtSAH7 is located 1420 bp upstream of the transcription start site and is responsible for inducing expression in vasculature tissues. Furthermore, we found that AtSAH7 expression is acutely increased under selenite treatment in response to oxidative stress, suggesting its involvement in a selenite-regulated biochemical network associated with ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Andreas Will, Hannes Richter, Patrick Rainer Winterhalter, Georg Pohnert, Holger Steinbrenner, Lars-Oliver Klotz
Summary: Methanethiol is a gas produced by microbial degradation of methionine, primarily originating from bacteria in the human large intestine. SELENBP1 has been identified as a methanethiol oxidase, converting it to other substances. Using a novel assay, researchers confirmed the loss of MTO function in SELENBP1 variants and found that mature enterocytes are capable of eliminating microbiome-derived methanethiol.
Article
Medicine, General & Internal
Xiaotian Zhang, Runqi Hong, Lanxin Bei, Zhiqing Hu, Ximin Yang, Tao Song, Liang Chen, He Meng, Gengming Niu, Chongwei Ke
Summary: This study found that the expression of SELENBP1 is significantly decreased in colorectal cancer (CRC) tissues compared to adjacent normal tissues, and further decreased in metastatic CRC. High expression of SELENBP1 is a predictor of favorable prognoses in CRC patients. Overexpression of SELENBP1 suppresses cell proliferation, migration, invasion, and tumorigenesis of CRC, potentially through inhibiting epithelial-mesenchymal transition.
Article
Biochemistry & Molecular Biology
Tabael L. Turan, Holger J. Klein, Julian Hackler, Livia Hoerner, Eddy Rijntjes, Theresia Reding Graf, Jan A. Plock, Lutz Schomburg
Summary: This study aimed to explore the feasibility of serum SELENBP1 as a biomarker for disease severity and clinical course in burn injury. The study found that serum SELENBP1 was initially elevated and rapidly declined within the first day. It was positively correlated with the Abbreviated Burn Severity Index (ABSI), and a higher ABSI was associated with increased risk of pulmonary infection. Baseline levels of serum SELENBP1 may serve as a novel but less accurate predictor of pulmonary infection risk.
Article
Biochemistry & Molecular Biology
Yingxia Song, Atsushi Kurose, Renshi Li, Tomoki Takeda, Yuko Onomura, Takayuki Koga, Junpei Mutoh, Takumi Ishida, Yoshitaka Tanaka, Yuji Ishii
Summary: The study conducted metabolomics and DNA microarray analysis on mice not treated with dioxin, revealing fluctuations in lipid metabolism-related gene expression levels in Selenbp1-deficient mice, including decreased Cyp4a expression and reduced Ppar alpha and Rxr alpha, ultimately leading to oxidative stress and alterations in lipid metabolism pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elisa B. Randi, Giovanna Casili, Simona Jacquemai, Csaba Szabo
Summary: The study found that SELENBP1 plays a crucial role in adipocyte differentiation in vitro. Silencing SELENBP1 led to decreased H2S levels, suppressed expression of the three classical H2S-producing enzymes, and significantly inhibited adipocyte differentiation.
Article
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Leon Gernoth, Andreas Will, Maria Schwarz, Verena Alexia Ohse, Anna Patricia Kipp, Holger Steinbrenner, Lars-Oliver Klotz
Summary: Selenium-binding protein 1 (SELENBP1) acts as a methanethiol oxidase (MTO) in humans, converting methanethiol to hydrogen peroxide, hydrogen sulfide, and formaldehyde. Copper ions are essential for this MTO activity, as demonstrated by mutagenesis studies. Selenium binding, on the other hand, is not required for MTO activity. SELENBP1 ortholog SEMO-1 in the nematode C. elegans also requires copper ions for MTO activity. SELENBP1 degrades volatile sulfur compounds (VSCs), including methanethiol, suggesting its role in mitigating malodors.
Article
Oncology
Zhongze Cui, Yangyang Li, Shuang He, Feifei Wen, Xiaoyang Xu, Lizhen Lu, Shuhua Wu
Summary: The study identified key gene VSIG2 associated with immune invasion and antigen presentation in colon adenocarcinoma using WGCNA analysis, indicating its important role in COAD development and progression. It could serve as a potential biomarker or therapeutic target for COAD.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Debashri Manna, Devanand Sarkar
Summary: Chemotherapy is a major treatment for cancers, but cancer cells often develop resistance through genetic and epigenetic alterations, allowing them to adapt to environmental stresses and treatment pressures. The oncogene AEG-1 plays a significant role in promoting tumorigenesis and chemoresistance in various cancers. Understanding the molecular mechanisms of AEG-1 could provide insights into overcoming chemoresistance in aggressive cancers.
Article
Biochemistry & Molecular Biology
Yi Jia, Xin Zhang, Yongmei Wang, Yang Liu, Jie Dai, Liangliang Zhang, Xian Wu, Jie Zhang, Hongxi Xiang, Yanping Yang, Zhu Zeng, Yulian Chen
Summary: This study suggests that SELENBP1 may be involved in the regulation of neurogenesis in depression and could serve as a potential target for diagnosing and treating depression. SELENBP1 levels were decreased in the blood of human patients with depression and in the hippocampus of mice with CUMS-induced depression. SELENBP1 knockout increased CUMS-induced depressive behavior in mice and caused dysregulation of inflammatory cytokines and oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Oncology
Shunsuke Kubota, Takuya Miura, Taiichi Wakiya, Tadashi Yoshizawa, Shintaro Goto, Hajime Morohashi, Yoshiyuki Sakamoto, Yota Tatara, Hiroshi Kijima, Kenichi Hakamada
Summary: This study found that extramural vascular invasion (EMVI) and tumor deposits (TD) are poor prognostic factors in rectal cancer (RC), especially when resistant to neoadjuvant chemotherapy (NAC). The differential expression of SELENBP1 may contribute to NAC resistance and poor prognosis in RC.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kazuki Kumon, Said M. Afify, Ghmkin Hassan, Shunsuke Ueno, Sadia Monzur, Hend M. Nawara, Hagar A. Abu Quora, Mona Sheta, Yanning Xu, Xiaoying Fu, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Summary: The study revealed that under chemical hypoxic conditions, CSCs may differentiate into blood cells, indicating an impact on tumor heterogeneity in the tumor microenvironment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fariborz Asghari Alashti, Bahram Goliaei, Zarrin Minuchehr
Summary: Early detection of colorectal cancer is important for better treatment outcomes. This study integrated multiple gene expression datasets and identified 17 common downregulated genes in colorectal cancer and colorectal adenoma. CLCA1 and SELENBP1 were identified as potential biomarkers for early detection of colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Oihana Iriondo, Yarong Liu, Grace Lee, Mostafa Elhodaky, Christian Jimenez, Lin Li, Julie Lang, Pin Wang, Min Yu
NATURE COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Janaina L. S. Donadio, Li Liu, Vincent L. Freeman, Dede N. Ekoue, Alan M. Diamond, Giovanna Bermano
Article
Biochemistry & Molecular Biology
Alan M. Diamond
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Endocrinology & Metabolism
Mostafa Elhodaky, Lenny K. Hong, Shrinidhi Kadkol, Alan M. Diamond
Review
Nutrition & Dietetics
Shrinidhi Kadkol, Alan M. Diamond
Article
Biochemistry & Molecular Biology
Lenny K. Hong, Shrinidhi Kadkol, Maria Sverdlov, Irida Kastrati, Mostafa Elhodaky, Ryan Deaton, Karen S. Sfanos, Heidi Wang, Li Liu, Alan M. Diamond
Summary: SELENOF is a selenoprotein involved in prostate cancer, with polymorphisms in the 3'-UTR region affecting the risk of prostate cancer mortality in African American men. Low levels of SELENOF in prostate cancer tissues may contribute to tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soumen Bera, Alan M. Diamond
Summary: The contribution of selenium and selenoproteins in prostate cancer etiology is not well understood. This review highlights the role of two selenium-containing proteins, selenium binding protein 1 and selenoprotein F, in modulating the metabolic characteristics of prostate cancer, including oxidative phosphorylation and ATP synthesis, and their potential implications in growth advantage and therapeutic resistance.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Hematology
Anne Gallivan, Mikail Alejandro, Amarachi Kanu, Nebeyat Zekaryas, Hart Horneman, Lenny K. Hong, Elliott Vinchinsky, Don Lavelle, Alan M. Diamond, Robert E. Molokie, Jagadeesh Ramasamy, Angela Rivers
Summary: Sickle cell disease is caused by a mutation of the fi-globin gene, resulting in the production of hemoglobin S. This leads to various symptoms and complications, including anemia, pain episodes, organ damage, and reduced life span. The pathophysiology involves the polymerization of HbS, which causes red blood cell deformability and the generation of reactive oxygen species. This study suggests that stress erythropoiesis contributes to mitochondrial retention, increased oxidative stress, and ultimately the progression of sickle cell disease.
EXPERIMENTAL HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Brenna Flowers, Oliwia Bochnacka, Allison Poles, Alan M. Diamond, Irida Kastrati
Summary: This review provides a summary of SELENOF's discovery, structure, cellular localization, and expression. It suggests a potential role for SELENOF in redox protein quality control, as well as lipid, glucose, and energy metabolism regulation. Recent evidence indicates that loss of SELENOF may contribute to prostate and breast cancer development, while its loss may be protective against colon cancer. Further investigation into SELENOF's molecular mechanisms and its impact on cancer is needed.
Review
Oncology
Victoria A. Forte, Dany K. Barrak, Mostafa Elhodaky, Lily Tung, Anson Snow, Julie E. Lang
CANCER BIOLOGY & MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Dede N. Ekoue, Emmanuel Ansong, Lenny K. Hong, Larisa Nonn, Virgilia Macias, Ryan Deaton, Rawan Rupnow, Peter H. Gann, Andre Kajdacsy-Balla, Alan M. Diamond
